Preparation, Characterization, and Swelling Behavior of PEGylated Guar Gum @ Ag Nanoparticles

Production cost savings by lowering basis weight has been a trend in papermaking. The strategy has been to decrease the amount of softwood kraft pulp and increase use of fillers and recycled fibers. These changes have a tendency to lower strength properties of both the wet and dry web. To compensate for the strength loss in the paper, a greater quantity of strength additives is often required, either dosed at the wet end or applied to the wet web by spray. In this pilot-scale study, it was shown how strength additives can be effectively applied with foam-based application technology. The technology can simultaneously increase dryness after wet pressing and enhance dry and wet web strength properties. Foam application of polyvinyl alcohol (PVA), ethylene vinyl alcohol (EVOH), carboxymethyl cellulose (CMC), guar gum, starch, and cellulose microfibrils (CMF) increased web dryness after wet pressing up to 5.2%-units compared to the reference sample. The enhanced dewatering with starch, guar gum, and CMF was detected with a bulk increase. Additionally, a significant increase in z-directional tensile strength of dry web and and in-plane tensile strength properties of wet web was obtained. Based on the results, foam application technology can be a very useful technology for several applications in the paper industry.

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A Biological Approach of Silver (Ag) Nanoparticles Synthesis Using Leaf Extract of Adhatoda Vasica

International Journal of Scientific Research ◽

10.15373/22778179/feb2014/57 ◽

2012 ◽

Vol 3 (2) ◽

pp. 177-179

Author(s):

Dr. K.Vinoth Kumar Dr. K.Vinoth Kumar ◽

◽

Dr. C. Udayasoorian Dr. C. Udayasoorian

Keyword(s):

Ag Nanoparticles ◽

Leaf Extract ◽

Adhatoda Vasica ◽

Biological Approach ◽

Nanoparticles Synthesis

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Formulation and Evaluation of Microbially- triggered tablets of Valdecoxib

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v2i1.8841 ◽

2010 ◽

Vol 2 (1) ◽

Author(s):

Surender Verma ◽

S. Singh ◽

D. Mishra ◽

Atul Gupta ◽

Rakesh Sharma

Keyword(s):

Phosphate Buffer ◽

Guar Gum ◽

Oral Route ◽

Matrix Tablets ◽

In Vitro Dissolution ◽

Wet Granulation ◽

Dissolution Study ◽

Caecal Content ◽

Model Drug

The objective of present study was to develop colon targeted drug delivery using bacterially triggered approach through oral route. Valdecoxib (COX-2 inhibitor) was chosen as a model drug in order to target it to colon which may prove useful in inflammatory bowel disease and related disorders. Matrix tablets of Valdecoxib were prepared by wet granulation technique utilizing different ratio of Guar gum and Sodium starch glycholate. The prepared matrix tablets were evaluated for uniformity of weight, uniformity of content, hardness and in vitro dissolution study in simulated gastric and intestinal fluid (Phosphate Buffer pH-1.2, pH-6.8 and pH-7.4), followed by Dissolution study in bio-relevant dissolution media Phosphate Buffer (pH-6.8) containing rat caecal content. The results revealed that the formulated batch had released lesser quantity of drug at pH 1.2 and pH 7.4 in 2 hors whereas in biorelevent dissolution media containing rat caecal content it released significantly higher amount of drug which was also significantly higher than the dissolution media of same pH without caecal content (microflora) and it was concluded that guar gum can be used as a potential carrier for targeting drugs to colon.

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pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.9.2.4 ◽

2019 ◽

Vol 9 (02) ◽

Author(s):

Sharma Pankaj ◽

Tailang Mukul

Keyword(s):

Drug Release ◽

Delivery System ◽

Targeted Delivery ◽

Guar Gum ◽

Acidic Environment ◽

Natural Polymers ◽

Weight Variation ◽

Curve Determination ◽

Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

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