Simultaneous Estimation of Lamotrigine and Clozapine by Simultaneous equation method in their Synthetic Mixture which use in Schizophrenia

Simultaneous estimation of active ingredients in multi-component pharmaceutical products normally requires the use of separation techniques, such as HPLC, HPTLC or GC, followed by their quantitation. Presented here are two spectrophotometric methods that do not require prior separation for simultaneous estimation of three drugs; acetaminophen, tramadol hydrochloride and domperidone in a tablet formulation. Shimadzu UV 1700 capable of multi-component analysis was used for quantitation. Method A is based on the simultaneous equation and method B on the multi-component analysis. The absorption maxima of the drugs found to be at 244nm, 271.5nm and 284.5nm respectively for acetaminophen, tramadol hydrochloride and domperidone in methanol/0.1 N HCl (1:2) solvent mixture. Acetaminophen, tramadol hydrochloride and domperidone obeyed Beer's law in the concentration range of 2-22 μg/ml, 10-55 μg/ml and 30-300 μg/ml respectively. The simultaneous equation method is based on the additivity of absorbances and multi-component analysis involves recording of absorbances of standard solutions at 244nm, 250nm, 271.5nm and 284.5nm. These were processed by means of statistical calculations and results of sample solution were obtained. Result of analysis for both methods were tested and validated for various parameters according to ICH guidelines. Key Words: simultaneous equation method; multicomponent analysis; acetaminophen; tramadol hydrochloride; domperidone. DOI: 10.3329/sjps.v3i1.2655S. J. Pharm. Sci. 3(1): 28-33

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Simultaneous Spectrophotometric Method for Determination of Emtricitabine and Tenofovir Disoproxil Fumarate in Three-Component Tablet Formulation Containing Rilpivirine Hydrochloride

International Scholarly Research Notices ◽

10.1155/2014/541727 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

S. Venkatesan ◽

N. Kannappan

Keyword(s):

Spectrophotometric Method ◽

Analytical Method ◽

Tenofovir Disoproxil Fumarate ◽

Dosage Form ◽

Simultaneous Equation ◽

Equation Method ◽

Simultaneous Estimation ◽

Ich Guidelines ◽

Tablet Dosage

Developing a single analytical method for estimation of individual drug from a multidrug composition is a very challenging task. A complexation, derivatization, extraction, evaporation, and sensitive-free direct UV spectrophotometric method is developed and validated for the simultaneous estimation of some antiviral drugs such as emtricitabine (EMT), tenofovir disoproxil fumarate (TDF), and rilpivirine HCl (RPV) in tablet dosage form by Vierordt’s method. The solutions of standard and sample were prepared in methanol. The λmax⁡ for emtricitabine, tenofovir disoproxil fumarate, and rilpivirine hydrochloride were 240.8 nm, 257.6 nm, and 305.6 nm, respectively. Calibration curves are linear in the concentration ranges 4–12 μg/ml for EMT, 6–18 μg/ml for TDF, and 0.5–1.5 μg/ml for RPV, respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines.

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Development and Validation of UV Spectroscopic Method for Simultaneous Estimation of Pantoprazole and Cinitapride in Bulk and in Capsule Dosage FormC

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.v9i4.14535 ◽

2018 ◽

Vol 9 (4) ◽

Author(s):

Gaur A ◽

Yashwant .

Keyword(s):

Dosage Form ◽

Spectroscopic Method ◽

Pharmaceutical Formulations ◽

Simultaneous Equation ◽

Equation Method ◽

Routine Analysis ◽

Simultaneous Estimation ◽

Development And Validation

A new, rapid, precise, selective and sensitive Vierodt��s/simultaneous equation method is developed for the simultaneous estimation of pantoprazole (PNT) and cinitapride (CNT) in combined dosage form. In the developed method, absorbance was measured at 289 nm (�� max of Pantoprazole) and 267.2 nm (�� max of Cinitapride). The drugs obeyed the Beer��s law in the concentration range of 13-65��g/ml and 1-5 ��g/ml respectively for pantoprazole and cinitapride. Accuracy of the method was determined by recovery studies and was found to be 101.32 % and 98.9 % for Pantoprazole and Cinitapride respectively. The developed method is simple, precise, rapid and selective. It can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.

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