Update on Nonneoplastic Pulmonary Lymphoproliferative Disorders and Related Entities

2010 ◽  
Vol 134 (5) ◽  
pp. 691-701 ◽  
Author(s):  
Donald G. Guinee
Keyword(s):  
Differential Diagnosis ◽  
Interstitial Pneumonitis ◽  
Lymphoid Hyperplasia ◽  
Lymphoproliferative Disorders ◽  
Data Sources ◽  
Follicular Bronchiolitis ◽  
Nodular Lymphoid Hyperplasia ◽  
Pulmonary Pathology

Abstract Context.—Recent discoveries have expanded the spectrum of nonneoplastic pulmonary lymphoproliferative disorders and have provided new insights into their pathogenesis and treatment. Objective.—To review the thoracic manifestations of immunoglobulin (Ig) G4–related sclerosing disease and summarize current concepts and differential diagnosis of follicular bronchiolitis, lymphocytic interstitial pneumonitis, and nodular lymphoid hyperplasia. Data sources.—Data sources include recent and old articles, cases from the personal files of the author, and cases borrowed with permission from other authors. Conclusions.—Additional studies will be needed to further refine and add to observations in this evolving area of pulmonary pathology.

Pulmonary Pseudoneoplasms

2010 ◽  
Vol 134 (3) ◽  
pp. 417-426 ◽  
Author(s):  
Eunhee Yi ◽  
Marie-Christine Aubry
Keyword(s):  
Differential Diagnosis ◽  
Clinical Diagnosis ◽  
Lymphoid Hyperplasia ◽  
Surgical Pathology ◽  
Data Sources ◽  
Thoracic Cavity ◽  
Organizing Pneumonia ◽  
Sclerosing Mediastinitis ◽  
Diagnosis Of Cancer ◽  
Inflammatory Pseudotumors

Abstract Context.—Not uncommonly, a surgical pathologist will be requested to review excised material, with a clinical diagnosis of cancer, in which no malignancy can be identified. Often, sampling may be the issue. However, different nonneoplastic processes may mimic cancer clinically and not be recognized histologically. These are commonly referred to as pseudoneoplasms and can involve the lung, pleura, and mediastinum. Objective.—To review the most commonly encountered pseudoneoplasms of the thoracic cavity in surgical pathology and discuss the main differential diagnosis. Data Sources.—Literature and personal review of cases with focus on inflammatory pseudotumors of the lung, organizing pneumonia, nodular lymphoid hyperplasia, apical cap, round atelectasis, and sclerosing mediastinitis with its pulmonary counterpart, hyalinizing granuloma. Conclusions.—When reviewing specimens that appear nondiagnostic for malignancy, it is important to consider one of these pseudoneoplasms in the differential diagnosis as they may explain the clinical and radiologic information.

Granulomatous Lung Disease: An Approach to the Differential Diagnosis

2010 ◽  
Vol 134 (5) ◽  
pp. 667-690 ◽  
Author(s):  
Sanjay Mukhopadhyay ◽  
Anthony A. Gal
Keyword(s):  
Differential Diagnosis ◽  
Lung Disease ◽  
Hypersensitivity Pneumonitis ◽  
Tissue Reaction ◽  
Data Sources ◽  
National Library ◽  
Diagnostic Challenge ◽  
Wegener Granulomatosis ◽  
Granulomatous Lung Disease ◽  
Pulmonary Pathology

Abstract Context.—Granulomas are among the most commonly encountered abnormalities in pulmonary pathology and often pose a diagnostic challenge. Although most pathologists are aware of the need to exclude an infection in this setting, there is less familiarity with the specific histologic features that aid in the differential diagnosis. Objective.—To review the differential diagnosis, suggest a practical diagnostic approach, and emphasize major diagnostically useful histologic features. This review is aimed at surgical pathologists who encounter granulomas in lung specimens. Data sources.—Pertinent recent and classic peer-reviewed literature retrieved from PubMed (US National Library of Medicine) and primary material from the institutions of both authors. Conclusions.—Most granulomas in the lung are caused by mycobacterial or fungal infection. The diagnosis requires familiarity with the tissue reaction as well as with the morphologic features of the organisms, including appropriate interpretation of special stains. The major noninfectious causes of granulomatous lung disease are sarcoidosis, Wegener granulomatosis, hypersensitivity pneumonitis, hot tub lung, aspiration pneumonia, and talc granulomatosis.

RARE CASE OF NODULAR LYMPHOID HYPERPLASIA OF LEFT LUNG IN THE PATIENT WITH PREVIOUS PULMONARY TUBERCULOSIS

2018 ◽  
Vol 40 (4) ◽  
pp. 332-335
Author(s):  
P V Kuzyk ◽  
M A Savchyna ◽  
S G Gychka
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lymphoproliferative Disorder ◽  
Clinical Laboratory ◽  
Left Lung ◽  
Lymphoid Hyperplasia ◽  
Morphological Examination ◽  
Nodular Lymphoid Hyperplasia ◽  
Lymph Nodes Dissection ◽  
The Right ◽  
Immunohistochemical Studies

Aim: To describe the case of rare benign lymphoproliferative disorder — pulmonary nodular lymphoid hyperplasia in the patient with previous pulmonary tuberculosis. Materials and Methods: In the case of pulmonary nodular lymphoid hyperplasia clinical, laboratory, instrumental and morphological examination was performed. Results: 44-year-old woman in 7 years after successfully treated infiltrative drug-susceptible tuberculosis of the right lung, was hospitalized with a suspected tumor of the left lung root. The patient underwent left-sided pneumonectomy with lymph nodes dissection. The results of histopathological and immunohistochemical studies evidenced on nodular lymphoid hyperplasia of the left lung. Conclusion: Pulmonary nodular lymphoid hyperplasia is a rare lymphoproliferative disorder of the lung with favorable prognosis. For the purpose of differential diagnosis, it is necessary to apply immunohistochemistry.

Pulmonary nodular lymphoid hyperplasia in pediatric patients with Hodgkin lymphoma

2020 ◽  
Vol 37 (5) ◽  
pp. 424-430
Author(s):  
Paola Quarello ◽  
Maurizio Bianchi ◽  
Alessandro Gambella ◽  
Luca Molinaro ◽  
Elisa Tirtei ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Pediatric Patients ◽  
Lymphoid Hyperplasia ◽  
Nodular Lymphoid Hyperplasia

Intestinal nodular lymphoid hyperplasia in a patient with chronic diarrhea and recurrent sinopulmonary infections

2000 ◽  
Vol 95 (8) ◽  
pp. 2147-2149 ◽  
Author(s):  
Mounzer Samman ◽  
Marc J. Zuckerman ◽  
Arjun Mohandas ◽  
Joan T. Hoffpauir ◽  
Stanislaus Ting
Keyword(s):  
Chronic Diarrhea ◽  
Lymphoid Hyperplasia ◽  
Nodular Lymphoid Hyperplasia

Placental Mesenchymal Dysplasia

2007 ◽  
Vol 131 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Zahida Parveen ◽  
Jane Elaine Tongson-Ignacio ◽  
Cory R. Fraser ◽  
Jeffery L. Killeen ◽  
Karen S. Thompson
Keyword(s):  
Differential Diagnosis ◽  
Clinical Presentation ◽  
Early Recognition ◽  
Data Sources ◽  
Molar Pregnancy ◽  
Close Attention ◽  
Normal Fetus ◽  
Fetal Complications ◽  
Microscopic Features ◽  
Placental Mesenchymal Dysplasia

Abstract Context.—Placental mesenchymal dysplasia is characterized by placentomegaly and may be mistaken for molar pregnancy both clinically and macroscopically because of the presence of “grapelike vesicles.” It may be associated with a completely normal fetus, a fetus with growth restriction, or a fetus with features of Beckwith-Wiedemann syndrome. Objective.—To review the etiology, molecular pathology, gross and microscopic features, clinical presentation, complications, and differential diagnosis of placental mesenchymal dysplasia. Data Sources.—The PubMed and the Medline databases were systematically searched for articles between 1970 and 2006. The following keywords were used: placental mesenchymal dysplasia, mesenchymal hyperplasia, molar pregnancy, pseudomolar pregnancy, Beckwith-Wiedemann syndrome, and placentomegaly. Relevant references from review articles were also searched. Conclusions.—Placental mesenchymal dysplasia should be considered in the differential diagnosis when the ultrasonographic findings show a cystic placenta. Close attention should be paid to fetal morphology for early recognition of fetal complications and to prevent unnecessary termination of pregnancy in cases associated with a normal fetus.

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