scholarly journals Chiral Hybrid Nanosystems and Their Biosensing Applications

2020 ◽  
Author(s):  
Vladimir E. Bochenkov ◽  
Tatyana I. Shabatina
Keyword(s):  
Refractive Index ◽  
Electric Fields ◽  
Metal Nanostructures ◽  
Order Structure ◽  
Molecular Adsorption ◽  
Label Free ◽  
Label Free Detection ◽  
Hybrid Nanosystems ◽  
Local Refractive Index

The presented chapter is devoted to chiral biosensing using various metal nanostructures and their hybrid nanosystems with optically active bio- and organic molecules. Plasmonic nanosystems and nanostructures provide an excellent platform for label-free detection of molecular adsorption by detecting tiny changes in the local refractive index or amplification of light-induced processes in biomolecules. Based on recent theoretical and experimental developments in plasmon-enhanced local electric fields, we consider the main types of molecular-plasmonic hybrid systems capable of generating an amplified chiroptical signal for such applications as detecting the presence of certain biomolecules and (in some cases) determination of their orientation and higher-order structure.

scholarly journals Chiral Plasmonic Biosensors

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 120 ◽  
Author(s):  
Vladimir Bochenkov ◽  
Tatyana Shabatina
Keyword(s):  
Refractive Index ◽  
Surface Plasmon Resonance ◽  
Plasmonic Nanostructures ◽  
Label Free ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Recent Developments ◽  
Detection Of Biomolecules ◽  
Local Refractive Index ◽  
Unique Capability

Biosensing requires fast, selective, and highly sensitive real-time detection of biomolecules using efficient simple-to-use techniques. Due to a unique capability to focus light at nanoscale, plasmonic nanostructures provide an excellent platform for label-free detection of molecular adsorption by sensing tiny changes in the local refractive index or by enhancing the light-induced processes in adjacent biomolecules. This review discusses the opportunities provided by surface plasmon resonance in probing the chirality of biomolecules as well as their conformations and orientations. Various types of chiral plasmonic nanostructures and the most recent developments in the field of chiral plasmonics related to biosensing are considered.

Label free detection of DNA hybridization by refractive index tapered fiber biosensor

2010 ◽  
Author(s):  
M. I. Zibaii ◽  
H. Latifi ◽  
E. Ghanati ◽  
M. Gholami ◽  
S. M. Hosseini
Keyword(s):  
Refractive Index ◽  
Dna Hybridization ◽  
Label Free ◽  
Tapered Fiber ◽  
Label Free Detection

Integration of digital microfluidics with whispering-gallery mode sensors for label-free detection of biomolecules

Lab on a Chip ◽  
2017 ◽  
Vol 17 (10) ◽  
pp. 1740-1748 ◽  
Author(s):  
Sentayehu F. Wondimu ◽  
Sebastian von der Ecken ◽  
Ralf Ahrens ◽  
Wolfgang Freude ◽  
Andreas E. Guber ◽  
...  
Keyword(s):  
Refractive Index ◽  
Digital Microfluidics ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Biosensor Arrays ◽  
Whispering Gallery ◽  
Label Free Detection ◽  
Detection Of Biomolecules

WGM biosensor arrays are integrated with a DMF system. The viability of the system is demonstrated by refractive-index and biosensing experiments.

Label-free determination of adenosine and mercury ions according to force mapping-based force-to-color variety

The Analyst ◽  
2018 ◽  
Vol 143 (18) ◽  
pp. 4400-4407 ◽  
Author(s):  
Qing Li ◽  
Gang Wei
Keyword(s):  
Label Free ◽  
Mercury Ions ◽  
Label Free Detection ◽  
Force Mapping

Force mapping can be used as a novel force-to-color sensing technique for the label-free detection of adenosine and Hg2+.

scholarly journals Determination of Local Refractive Index for Protein and Virus Crystals in Solution by Mach-Zehnder Interferometry

1995 ◽  
Vol 231 (1) ◽  
pp. 92-98 ◽  
Author(s):  
T. Cole ◽  
A. Kathman ◽  
S. Koszelak ◽  
A. Mcpherson
Keyword(s):  
Refractive Index ◽  
Local Refractive Index

scholarly journals Direct and Competitive Optical Grating Immunosensors for Determination of Fusarium Mycotoxin Zearalenone

Toxins ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 43
Author(s):  
Inna Székács ◽  
Nóra Adányi ◽  
István Szendrő ◽  
András Székács
Keyword(s):  
Environmental Safety ◽  
Detection Methods ◽  
Label Free ◽  
Detection Range ◽  
Fusarium Mycotoxin ◽  
Label Free Detection ◽  
Optical Grating ◽  
Covalent Immobilisation ◽  
Magnitude Improvement

Novel optical waveguide lightmode spectroscopy (OWLS)-based immunosensor formats were developed for label-free detection of Fusarium mycotoxin zearalenone (ZON). To achieve low limits of detection (LODs), both immobilised antibody-based (direct) and immobilised antigen-based (competitive) assay setups were applied. Immunoreagents were immobilised on epoxy-, amino-, and carboxyl-functionalised sensor surfaces, and by optimising the immobilisation methods, standard sigmoid curves were obtained in both sensor formats. An outstanding LOD of 0.002 pg/mL was obtained for ZON in the competitive immunosensor setup with a dynamic detection range between 0.01 and 1 pg/mL ZON concentrations, depending on the covalent immobilisation method applied. This corresponds to a five orders of magnitude improvement in detectability of ZON relative to the previously developed enzyme-linked immonosorbent assay (ELISA) method. The selectivity of the immunosensor for ZON was demonstrated with structural analogues (α-zearalenol, α-zearalanol, and β-zearalanol) and structurally unrelated mycotoxins. The method was found to be applicable in maize extract using acetonitrile as the organic solvent, upon a dilution rate of 1:10,000 in buffer. Thus, the OWLS immunosensor method developed appears to be suitable for the quantitative determination of ZON in aqueous medium. The new technique can widen the range of sensoric detection methods of ZON for surveys in food and environmental safety assessment.

Ultrasensitive and label-free detection of creatine based on CdO nanoparticles: a real sample approach

2017 ◽  
Vol 41 (14) ◽  
pp. 6667-6677 ◽  
Author(s):  
Mohammed M. Rahman ◽  
Mohammad Musarraf Hussain ◽  
Abdullah M. Asiri
Keyword(s):  
Dynamic Range ◽  
Limit Of Detection ◽  
Cadmium Oxide ◽  
Real Sample ◽  
Label Free ◽  
Long Term Stability ◽  
Label Free Detection ◽  
Cdo Nanoparticles ◽  
Low Dimensional

Low-dimensional cadmium oxide nanoparticles (CdO NPs) were prepared by a facile wet-chemical method, which later electrochemically investigated for the determination of selective creatine and measured the analytical sensor parameters such as sensitivity, limit of detection (LOD), linear dynamic range (LDR), long-term stability, and real-sample validation.

scholarly journals Determination of local refractive index variations in thin films by heterodyne interferometric scanning near-field optical microscopy

2009 ◽  
Vol 80 (9) ◽  
pp. 093706 ◽  
Author(s):  
Séverine Diziain ◽  
Jean-Marc Merolla ◽  
Michel Spajer ◽  
Giacomo Benvenuti ◽  
Ali Dabirian ◽  
...  
Keyword(s):  
Thin Films ◽  
Refractive Index ◽  
Optical Microscopy ◽  
Near Field ◽  
Local Refractive Index

scholarly journals Rayleigh anomaly-enabled mode hybridization in gold nanohole arrays by scalable colloidal lithography for highly-sensitive biosensing

Nanophotonics ◽  
2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Zhiliang Zhang ◽  
Feng Zhao ◽  
Renxian Gao ◽  
Chih-Yu Jao ◽  
Churong Ma ◽  
...  
Keyword(s):  
Refractive Index ◽  
Plasmonic Nanostructures ◽  
Label Free ◽  
Colloidal Lithography ◽  
Large Area ◽  
Nanohole Array ◽  
Highly Sensitive ◽  
Label Free Detection ◽  
Nanohole Arrays ◽  
Rayleigh Anomaly

Abstract Plasmonic sensors exhibit tremendous potential to accomplish real-time, label-free, and high-sensitivity biosensing. Gold nanohole array (GNA) is one of the classic plasmonic nanostructures that can be readily fabricated and integrated into microfluidic platforms for a variety of applications. Even though GNA has been widely studied, new phenomena and applications are still emerging continuously expanding its capabilities. In this article, we demonstrated narrow-band high-order resonances enabled by Rayleigh anomaly in the nanohole arrays that are fabricated by scalable colloidal lithography. We fabricated large-area GNAs with different hole diameters, and investigated their transmission characteristics both numerically and experimentally. We showed that mode hybridization between the plasmon mode of the nanoholes and Rayleigh anomaly of the array could give rise to high-quality decapole resonance with a unique nearfield profile. We experimentally achieved a refractive index sensitivity, i.e., RIS up to 407 nm/RIU. More importantly, we introduced a spectrometer-free refractive index sensing based on lens-free smartphone imaging of GNAs with (intensity) sensitivity up to 137%/RIU. Using this platform, we realized the label-free detection of BSA molecules with concentration as low as 10−8 M. We believe our work could pave the way for highly sensitive and compact point-of-care devices with cost-effective and high-throughput plasmonic chips.

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