scholarly journals Current Scenario of Regenerative Medicine: Role of Cell, Scaffold and Growth Factor

2021 ◽  
Author(s):  
Nilkamal Pramanik ◽  
Tanmoy Rath
Keyword(s):  
Growth Factors ◽  
Regenerative Medicine ◽  
Organ Transplantation ◽  
Tissue Injury ◽  
Human Life ◽  
Organ Donor ◽  
Tissue Reconstruction ◽  
Current Scenario ◽  
Tissue Implantation ◽  
Triangular Relationship

Impairment of the clinical tissue-implantation is due to the lack of a suitable organ donor and immunogenic rejection, which leads to the cause for the enormous loss of human life. The introduction of artificial regeneration of tissues by Langer and Vacanti in 1993, has revolutionized in the field of surgical organ transplantation, to alleviate the problem of tissue injury-related death. There is no doubt that the term “regenerative medicine” to open a new space of tissue reconstruction, but the complications that arise due to the proper machinery of the cell, supporting biomaterials and growth factors has yet to be resolved to expand its application in a versatile manner. The chapter would provide a significant overview of the artificial tissue regeneration while a triangular relationship between cells, matrixes, and growth factors should be established mentioning the necessity of biomedical tools as an alternative to organ transplantation.

Trans-dentinal Stimulation of Tertiary Dentinogenesis

2001 ◽  
Vol 15 (1) ◽  
pp. 51-54 ◽  
Author(s):  
A.J. Smith ◽  
P.E. Murray ◽  
A.J. Sloan ◽  
J.B. Matthews ◽  
S. Zhao
Keyword(s):  
Growth Factors ◽  
Tissue Injury ◽  
Careful Consideration ◽  
Active Components ◽  
Restorative Treatment ◽  
Cellular Events ◽  
Dentin Matrix ◽  
Dentin Thickness ◽  
Tertiary Dentinogenesis ◽  
Stimulation Of

Trans-dentinal stimulation of tertiary dentinogenesis has long been recognized, and has traditionally been ascribed to diffusion of irritant substances arising during injury and restorative treatment. Identification of bio-active components, especially growth factors including TGF-βs, sequestered within dentin matrix provides a new explanation for cellular signaling during tertiary dentinogenesis. Both isolated dentin matrix components and pure growth factors (TGF-βs) have been shown to signal cellular events leading to reactionary and reparative tertiary dentinogenesis. Release of these bio-active components from dentin matrix may arise during carious attack and other injury to the tissue, and also during subsequent surgical intervention and restoration of the tooth. Both cavity-conditioning agents and leaching from restorative materials may contribute to release of these components. Distance of diffusion, as determined by cavity residual dentin thickness, and other restorative parameters may influence the signaling process after release of these components. Careful consideration of the interplay between tissue injury and surgical and restorative material factors is required for optimum exploitation of the exquisite regenerative capacity of dentin-pulp for more biological approaches to clinical treatment of dental disease.

scholarly journals Real-Time Healthcare Intelligence in Organ Transplantation

2018 ◽  
pp. 128-152
Author(s):  
Bruno Fernandes ◽  
Cecília Coimbra ◽  
António Abelha
Keyword(s):  
Decision Making ◽  
Organ Transplantation ◽  
Organ Donor ◽  
Decision Making Process ◽  
Organ Donors ◽  
Potential Organ Donor ◽  
Critical Areas ◽  
Deceased Donors ◽  
End Stage ◽  
Donor Criteria

Organ transplantation is the best and often the only treatment for patients with end-stage organ failure. However, the universal shortage of deceased donors results in a worrying situation that must be addressed. Brain dead donors constitute the largest share of organ donors, but identifying a patient that may progress to brain death can be a complex task. Therefore, the urgent need of intelligent solutions to support the decision-making process is crucial in critical areas as the organ transplantation is. This work aims at acquiring knowledge on the potential organ donor criteria for further detection and implementing a platform to assist the process of identification of potential organ donors at Centro Hospitalar do Porto – Hospital de Santo António. The developed system is currently implemented and displays a steady and competent behavior providing consequently a way to have more control of the information needed for the decision-making process

scholarly journals Knowledge and attitude of law, medicine, and mass-communication students towards deceased organ donation

2020 ◽  
Vol 8 (1) ◽  
pp. 22
Author(s):  
Pragya Paneru ◽  
Shyam S. Budhathoki ◽  
Samyog Uprety ◽  
Birendra K. Yadav ◽  
Rashmi Mulmi ◽  
...  
Keyword(s):  
Organ Donation ◽  
Organ Failure ◽  
Organ Transplantation ◽  
Mass Communication ◽  
Organ Donor ◽  
Cross Sectional Study ◽  
World Health ◽  
Cross Sectional ◽  
Deceased Organ Donation ◽  
Knowledge And Attitude

Background: With the global increase in the incidence organ failure and subsequent advancement in the medical technology, organ transplantation is growing as the best choice of treatment among the patients with various kinds of organ failure. However, the rate of deceased organ donation is relatively low in South-East Asia regions, including Nepal. This has created a mismatch between the demand and supply of organs for transplantation. World Health Organization encourages organ transplantation from a deceased organ donor as there is no risk to the donor. Thus, this paper aimed to assess knowledge and attitude of literate group specifically towards deceased organ donation.Methods: This was a cross-sectional study conducted among 299 students selected conveniently from medicine, law, and mass communication streams from 9 different colleges (3 colleges from each stream) of Kathmandu. Data was collected through a self-administered questionnaire. Knowledge level was classified into three different categories based on obtained scores and attitude was analyzed based on five-point Likert scale.Results: Almost half (48.8%) of the respondents while only 7% had high level of knowledge on the organ donation and transplantation. Similarly, 95% of the people had positive attitude towards organ donation. However, there was a weak correlation between knowledge and attitude of the respondents. None of the respondents carried an organ donation card.Conclusions: There is a need to plan robust strategies to educate people on organ donation so that they can make pragmatic decisions to register their names for deceased organ donation.

scholarly journals The application of resveratrol to mesenchymal stromal cell-based regenerative medicine

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Chenxia Hu ◽  
Lanjuan Li
Keyword(s):  
Regenerative Medicine ◽  
Tissue Injury ◽  
Lineage Commitment ◽  
Root Extract ◽  
Therapeutic Effects ◽  
Aging Effects ◽  
Chronic Injury ◽  
Self Renewal

Abstract Currently, the transplantation of mesenchymal stromal cells (MSCs) has emerged as an effective strategy to protect against tissue and organ injury. MSC transplantation also serves as a promising therapy for regenerative medicine, while poor engraftment and limited survival rates are major obstacles for its clinical application. Although multiple studies have focused on investigating chemicals to improve MSC stemness and differentiation in vitro and in vivo, there is still a shortage of effective and safe agents for MSC-based regenerative medicine. Resveratrol (RSV), a nonflavonoid polyphenol phytoalexin with a stilbene structure, was first identified in the root extract of white hellebore and is also found in the roots of Polygonum cuspidatum, and it is widely used in traditional Chinese medicine. RSV is a natural agent that possesses great therapeutic potential for protecting against acute or chronic injury in multiple tissues as a result of its antioxidative, anti-inflammatory, and anti-cancer properties. According to its demonstrated properties, RSV may improve the therapeutic effects of MSCs via enhancing their survival, self-renewal, lineage commitment, and anti-aging effects. In this review, we concluded that RSV significantly improved the preventive and therapeutic effects of MSCs against multiple diseases. We also described the underlying mechanisms of the effects of RSV on the survival, self-renewal, and lineage commitment of MSCs in vitro and in vivo. Upon further clarification of the potential mechanisms of the effects of RSV on MSC-based therapy, MSCs may be able to be more widely used in regenerative medicine to promote recovery from tissue injury.

Potential Role of Growth Factors in Diminishing Radiation Therapy Neural Tissue Injury

2005 ◽  
Vol 32 ◽  
pp. 67-70 ◽  
Author(s):  
Nicolaus H. Andratschke ◽  
Carsten Nieder ◽  
Roger E. Price ◽  
Belinda Rivera ◽  
K. Kian Ang
Keyword(s):  
Radiation Therapy ◽  
Growth Factors ◽  
Potential Role ◽  
Tissue Injury ◽  
Neural Tissue

scholarly journals Growth Factors in Regeneration and Regenerative Medicine: “the Cure and the Cause”

2020 ◽  
Vol 11 ◽  
Author(s):  
Konstantin Yu. Kulebyakin ◽  
Peter P. Nimiritsky ◽  
Pavel I. Makarevich
Keyword(s):  
Growth Factors ◽  
Regenerative Medicine

scholarly journals Does It Matter How We Die? Ethical and Legal Issues Raised by Combining Euthanasia and Organ Transplantation

2019 ◽  
Vol 86 (4) ◽  
pp. 359-365 ◽  
Author(s):  
Margaret Somerville
Keyword(s):  
Organ Donation ◽  
Organ Transplantation ◽  
Human Dignity ◽  
Healthcare Professionals ◽  
Conflicts Of Interest ◽  
Human Life ◽  
Definition Of Death ◽  
Dead Donor Rule ◽  
Ethical And Legal Issues ◽  
Definition Of

If, in jurisdictions with legalized euthanasia, obtaining organs for transplant from euthanized people is allowed, must their organs be taken only after death or should euthanasia be allowed to be performed by removal of vital organs? Asked another way, if “Donation after Death” is practiced, why not “Death by Donation?” The article addresses two questions. First, “What issues does connecting euthanasia and organ donation raise?” They include dealing with uncertainty regarding the definition of death, defining what constitutes conscientiously objecting healthcare professionals' involvement in euthanasia, and whether connecting euthanasia and transplantation makes conflicts of interest for healthcare professionals unavoidable. Additional issues raised by death by donation include breach of the “dead-donor rule”; what would constitute informed consent to it; and what impact its acceptance would have on important foundational societal values, especially respect for human dignity and human life. The second question is “Why might some people who agree with euthanasia and even organ donation after death by euthanasia find death by donation ethically unacceptable?” Considerations again include its harmful impact on upholding respect for human dignity and human life and that the “wisdom of repugnance” could be informing these people's reaction. It is concluded that in order to avoid serious breaches of ethics, organ transplantation and euthanasia should not be linked in any way.

Useful applications of growth factors for cardiovascular regenerative medicine

2020 ◽  
Vol 38 (1) ◽  
pp. 35-63
Author(s):  
Maria Rosaria De Pascale ◽  
Nunzia Della Mura ◽  
Michele Vacca ◽  
Claudio Napoli
Keyword(s):  
Growth Factors ◽  
Regenerative Medicine
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