Clinico-haemato-biochemical and oxidative stress evaluation of hepato-renal dysfunction in dogs with total cholesterol as a biomarker for hepatic diseases

2020 ◽  
Vol 44 (4) ◽  
pp. 226-234
Author(s):  
Shvesh Bandivadekar ◽  
Madhu Swamy ◽  
Yamini Verma ◽  
Amita Dubey
Keyword(s):  
Oxidative Stress ◽  
Total Cholesterol ◽  
Renal Dysfunction ◽  
Stress Evaluation ◽  
Hepatic Diseases ◽  
And Oxidative Stress

scholarly journals Citrus sinensis and Vitis vinifera Protect Cardiomyocytes from Doxorubicin-Induced Oxidative Stress: Evaluation of Onconutraceutical Potential of Vegetable Smoothies

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 378 ◽  
Author(s):  
Giacomo Pepe ◽  
Emanuela Salviati ◽  
Shara Francesca Rapa ◽  
Carmine Ostacolo ◽  
Stella Cascioferro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Citrus Sinensis ◽  
Breast Adenocarcinoma ◽  
Vitis Vinifera L ◽  
Stress Evaluation ◽  
Apoptotic Activity ◽  
And Oxidative Stress ◽  
Potential Use ◽  
Mcf 7

The interest towards nutraceuticals able to counteract drug side effects is continuously growing in current chemotherapeutic protocols. In the present study, we demonstrated that smoothies containing mixtures of Citrus sinensis and Vitis vinifera L. cv. Aglianico N, two typical fruits of the Mediterranean diet, possess bioactive polyphenols that protect cardiomyocytes against doxorubicin-induced oxidative stress. The polyphenolic extracts isolated from Citrus sinensis- and Vitis vinifera-based functional smoothies were deeply characterized by Liquid Chromatography-Mass Spectrometry methods. Subsequently, the functional smoothies and relative mixtures were tested to verify their ability to affect cellular viability and oxidative stress parameters in embryonic cardiomyocyte cells (H9c2), and human breast adenocarcinoma cell line (MCF-7) exposed to doxorubicin. Interestingly, we found that the mix resulting from Citrus sinensis and Vitis vinifera association in ratio 1:1 was able to reduce cardiomyocytes damage induced by anthracyclines, without significantly interfering with the pro-apoptotic activity of the drug on breast cancer cells. These results point out the potential use of vegetable smoothies as adjuvants functional foods for chemotherapeutic anticancer protocols.

Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats

2013 ◽  
Vol 40 (5) ◽  
pp. 3681-3691 ◽  
Author(s):  
Sam Daniel Mershiba ◽  
M. Velayutham Dassprakash ◽  
Sundara Dhakshinamurthy Saraswathy
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Renal Dysfunction ◽  
And Oxidative Stress

Gill histopathological and oxidative stress evaluation in native fish captured in Portuguese northwestern rivers

2013 ◽  
Vol 90 ◽  
pp. 157-166 ◽  
Author(s):  
S. Pereira ◽  
A.L. Pinto ◽  
R. Cortes ◽  
A. Fontaínhas-Fernandes ◽  
A.M. Coimbra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Native Fish ◽  
Stress Evaluation ◽  
And Oxidative Stress

In Vivo Genotoxicity and Oxidative Stress Evaluation of an Ethanolic Extract from Piquiá (Caryocar villosum) Pulp

2013 ◽  
Vol 16 (3) ◽  
pp. 268-271 ◽  
Author(s):  
Mara Ribeiro Almeida ◽  
Alexandre Ferro Aissa ◽  
Tarsila Daysy Ursula Hermogenes Gomes ◽  
Joana D'Arc Castania Darin ◽  
Renan Campos Chisté ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ethanolic Extract ◽  
Stress Evaluation ◽  
And Oxidative Stress

Terminalia arjuna supplementation ameliorates high fat diet-induced oxidative stress in nephrotoxic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Pallavi S. Kanthe ◽  
Bheemshetty S. Patil ◽  
Kusal K. Das
Keyword(s):  
Oxidative Stress ◽  
Serum Creatinine ◽  
Renal Dysfunction ◽  
High Fat Diet ◽  
Terminalia Arjuna ◽  
Histopathological Analysis ◽  
High Fat ◽  
Morphometrical Analysis ◽  
Kidney Functions ◽  
And Oxidative Stress

Abstract Objectives Dietary high fat possibly causes oxidative stress; also it makes deleterious effect on kidney functions and land up in lipotoxicity in renal tissue. Lipotoxicity is the pathological situation where lipid Peroxidation occurs and generates reactive oxygen species (ROS). Overproduction of ROS than antioxidant present in tissues cause oxidative stress. Terminalia arjuna is found to be potential antioxidant that counteract oxidative stress and possibly maintain glomerular integrity. Methods Ethanolic extract of T. arjuna (ETO) was prepared and phytochemical analysis was done. Rats were divided into four groups, having six rats in each group as following; group 1-Control (20% fat); group 2 (ETO 100 mg/kg/b.wt); group 3 (30% fat) and group 4 (30% fat + ETO 100 mg/kg/b.wt). Dietary and ETO supplementation were continued for 21 days. Gravimetric, kidney functions (blood urea and serum creatinine) and oxidative stress markers like MDA, SOD and GSH were evaluated. Histopathological analysis was done on kidney along with measurement of glomerular integrity. Morphometrical analysis of glomerular integrity was evaluated by measuring glomerular length, width, glomerular area and Bowman’s capsule radius. One way ANOVA was done for analysis of data. Results Blood urea and serum creatinine levels were significantly higher in high fat fed rats indicating renal dysfunction. High fat diet showed significant increase in MDA, decrease in SOD and GSH in rats fed with high fat diet, which indicate generation of oxidative stress. Supplementation of ETO showed amelioratic effect against high fat diet induced renal dysfunction and oxidative stress. Histopathological findings were significantly corroborated with morphometrical analysis of glomerular integrity. Conclusions Ethanolic extracts of T. arjuna supplementation found to be beneficial against high fat induced renal alterations in terms of functions and architecture.

Effect of administration of methanol root bark extract of Cussonia arborea on serum lipid profile and oxidative biomarker parameters in alloxan-induced diabetic rats

2016 ◽  
Author(s):  
Patrick Emeka Aba ◽  
Isaac Uzoma Asuzu
Keyword(s):  
Oxidative Stress ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Methanol Extract ◽  
Diabetic Rats ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark ◽  
Oxidative Stress Biomarkers ◽  
And Oxidative Stress

This study investigated the effects of methanol extract of Cussonia arborea on serum lipid and oxidative stress biomarkers of alloxan-induced diabetic rats. A total of 72 male albino rats assigned into 6 groups of 12 rats per group were used. Groups 1-5 were made diabetic while group 6 were normal. Groups 1-4 were treated with 62.5, 125, 250 mg/kg of the extract and 2 mg/kg glibenclamide respectively while groups 5 and 6 received 10 ml/kg distilled water each. Total cholesterol, triglyceride, high density lipoprotein (HDL), malondiadehyde, catalase, and superoxide dismutase (SOD) were assayed on days 28, 56 and 84 post treatment. The results indicated that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglyceride, malondialdehyde but significantly (p<0.05) increased the activities of SOD, catalase and the levels of HDL when compared to negative control. It was therefore concluded that methanol extract of C. arborea mitigated dyslipidaemia and oxidative stress.

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