scholarly journals The role of growth factors in extraction wound healing

2015 ◽  
Vol 31 (72) ◽  
pp. 1524-1537
Author(s):  
Simona Stojanovic ◽  
Milos Tijanic ◽  
Goran Jovanovic ◽  
Milan Spasic ◽  
Branislava Stojkovic ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors

scholarly journals Complements and the Wound Healing Cascade: An Updated Review

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Hani Sinno ◽  
Satya Prakash
Keyword(s):  
Health Care ◽  
Wound Healing ◽  
Growth Factors ◽  
Health Care System ◽  
Complement Cascade ◽  
Patient Morbidity ◽  
Multistep Process ◽  
The Usa ◽  
Skin Healing

Wound healing is a complex pathway of regulated reactions and cellular infiltrates. The mechanisms at play have been thoroughly studied but there is much still to learn. The health care system in the USA alone spends on average 9 billion dollars annually on treating of wounds. To help reduce patient morbidity and mortality related to abnormal or prolonged skin healing, an updated review and understanding of wound healing is essential. Recent works have helped shape the multistep process in wound healing and introduced various growth factors that can augment this process. The complement cascade has been shown to have a role in inflammation and has only recently been shown to augment wound healing. In this review, we have outlined the biology of wound healing and discussed the use of growth factors and the role of complements in this intricate pathway.

scholarly journals Role of growth factors and biomaterials in wound healing

2018 ◽  
Vol 46 (sup1) ◽  
pp. 906-911 ◽  
Author(s):  
Farshad Zarei ◽  
Maryam Soleimaninejad
Keyword(s):  
Wound Healing ◽  
Growth Factors

scholarly journals Cloning, Expression and Effects of P. americana Thymosin on Wound Healing

2019 ◽  
Vol 20 (19) ◽  
pp. 4932 ◽  
Author(s):  
Jie Jing ◽  
Xiaohong Sun ◽  
Chuang Zhou ◽  
Yifan Zhang ◽  
Yongmei Shen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Tissue Regeneration ◽  
Dna Sequences ◽  
Wound Repair ◽  
Periplaneta Americana ◽  
American Cockroach ◽  
Promote Wound Healing ◽  
Fibroblast Migration

The American cockroach (Periplaneta americana) is a medicinal insect. Its extract is used clinically to promote wound healing and tissue regeneration, but the effective medicinal components and mechanisms are not yet clear. It has been reported that human thymosin beta 4 (Tβ4) may accelerate skin wound healing, however, the role of P. americana thymosin (Pa-THYs) is still poorly understood. In the present study, we identify and analyze the DNA sequences of Pa-THYs by bioinformatics analysis. Then we clone, express, and purify the Pa-THYs proteins and evaluate the activity of recombinant Pa-THYs proteins by cell migration and proliferation assays in NIH/3T3 cells. To elucidate the role of Pa-THYs in wound healing, a mouse model is established, and we evaluate wound contraction, histopathological parameters, and the expressions of several key growth factors after Pa-THYs treatment. Our results showed that three THY variants were formed by skipping splicing of exons. Pa-THYs could promote fibroblast migration, but have no effect on fibroblast proliferation. In wound repair, Pa-THYs proteins could effectively promote wound healing through stimulating dermal tissue regeneration, angiogenesis, and collagen deposition. On the molecular mechanism, Pa-THYs also stimulated the expression of several key growth factors to promote wound healing. The data suggest that Pa-THYs could be a potential drug for promoting wound repair.

scholarly journals Role of Growth Factors-Rich Plasma, Gel and Membrane in Dermal Wound Healing and Injured Tissue Restoration and Regeneration

2021 ◽  
Vol 3 (6) ◽  
pp. 14-23
Author(s):  
Tariq Mehmood Dar ◽  
Kashif Ali Samin
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Wound Care ◽  
Tissue Repair And Regeneration ◽  
Injured Tissue ◽  
Plasma Injection ◽  
Age Related ◽  
Speed Up

Background: The socioeconomic burden on society grows as the incidences of chronic age-related degenerative diseases increase which demand extensive wound care as well. To speed up the healing of cutaneous wounds, new wound healing treatments must be researched, trialed & developed. Regeneration therapies are gaining popularity since they are less invasive than other treatments. Method: Published research paper have been reviewed to develop a concept and analyze the role of Platelet-rich plasma (PRP) and Growth factors-rich plasma in speedy wound healing and tissue regeneration. Three patients with diabetic ulcers have been selected and applied Growth factors-rich plasma and membrane treatment on weekly basis and analyzed the results. Results: Growth factors-rich plasma injection and membrane application on wound have produced remarkable wound healing outcome within 3 to 6 applications with new vascularization and re-epithelialization.  Conclusion: Growth factors-rich plasma and membrane application on wound gained favor as a wound-healing therapy due to its constituents which have remarkable potential to speed up the injured tissue repair and regeneration. The release of cytokines with platelet-derived growth molecules enveloped in alpha-granule, promote & facilitate wound healing.

The role of growth factors and extracellular matrix in wound healing following laryngotracheal reconstruction

1997 ◽  
Vol 117 (2) ◽  
pp. P82-P82
Author(s):  
D WALNER ◽  
S HEFFELFINGER ◽  
M ABRAMS ◽  
M MILLER ◽  
R COTTON ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factors ◽  
Laryngotracheal Reconstruction

The Role of Growth Factors in Wound Healing

1991 ◽  
Vol 4 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Eveline Blitstein-Willinger
Keyword(s):  
Wound Healing ◽  
Growth Factors

scholarly journals MICRO AND NANOPARTICLES FOR THE DELIVERY OF GROWTH FACTORS IN DIABETIC WOUNDS

2021 ◽  
Vol 10 (5) ◽  
pp. 3552-3559
Author(s):  
S Sanju
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Recovery Process ◽  
Diabetic Wound ◽  
Critical Factors ◽  
Low Oxygen ◽  
Short Period ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds

Diabetic wound (DW) is one of the leading complications of diabetes patients with a long history. It also puts an economic burden on people recovering from injuries to manage medication. The critical factors in the treatment of DW are infection, inflammation, and low oxygen level. Since these non-healing injuries are linked to the extended recovery process, current treatments are studied only for a short period. The areas covered in this article are an overview of DM, Pathophysiology of DW, stages of wound healing (Hemostasis, Inflammation, Proliferation, Maturation), the role of growth factor in diabetic wound healing, advantages of micro and nanoparticles over other drug delivery systems and micro and nanoparticles for the delivery of growth factors with different studies.

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