scholarly journals Introducer Percutaneous Endoscopic Gastrostomy in Palliative Care of Patients with Esophageal Cancer

2020 ◽  
Author(s):  
Prasit Mahawongkajit
Keyword(s):  
Palliative Care ◽  
Esophageal Cancer ◽  
Cancer Cells ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Invasive Procedure ◽  
Safe Alternative ◽  
Endoscopic Gastrostomy ◽  
Gastric Feeding ◽  
Nutritional Benefits ◽  
Esophageal Cancer Cells

In the treatment of esophageal cancer and palliative care, nutritional status plays an important role in the patients’ tolerance of treatment, affects the quality of life, and outcomes. Alimentation in such patients can be achieved by enteral or parenteral nutrition but the enteral route is the preferring option. Pre-pyloric feeding is easier and may result in greater nutritional benefits than post-pyloric feeding. Gastrostomy is the conventional option for intra-gastric feeding, hydration, and drug administration. Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure and is currently the procedure of choice. Two PEG techniques are clinically used worldwide: pull and push or introducer method. The pull-type technique is the most commonly used method, but the concerning point is that the implantation of esophageal cancer cells into the gastrostomy stroma. The introducer method is a safe alternative and effective technique for enteral feeding to the stomach with the avoidance of cancer cells seeding.

PS02.134: COMPARISON OF PUSH PERCUTANEOUS ENDOSCOPIC GASTROSTOMY WITH OPEN GASTROSTOMY IN ADVANCED ESOPHAGEAL CANCER PATIENTS

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 159-159
Author(s):  
Prasit Mahawongkajit
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Conflicts Of Interest ◽  
Invasive Procedure ◽  
Feeding Tube ◽  
Treatment Quality ◽  
Advanced Esophageal Cancer ◽  
Endoscopic Gastrostomy ◽  
Improve Patient

Abstract Background In esophageal cancer treatment, nutrition by feeding tube has been demonstrated to improve patient tolerance of treatment, quality of life, and long term outcomes. The open gastrostomy and percutaneous endoscopic gastrostomy (PEG) push technique are procedures that avoid cancer cells seeding and also improve patient nutritional status. The aim of this study is to compare the results of the push PEG and open gastrostomy in patients with advanced esophageal cancer. Methods A retrospective study was analyzed in the advanced esophageal cancer patients who indicated and received feeding support between January 2016 and December 2017. Results 28 patients in push PEG and 36 patients in open gastrostomy presented the following comparative data: mean operative duration time shorter in push PEG (11.9 min) than open gastrostomy (35.1 min), less blood loss in push PEG (0.8 mL) than open gastrostomy (5.6 mL), less pain score in push PEG (2.4) than open gastrostomy (5.9) and shorter hospitalization in push PEG (1.8 days) than open gastrostomy (2.6 days). Both groups showed no readmission or 30 day mortality. The adverse events of open gastrostomy demonstrated higher than push PEG group. Conclusion Both push PEG and open gastrostomy were the safe options for advanced esophageal cancer patients indicating for enteral nutrition and to avoid cancer cell seeding. The push PEG demonstrated the effective minimally invasive procedure, was safe and with fewer complications. Disclosure All authors have declared no conflicts of interest.

scholarly journals EMT Participates in the Regulation of Exosomes Secretion and Function in Esophageal Cancer Cells

2021 ◽  
Vol 20 ◽  
pp. 153303382110330
Author(s):  
Chuangui Chen ◽  
Zhao Ma ◽  
Hongjing Jiang
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Promoting Effect ◽  
Migration Ability ◽  
Mesenchymal Transition ◽  
Invasion And Migration ◽  
And Migration ◽  
And Function ◽  
Esophageal Cancer Cells

Epithelial-mesenchymal transition (EMT) is a key step in tumor invasion and distant metastasis. Abundant evidence has documented that exosomes can mediate EMT of tumor cells and endow them with the ability of invasion and migration. However, there are few studies focusing on whether EMT can reverse the secretion of exosomes. In this study, 2 esophageal cancer cells (FLO-1 and SK-GT-4) were selected to compare the migration ability and EMT activation, and to further analyze the secretion ability of exosomes of the 2 cell lines. According to the results, inhibited activation of EMT in FLO-1 cells with relatively high migration ability could effectively reduce the secretion of exosomes. Besides, in SK-GT-4 cells, EMT activation induced by TGF-β could promote the secretion of exosomes. FLO-1 cell derived exosomes exhibited a paracrine effect of promoting the migration of SK-GT-4 cells, and the use of EMT inhibitors could weaken this ability. Furthermore, inhibition of EMT could change the relative content of some miRNAs in exosomes, with a particularly significant downregulation in the expression of miR-196-5p, miR-21-5p and miR-194-5p. Significantly, artificial transfection of the 3 miRNAs into exosomes by electroporation resulted in the recovery of migration-promoting effect of exosomes. Subsequent experiments further revealed that the effect of EMT on these miRNAs could be explained by the intracellular transcription level or the specific sorting mechanism of exosomes. To sum up, our study undoubtedly reveals that EMT has a regulatory effect on exosomes in the quantity and contents in esophageal cancer cells. Significantly, findings in our study provide experimental evidence for the interaction of EMT with the secretion and sorting pathway of exosomes, and also give a new direction for the further study of tumor metastasis.

Metastatic hypopharyngeal and esophageal cancer to a percutaneous endoscopic gastrostomy site

Esophagus ◽  
2008 ◽  
Vol 5 (3) ◽  
pp. 155-156 ◽  
Author(s):  
Naruo Kawasaki ◽  
Yutaka Suzuki ◽  
Takakuni Kato ◽  
Kazuto Tsuboi ◽  
Akira Matsumoto ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Endoscopic Gastrostomy

scholarly journals Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1065
Author(s):  
Joseph-Hang Leung ◽  
Hong-Thai Nguyen ◽  
Shih-Wei Feng ◽  
Sofya B. Artemkina ◽  
Vladimir E. Fedorov ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Carrier Transport ◽  
X Ray Diffraction ◽  
Photoelectrochemical Response ◽  
Carrier Separation ◽  
Human Esophageal Cancer ◽  
P Type ◽  
Esophageal Cancer Cells

P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller photocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement.

scholarly journals Inhibition of pRB Pathway Differentially Modulates Apoptosis in Esophageal Cancer Cells

2017 ◽  
Vol 10 (5) ◽  
pp. 726-733 ◽  
Author(s):  
Rossana C. Soletti ◽  
Deborah Biasoli ◽  
Nathassya A.L.V. Rodrigues ◽  
João M.A. Delou ◽  
Renata Maciel ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Esophageal Cancer Cells

scholarly journals Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Gizem Calibasi Kocal ◽  
Sinan Güven ◽  
Kira Foygel ◽  
Aaron Goldman ◽  
Pu Chen ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Phenotypic Plasticity ◽  
Cancer Cells ◽  
Esophageal Cancer Cells

Enhancement of radiotherapeutic efficacy for esophageal cancer by paclitaxel-loaded red blood cell membrane nanoparticles modified by the recombinant protein anti-EGFR-iRGD

2018 ◽  
Vol 33 (5) ◽  
pp. 707-724 ◽  
Author(s):  
Wei Ren ◽  
Huizi Sha ◽  
Jing Yan ◽  
Puyuan Wu ◽  
Ju Yang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cell Membrane ◽  
Recombinant Protein ◽  
Blood Cell ◽  
Cancer Cells ◽  
Red Blood Cell ◽  
Enhancement Ratio ◽  
Red Blood Cell Membrane ◽  
Egfr Expression ◽  
Esophageal Cancer Cells

Paclitaxel is widely used as a radiosensitizer for various tumors, including esophageal cancer, but its therapeutic effect remains to be improved. In this study, we constructed a novel nano-radiosensitizer, anti-EGFR-iRGD-conjugated (iE)-PRNPs, by conjugating the recombinant protein anti-epidermal growth factor receptor (EGFR)-internalizing arginine-glycine-aspartic (iRGD) to the surface of paclitaxel-loaded red blood cell membrane nanoparticles (PRNPs). The iE-PRNPs were confirmed to possess tumor-targeting, high penetrability, and sustained release properties that free paclitaxel does not possess. Compared with that of paclitaxel, the sensitizer enhancement ratio of iE-PRNPs was significantly increased (1.32-fold and 1.25-fold) in esophageal cancer cells with high and low expression levels of EGFR, respectively. Additionally, compared with that of unmodified PRNPs, the sensitizer enhancement ratio of iE-PRNPs in EGFR-overexpressing esophageal cancer cells was significantly increased (1.27-fold), while that of PRNPs in esophageal cancer cells with a low EGFR expression level increased slightly (1.06-fold). The improved radiosensitization effect was associated with enhanced G2/M arrest, increased reactive oxygen species, and more effective induction of DNA double-strand breaks. In summary, iE-PRNPs appear to be a novel type of radiosensitizer with the potential to overcome the bottleneck of esophageal cancer radiotherapeutic efficacy.

scholarly journals Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Eileen Looby ◽  
Mohamed MM Abdel-Latif ◽  
Veronica Athié-Morales ◽  
Shane Duggan ◽  
Aideen Long ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Cox 2 ◽  
Esophageal Cancer Cells
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