Primary Neuroendocrine Tumors of the Ureter: A Short Review

2016 ◽  
Vol 140 (7) ◽  
pp. 714-717 ◽  
Author(s):  
Andres M. Acosta ◽  
Andre Kajdacsy-Balla
Keyword(s):  
Neuroendocrine Tumors ◽  
Multimodal Treatment ◽  
Clinical Presentation ◽  
Treatment Approach ◽  
Short Review ◽  
Small Cell ◽  
Neuroendocrine Cells ◽  
Dense Granules ◽  
Multimodal Treatment Approach ◽  
Ureteral Neoplasms

Neuroendocrine tumors represent 0.05% of urinary tract malignancies, and most originate in the bladder. Their pathogenesis is debated, since ureters are thought to lack neuroendocrine cells. Morphologically, most ureteral neuroendocrine tumors demonstrate the typical small cell neuroendocrine appearance, are immunohistochemically positive for synaptophysin/chromogranin A/CD56, and show electron-dense granules by electron microscopy. Clinical presentation is similar to that of other more common ureteral neoplasms. Prognosis is usually dismal, but a multimodal treatment approach including platinum-based adjuvant or neoadjuvant chemotherapy seems to be beneficial.

scholarly journals Poorly Differentiated Small-Cell-Type Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review

2018 ◽  
Vol 11 (3) ◽  
pp. 676-681 ◽  
Author(s):  
Kishore Kumar ◽  
Rafeeq Ahmed ◽  
Chime Chukwunonso ◽  
Hassan Tariq ◽  
Masooma Niazi ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Tumor Grade ◽  
Small Cell ◽  
The Body ◽  
Neuroendocrine Cells ◽  
Cell Type ◽  
Variable Response ◽  
Ki 67 ◽  
Platinum Based Chemotherapy ◽  
Poorly Differentiated

Neuroendocrine cells are widespread throughout the body and can give rise of neuroendocrine tumors due to abnormal growth of the chromaffin cells. Neuroendocrine tumors divide into many subtypes based on tumor grade (Ki-67 index and mitotic count) and differentiation. These tumors can be further divided into secretory and nonsecretory types based on the production of peptide hormone by tumor cells. Poorly differentiated small-cell-type neuroendocrine tumors are one of the subtypes of neuroendocrine tumors. These tumors are less common; however, they tend to be locally invasive and aggressive in behavior with poor overall median survival. Treatment of the nonsecretory small-cell type is modeled to small-cell lung cancer with a regimen consisting of platinum-based chemotherapy and etoposide with variable response. Here, we present a case of poorly differentiated small-cell neuroendocrine tumor originating from the prostate.

1006 LONG‐TERM EFFICACY OF A MULTIMODAL TREATMENT APPROACH FOR PATIENTS SUFFERING FROM CHRONIC PAIN

2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
A. Schütze ◽  
K. Grosse ◽  
U. Kaiser ◽  
M. Schiller ◽  
B. Konrad ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Multimodal Treatment ◽  
Treatment Approach ◽  
Multimodal Treatment Approach ◽  
Term Efficacy

scholarly journals Rectal Cancer: Multimodal Treatment Approach

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Manousos-Georgios Pramateftakis ◽  
Dimitrios Kanellos ◽  
Paris P. Tekkis ◽  
Nikolaos Touroutoglou ◽  
Ioannis Kanellos
Keyword(s):  
Rectal Cancer ◽  
Multimodal Treatment ◽  
Treatment Approach ◽  
Multimodal Treatment Approach

Malignant Peripheral Nerve Sheath Tumor of the Vulva: A Multimodal Treatment Approach

2002 ◽  
Vol 85 (2) ◽  
pp. 365-371 ◽  
Author(s):  
Nicholas C. Lambrou ◽  
Ramin Mirhashemi ◽  
Aaron Wolfson ◽  
Paul Thesiger ◽  
Manuel Penalver
Keyword(s):  
Peripheral Nerve ◽  
Multimodal Treatment ◽  
Treatment Approach ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Multimodal Treatment Approach ◽  
Nerve Sheath

scholarly journals Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review

2016 ◽  
Vol 140 (10) ◽  
pp. 1157-1162 ◽  
Author(s):  
Andres M. Acosta ◽  
Elizabeth Louise Wiley
Keyword(s):  
Clinical Presentation ◽  
Advanced Disease ◽  
Locally Advanced ◽  
Large Cell ◽  
Short Review ◽  
Neuroendocrine Cells ◽  
Architectural Patterns ◽  
Combined Lesions ◽  
Adenocarcinoma Component ◽  
Original Classification

Mixed adenoneuroendocrine carcinomas (MANECs) are composite neoplasms with areas of adenocarcinoma or squamous cell carcinoma intermingled with neuroendocrine carcinoma or neuroendocrine tumor, each composing at least 30% of the neoplasm. MANECs are very infrequent overall, and they are more commonly diagnosed in the appendix, colon, and stomach. Biliary MANECs are particularly rare, and their histogenesis is debated because neuroendocrine cells are seldom identified in the normal biliary tract. They can show one of the 3 different architectural patterns described in Lewin's original classification: collision tumors, combined lesions, or amphicrine neoplasms. The neuroendocrine component is usually of a high grade, with small or large cell cytomorphology, whereas the adenocarcinoma component is either an intestinal or biliary type. Clinical presentation is characterized by locally advanced disease at the time of initial diagnosis. Recent studies suggest that treatment should be guided by the most aggressive histologic component.

Do Patients With Cervical Radiculopathy Benefit From the Addition of Cervical Traction to a Rehabilitation Program? A Critically Appraised Topic

2017 ◽  
Vol 22 (3) ◽  
pp. 18-25
Author(s):  
Nicole Vetroczky ◽  
Christine A. Lauber
Keyword(s):  
Multimodal Treatment ◽  
Treatment Approach ◽  
Cervical Radiculopathy ◽  
Rehabilitation Program ◽  
Clinical Question ◽  
Cervical Pain ◽  
Bottom Line ◽  
Multimodal Treatment Approach ◽  
Cervical Traction

Clinical Question:In patients with cervical radiculopathy and associated pain, is there a benefit to including intermittent, mechanical cervical traction to a multimodal treatment approach to reduce cervical pain and disability?Clinical Bottom Line:The majority of best evidence suggests favorable outcomes regarding decreasing cervical pain and disability with the inclusion of intermittent, mechanical cervical traction into a multimodal treatment approach.

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