scholarly journals Therapeutic Effect of Infra-Low-Frequency Neurofeedback Training on Children and Adolescents with ADHD

2021 ◽  
Author(s):  
Horst Schneider ◽  
Jennifer Riederle ◽  
Sigrid Seuss
Keyword(s):  
Impulse Control ◽  
Performance Test ◽  
Clinical Symptoms ◽  
Test Procedure ◽  
Substantial Reduction ◽  
Low Frequency ◽  
Time Variability ◽  
Childhood And Adolescence ◽  
Pharmaceutical Therapy ◽  
Before And After

In this observational study the outcomes of an EEG-based infra-low-frequency (ILF) neurofeedback intervention on patients with attention deficit (hyperactivity) disorder (ADHD) are presented. The question is addressed whether this computer-aided treatment, which uses a brain-computer-interface to alleviate the clinical symptoms of mental disorders, is an effective non-pharmaceutical therapy for ADHD in childhood and adolescence. In a period of about 15 weeks 196 ADHD patients were treated with about 30 sessions of ILF neurofeedback in an ambulant setting. Besides regular evaluation of the severity of clinical symptoms, a continuous performance test (CPT) for parameters of attention and impulse control was conducted before and after the neurofeedback treatment. During and after the therapy, the patients did not only experience a substantial reduction in the severity of their ADHD-typical clinical symptoms, but also their performance in a continuous test procedure was significantly improved for all examined parameters of attention and impulse control, like response time, variability of reaction time, omission errors and commission errors. In a post neurofeedback intervention assessment 97% of patients reported improvement in symptoms of inattention, hyperactivity or impulsivity. Only 3% of the patients claimed no noticeable alleviation of ADHD-related symptoms. These results suggest that ILF neurofeedback is a clinically effective method that can be considered as a treatment option for ADHD and might help reducing or even avoiding psychotropic medication.

scholarly journals PREVALENCE AND CHARACTERISTICS OF TUBERCULOSIS IN HIV-INFECTED PATIENTS CONSIDERING THE 299GLY ALLELE TLR4 GENE CARRIAGE

2021 ◽  
Vol 21 (2) ◽  
pp. 62-66
Author(s):  
T. I. Koval ◽  
A. H. Marchenko ◽  
T. M. Kotelevska ◽  
N. P. Lymarenko ◽  
O. V. Artemieva
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Opportunistic Infections ◽  
Clinical Symptoms ◽  
Low Frequency ◽  
Modern Medicine ◽  
Hiv Positive ◽  
Before And After ◽  
Tlr4 Gene ◽  
Immunodeficiency Syndrome

Human immunodeficiency virus (HIV) infection remains one of the most acute problems of modern medicine. Tuberculosis is known as the leading cause of death among the opportunistic infections in HIV-positive people; moreover, TB is also known as resulting in one of three deaths associated with acquired immunodeficiency syndrome. It should be stressed the TB course against the background of HIV infection demonstrates the atypical characteristics, nonspecific clinical symptoms with increasing frequency of extrapulmonary lesions, minimal radiological manifestations, low frequency of the pathogen excretion, and rapid course of the disease. In recent years, researchers around the world have paid considerable attention to studying the effects of genetic variation of genes on the course of infectious diseases in humans, including HIV and tuberculosis, and in particular, to investigating Tool-receptors, innate immune system receptors, which interact with pathogens and stimulate effector mechanisms of innate immunity. The objective of this study is to determine the prevalence and evaluate the features of the TB course before and during the antiretroviral therapy, considering the carriage of the 299Gly allele of the TLR4 gene. To assess the manifestations, clarify the clinical characteristics of the disease in the dynamics before and during the antiretroviral therapy, a retrospective cohort examination of 181 HIV-positive patients before and after the therapy was carried out. The study has demonstrated that, despite the virological and immunological effectiveness of the treatment, the TB detection in HIV-infected patients taking antiretroviral therapy remained almost constant compared to the period before antiretroviral therapy (17.0% vs. 14.9%, > 0.05). Analysis of genotypes of the TLR4 gene showed that during the observation period before antiretroviral therapy in patients with the 299Gly allele there was a 6.3-fold higher risk of developing of disseminated TB forms (OR = 6.29 [95% 1.20-32.99], p = 0.044), compared with carriers of Asp299Asp genotype. In HIV-infected patients with the 299Gly allele of the TLR4 gene on the background of antiretroviral therapy, the risk of TB development is 3.4 times higher (p = 0.008) than in carriers of its homozygous genotype.

An unusual observation of a plasma structure in the mid-latitude ionosphere

2020 ◽  
Author(s):  
Alan Wood ◽  
Gareth Dorrian ◽  
Richard Fallows
Keyword(s):  
Large Scale ◽  
Substantial Reduction ◽  
Low Frequency ◽  
Global Navigation Satellite Systems ◽  
Radio Waves ◽  
Satellite Systems ◽  
Cygnus A ◽  
Before And After ◽  
Order Of Magnitude ◽  
Global Navigation Satellite

<p>The LOFAR (Low Frequency Array) is one of the world’s leading radio telescopes, operating across the frequency band 10-250 MHz. As radio waves from astronomical sources pass through the ionosphere, they can undergo refraction and/or diffraction. The variations in the intensity of the received signal are caused by irregularities with a spatial scale size ranging from the Fresnel dimension to an order of magnitude below this value. The received signal can therefore be used to infer information on plasma structures in the ionosphere. As the frequencies used are significantly lower than the 1.4 GHz typically associated with Global Navigation Satellite Systems (GNSS), the plasma structures that affect the signals received by LOFAR are significantly larger, typically of the order of kilometres.</p><p>On 14<sup>th</sup> July 2018 the Dutch stations of LOFAR observed the strong natural radio sources Cassiopeia A and Cygnus A between 17:00 UT and 18:05 UT at a frequency range of 20-80 MHz. During the observation, the signal intensity received by many of the stations underwent a substantial reduction across all frequencies, lasting approximately 10 minutes. Immediately before and after this, periodic enhancements in the signal strength were observed. These enhancements showed a noticeable frequency dependence, with longer period oscillations at lower frequencies. The feature was not observed simultaneously by the stations and evolved during the observations. Such a feature is most likely to be the result of a large-scale density structure in the ionosphere, which appears to move west and north over the northern Netherlands.</p><p>The deep fading of the received signal may be due to the presence of sporadic-E, which is a consequence of variations in the neutral wind speed with altitude in the presence of the geomagnetic field, resulting in plasma accumulating in a thin layer. This can cause incident radio waves to be strongly refracted, affecting the strength of the received signal. The wave-like structure immediately before and after the deep fade is a likely consequence of scattering of the observed signal.</p>

Self-Report vs. Computerized Measures of Impulsivity as a Correlate of Suicidal Behavior

Crisis ◽  
2001 ◽  
Vol 22 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Netta Horesh
Keyword(s):  
Suicidal Behavior ◽  
Attention Deficit Disorder ◽  
Impulse Control ◽  
Performance Test ◽  
Adolescent Suicide ◽  
Continuous Performance Test ◽  
Self Report ◽  
Suicide Attempters ◽  
Computerized Measures ◽  
Adolescent Suicide Attempters

Objectives: To compare the use of a self-report form of impulsivity versus a computerized test of impulsivity in the assessment of suicidal adolescent psychiatric inpatients. Methods: Sixty consecutive admissions to an adolescent in patient unit were examined. The severity of suicidal behavior was measured with the Childhood Suicide Potential Scale (CSPS), and impulse control was measured with the self report Plutchik Impulse Control Scale (ICS) and with the Test of Variables of Attention (TOVA), a continuous performance test (CPT). The TOVA is used to diagnose adolescents with attention deficit disorder. Results: There was a significant but low correlation between the two measures of impulsivity. Only the TOVA commission and omission errors differentiated between adolescent suicide attempters and nonattempters. Conclusions: Computerized measures of impulsivity may be a useful way to measure impulsivity in adolescent suicide attempters. Impulsivity appears to play a small role only in nondepressed suicidal adolescents, especially boys.

scholarly journals Therapeutic Use of Cerebellar Intermittent Theta Burst Stimulation (iTBS) in a Sardinian Family Affected by Spinocerebellar Ataxia 38 (SCA 38)

2021 ◽  
Author(s):  
Angela Sanna ◽  
Paolo Follesa ◽  
Paolo Tacconi ◽  
Mariangela Serra ◽  
Maria Giuseppina Pisu ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Rating Scale ◽  
Clinical Symptoms ◽  
Therapeutic Use ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Motor Cortex Excitability ◽  
Before And After ◽  
Theta Burst ◽  
Serum Bdnf

AbstractSpinocerebellar ataxia 38 (SCA 38) is an autosomal dominant disorder caused by conventional mutations in the ELOVL5 gene which encodes an enzyme involved in the synthesis of very long fatty acids, with a specific expression in cerebellar Purkinje cells. Three Italian families carrying the mutation, one of which is of Sardinian descent, have been identified and characterized. One session of cerebellar intermittent theta burst stimulation (iTBS) was applied to 6 affected members of the Sardinian family to probe motor cortex excitability measured by motor-evoked potentials (MEPs). Afterwards, patients were exposed to ten sessions of cerebellar real and sham iTBS in a cross-over study and clinical symptoms were evaluated before and after treatment by Modified International Cooperative Ataxia Rating Scale (MICARS). Moreover, serum BDNF levels were evaluated before and after real and sham cerebellar iTBS and the role of BDNF Val66Met polymorphism in influencing iTBS effect was explored. Present data show that one session of cerebellar iTBS was able to increase MEPs in all tested patients, suggesting an enhancement of the cerebello-thalamo-cortical pathway in SCA 38. MICARS scores were reduced after ten sessions of real cerebellar iTBS showing an improvement in clinical symptoms. Finally, although serum BDNF levels were not affected by cerebellar iTBS when considering all samples, segregating for genotype a difference was found between Val66Val and Val66Met carriers. These preliminary data suggest a potential therapeutic use of cerebellar iTBS in improving motor symptoms of SCA38.

scholarly journals Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors: an operative technique and short-term outcomes of 20 consecutive cases

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiaorong Yan ◽  
Huiqing Wang ◽  
Cai Li ◽  
Yuanxiang Lin ◽  
Lin Lin ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Spinal Deformity ◽  
Tumor Recurrence ◽  
Clinical Symptoms ◽  
Short Term ◽  
Before And After ◽  
Intradural Extramedullary ◽  
Controlled Surgery

Abstract Background To present a surgical technique for the treatment of intradural extramedullary (IDEM) tumors by using endoscopically controlled surgery with open hemilaminectomy technique. Methods In this study, 20 patients with 22 IDEM tumors were enrolled. An endoscopically controlled surgery with open hemilaminectomy was employed to remove the tumors. Data related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up analysis. Results All the tumors in 20 patients were well removed. The clinical symptoms were significantly reduced in all the patients as well. The short-term follow-up data showed that there was no tumor recurrence or spinal deformity. Conclusion The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM tumors. It may be an effective surgical method for treating IDEM tumors. Larger samples and longer follow-up data are needed to verify its long-term effectiveness.

Effects of activation frequency and force on low-frequency fatigue in human skeletal muscle

1999 ◽  
Vol 86 (4) ◽  
pp. 1337-1346 ◽  
Author(s):  
Stuart A. Binder-Macleod ◽  
David W. Russ
Keyword(s):  
Healthy Subjects ◽  
Human Skeletal Muscle ◽  
Low Frequency ◽  
Variable Frequency ◽  
Activation Pattern ◽  
Constant Frequency ◽  
Mean Frequency ◽  
Before And After ◽  
Low Frequency Fatigue ◽  
Force Time

No comparison of the amount of low-frequency fatigue (LFF) produced by different activation frequencies exists, although frequencies ranging from 10 to 100 Hz have been used to induce LFF. The quadriceps femoris of 11 healthy subjects were tested in 5 separate sessions. In each session, the force-generating ability of the muscle was tested before and after fatigue and at 2, ∼13, and ∼38 min of recovery. Brief (6-pulse), constant-frequency trains of 9.1, 14.3, 33.3, and 100 Hz and a 6-pulse, variable-frequency train with a mean frequency of 14.3 Hz were delivered at 1 train/s to induce fatigue. Immediately postfatigue, there was a significant effect of fatiguing protocol frequency. Muscles exhibited greater LFF after stimulation with the 9.1-, 14.3-, and variable-frequency trains. These three trains also produced the greatest mean force-time integrals during the fatigue test. At 2, ∼13, and ∼38 min of recovery, however, the LFF produced was independent of the fatiguing protocol frequency. The findings are consistent with theories suggesting two independent mechanisms behind LFF and may help identify the optimal activation pattern when functional electrical stimulation is used.

scholarly journals Perturbations in Eosinophil Homeostasis following Treatment of Lymphatic Filariasis

2000 ◽  
Vol 68 (1) ◽  
pp. 93-99 ◽  
Author(s):  
Ramya Gopinath ◽  
L. E. Hanna ◽  
V. Kumaraswami ◽  
V. Perumal ◽  
V. Kavitha ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Wuchereria Bancrofti ◽  
Activation Markers ◽  
Interleukin 5 ◽  
Hla Dr ◽  
Before And After ◽  
Early Peak ◽  
Eosinophil Activation ◽  
Later Phase ◽  
Second Peak

ABSTRACT Treatment of patients with patent Wuchereria bancroftiinfection results in an acute clinical reaction and peripheral eosinophilia. To investigate the dynamics of the eosinophil response, changes in eosinophil activation and degranulation and plasma levels of eosinophil-active chemokines and cytokines were studied in 15 microfilaremic individuals in south India by sequential blood sampling before and after administration of 300 mg of diethylcarbamazine (DEC). Clinical symptoms occurred within 24 h. Plasma interleukin-5 (IL-5) and RANTES levels peaked 1 to 2 days posttreatment, preceding a peak peripheral eosinophil count at day 4. Major basic protein secretion from eosinophils paralleled IL-5 secretion, while levels of eosinophil-derived neurotoxin peaked at day 13 after treatment. Expression of the activation markers HLA-DR and CD25 on eosinophils rose markedly immediately after treatment, while expression of VLA-4 and α4β7 showed an early peak within 24 h and a second peak at day 13. Thus, the posttreatment reactions seen in filarial infections can be divided into an early phase with killing of microfilariae, clinical symptomatology, increases in plasma IL-5 and RANTES levels, and eosinophil activation and degranulation and a later phase with expression of surface integrins on eosinophils, recruitment of eosinophils from the bone marrow to tissues, and clearance of parasite antigen.

scholarly journals Kinetic Analysis of Mouse Brain Proteome Alterations Following Chikungunya Virus Infection before and after Appearance of Clinical Symptoms

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91397 ◽  
Author(s):  
Christophe Fraisier ◽  
Penelope Koraka ◽  
Maya Belghazi ◽  
Mahfoud Bakli ◽  
Samuel Granjeaud ◽  
...  
Keyword(s):  
Virus Infection ◽  
Kinetic Analysis ◽  
Mouse Brain ◽  
Chikungunya Virus ◽  
Clinical Symptoms ◽  
Before And After ◽  
Brain Proteome

Effect of Incisions in the Brainstem Commissural Network on the Short-Term Vestibulo-Ocular Adaptation of the CAT

1991 ◽  
Vol 1 (3) ◽  
pp. 223-239
Author(s):  
G. Cheron
Keyword(s):  
Low Frequency ◽  
Adaptive Plasticity ◽  
Training Procedure ◽  
Optokinetic Response ◽  
Mean Values ◽  
Ocular Reflex ◽  
Optokinetic Reflex ◽  
Before And After ◽  
Vestibulo Ocular Reflex ◽  
Vor Adaptation

This study was intended to test the adaptive plasticity of the vestibulo-ocular reflex before and after either a midsagittal or parasagittal incision in the brainstem. Eye movements were measured with the electromagnetic search coil technique during the vestibulo-ocular reflex (VORD) in the dark, the optokinetic reflex (OKN), and the visuo-vestibular adaptive training procedure. Two types of visual-vestibular combined stimulation were applied by means of low frequency stimuli (0.05 to 0.10 Hz). In order to increase or decrease the VORD gain, the optokinetic drum was oscillated either 180∘ out-of-phase or in-phase with the vestibular stimulus turntable. This “training” procedure was applied for 4 hours. Initial measurements of the VORD were normal with a mean gain value of 0.92 ± 0.08. After 4 hours of “training” with the out-of-phase condition (180∘), VORD gain reached mean values of 1.33 ± 0.11 (n = 6 cats). In the in-phase combination, the mean VORD gain decreased from 1.0 to 0.63 ± 0.02 (n = 2 cats). No significant change of VORD phase was found in any of the cats. Midsagittal or parasagittal pontomedullary brainstem incisions were performed in 4 cats. Recovery of the VOR was tested on the 2nd, 7th, and 30th day after operation. After the 30th day, recovery of the VORD gain stabilized at about 66% of the initial preoperative value. At this stage of the recovery, the optokinetic response (OKN) of the midsagittal-Iesioned cats was practically normal: in the parasagittal-Jesioned cats, the postoperative OKN responses were asymmetric. After stabilization of recovery, lesioned cats were trained with the same adaptation procedure. Although the direct effect of the visuo-vestibular combined stimulation during the training was still operative in all lesioned cats, the adaptive plasticity was completely abolished by the lesions. These results suggest that the commissural brainstem network may play a crucial role in the acquisition of the forced VOR adaptation.

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