Primary Peritoneal Serous Borderline Tumors

2007 ◽  
Vol 131 (1) ◽  
pp. 138-144 ◽  
Author(s):  
C. P. T. Robert L. Hutton, MC ◽  
M. A. J. Scott R. Dalton, MC
Keyword(s):  
Clinical Presentation ◽  
Incidental Finding ◽  
Serous Carcinoma ◽  
Borderline Tumor ◽  
Epithelial Proliferation ◽  
National Library ◽  
Psammoma Bodies ◽  
Serous Borderline Tumor ◽  
History Of ◽  
Papillary Serous Carcinoma

Abstract Context.—Primary peritoneal serous borderline tumor is a rare epithelial proliferation that can present as an incidental finding at laparotomy and raises concern for a primary ovarian tumor with peritoneal implants. Objective.—To present a brief history of this condition and describe its distinctive histology and clinical presentation, as well as to review the chief differential diagnostic considerations, to include mesothelial proliferations, endosalpingiosis, endometriosis, high-grade primary peritoneal papillary serous carcinoma, and implants from primary ovarian serous neoplasms. Data Sources.—Relevant articles indexed in PubMed (National Library of Medicine) between 1966 and 2005, references thereof, and reference surgical pathology texts. Conclusions.—Primary peritoneal serous borderline tumor should be considered in the differential diagnosis of an epithelial proliferation with prominent psammoma bodies on the peritoneal surface of specimens submitted for nongynecologic complaints.

Malignant Transformation of a Serous Borderline Tumor and Early Metastasis of Associated Low-Grade Serous Carcinoma Detected on Screening Mammography

2011 ◽  
Vol 29 (30) ◽  
pp. e763-e765 ◽  
Author(s):  
Donata Rohsbach ◽  
Fabian Trillsch ◽  
Marc Regier ◽  
Matthias Choschzick ◽  
Friedrich Kommoss ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Screening Mammography ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
Early Metastasis ◽  
Serous Borderline Tumor

A Micropapillary Variant of Transitional Cell Carcinoma Arising in the Ureter

2000 ◽  
Vol 124 (9) ◽  
pp. 1347-1348 ◽  
Author(s):  
Russell Vang ◽  
Jacki Abrams
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Inflammatory Cells ◽  
World Health ◽  
Serous Carcinoma ◽  
Ureteral Stricture ◽  
Borderline Tumor ◽  
Nephrogenic Adenoma ◽  
Serous Borderline Tumor

Abstract A 79-year-old woman was evaluated for a ureteral stricture related to laser ablation of a tumor 6 months earlier at another institution. A ureteroscopic examination revealed an exophytic papillary tumor that was resected and examined histologically. The tumor was characterized by delicate papillae with thin stromal cores and numerous secondary micropapillae lined by small cuboidal to low columnar cells with uniform low-to-intermediate–grade nuclei, reminiscent of a serous borderline tumor of müllerian origin. The cell linings were 1 to 4 layers thick; mitotic figures were easily identified. The underlying stroma appeared edematous and contained scattered chronic inflammatory cells. No invasion was identified. After ascertaining that the patient had no known gynecologic neoplasm, the differential diagnoses considered included papillary nephrogenic adenoma, clear cell carcinoma, and the recently described entity of micropapillary transitional cell carcinoma. Because of the striking resemblance to serous carcinoma and the presence of significant mitotic activity, this case was felt to represent a case of micropapillary transitional cell carcinoma (World Health Organization grade 1 to 2) occurring in the ureter. To our knowledge, this tumor had some unique features (no areas of grade 3 nuclei or invasion) that have not been reported in tumors occurring in the urinary bladder. The transitional cell nature of the tumor cells was supported by the immunohistochemical staining pattern. The anatomic distribution of micropapillary transitional cell carcinoma is now expanded to include the ureter, and this tumor should be considered in the differential diagnosis for papillary lesions occurring in the ureter.

Impact of tubal ligation on the natural history of uterine papillary serous carcinoma

2012 ◽  
Vol 127 (1) ◽  
pp. S6
Author(s):  
T. Ayeni ◽  
M. Al Hilli ◽  
A. Mariani ◽  
J. Bakkum-Gamez ◽  
S. Dowdy ◽  
...  
Keyword(s):  
Natural History ◽  
Tubal Ligation ◽  
Serous Carcinoma ◽  
Uterine Papillary Serous Carcinoma ◽  
History Of ◽  
Papillary Serous Carcinoma

scholarly journals KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Sarah Bouri ◽  
Jean-Christophe Noël ◽  
Xavier Catteau ◽  
Walid Al Hajj Obeid ◽  
Ilyas Svistakov ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Epithelial Membrane Antigen ◽  
Borderline Tumor ◽  
Cancer Antigen 125 ◽  
Psammoma Bodies ◽  
Kras Gene ◽  
Serous Borderline Tumor ◽  
Cytokeratin 5 ◽  
Generation Sequencing ◽  
Tumor Gene

Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities. We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy. Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae. The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies. The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm’s tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA). The diagnosis of a serous borderline tumor of the testis was proposed. Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation. To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation.

scholarly journals A Rare Case of Ovarian Serous Borderline Tumor with Brain Metastasis

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Sonia Veran-Taguibao ◽  
Roberto Alvaro A. Taguibao ◽  
Nicolas Gallegos ◽  
Ted Farzaneh ◽  
Ronald Kim ◽  
...  
Keyword(s):  
Ovarian Tumor ◽  
Serous Cystadenoma ◽  
Serous Carcinoma ◽  
Borderline Tumor ◽  
Younger Women ◽  
Excellent Outcome ◽  
Serous Borderline Tumor ◽  
Stage 1 ◽  
The Brain ◽  
Micropapillary Pattern

Background. Serous borderline tumor represents a group of noninvasive tumor of the ovary bridging between benign serous cystadenoma and serous carcinoma. They are commonly seen in younger women and usually have an excellent outcome but seldom show local recurrence (J. F. Leake et al. 1991). Metastasis to the lymph nodes has rarely been reported (M. D. Chamberlin et al., 2001; M. B. Verbruggen et al., 2006). Moreover, the brain is exceptionally a rare metastatic site for ovarian tumor. There is one case of an advanced staged SBT with micropapillary pattern metastasis to the brain recently and by far it is the most distant metastasis reported (M. D. Martin et al., 2017). However, to the best of our knowledge, no report has been documented for a recurrent stage 1 typical SBT metastasizing to the brain.

scholarly journals Clinicopathologic and Molecular Features of Paired Cases of Metachronous Ovarian Serous Borderline Tumor and Subsequent Serous Carcinoma

2019 ◽  
Vol 43 (11) ◽  
pp. 1462-1472 ◽  
Author(s):  
Michael Herman Chui ◽  
Deyin Xing ◽  
Felix Zeppernick ◽  
Zoe Q. Wang ◽  
Charlotte G. Hannibal ◽  
...  
Keyword(s):  
Serous Carcinoma ◽  
Borderline Tumor ◽  
Serous Borderline Tumor ◽  
Molecular Features

scholarly journals Primary Peritoneal Cancer Two Decades after a Bilateral Salpingo-Oophorectomy

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Melinda Rodowa ◽  
Amir H. Salehi ◽  
Jacob McGee
Keyword(s):  
Pelvic Mass ◽  
Serous Carcinoma ◽  
Abdominal Girth ◽  
Primary Peritoneal Cancer ◽  
Peritoneal Cancer ◽  
Occult Malignancy ◽  
Pathologic Assessment ◽  
History Of ◽  
Papillary Serous Carcinoma ◽  
Risk Reducing

Bilateral salpingo-oophorectomy (BSO) is increasingly employed as a risk-reducing strategy for epithelial ovarian cancer (EOC). We report the third case of a patient developing primary peritoneal cancer two decades after a bilateral salpingo-oophorectomy. This 66-year-old female underwent a hysterectomy for pelvic pain at age 28 and a subsequent bilateral salpingo-oophorectomy (BSO) at age of 45 for a pelvic mass. Presenting with a 6-month history of increasing abdominal girth, decreased energy, and a reduction in appetite, she was consented for a unilateral salpingo-oophorectomy, omentectomy, and cytoreductive surgery. Pathology specimens revealed a high grade metastatic papillary serous carcinoma consistent with a primary gynecologic origin. It is unlikely that an occult malignancy was missed at the time of pathologic assessment following her previous BSO; therefore it provides evidence that primary peritoneal cancers can arise through the malignant transformation of benign endosalpingiosis.

scholarly journals Case Report: Borderline tumor and primary peritoneal carcinoma - a rare synchronism

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1630
Author(s):  
Mariana Rei ◽  
Sofia Raposo ◽  
Paulo Figueiredo ◽  
Rita Sousa ◽  
Luís Sá
Keyword(s):  
Tumor Biology ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Borderline Tumor ◽  
High Grade ◽  
Peritoneal Carcinoma ◽  
Non Invasive ◽  
Serous Borderline Tumor ◽  
And Behavior ◽  
Serous Tumors

Ovarian borderline serous tumors present with peritoneal involvement in 20% of cases, either as non-invasive or invasive implants, the latter also known as extraovarian low-grade serous carcinoma. The coexistence of high-grade serous carcinoma is rare, suggesting a synchronous neoplasia with a distinct and independent tumor biology and behavior. We aim to describe a case of a synchronous ovary-peritoneum neoplasia: serous borderline tumor and primary peritoneal high-grade serous carcinoma. A discussion and literature review concerning the optimal diagnostic and therapeutic approach is provided.

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