Effect of Time Since Death on Morphological Changes of Red and White Blood Cells-An Autopsy based Study at S.M.S. Medical College & Attached Group of Hospitals, Jaipur During the Year 2016–2017

2019 ◽  
Vol 19 (2) ◽  
pp. 145
Author(s):  
Shiv Shanker Jat ◽  
R.K. Punia ◽  
Mukesh Kumar Khichi ◽  
Shashank Sharma
Keyword(s):  
Blood Cells ◽  
Morphological Changes ◽  
White Blood Cells ◽  
Time Since Death ◽  
Medical College

Therapeutic Effects of Citric and Succinic Acids in Rats Exposed to Inactivated M. tuberculosis

2021 ◽  
pp. 69-75
Author(s):  
SV Skupnevskiy ◽  
GM Trukhina ◽  
EG Pukhaeva ◽  
AK Badtiev ◽  
FK Rurua ◽  
...  
Keyword(s):  
Body Weight ◽  
Mycobacterium Tuberculosis ◽  
Succinate Dehydrogenase ◽  
Blood Cells ◽  
Morphological Changes ◽  
White Blood Cells ◽  
Therapeutic Effects ◽  
X Rays ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant

Introduction. The search for methods of correcting pathogenetic disorders related to Mycobacterium tuberculosis, the causative agent of tuberculosis, a highly hazardous communicable and socially significant disease, determines the relevance of the research and its objective to study the role of citric and succinic acids in protective and adaptive processes in warm-blooded animals with connective tissue disorders induced by inactivated mycobacteria. Materials and methods. The study was conducted on male Wistar rats with diseases induced by complete Freund’s adjuvant (a mineral oil emulsion containing heat-killed Mycobacterium tuberculosis). The animals were given a feed-added mixture of organic acids at 17 mg/kg body weight (minimum) and 88 mg/kg body weight (maximum) for 4 weeks. Hematology and bio�chemistry tests were performed using standard methods. The activity of succinate dehydrogenase in blood lymphocytes was determined by the cytobiochemical method. X-rays were obtained using stationary veterinary imaging equipment. Results. The protective effect of carboxylic acids in the exposed animals with Freund’s adjuvant-induced leukocytosis (expressed by a 28 % increase in white blood cells compared to the negative control, p < 0.05), oxidative stress (expressed by an increase in the concentration of malondialdehyde (MDA) by 40 %, p < 0.001, and in inhibition of catalase by 4 %), and subchondral bone sclerosis was characterized by a dose-dependent reduction in immunotoxic manifestations of the disease such as normalization of the number of white blood cells (p < 0.05 compared to model animals); a 27 % reduction in MDA, p < 0.001, a 10 % catalase activation, p < 0.01; succinate dehydrogenase normalization, and a decrease in dystrophic changes in the articular system of animals. Conclusion. The results of hematological, biochemical and radiological tests prove that pathological biochemical and morphological changes related to administration of inactivated M. tuberculosis to warm-blooded animals can be modified by a mixture of citric and succinic acids added to feed, which allows a better understanding of the pathogenesis and an increased therapy effectiveness.

About morphological changes in blood in rubella

1904 ◽  
Vol 4 (1-2) ◽  
pp. 105-106
Author(s):  
N Y Chistovich ◽  
O A Shestakova
Keyword(s):  
Blood Cells ◽  
Morphological Changes ◽  
White Blood Cells ◽  
Normal Blood ◽  
Blood Composition

On the basis of 4 investigated hematologically patients (children 7-10 years old), the authors come to the next conclusions. By comparison with the data of normal blood composition, it turns out that the total number of white blood cells, corpuscles in patients with rubella is in the norm (out of three increased in one to 13876-21503; norm 3900-11352).

Effects of Motherwort Total Alkaloids on Prostatitis Model of Mice

2014 ◽  
Vol 926-930 ◽  
pp. 1049-1053
Author(s):  
Ming San Miao ◽  
Lin Guo ◽  
Shuo Tian
Keyword(s):  
Blood Cells ◽  
Dose Group ◽  
Morphological Changes ◽  
White Blood Cells ◽  
High Dose Group ◽  
High Dose ◽  
Pathological Changes ◽  
Mice Model ◽  
Total Alkaloids ◽  
Medium Dose

Abstract Objective: To investigate the effect of Motherwort total alkaloids on prostatitis model of mice.Methods:Different groups of mice for Motherwort total alkaloids are given high,medium,low suspension.Observe the number of white blood cells , lecithin corpuscle density groups in prostatic fluid and the morphological changes of prostate,testis, epididymis.Results:Compared with the model group, the Motherwort total alkaloidss high, medium dose group can significantly reduce the number of white blood cells of prostate in mice model of prostatitis and increase lecithin corpuscle number (P<0.01); the Motherwort total alkaloidss high dose group significantly reduce the pathological changes of prostatitis (P<0.01); the Motherwort total alkaloidss medium dose group significantly reduce the pathological changes of prostatitis (P<0.05). the Motherwort total alkaloidss high dose group significantly reduce the pathological changes of testis (P<0.05)and it can significantly reduce the pathological changes of the epididymis (P<0.01).Conclusion:Motherwort total alkaloids has a therapeutic effect on prostatitis model of mice .

Hyperthermia associated morphological changes in white blood cells

2021 ◽  
Author(s):  
Ting Hon Stanford Li ◽  
Man Sin Wong ◽  
Hung Fan Wong ◽  
Wai Shan Wong ◽  
Ching Bill Chan
Keyword(s):  
Blood Cells ◽  
Morphological Changes ◽  
White Blood Cells

scholarly journals Effect of Examination stress on heart rate, blood pressure and white blood cells.

2021 ◽  
Vol 28 (01) ◽  
Author(s):  
Umair Ali Soomro ◽  
Shumail Saeed Siddiqui ◽  
Kashif Rasheed Shaikh ◽  
Shumaila Shaikh ◽  
Shagufta Memon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Medical Students ◽  
Blood Cells ◽  
White Blood Cells ◽  
Systemic Blood Pressure ◽  
Medical College ◽  
Before And After ◽  
Physiological Homeostasis ◽  
Examination Stress

Objectives: To analyze the effects of Examination stress on heart rate, blood pressure and white blood cells among medical college students. Study Design: Observational study. Setting: Department of Pathology, Indus Medical College, Tando Muhammad Khan Sindh. Period: September 2018 to April 2019. Material & Methods: 200 medical students were selected according to inclusion and exclusion criteria. Heart rate was measured manually. Systemic Blood pressure (BP) was recorded by Sphygmomanometer. Mean arterial BP was calculated as diastolic BP+1/3 of pulse pressure. Blood slides were stained with Leishman`s stain and white blood cells were counted using microscope.  Data was analyzed by using Statistical Package for Social Sciences (ver 22.0) for windows Microsoft. Results: Age of study subjects was noted as 20.23±1.23 years.  Body weight and Body mass index (BMI) were noted as 64.93±7.53 Kg (P=0.0001) and 27.5±5.3 (P=0.67). Of total 200, 109 (54.5%) were male and 91 (45.5%) were female (P=0.0001). Heart rate, Systolic, Diastolic and Mean arterial BP differed significantly before and after examination stress (P<0.05). White blood cells before examination were found as 7310.43±708.5 x103/µL compared to 8202.39±677.26 during examination stress (P=0.0001). Conclusion: Examination stress perturbs the physiological homeostasis as changes in heart rate, blood pressure and White blood cells are noted among medical students. Psychological and physical strategies for coping the stress should be considered for the young medical students.

scholarly journals Changes in hematological parameters and gill morphology in common carp exposed to sub-lethal concentrations of Malathion

2016 ◽  
Vol 2 (3) ◽  
pp. 370-378 ◽  
Author(s):  
Sadia Sharmin ◽  
Md Abdus Salam ◽  
Farhana Haque ◽  
Md Sadiqul Islam ◽  
Md Shahjahan
Keyword(s):  
Common Carp ◽  
Blood Cells ◽  
Morphological Changes ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Hemoglobin Concentration ◽  
Blood Parameters ◽  
Mean Corpuscular Hemoglobin ◽  
Agricultural Field ◽  
Corpuscular Hemoglobin

Malathion is an organophosphorous insecticide widely used in the agricultural field in Bangladesh and reach in the aquatic environment through rain wash. In the present study, we examined the effects of Malathion on hematological parameters and gills morphology in common carp exposed to two sub-lethal concentrations (1.5 and 3.0 mg/L) for a period of 192h (8 days). For hematological parameters fish were sacrificed at 24, 48, 72, and 96h after start of exposure. Gills were collected at 192h after start of exposure. The blood glucose level was significantly elevated with increasing the concentration of Malathion. Red blood cells (RBCs), hemoglobin (Hb) and hematocrit (Hct) values were significantly decreased after the exposure of Malathion. Significant increments were observed in case of the mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC), while no distinct changes were noted for mean corpuscular hemoglobin (MCH). Interestingly, white blood cells (WBCs) count was significantly increased with toxicity of Malathion. Several morphological changes, such as telangiectasia, blood lamellar congestion, hypertrophy of filaments, lamellar fusion were observed in the gills of fish exposed to Malathion. The present study revealed that the insecticide had adverse effects on various blood parameters and gills morphology in common carp. Thus, the use of insecticide in the agriculture field may be a threat to fauna and flora of the aquatic environment.Asian J. Med. Biol. Res. September 2016, 2(3): 370-378

scholarly journals A comprehensive study on haematological and platelet related changes following septoplasty

2020 ◽  
Vol 6 (11) ◽  
pp. 1975
Author(s):  
Shivakumar Senniappan ◽  
Naveen Giritharan
Keyword(s):  
Blood Cells ◽  
Vascular Inflammation ◽  
White Blood Cells ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Medical College ◽  
Cytokines And Chemokines ◽  
Endothelium Damage

<p class="abstract"><strong>Background:</strong> Septoplasty is an elective surgical procedure indicated for the improvement of anatomic nasal airway obstruction. Platelets have an important role in endothelium damage repair and regulating hemostasis. Platelets produce pro-inflammatory mediators such as cytokines and chemokines during vascular inflammation. Aim of the study was to determine various types of changes that occur in Haematology and Platelet profile in patients after they undergo Septoplasty.</p><p class="abstract"><strong>Methods:</strong> The study was conducted between January 2019 to June 2020 on 50 patients attending ENT OPD in Vinayaka Mission’s KirupanandhaVariyar Medical College and Hospital, Salem. 50 patients fulfilling inclusion/ exclusion criteria who give informed consent were included in the study.  </p><p class="abstract"><strong>Results:</strong> The parameters with no significant differences were found in red blood cells, white blood cells, platelet count, erythrocyte sedimentation rate, haemoglobin (Hb), hematocrit (Htc), mean corpuscular volume, mean corpuscular hemoglobin concentration (MCHC), and platelet distribution width values. mean platelet volume (MPV) value was decreased, platelet-to-lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) values were increased.</p><p class="abstract"><strong>Conclusions:</strong> In our study, MPV value was decreased, PLR and NLR values were increased significantly after septoplasty. Also, the decrease in nasal obstruction symptom evaluation (NOSE) score after surgery is the confirmatory parameter proving that septoplasty not only improves the quality of life but also significantly corrects the altered blood and platelet related parameters in nasal septal deviation patients.</p>

scholarly journals Haematological and morphological evaluation of feline whole blood units collected for transfusion purposes

2018 ◽  
Vol 21 (8) ◽  
pp. 732-740 ◽  
Author(s):  
Eva Spada ◽  
Roberta Perego ◽  
Luciana Baggiani ◽  
Daniela Proverbio
Keyword(s):  
Whole Blood ◽  
Blood Cells ◽  
Morphological Changes ◽  
White Blood Cells ◽  
Haemoglobin Concentration ◽  
In Vivo Studies ◽  
Mean Cell Volume ◽  
Distribution Width

ObjectivesDespite the increasing availability of feline blood collected and stored for transfusion purposes, few studies have been performed on feline blood units. The aim of this prospective in vitro study was to evaluate haematological and morphological changes in feline blood cells in whole blood units between collection and end of storage.MethodsHaematological examination (red blood cells [RBCs], haemoglobin, haematocrit, red cell distribution width, mean cell volume, mean cell haemoglobin concentration, mean cell haemoglobin, white blood cells [WBCs] and platelet [PLT] count) was performed on 40 non-leukoreduced feline whole blood units at the time of collection (day[D]0) and after storage (D35). The blood was collected into citrate–phosphate–dextrose–adenine anticoagulant-preservative solution using an open system in a veterinary blood bank and stored for 35 days at 4 ± 2°C. Twenty of these feline whole blood units were also analysed for blood cell morphology (normal RBCs, macrocytes, echinocytes, spherocytes, schistocytes, lysed RBCs, RBCs with Heinz bodies and recognisable WBC and PLT count). Differences between the two examination times were statistically analysed.ResultsThere was a statistically significant decrease in WBC and PLT counts after storage at D35 ( P <0.0001 for both). The most significant cellular morphological changes after storage were an increase in echinocyte count ( P = 0.0001), and lysed RBCs ( P <0.0001), and a decrease in normal RBCs ( P <0.0001). Recognisable WBCs – mainly lymphocytes – were present at the end of storage.Conclusions and relevanceThis study showed that significant morphological changes occur in RBCs in feline blood units during storage for 35 days. In vivo studies are required to establish if these changes could affect the ability of stored RBCs to circulate and provide adequate oxygen delivery after transfusion.

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