Serum 25-Hydroxy Vitamin D levels in Type 2 Diabetes Mellitus-A Comparative study

Author(s):  
Mallikarjuna Swamy ◽  
Arati Ganiger ◽  
Shankar DS Prasad ◽  
Sanjeev Ratna
2017 ◽  
Vol 10 (2) ◽  
pp. 61
Author(s):  
Mohammad Shiblee Zaman ◽  
Md. Matiur Rahman ◽  
Subrata Kumar Biswas ◽  
Md. Mozammel Hoque ◽  
Khondakar Alwan Nahid

<p>The present study was aimed to evaluate the association of serum 25-hydroxy vitamin D and parathormone in 46 patients of type 2 diabetes mellitus with diabetic retinopathy [non-proliferative, (n=27); proliferative (n=19)]. Twenty one diabetic patients without retinopathy were taken as control. Serum 25-hydroxy vitamin D and intact parathyroid hormone were measured by chemiluminescence microparticle immunoassay. Concentration of 25-hydroxy vitamin D differed significantly among groups (p=0.018) and it was significantly lower in proliferative diabetic retinopathy than no diabetic retinopathy (p=0.003). Logistic regression analysis revealed that vitamin D deficiency [25-hydroxy vitamin D &lt;20 ng/mL] was indepen-dently associated with development of diabetic retinopathy (p=0.007, OR 20.90, 95%CI 2.33-187.23). In conclusion, vitamin D deficiency is associated with diabetic retinopathy complicating type 2 diabetes mellitus.</p>


Author(s):  
Sarah T. Al-Mofarji ◽  
Haider .K. Hussien ◽  
Nadira Salman Mohamed ◽  
Sundus Fadhil Hantoosh ◽  
Mohammed Khudier Abass ◽  
...  

Objectives: The present research aimed to find an association between infection by  Helicobacter pylori and vitamin D deficiency in type 2 diabetes mellitus among Iraqi individuals attending Al-Yarmouk Teaching Hospital. Methods: According to fasting blood glucose,  the samples were divided into a non-diabetic group with ten diabetic individuals and a diabetic group with thirty individuals. Results: The anti-H. Pylori (IgG) levels were 86.77± 58.62 NTU/µL in diabetic patients compared with 10.12 ± 7.40 NTU/µL in non- diabetic group. Vitamin D levels were decreased significantly in infected patients compared to non-infected subjects. Conclusion: The H pylori-infected patients have recorded the lowest level of vitamin D than non-infected individuals.


2020 ◽  
Vol 2 (1) ◽  
pp. 8-12
Author(s):  
Desi Novita ◽  
Meida Nugrahalia ◽  
Ida Fauziah

Vitamin D as an immunomodulator play an important role in controlling glycemic levels and reducing the risk of diabetes. HbA1c as a substance formed from glucose binding with hemoglobin which has a good relationship with average blood sugar levels of fasting, daily and 3 months. This research was conducted to determine the relationship between vitamin D levels and HbA1c in patients with type 2 diabetes mellitus. This research used descriptive methods and the research samples were all patients who suffer from type 2 diabetes mellitus in the clinical laboratory of Thamrin Medan. Data were obtained by checking vitamin D and HbA1c levels in patients blood serum. The number of samples in this research were 47 people. The results of this research indicate that there is a very weak relationship between vitamin D levels and HbA1c, with r = 0,225 and R = 5,1%, therefore, it was clearly presented that effect of vitamin D on HbA1c is 5,1%.


2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Mengxue Yang ◽  
Jun Liu ◽  
Xue Zhou ◽  
Heyuan Ding ◽  
Jie Xu ◽  
...  

The correlation between serum 25-hydroxy vitamin D (25(OH)D) levels and lower extremity atherosclerotic disease and the predictive value of 25(OH)D for early-stage lower extremity atherosclerotic disease in patients with type 2 diabetes mellitus (T2DM) were explored. In total, 620 subjects (590 T2DM patients and 30 healthy subjects) completed a questionnaire. All subjects were divided into four groups according to serum 25(OH)D concentration quartile: Q1 (<12.18 ng/ml), Q2 (12.18~20.65 ng/ml), Q3 (20.65~31.97 ng/ml), and Q4 (>31.97 ng/ml). Participants were also divided into four groups based on the degree of lower extremity arteriostenosis: A1 (T2DM), A2 (T2DM with mild lower extremity vascular lesions (LEVL)), A3 (T2DM with moderate LEVL), and A4 (T2DM with severe LEVL). The incidence of lower extremity artery plaque was significantly higher in groups Q1 and Q2 than in group Q4 (both P<0.05). The concentration of 25(OH)D was significantly lower in group A4 than in groups A1 and A2. Pearson correlation analysis revealed that the degree of lower extremity vascular stenosis was positively correlated with age, smoking, and HbA1c, CRP, and LDL-C levels and negatively correlated with 25(OH)D concentrations. Logistic regression analysis demonstrated that 25(OH)D concentrations exerted a protective effect against LEVL in T2DM patients. Serum 25(OH)D concentrations may be correlated with the incidence of macrovascular disease in T2DM patients. A low serum 25(OH)D concentration is an independent risk factor for lower extremity vascular pathological changes and acts as a prognostic index for lower extremity atherosclerotic disease.


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