Glomangiomyoma (Glomus Tumor) of the Kidney

2005 ◽  
Vol 129 (9) ◽  
pp. 1172-1174 ◽  
Author(s):  
Noman H. Siddiqui ◽  
Agnieszka Rogalska ◽  
Indu S. Basil
Keyword(s):  
Electron Microscopy ◽  
Smooth Muscle ◽  
Glomus Tumor ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Thin Filaments ◽  
Glomus Tumors ◽  
Computed Tomographic ◽  
Dense Bodies ◽  
Computed Tomographic Scan

Abstract We report herein a case of glomus tumor arising in the kidney of a 55-year-old woman, which was found incidentally on a computed tomographic scan. Partial nephrectomy revealed a 2-cm encapsulated mass that was architecturally similar to glomus tumor. Immunohistochemistry showed positivity of tumor cells for vimentin and smooth muscle actin. On electron microscopy, cytoplasmic thin filaments and dense bodies were seen, confirming the smooth muscle nature of the tumor. Glomus tumors arising in visceral organs are rare, and those arising in kidney are exceedingly rare.

Benign Myoepithelioma of the Lung

2001 ◽  
Vol 125 (11) ◽  
pp. 1494-1496
Author(s):  
Ravindra Veeramachaneni ◽  
Janis Gulick ◽  
Ari O. Halldorsson ◽  
Thanh T. Van ◽  
Ping L. Zhang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Emission Tomography ◽  
Muscle Actin ◽  
Computed Tomographic ◽  
Spindle Cells ◽  
Positron Emission ◽  
Computed Tomographic Scan ◽  
Wedge Biopsy

Abstract This report describes a benign myoepithelioma of the lung that occurred in a 60-year-old woman. The patient had experienced hoarseness for 6 weeks, and a computed tomographic scan showed a nodule of approximately 2 cm in diameter at the peripheral portion of her right upper lung. Positron emission tomography showed no uptake of F-18 fluorodeoxyglucose in the nodule. Wedge biopsy of the lesion showed benign spindle cells arranged in a whorled pattern. The cells were positive for both cytokeratin and smooth muscle actin, which corresponded to the presence of tonofilaments and myofilaments that were identified ultrastructurally. The features of the present case of benign myoepithelioma that differ from features of previously reported benign and malignant cases of myoepithelioma in the lung are discussed in the report.

Malignant Glomus Tumor of the Urinary Bladder

2005 ◽  
Vol 129 (7) ◽  
pp. 940-942 ◽  
Author(s):  
Hyo Sub Shim ◽  
Young Deuk Choi ◽  
Nam Hoon Cho
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Basement Membrane ◽  
Glomus Tumor ◽  
Malignant Tumors ◽  
Smooth Muscle Actin ◽  
Pulmonary Nodules ◽  
Histochemical Staining ◽  
Muscle Actin ◽  
Glomus Tumors

Abstract We present a case of a malignant glomus tumor arising in the urinary bladder of a 57-year-old woman with metastatic pulmonary nodules who died 2 months later. Pathologically and clinically confirmed malignant glomus tumors are exceedingly rare, especially those that arise in the visceral organs. The present case retained its architectural similarity to a benign glomus tumor and consisted of sheets of highly malignant round cells showing cytoplasmic positivity for smooth muscle actin. On reticulin histochemical staining, we found that reticulum fibrils surrounded individual tumor cells, suggesting cellular investment by basement membrane. We discuss the concept of malignant glomus tumors and emphasize the criteria that distinguish them from other malignant tumors.

scholarly journals Ca2+-dependent regulation of vascular smooth-muscle caldesmon by S.100 and related smooth-muscle proteins

1991 ◽  
Vol 277 (3) ◽  
pp. 819-824 ◽  
Author(s):  
K Pritchard ◽  
S B Marston
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Bovine Brain ◽  
Protein Yield ◽  
Muscle Actin ◽  
Muscle Proteins ◽  
Related Protein ◽  
Thin Filaments ◽  
S 100 ◽  
Related Proteins

1. We have investigated the ability of bovine brain S.100, and of three related proteins from sheep aorta smooth muscle, to confer Ca(2+)-sensitivity on thin filaments reconstituted from smooth-muscle actin, tropomyosin and caldesmon. 2. At 37 degrees C in pH 7.0 buffer containing 120 mM-KCl, approximately stoichiometric amounts of S.100 reversed caldesmon's inhibition of the activation of myosin MgATPase by smooth-muscle actin-tropomyosin. The [S.100] which reversed by 50% the inhibition by caldesmon (the E.C.50) was 2.5 microM when [caldesmon] = 2-3 microM in the assay mixture. When [KCl] was decreased to 70 mM, E.C.50 = 11.5 microM; at 25 degrees C in 70 mM-KCl, up to 20 microM-S.100 had no effect. When skeletal-muscle actin rather than smooth-muscle actin was used to reconstitute thin filaments, 20 microM-S.100 did reverse inhibition by caldesmon, at 25 degrees C in buffer containing 70 mM-KCl. This dependence on conditions is also characteristic of the calmodulin-caldesmon interaction. 3. These results suggested that S.100 or a related protein might interact with caldesmon in smooth muscle. We therefore attempted to prepare such a protein from sheep aorta. Three proteins were purified: an Mr-17,000 protein (yield 16 mg/kg), an abundant Mr-11,000 protein (yield 48 mg/kg), and an Mr-9000 protein (yield 4 mg/kg). Neither of the last two low-Mr proteins had any effect on activation of myosin MgATPase by reconstituted thin filaments. The protein of Mr 17,000 had Ca(2+)-sensitizing activity, and behaved exactly like brain calmodulin in the assay system.

Feline Cystic Thymoma: A Clinicopathologic, Immunohistologic, and Electron Microscopic Study of 14 Cases

2003 ◽  
Vol 5 (1) ◽  
pp. 27-35 ◽  
Author(s):  
AK Patnaik ◽  
PH Lieberman ◽  
RA Erlandson ◽  
C Antonescu
Keyword(s):  
Electron Microscopy ◽  
Smooth Muscle ◽  
Epithelial Cells ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Electron Microscopic ◽  
Germinal Centres ◽  
Factor Viii Antigen ◽  
Cell Components ◽  
Microscopic Features

Cystic thymoma was diagnosed in 14 cats in a period of 6 years. The most common clinical sign was laboured breathing. The tumours were characterized by various-sized cystic spaces with central vessels. The epithelial cells varied from oval to spindle to polygonal cells enclosing cystic spaces or in pure epithelial cell components. The nuclei of the neoplastic cells had scattered chromatin and small nucleoli. The cytoplasm was pale eosinophilic. The concentration of mature lymphocytes varied from area to area with rare germinal centres. Immunohistochemically, the epithelial cells stained only with AE1/AE3. The central vessels were positive for vimentin, smooth muscle actin, and factor VIII antigen. Electron microscopy revealed that the cyst walls were lined by epithelial cells that were joined by desmosomes, and the walls were well separated from the cystic spaces by a well-defined basement membrane. The neoplastic epithelial cells contained scattered tonofilaments. Three of the cats had metastasis to the lymph nodes and lungs. Two novel cases of ectopic cystic thymoma have also been described. Results of this study reveal that cystic thymoma is uncommon in cats, and that the histomorphologic, immunohistochemical, and electron microscopic features are similar to those of cystic thymoma in humans.

scholarly journals A Primary Pulmonary Glomus Tumor: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Yasushi Ariizumi ◽  
Hirotaka Koizumi ◽  
Masahiro Hoshikawa ◽  
Takuo Shinmyo ◽  
Kouji Ando ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Tumor Cells ◽  
Epithelial Membrane Antigen ◽  
Glomus Tumor ◽  
Lung Tumor ◽  
Smooth Muscle Actin ◽  
Relevant Literature ◽  
Sclerosing Hemangioma ◽  
Glomus Tumors ◽  
Clear Cytoplasm

A case of a glomus tumor originating from the lung is reported. A 43-year-old female had undergone resection of a right lung tumor following a clinical diagnosis of carcinoid, sclerosing hemangioma, or other sarcoma. Histologically, the tumor comprised uniform small round to oval cells with centrally located nucleus, a clear cytoplasm, and apparent cell borders. The tumor also showed a focally hemangiopericytomatous pattern with irregularly branching or dilated vessels. Electron microscopy revealed smooth muscle differentiation of the tumor cells. Immunostaining further revealed that the tumor cells expressed smooth muscle actin, h-caldesmon, muscle specific actin (HHF-35), but not cytokeratin, epithelial membrane antigen, synaptophysin, or chromogranin A. Based on these findings, a diagnosis of primary pulmonary glomus tumor was established. Glomus tumors of the lung are very rare and only 21 cases have been reported to date. The histological features of the present tumor and the relevant literature are discussed.

Appearance of myofibroblast during the healing of experimental corneal wound

1993 ◽  
Vol 51 ◽  
pp. 386-387
Author(s):  
Masamichi Ishizaki ◽  
Kyoko Wakamatsu ◽  
Takakuni Matsunami ◽  
Nobuaki Yamanaka ◽  
Toshikazu Saiga ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Smooth Muscle ◽  
Stromal Cells ◽  
Smooth Muscle Actin ◽  
Corneal Stroma ◽  
Uranyl Acetate ◽  
Muscle Actin ◽  
Thin Sections ◽  
Corneal Wound ◽  
Fibroblastic Cells

It is well known that corneal stroma cells (keratocytes) can transform to fibroblasts during the corneal wound healing. We have studied the expression of α-smooth muscle actin, vimentin and desmin in fibroblastic cells of the alkali-burneo and lacerated corneas in the rabbits by means of immunohistochemistry and electron microscopy.Methods. Rabbits were anesthetized, and central corneal alkali-burn and laceration were produced. The injured corneas healed for 1 day to 45 days, and 18 days embryonic rabbit corneas were immunostained with monoclonal antibodies against α-smooth muscle actin, vimentin and desmin. For transmission electron microscopy, two techniques were used for the staining of ultra-thin sections: 1) uranyl acetate and Reynold's lead citrate and 2) the tannic acid method of Kajikawa.Results. Antibody against α-smooth muscle actin reacted with fibroblastic cells in injured corneas (Fig 1) but not with stromal cells in normal and embryonic corneas. Antivimentin antibody strongly reacted with the fibroblastic cells in injured corneas (Fig 2) and stromal cells in normal and embryonic corneas.

scholarly journals Glomus Tumor of the Stomach: A Rare Cause of Upper Gastrointestinal Bleeding

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Enzo Fabrício Ribeiro Nascimento ◽  
Fábio Piovezan Fonte ◽  
Roberta Laís Mendonça ◽  
Ronaldo Nonose ◽  
Carlos Alberto Fonte de Souza ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Gastrointestinal Bleeding ◽  
Glomus Tumor ◽  
Upper Gastrointestinal Bleeding ◽  
Smooth Muscle Actin ◽  
Muscularis Propria ◽  
Gastric Body ◽  
Ki 67 ◽  
Glomus Tumors ◽  
Upper Gastrointestinal

Introduction. Glomus tumors (GTs) are benign neoplasm originating from the glomus body, commonly described in subungual region. The involvement abdominal is rare. Our aim is to describe a case of glomus tumor of the stomach that presented upper gastrointestinal bleeding. A 34-year-old woman was admitted with upper gastrointestinal bleeding and underwent an upper endoscopy that showed bleeding arising from an ulcerated lesion, treated by sclerosis therapy. A new endoscopy confirmed a submucosal lesion in upper portion of the stomach. During the laparotomy, a tumor at the upper anterior wall of gastric body was found and resected by a vertical gastrectomy. The pathological exam revealed hyperplastic smooth muscle fibers of the muscularis propria of the stomach wall, surrounded by hyaline stroma. The immunohistochemistry panel was positive for smooth muscle actin and type IV collagen, with low rate of mitosis studied by Ki-67 which allowed the final diagnosis of a gastric glomus tumor.Discussion. The majority of intraperitoneal glomus tumors occur in the stomach, and it is phenotypically similar to those localized in peripheral sites. Gastric GT generally is a benign tumor although it can be malignant and have the potential to metastasize.Conclusion. Even though gastric glomus tumor is rarely described, it should be considered as a possible cause of a major upper gastrointestinal bleeding.

scholarly journals Ca2+-calmodulin binding to caldesmon and the caldesmon-actin-tropomyosin complex. Its role in Ca2+ regulation of the activity of synthetic smooth-muscle thin filaments

1989 ◽  
Vol 257 (3) ◽  
pp. 839-843 ◽  
Author(s):  
K Pritchard ◽  
S B Marston
Keyword(s):  
Smooth Muscle ◽  
Thin Filament ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Polarization Method ◽  
Thin Filaments ◽  
Calmodulin Binding ◽  
Muscle Thin Filament ◽  
Mgatpase Activity

We measured the concentration of calmodulin required to reverse inhibition by caldesmon of actin-activated myosin MgATPase activity, in a model smooth-muscle thin-filament system, reconstituted in vitro from purified vascular smooth-muscle actin, tropomyosin and caldesmon. At 37 degrees C in buffer containing 120 mM-KCl, 4 microM-Ca2+-calmodulin produced a half-maximal reversal of caldesmon inhibition, but more than 300 microM-Ca2+-calmodulin was necessary at 25 degrees C in buffer containing 60 mM-KCl. The binding affinity (K) of caldesmon for Ca2+-calmodulin was measured by a fluorescence-polarization method: K = 2.7 x 10(6) M-1 at 25 degrees C (60 mM-KCl); K = 1.4 x 10(6) M-1 at 37 degrees C in 70 mM-KCl-containing buffer; K = 0.35 x 10(6) M-1 at 37 degrees C in 120 mM-KCl- containing buffer (pH 7.0). At 37 degrees C/120 mM-KCl, but not at 25 degrees C/60 mM-KCl, Ca2+-calmodulin bound to caldesmon bound to actin-tropomyosin (K = 2.9 x 10(6) M-1). Ca2+ regulation in this system does not depend on a simple competition between Ca2+-calmodulin and actin for binding to caldesmon. Under conditions (37 degrees C/120 mM-KCl) where physiologically realistic concentrations of calmodulin can Ca2+-regulate synthetic thin filaments, Ca2+-calmodulin reverses caldesmon inhibition of actomyosin ATPase by forming a non-inhibited complex of Ca2+-calmodulin-caldesmon-(actin-tropomyosin).

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