Subcutaneous Phaeohyphomycosis Caused by Cladophialophora bantiana

2005 ◽  
Vol 129 (6) ◽  
pp. 794-797
Author(s):  
Sean M. Hussey ◽  
Rita Gander ◽  
Paul Southern ◽  
Mai P. Hoang
Keyword(s):  
Lupus Erythematosus ◽  
Clinical Symptoms ◽  
African American Woman ◽  
American Woman ◽  
Systemic Lupus ◽  
History Of ◽  
Skin Nodules ◽  
Subcutaneous Phaeohyphomycosis ◽  
Purulent Drainage

Abstract Primary subcutaneous phaeohyphomycosis can rarely be caused by Cladophialophora bantiana, and we present the histologic and culture findings of such a case. A 32-year-old African American woman with systemic lupus erythematosus presented with a 2-year history of multiple, recurrent, tender, and ulcerated skin nodules with purulent drainage on her upper back. Histologic sections of the excision demonstrated features of phaeohyphomycosis. Culture findings were characteristic of C bantiana. Of interest, at age 10 she had sustained traumatic implantation of wood splinters into this area during a tornado, yet clinical symptoms of a subcutaneous infection did not manifest until she developed lupus erythematosus at age 27. Our case highlights the role of trauma and immunosuppression in the pathogenesis of subcutaneous phaeohyphomycosis.

scholarly journals Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Maria Salgado Guerrero ◽  
Oscar Mena Miranda ◽  
Ana B. Arevalo ◽  
Nevena Barjaktarovic ◽  
Barbara Mendez
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
African American Woman ◽  
Severe Disease ◽  
American Woman ◽  
Autoimmune Disorder ◽  
Prior History ◽  
Systemic Lupus ◽  
Initial Manifestation ◽  
History Of

Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous autoimmune disorder characterized by rapid, widespread vesiculobullous lesions in patients with Systemic Lupus Erythematosus (SLE). BSLE can present as the initial manifestation of SLE and may be a marker of severe disease. In this case report, we present a case of a 22-year-old African American woman with BSLE and impaired renal function with subsequent nephrotic range proteinuria concerning for lupus nephritis and autoimmune hemolytic anemia, refractory to systemic corticosteroids, immunoglobulin, and mycophenolate mofetil, requiring dapsone after careful desensitization due to prior history of angioedema with sulfa drugs. This case highlights the importance of the prompt recognition of BSLE as the initial manifestations of SLE and illustrates the association of BSLE with severe disease and the benefit of concomitant use of dapsone with corticosteroids and other immunosuppressant drugs, even in patients with a history of sulfa allergy.

scholarly journals Diet in Rheumatoid Arthritis versus Systemic Lupus Erythematosus: Any Differences?

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 772
Author(s):  
Alessia Alunno ◽  
Francesco Carubbi ◽  
Elena Bartoloni ◽  
Davide Grassi ◽  
Claudio Ferri ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Musculoskeletal Diseases ◽  
Normal Subjects ◽  
Experimental Models ◽  
Systemic Lupus ◽  
History Of ◽  
Indirect Action

In recent years, an increasing interest in the influence of diet in rheumatic and musculoskeletal diseases (RMDs) led to the publication of several articles exploring the role of food/nutrients in both the risk of developing these conditions in normal subjects and the natural history of the disease in patients with established RMDs. Diet may be a possible facilitator of RMDs due to both the direct pro-inflammatory properties of some nutrients and the indirect action on insulin resistance, obesity and associated co-morbidities. A consistent body of research has been conducted in rheumatoid arthritis (RA), while studies in systemic lupus erythematosus (SLE) are scarce and have been conducted mainly on experimental models of the disease. This review article aims to outline similarities and differences between RA and SLE based on the existing literature.

scholarly journals Haemophagocytic lymphohistiocytosis with collapsing lupus podocytopathy as an unusual manifestation of systemic lupus erythematosus with APOL1 double-risk alleles

2019 ◽  
Vol 12 (1) ◽  
pp. bcr-2018-227860 ◽  
Author(s):  
Bhavin Chokshi ◽  
Vivette D’Agati ◽  
Lilian Bizzocchi ◽  
Beverly Johnson ◽  
Barbara Mendez ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
African American Woman ◽  
American Woman ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Systemic Lupus ◽  
Risk Alleles ◽  
Proliferative Lupus Nephritis ◽  
Life Threatening ◽  
Lupus Podocytopathy

Haemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening syndrome caused by excessive immune activation. Secondary HLH has been described in autoimmune diseases. We detail the case of a 28-year-old African American woman who developed HLH in the setting of systemic lupus erythematosus with collapsing lupus podocytopathy superimposed on mesangial proliferative lupus nephritis class II. Genotyping for APOL1 risk alleles revealed the presence of double (G1/G2) risk alleles. Our patient achieved a complete renal recovery and resolution of HLH within 1 month of treatment with steroids and mycophenolate mofetil, highlighting the importance of prompt, aggressive therapy.

scholarly journals Catastrophic Antiphospholipid Syndrome Presenting as Bilateral Central Retinal Artery Occlusions

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Steven S. Saraf ◽  
Yogin P. Patel ◽  
Ankit Desai ◽  
Uday R. Desai
Keyword(s):  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Vision Loss ◽  
African American Woman ◽  
American Woman ◽  
Central Retinal Artery ◽  
Systemic Lupus ◽  
Catastrophic Antiphospholipid Syndrome ◽  
Retinal Hemorrhages ◽  
Retinal Artery

A previously healthy 22-year-old African American woman presented with bilateral vision loss associated with headache. Her ocular examination was significant for bilateral retinal arterial “boxcarring,” retinal whitening, retinal hemorrhages, and cherry red spots. She was diagnosed with bilateral central retinal artery occlusions and was hospitalized due to concomitant diagnosis of stroke and hypercoagulable state. She was also found to be in heart failure and kidney failure. Rheumatology was consulted and she was diagnosed with catastrophic antiphospholipid syndrome in association with systemic lupus erythematosus. Approximately 7 months after presentation, the patient’s vision improved and remained stable at 20/200 and 20/80.

scholarly journals Important Role of Caregiver in Management of Systemic Lupus Erythematosus on Patient with Mental Retardation

2017 ◽  
Vol 1 ◽  
Author(s):  
Dwi Ariani ◽  
Yuniardini Septorini Wimardhani
Keyword(s):  
Mental Retardation ◽  
Patient Compliance ◽  
Lupus Erythematosus ◽  
Extended Period ◽  
Systemic Steroid ◽  
Systemic Lupus Erythematous ◽  
Systemic Lupus ◽  
Tissue Damages ◽  
History Of

<p class="AbstractContent"><strong>Background:</strong> Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease causing inflammation, pain and tissue damages. The systemic steroid and antimalarial agents are SLE’s standard therapies. The challenges in achieving significant result include the extended period of treatment. Therefore, the patients' compliance to the dentist’s treatment is crucial. There are some conditions where patient's compliance is difficult to obtain, for example in patients with mental retardation. To be able to receive information and treatment well, it takes an important role of caregiver to communicate and to assist the daily care.</p><p class="AbstractContent"><strong>Objective</strong>: To give an overview of management challenges of a case of SLE in a patient with mental retardation in which requires good cooperation with the caregiver to obtain optimal results.</p><p class="AbstractContent"><strong>Case report and management</strong>: A 22-year-old female patient with mental retardation with her caregiver, counseled from the Department of Dermatology and Venereology of Cipto Mangunkusumo Hospital (RSCM) with a working diagnosis of Bullous Systemic Lupus Erythematous. She had been on three years’ treatment for blisters all over her body. Condition improvement of the skin had occurred a week before the visit, accompanied by a history of canker sores on her lips and mouth for three days. Clinical features on lips and mouth showed the oral manifestations of bullous SLE. Topical corticosteroids, alternately with saline, as well as clobetasol propionate 0.05% cream for topical treatment in lips, have given for therapies. The caregiver has been educated to help the patient for maintaining her oral hygiene and using her drugs on a regular basis. Improving the teeth and mouth condition and patient compliance levels seen in control visits.</p><p class="AbstractContent"><strong>Conclusion</strong>: Effective communication, information, and education to the caregiver are critical in the management of SLE patient with mental retardation. Establishment of trust and equality goals of care is necessary to overcome the limitations of communication and patient compliance in this case.</p>

“Lupus” Anticoagulant and Thrombosis – Possible Role of Inhibition of Prostacyclin Formation

1982 ◽  
Vol 48 (01) ◽  
pp. 038-040 ◽  
Author(s):  
L O Carreras ◽  
J G Vermylen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Lupus Anticoagulant ◽  
Vascular Tissue ◽  
Inhibitory Effect ◽  
Severe Thrombocytopenia ◽  
Systemic Lupus ◽  
History Of ◽  
One Year

SummaryA “lupus” anticoagulant was discovered in 14 patients over a one year period. Only three of them had systemic lupus erythematosus. Bleeding manifestations were only present in one patient with concomitant severe thrombocytopenia. In contrast, eight patients had a history of thrombosis; five of them presented repeated thrombotic episodes. Obstetrical complications (recurrent abortion, fetal death, or intrauterine growth retardation) were observed in six patients. An inhibitory effect of plasma on the production of prostacyclin by vascular tissue was detected in eight patients, six of whom had thrombosis. We suggest that inhibition of prostacyclin formation could play a major role in the pathogenesis of thrombosis and obstetrical problems in some patients with this type of anticoagulant, even in the absence of systemic lupus erythematosus.

The role of microRNAs (MiR-125a and MiR-146a), RANTES, and IFN-γin systemic lupus erythematosus

2020 ◽  
Vol 23 (13) ◽  
Author(s):  
Ikram khazal Qasim Al- hasso ◽  
Aida Rashid Al- Derzi ◽  
Ahmed Abdul-hassan Abbas ◽  
Faiq I. Gorial ◽  
Ahmed Sameer Alnuimi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Therapeutic Exercise in Systemic Lupus Erythematosus: Review Article

2019 ◽  
pp. 44-56
Author(s):  
Rahmatika R ◽  
Rudy Handoyo ◽  
Tanti Ajoe K
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Resistance Exercise ◽  
Lupus Erythematosus ◽  
Functional Performance ◽  
Clinical Symptoms ◽  
Activity Index ◽  
Heart Rate Recovery ◽  
Therapeutic Exercise ◽  
Systemic Lupus ◽  
Performance Functional

ABSTRACTIntroduction: Systemic Lupus Erythematosus (SLE) is a prototype of an autoimmune disease characterized by the production of antibodies against cell nucleus components with a broad spectrum of clinical patterns. The SLE will cause long-term complications so that SLE patients tend to have sedentary lifestyle and decrease physical activity which reduces exercise capacity. The aim of therapeutic exercise is to improve a variety of clinical symptoms in SLE patients by alleviate the inflammatory process andmodifying the disease’s natural course. Methods: All of references have searched in 2018 within the areas of rheumatology, immunology,cardiology, physical education and physiotherapy. Results: Therapeutic exercise in SLE has an anti-inflammatory effect by inhibiting the release of inflammatory mediators including TNF-α. Therapeutic exercise in the form of aerobic and resistance exercise able to improve aerobic capacity, reduced fatigue, increasing chronotropic reserve, heart rate recovery, functional performance, functional capacity, muscle strength and increase bone turn over.Therapeutic exercise was not aggravated disease activity as measured by SLE Activity Index (SLEDAI) and SLE Activity Measure (SLAM) index. Conclusion: Supervised aerobic and resistance exercise seems to help improve health, vitality and self perceived physical capacity in SLE patients.

Self-Reflective Insights on What I Have Learned in an Evolving Academic Career Model: Accounting Scholarship, Administration, and Diversity

2018 ◽  
Vol 33 (3) ◽  
pp. 5-16 ◽  
Author(s):  
Carolyn M. Callahan
Keyword(s):  
African American Woman ◽  
Academic Career ◽  
American Woman ◽  
Vantage Point ◽  
Business College ◽  
Personal Experiences ◽  
Career Model ◽  
Accounting Model ◽  
The Impact

ABSTRACT In this paper, I offer personal insights based on my experiences (thus far) in an evolving academic accounting career model. While I value all aspects of an academic career responsibilities (teaching, research, and service), this narrative focuses primarily on the role of accounting scholarship and, broadly, the impact of diversity on the same. I offer these perspectives and personal experiences from the unique vantage point as an African American woman, focused first on contributing to top-tired accounting scholarship, and more recently on roles as an administrator of an accounting department and business college. While my academic journey is unique by objective measures (often dubbed “trailblazing” by others), I offer suggestions that may be useful to any academic who is dedicated to success in our field. Given the evolving accounting model and challenges ahead, my overriding goal remains to encourage junior accounting colleagues to persevere, as an accounting academic career is richly rewarding.

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