scholarly journals Evolution of COVID-19 Testing and the Role of Rapid Antigen Testing in Molecular-Focused World

2021 ◽  
Author(s):  
Nam K. Tran ◽  
Larissa May
Keyword(s):  
Antigen Testing

scholarly journals Outbreak of Histoplasmosis in a School Party That Visited a Cave in Belize: Role of Antigen Testing in Diagnosis

2002 ◽  
Vol 9 (1) ◽  
pp. 48-50 ◽  
Author(s):  
Jane A. Buxton ◽  
Meenakshi Dawar ◽  
L. Joseph Wheat ◽  
William A. Black ◽  
Nelson G. Ames ◽  
...  
Keyword(s):  
Antigen Testing

scholarly journals Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening

2021 ◽  
Vol 10 (17) ◽  
pp. 3854
Author(s):  
Vicente Martín-Sánchez ◽  
Tania Fernández-Villa ◽  
Ana Carvajal Urueña ◽  
Ana Rivero Rodríguez ◽  
Sofía Reguero Celada ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Diagnostic Test ◽  
Internal Validity ◽  
High Specificity ◽  
Population Based ◽  
Predictive Values ◽  
Asymptomatic Patients ◽  
Screening Performance ◽  
Antigen Testing

This study evaluates a population-based screening of asymptomatic people, using a rapid antigen diagnostic test (RADT), in areas of high transmission. To detect sources of SARS-CoV-2 infection, nasopharyngeal samples were taken and were tested using RADT. Confirmatory RT-qPCR tests were performed in both positive and negative cases. The internal validity of the RADT, the prevalence of infection, and the positive and negative predictive values (PPV and NPV) were estimated, based on the percentages of confirmed cases with 95% confidence interval. Of the 157,920 people registered, 50,492 participated in the screening; 50,052 were negative, and 440 were positive on the RADT (0.87%). A total of 221 positive RADT samples were reanalysed using RT-qPCR and 214 were confirmed as positive (96.8%; 95% CI: 93.5–98.7%), while 657 out of 660 negative RADT samples were confirmed as RT-qPCR negative (99.5%; 95% CI 98.7–99.9%). The sensitivity obtained was 65.1% (38.4–90.2%) and the specificity was 99.97% (99.94–99.99%). The prevalence of infection was 1.30% (0.95–2.13%). The PPVs were 95.4% (85.9–98.9%) and 97.9% (93.3–99.5%), respectively, while the NPVs were 99.7% (99.4–100%) and 99.2% (98.7–100%), respectively. The high specificity found allow us to report a high screening performance in asymptomatic patients, even in areas where the prevalence of infection was less than 2%.

scholarly journals Utility of endobronchial ultrasound guided trans-bronchial needle aspiration in diagnosis of melioidosis - case series and review of literature

2020 ◽  
Vol 90 (3) ◽  
Author(s):  
Mujeeb Rahman K.K ◽  
Sourin Bhuniya ◽  
Bijayini Behera ◽  
Prasanta Raghab Mohapatra ◽  
Rajesh Kumar ◽  
...  
Keyword(s):  
Point Of Care ◽  
Case Series ◽  
Needle Aspiration ◽  
Endobronchial Ultrasound ◽  
Mediastinal Lymphadenopathy ◽  
Review Of Literature ◽  
Ultrasound Guided ◽  
Transbronchial Needle Aspiration ◽  
Antigen Testing

Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is routinely performed for diagnostic evaluation of mediastinal lymphadenopathy due to various etiologies with excellent sensitivity and specificity. Melioidosis can have atypical features like isolated mediastinal lymphadenopathy mimicking as tuberculosis or lymphoma. Differentiation of such atypical melioidosis presentation become difficult due to similar clinical, radiological and even similar EBUS lymph node characteristics. Role of EBUS TBNA in diagnosing melioidosis is under investigated and sparsely reported. We describe two cases of melioidosis diagnosed by point of care rapid lateral flow immunoassay antigen testing and culture of EBUS-TBNA samples from necrotic mediastinal lymph nodes.

The potential role of HCV core antigen testing in diagnosing HCV infection

2012 ◽  
Vol 17 (7 Pt B) ◽  
pp. 1431-1435 ◽  
Author(s):  
George J Dawson
Keyword(s):  
Potential Role ◽  
Hcv Infection ◽  
Core Antigen ◽  
Hcv Core Antigen ◽  
Antigen Testing

scholarly journals 396. Clinical Features of Proven and Probable Cases of Histoplasmosis and the Role of Urinary Histoplasma Antigen Testing: A Case Series From India

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S152-S153
Author(s):  
Nitin Bansal ◽  
Nandini Sethuraman ◽  
Madhumitha R. ◽  
P Senthur Nambi ◽  
Suresh Kumar D ◽  
...  
Keyword(s):  
Clinical Features ◽  
Case Series ◽  
Antigen Testing

scholarly journals Healthcare-associated Legionnaires’ disease: Limitations of surveillance definitions and importance of epidemiologic investigation

2017 ◽  
Vol 18 (6) ◽  
pp. 307-310 ◽  
Author(s):  
Laila M Castellino ◽  
Shantini D Gamage ◽  
Patti V Hoffman ◽  
Stephen M Kralovic ◽  
Mark Holodniy ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
Sequence Type ◽  
Significant Morbidity ◽  
Urinary Antigen ◽  
Epidemiologic Investigation ◽  
Urinary Antigen Testing ◽  
Legionnaires Disease ◽  
Healthcare Associated ◽  
Antigen Testing

Healthcare-associated Legionnaires’ disease (HCA LD) causes significant morbidity and mortality, with varying guidance on prevention. We describe the evaluation of a case of possible HCA LD and note the pitfalls of relying solely on an epidemiologic definition for association of a case with a facility. Our detailed investigation led to the identification of a new Legionella pneumophila serogroup 1 sequence type, confirmed a healthcare association and helped build the framework for our ongoing preventive efforts. Our experience highlights the role of routine environmental cultures in the assessment of risk for a given facility. As clinicians increasingly rely on urinary antigen testing for the detection of L. pneumophila, our investigation emphasises the importance of clinical cultures in an epidemiologic investigation.

scholarly journals The dark side of SARS-CoV-2 rapid antigen testing: screening asymptomatic patients

2021 ◽  
Author(s):  
Giorgia Caruana ◽  
Laure-Line Lebrun ◽  
Oriane Aebischer ◽  
Onya Opota ◽  
Luis Urbano ◽  
...  
Keyword(s):  
Hospital Admissions ◽  
Screening Method ◽  
Dark Side ◽  
Pcr Analysis ◽  
Rt Pcr ◽  
Asymptomatic Patients ◽  
Antigen Tests ◽  
Outpatient Settings ◽  
Antigen Testing

AbstractMost of the reports describing SARS-CoV-2 rapid antigen tests (RATs) performances derive from COVID-19 symptomatic subjects in outpatient settings during periods of highest incidence of infections and high rates of hospital admissions. Here we investigated the role of RATs in an Emergency Department, as a screening tool before admission for COVID-19 asymptomatic patients. Each patient was screened with two simultaneous nasopharyngeal swabs: one immediately analyzed at the bedside using RAT and the other sent to the laboratory for RT-PCR analysis. A total of 116 patients were screened at hospital admission in a 250-bed community hospital in Morges (EHC), Switzerland. With a disease prevalence of 6% based on RT-PCR results, RAT detected only two out of seven RT-PCR positive patients (sensitivity 28.6%) and delivered two false positive results (specificity 98.2%), thus resulting not fiable enough to be used as a screening method in this clinical scenario.

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