Epidemiological and clinical analyses of corneal transplants performed in a reference eye center in Recife, Brazil

BackgroundThis study examined whether corneas from bacteremic donors could be used for corneal transplant.MethodsCorneas donated to the National Eye Bank of Taiwan between 1 January 2014 and 30 June 2017 were included in this study. All the corneas had corneoscleral rim cultures during the retrieval process and were hypothermic preserved in the Optisol-GS storage medium. A microbial work-up flow chart was used for the sterility check of all grafts. Bacteremic donors were defined as those whose last blood culture before corneal donation was positive. The microbial contamination rates, the endothelial cell densities, the tissue utility rates and early complications after transplants were compared between the corneas from bacteremic versus non-bacteremic donors.Results697 corneas from 356 donors were analysed, 70 of which were from bacteremic donors. The microbial contamination rates of the corneas from bacteremic and non-bacteremic donors (7.1% vs 9.1%)(p=0.30) were close. None of the contaminated corneas grew the same bacterial strains as those from their blood cultures. The corneas from bacteremic donors and non-bacteremic donors have similar endothelial cell densities (2931±297 cells/mm2 vs 2903 ± 470 cells/mm2) (p=0.63). Corneas from bacteremic and non-bacteremic donors shared a similar utility rate (98.6% vs 99.4%)(p=0.41). None of the corneas caused infectious complications after transplants.ConclusionOur study showed that corneas from bacteremic and non-bacteremic donors have equally low contamination rates and are of the same quality in terms of endothelial cell density and safety.

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Effect of Gas-Permeable Contact Lenses on the Endothelium of Corneal Transplants

Archives of Ophthalmology ◽

10.1001/archopht.1991.01080120087032 ◽

1991 ◽

Vol 109 (12) ◽

pp. 1703 ◽

Cited By ~ 10

Author(s):

Mark G. Speaker

Keyword(s):

Contact Lenses ◽

Corneal Transplants

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Long-term survival of corneal transplants and visual outcomes among private patients of corneal surgeons in Metropolitan Manila (the Philippines)

Asian Journal of Ophthalmology ◽

10.35119/asjoo.v15i4.331 ◽

2017 ◽

Vol 15 (4) ◽

Author(s):

David Francis Fullon Chan ◽

Ma. Dominga B. Padilla

Keyword(s):

Survival Rates ◽

The Philippines ◽

Clinical Findings ◽

Data Sets ◽

Eye Bank ◽

Term Survival ◽

Visual Outcomes ◽

Corneal Transplants ◽

Tissue Characteristics

PURPOSE: There are currently no published studies on the outcomes of keratoplasty in the Philippines. This study aimed to report graft survival rates at years 1, 3, and 5 after surgery, visual outcomes, and causes of graft failure among private patients of corneal surgeons in Metropolitan Manila receiving tissue from a single local eye bank in the period 2008-2012. DESIGN: Retrospective cohort, multicenter study. METHODS: POPULATION: Private patients of Metro Manila corneal surgeons, receiving tissue from the Santa Lucia International Eye Bank of Manila in 2008-2012. 241 of 593 yielded sufficiently complete data sets. PROCEDURE: Donor and tissue characteristics, pre-op and latest follow-up characteristics/clinical findings were retrieved and processed. Data from the eye bank was merged with follow-up data from surgeons submitted March-October 2014. MAIN OUTCOME MEASURES: Survival rates at 1, 3, and 5 years; best-corrected visual acuity as of latest follow-up; causes of failure. RESULTS: 1-year survival: 90.4%, 3-year: 71.5%, 5-year: ~52.7%. Overall, 43.5% had VA of 20/50 or better, and 25% counting fingers or worse, with variations across diagnoses. CONCLUSION: Though small in sample size and response rate, survival trends parallel studies with larger populations elsewhere. Specific trends like favorable survival in keratoconus were consistent. Indications for surgery have changed little since 2005, but regraft has become the most common indication. Further data collection and completion are required for multivariate analysis on factors regarding survival. Inflammation, infection, trauma, poor adherence are among the identified reasons for failure.

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Awareness and Attitudes toward Corneal Transplants among Applicants and Staff of a Driver, Vehicle and Licensing Authority (DVLA) in Ghana

10.21203/rs.2.174/v1 ◽

2019 ◽

Author(s):

Seth Lartey ◽

ELLEN KONADU ANTWI-ADJEI ◽

Solomon Agyapong ◽

Abdul-Kabir Mohammed ◽

Derrick N.O. Mensah ◽

...

Keyword(s):

Cross Sectional Study ◽

Corneal Transplant ◽

Cross Sectional ◽

Willingness To Donate ◽

Corneal Transplants ◽

Drivers License ◽

Study Population ◽

Good Potential ◽

Potential Mode ◽

Age Range

Abstract Introduction: Corneal transplantations are surgeries performed for irreparable corneal diseases and damage. However, there is a gap between the number of potential recipients and the number of donor corneas available. The main aim of the study was to determine the awareness and attitudes towards corneal transplants among applicants and staff of DVLA, Kumasi-Ghana. Materials and Methods: A descriptive cross-sectional study was conducted. 100 participants were selected using convenient sampling method. A structured questionnaire was used to elicit responses from participants concerning awareness and attitudes toward corneal transplant. Results: The mean ± SD age of the participants was 32.05 ± 11.48years and age range, 18-67years. Males were 66% whilst females constituted 34%. 32.7% of the participants were aware of corneal transplant. Majority of the participants were Christians (83.1%) and Singles (63%). Television was the source of information with the highest preponderance (49.4%). 67.3% were willing to donate their corneas after death. 63.9% were willing to indicate their donor statuses on drivers’ license form which had a significant association with willingness to donate cornea after death (p<0.05, ᵪ2= 12.187). Conclusion: There is a poor level of awareness (32.7%) of transplant donation amongst the study population but and a good level of willingness to donate organs (67%). Consent via driving license would seem to be a good potential mode of obtaining consent to supplement the harvesting of adequate tissues for transplant if adequate awareness is created. Keywords: Knowledge, Willingness, Unwillingness, Cornea, DVLA

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Artificial corneas versus donor corneas for repeat corneal transplants

Cochrane Database of Systematic Reviews ◽

10.1002/14651858.cd009561.pub2 ◽

2014 ◽

Cited By ~ 1

Author(s):

Esen K Akpek ◽

Majed Alkharashi ◽

Frank S Hwang ◽

Sueko M Ng ◽

Kristina Lindsley

Keyword(s):

Corneal Transplants ◽

Artificial Corneas ◽

Donor Corneas

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A Review of Pediatric Corneal Transplants: Perioperative, Operative, and Postoperative Management

International Ophthalmology Clinics ◽

10.1097/iio.0000000000000398 ◽

2021 ◽

Vol 62 (1) ◽

pp. 15-31

Author(s):

Benjamin Park ◽

Melody Ziari ◽

Hannah Muniz Castro ◽

Shazia F. Ali

Keyword(s):

Postoperative Management ◽

Corneal Transplants

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Corneal Sensitivity after Penetrating Keratoplasty

European Journal of Ophthalmology ◽

10.1177/112067219300300203 ◽

1993 ◽

Vol 3 (2) ◽

pp. 66-70 ◽

Cited By ~ 8

Author(s):

I. Tuğal Tutkun ◽

K. Akarçay ◽

L. Közer Bilgin ◽

N. Sansoy ◽

M. Urgancioğlu

Keyword(s):

Correlation Analysis ◽

Postoperative Period ◽

Preoperative Diagnosis ◽

Penetrating Keratoplasty ◽

Test Results ◽

Clinical Testing ◽

Corneal Sensitivity ◽

Graft Size ◽

Progressive Improvement ◽

Corneal Transplants

In order to determine corneal sensitivity after penetrating keratoplasty, 71 corneal transplants and their recipient beds were tested using the Cochet-Bonnet esthesiometer. The periods from surgery to examination were two weeks to 15 years. When the test results were divided into six groups according to the postoperative period, correlation analysis revealed a progressive improvement of sensitivity in the central and peripheral graft as well as in the recipient cornea. Only one graft had normal central sensitivity at 24 months; 36 grafts were completely anesthetic while 35 grafts had some level of sensitivity at the time of last clinical testing. Age, preoperative diagnosis or graft size were not correlated with the recovery of sensitivity. The extent and time of reinnervation in corneal grafts varied in individual patients.

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