Detection of Human Papillomavirus 33 in Erosive Oral Lichen Planus

Background: A correlation is suggested between oral lichen planus (OLP) and the human papillomavirus (HPV) with possible malignant transformation potential in OLP. Objectives: The present study aimed at evaluating the prevalence of HPV-16 and HPV-18 as the most recognized oncogenic subtypes and relatively recently introduced subtype HPV33 in OLP samples. Methods: This retrospective study was carried out on 32 OLP samples (consisting of 12 reticular and 20 erosive forms) and 20 healthy oral mucosa samples. Polymerase chain reaction (PCR) was undertaken to identify HPV Deoxyribonucleic Acid (DNA). Subsequently, the samples positive for HPV DNA underwent PCR analysis again with the specific primers. The data were analyzed statistically by Fisher’s exact test regarding the significance level of lower than 0.05. Results: Eight out of 32 OLP samples (25%) and none of the 20 normal mucosa samples (0%) exhibited HPV DNA. The presence of HPV in the OLP group was significantly higher than that in the normal mucosa (P = 0.014). Also, all the samples that exhibited HPV DNA were registered as the erosive form. Besides, one sample (3.12%) exhibited the 873-bp band, which was attributed to HPV-18, and 7 samples (21.87%) exhibited the 300-bp band, which was attributed to HPV-33. Conclusions: Based on the recent findings in the current study of the Iranian population, the presence of high-risk HPV subtypes, whether primarily or as a secondary infection, can suggest the malignant transformation potential for the studied OLP samples. The exclusive presence of these subtypes in the erosive type of this lesion and the noticeable presence of HPV-33 might reflect this issue’s importance. However, further studies are necessary to evaluate the possibility of a higher proliferation rate of HPV in erosive lichen planus and identify its possible malignant transformation mechanism.

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Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies

Journal of Clinical Advances in Dentistry ◽

10.29328/journal.jcad.1001024 ◽

2021 ◽

Vol 5 (1) ◽

pp. 005-011

Author(s):

Saleh Wafaa ◽

Youssef Jilan M ◽

Ata Fatma ◽

Anees Mohamed M ◽

Cha Seunghee ◽

...

Keyword(s):

Human Papillomavirus ◽

Hepatitis C ◽

Malignant Transformation ◽

Lichen Planus ◽

Potential Risk ◽

Clinical Studies ◽

Animal Studies ◽

Oral Lichen Planus ◽

Chronic Inflammatory Disease ◽

Oral Lichen

Oral lichen planus (OLP) is an autoimmune chronic inflammatory disease. The potential risk of malignant transformation in OLP remains controversial. The aim of the present study was to review original clinical studies published in indexed databases, which assessed the potential risk cofactors which were implicated in the malignant transformation of oral lichen planus. We focused our search to include most of the studies that reported malignant transformation of oral lichen planus using different combinations of the following key indexing terms: oral lichen planus, malignant transformation, smoking, alcohol, chronic inflammation, candida, human papillomavirus (HPV), hepatitis C virus (HCV) and immunosuppression. The animal studies were excluded from our study. Despite a dearth of studies on this topic we have identified consumption of tobacco and/or alcohol, the presence of erosive and/or atrophic areas, infection with candida, HCV, HPV, and immunosuppression as significant cofactors. Patients with OLP with these risk co-factors are at risk of malignant transformation should, therefore be followed up for an extensive period or even for life.

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Oral Lichen Planus – A Case Report with Current Trends Review of Literature

IRA-International Journal of Applied Sciences (ISSN 2455-4499) ◽

10.21013/jas.v5.n1.p2 ◽

2016 ◽

Vol 5 (1) ◽

pp. 6

Author(s):

Umamaheswari G ◽

Suganya. R ◽

Sivaramakrishnan. M ◽

Vidyalakshmi. S

Keyword(s):

Malignant Transformation ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Young Male ◽

Skin Lesions ◽

Hair Follicles ◽

World Population ◽

Cutaneous Lesions ◽

Transformation Potential ◽

Oral Lichen

<div><p><em>Lichen planus (LP) is an autoimmune chronic mucocutaneous dermatosis that commonly affects skin, mucous membrane, hair follicles & nails. Skin lesions present as recurrent violaceous, keratotic pruritic patches whereas oral lichen planus presents with various pattern. Oral lesions of LP is approximately of 1- 2% of general population while 10-20% of patients demonstrate oral as well as cutaneous lesions. Females are most commonly affected with age group ranging from 40-70 years and showing prevalence rates varying from 0.5% to 2.6% of the world population. The malignant transformation potential of LP into oral squamous cell carcinoma (OSCC) is 0.3-3%. Epithelial dysplasia is considered to be a risk factor for malignant transformation into OSCC. The objective of this paper is to report a case of oral lichen planus showing features of dysplasia in a young male patient. <strong></strong></em></p></div>

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Oral Lichen Planus in Thai Patients Has a Low Prevalence of Human Papillomavirus

ISRN Dentistry ◽

10.1155/2013/362750 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Pratanporn Arirachakaran ◽

Jira Chansaengroj ◽

Woradee Lurchachaiwong ◽

Patnarin Kanjanabud ◽

Kobkan Thongprasom ◽

...

Keyword(s):

Human Papillomavirus ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Cell Function ◽

Hpv Infection ◽

Predisposing Factor ◽

Hpv Dna ◽

Tissue Biopsy ◽

Low Prevalence ◽

Oral Lichen

Background. Oral lichen planus (OLP) is a common chronic inflammatory immune-mediated disease, with an etiopathogenesis associated with cell-mediated immunological dysfunction. Viral infection has been hypothesized as a predisposing factor in the pathogenesis of this disease. Viruses may alter host cell function by inducing the abnormal expression of cellular proteins leading to disease development. However, reports on the relationship between human papillomavirus (HPV) and OLP are inconclusive. Objective. To explore the association between HPV and OLP in Thai patients. Materials and Methods. DNA was extracted from thirty-seven fresh-frozen tissue biopsy specimens from OLP lesions, and polymerase chain reaction assay for the L1 and E1 genes covering 32 types of high- and low-risk HPV was performed. Results. HPV DNA was detected in one tissue biopsy from an atrophic-type OLP lesion. All control samples were negative. Genomic sequencing of the E1 gene PCR product demonstrated that the HPV-type 16 found in the lesion is closely related to the East Asian type. Conclusion. Our data indicate a low prevalence of HPV infection in OLP lesions in Thai patients.

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