A Historical Perspective and Exposé on Serrated Polyps of the Colorectum

2016 ◽  
Vol 140 (10) ◽  
pp. 1079-1084 ◽  
Author(s):  
Eun-Young Karen Choi ◽  
Henry D. Appelman
Keyword(s):  
Historical Perspective ◽  
Hyperplastic Polyp ◽  
Colorectal Polyps ◽  
Hyperplastic Polyps ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Serrated Polyps ◽  
The Third ◽  
The Past ◽  
Serrated Polyp

This article offers a historical perspective on the discovery of 3 types of serrated colorectal polyps recognized in the past 60 years. The first to be discovered was the hyperplastic polyp, which is still the most commonly encountered serrated polyp. In the past 20 years, the carcinoma-associated sessile serrated adenoma/polyp has been recognized, but its diagnosis can be difficult owing to overlapping histologic features with hyperplastic polyps. Less is known about the third type, the traditional serrated adenoma, because it is far less common than the other 2 types, and its association with cancer is currently under investigation.

Significant difference of c-type lectin-like receptor 2 between colorectal cancer and polyp subgroups

2021 ◽  
pp. 1-7
Author(s):  
Meng-Lin Zhang ◽  
Wen-Juan Huang ◽  
Chen-Xi Yue ◽  
Ming-Ming Li ◽  
Na Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Hyperplastic Polyp ◽  
Colorectal Polyps ◽  
Curve Analysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sessile Serrated Adenoma ◽  
Roc Curve Analysis ◽  
Serrated Adenoma ◽  
Node Metastasis ◽  
Significant Difference

BACKGROUND: Platelets play a key role in tumor progression and metastasis. C-type lectin-like receptor 2 (CLEC-2) is the receptor expressed on platelets and the marker of platelet activation. OBJECTIVE: This study aims to determine whether soluble CLEC-2 levels differ between patients with benign colorectal polyps and those with colorectal cancer (CRC). METHODS: We measured plasma soluble CLEC-2 by enzyme-linked immunosorbent assay in 150 patients with colorectal polyps, 150 CRC patients without metastasis, 150 CRC liver metastasis, and 150 control subjects. RESULTS: The CRC patients had higher soluble CLEC-2 levels than patients with colorectal polyps (p< 0.001). Moreover, CRC patients with liver metastases displayed higher CLEC-2 levels than those in CRC patients without metastases (p< 0.001). In the CRC patients, CLEC-2 levels were correlated with lymph node metastasis and advanced stage. In the patients with polyps, there was a significant difference in CLEC-2 levels among patients with hyperplastic polyp, sessile serrated adenoma, and traditional serrated adenoma (p< 0.001). The ROC curve analysis revealed CLEC-2 had an optimal sensitivity of 77.3% and specificity of 94.6% for the screening of CRC, and sensitivity of 71.0% and specificity of 76.7% for the differential diagnosis of colorectal polyps and CRC. CONCLUSIONS: CRC patients have higher CLEC-2 levels than patients with colorectal polyps and healthy controls. Moreover, there is a significant difference in CLEC-2 levels among polyp subtypes. Further research is warranted.

The stem cell marker CD133 is highly expressed in sessile serrated adenoma and its borderline variant compared with hyperplastic polyp

2013 ◽  
Vol 66 (5) ◽  
pp. 403-408 ◽  
Author(s):  
Mahin Mohammadi ◽  
Michael Bzorek ◽  
Jesper Hansen Bonde ◽  
Hans J Nielsen ◽  
Susanne Holck
Keyword(s):  
Hyperplastic Polyp ◽  
Observer Variation ◽  
Stem Cell Marker ◽  
Routine Practice ◽  
Neoplastic Progression ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Serrated Polyps ◽  
Cd133 Expression ◽  
Recorded Data

Non-dysplastic serrated polyps (ND-SP) represent a heterogeneous group of colorectal lesions that comprise hyperplastic polyp (HP) and the non-dysplastic subset of sessile serrated adenoma/polyp/lesion (SSA/P/L) and its borderline variant (BSSA/P/L). Given the observer variation in their histological typing, the identification of reliable markers that assist in the characterisation is warranted. Most important is the identification of polyp qualities that may reflect the patients’ risk of developing colorectal cancer. To address these issues, CD133 may represent a potential adjunct. Here we studied the discriminatory value of CD133 expression in the classification of ND-SPs and its distribution pattern in relation to synchronous colorectal carcinoma (SCRC). 39 SSA/P/Ls, 27 BSSA/P/Ls and 21 matched HPs were immunostained for CD133. The data were further correlated to the presence of SCRC and to polyp site and size. Ignoring SCRC status, CD133 was expressed more prominently in SSA/P/Ls than in HPs. The values for BSSA/P/Ls fell in between, yet closer to the SSA/P/L scorings. This observation was retained in the context of SCRC and for SSA/P/Ls not associated with SCRC. Right-sidedness and large size of the polyps more commonly associated with increased CD133 expression. CD133 expression was not a significant discriminator as to the SCRC status. BSSA/P/Ls are more closely aligned to SSA/P/L and further that SSA/P/L and BSSA/P/Ls fundamentally differ from HP by their CD133 immunoprofile, a notion that can be exploited in the diagnostic routine practice. Recorded data further indirectly support the idea that SSA/P/Ls are more prone to neoplastic progression than are HPs.

scholarly journals A retrospective study on pathological and clinical characteristics of 52 cases with the colorectal serrated polyp

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Xu Li Hua ◽  
Li Qian Jun ◽  
Shen Xiao Feng ◽  
Da Jing ◽  
Zhu Ya Wen
Keyword(s):  
Retrospective Study ◽  
Clinical Characteristics ◽  
Endoscopic Examination ◽  
Malignant Potential ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Serrated Polyps ◽  
Creative Commons ◽  
Serrated Polyp ◽  
Open Access Article

Background and Objective: Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential. The aim of the study was to evaluate the endoscopic, clinic and pathologic characteristics of colorectal serrated polyps. Methods: The endoscopic, clinic and pathologic characteristics of 52 cases with colorectal serrated polyps between January 2014 and May 2018 in our hospital were analyzed. retrospectively. Results: The prevalence of serrated polyps was 0.39% (52/13,346). The proportions of hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA) of all serrated polyps were 61.5%, 17.3%, and 21.2%, respectively, which showed a lower proportion of TSA and SSA/P and a higher proportion of HP. Conclusions: The overall detection rate of colorectal serrated polyps was relatively low, and it is necessary to discriminate between SSAPs and HPs during endoscopic examination because of the malignant potential. How to cite this:Hua XL, Jun LQ, Feng SX, Jing D, Wen ZY. A retrospective study on pathological and clinical characteristics of 52 cases with the colorectal serrated polyp. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.238 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Mo1739 – Molecular Markers, Mlh1 and Msi Status Differentiate Hyperplastic Polyps from Sessile Serrated Adenoma/Polyps Among African American Patients

2019 ◽  
Vol 156 (6) ◽  
pp. S-828
Author(s):  
Hassan Ashktorab ◽  
Priyanka Kanth ◽  
Nazli Atefi ◽  
Saman Azam ◽  
Babak Shokrani ◽  
...  
Keyword(s):  
African American ◽  
Molecular Markers ◽  
Hyperplastic Polyps ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma

scholarly journals Use of endocytoscopy for identification of sessile serrated adenoma/polyps and hyperplastic polyps by quantitative image analysis of the luminal areas

2017 ◽  
Vol 05 (08) ◽  
pp. E769-E774 ◽  
Author(s):  
Yushi Ogawa ◽  
Shin-ei Kudo ◽  
Yuichi Mori ◽  
Nobunao Ikehara ◽  
Yasuharu Maeda ◽  
...  
Keyword(s):  
Roc Analysis ◽  
Normal Mucosa ◽  
Receiver Operating Curve ◽  
Hyperplastic Polyps ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Important Indicator ◽  
Cutoff Value ◽  
Luminal Area ◽  
Magnifying Chromoendoscopy

Abstract Background and study aims Recent studies that used magnifying chromoendoscopy and endocytoscopy (EC) to investigate endoscopic features of sessile serrated adenoma/polyps (SSA/Ps) suggested that a dilated crypt opening was an important indicator of SSA/Ps. However, no studies to date have measured the actual extent of dilatation. Hence, we investigated retrospectively the luminal areas using EC to determine a cutoff value for differentiating SSA/Ps from hyperplastic polyps (HPs). Patients and methods A total of 101 lesions, including 25 SSA/Ps, 66 HPs, and 10 normal mucosal samples, assessed by an integrated-type EC were collected. For each lesion, 1 image that showed the widest lumen was selected and the average area of the contiguous 3 lumens were calculated. The cutoff value differentiating SSAPs from HPs was determined by receiver operating curve (ROC) analysis. Results The mean luminal areas of SSA/Ps and HPs were 4152 μm2 and 2117 μm2, respectively. ROC analysis found that a luminal area cutoff of 3068 μm2 had a sensitivity of 80.0 %, a specificity of 77.3 %, an accuracy of 78.0 %, and an area under the ROC curve of 0.865. Furthermore, a cutoff of ≥ 556 μm2 was found to accurately distinguish between HPs and normal mucosa (sensitivity 98.5 %, specificity 100 %, accuracy 98.7 %, and AUC 0.998). Conclusions EC analysis of the luminal area is useful for differentiating between SSAPs and HPs. This approach could be adapted for computer-aided diagnosis of SSA/P.

Pedunculated Serrated Polyp With Histologic Features of Sessile Serrated Adenoma

2013 ◽  
Vol 37 (7) ◽  
pp. 1039-1043 ◽  
Author(s):  
Mi-Jung Kim ◽  
Eun-Jung Lee ◽  
Sung-Min Chun ◽  
Se-Jin Jang ◽  
Chan-Ho Kim ◽  
...  
Keyword(s):  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Serrated Polyp

scholarly journals Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
A. J. McCarthy ◽  
S. M. O’Reilly ◽  
J. Shanley ◽  
R. Geraghty ◽  
E. J. Ryan ◽  
...  
Keyword(s):  
Screening Programme ◽  
Colorectal Polyps ◽  
Left Colon ◽  
Serrated Adenoma ◽  
Serrated Polyps ◽  
Cancer Screening Programme ◽  
Serrated Lesions ◽  
The Right ◽  
The Impact

Background. As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim. Our aim was to characterize the clinicopathological features of a series of SSL/Ps & TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps & TSAs. Methods. We identified all colorectal serrated polyps between 01/01/2004 and 31/05/2016, by searching the laboratory information system for all cases assigned a “serrated adenoma” SNOMED code. All available and suitable slides were reviewed by one pathologist, who was blinded to the original diagnosis and the site of the polyp. Subsequently discordant cases, SSL/Ps with dysplasia, and all TSAs were reviewed by a second pathologist. Results. Over a 149-month period, 759 “serrated adenoma” polyps were identified, with 664 (from 523 patients) available for review. 41.1% were reviewed by both pathologists; 15.1% (100/664) were reclassified, with the majority being changed from SSL/P to hyperplastic polyp (HYP) (66/664; 9.9%). 80.3% of these HYPs were located in the left colon, and the majority exhibited prolapse effect. There were 520 SSL/Ps (92.2%) & 40 TSAs (7.1%). The majority of SSL/Ps were in the right colon (86.7%) and were small (64.5% <1 cm), while most TSAs were in the left colon (85.7%) and were large (73.1%≥1 cm). 6.7% of SSL/Ps exhibited dysplasia, the majority of which were large (66.7%≥1 cm). Following consensus review, 13/520 (2.5%) SSL/Ps were downgraded from SSL/P with dysplasia to SSL/P without dysplasia. Detection of SSL/Ps peaked in the most recent years reviewed (87.5% reported between 2013 and 2016, inclusive), coinciding with the introduction of “BowelScreen” (the Irish FIT-based colorectal cancer screening programme). Conclusions. Awareness of, and adherence to, diagnostic criteria is essential for accurate classification of colorectal polyps.

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