Reactive Oxygen Species and Antioxidant Defense Mechanisms in the Oral Cavity: a Review

2015 ◽  
Vol 1 (1) ◽  
pp. 41
Author(s):  
Jaisika Rajpal ◽  
Aakash Arora ◽  
Ruchika Prasad
Keyword(s):  
Reactive Oxygen Species ◽  
Oral Cavity ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Isolation of a Psychrotolerant and UV-C-Resistant Bacterium from Elephant Island, Antarctica with a Highly Thermoactive and Thermostable Catalase

2020 ◽  
Vol 8 (1) ◽  
pp. 95
Author(s):  
María T. Monsalves ◽  
Gabriela P. Ollivet-Besson ◽  
Maximiliano J. Amenabar ◽  
Jenny M. Blamey
Keyword(s):  
Reactive Oxygen Species ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Reactive Oxygen ◽  
Antioxidant Defense System ◽  
Oxygen Species ◽  
Cold Temperatures ◽  
Wide Range ◽  
Antioxidant Defense Systems ◽  
Uv C

Microorganisms present in Antarctica have to deal not only with cold temperatures but also with other environmental conditions, such as high UV radiation, that trigger the generation of reactive oxygen species. Therefore, Antarctic microorganisms must have an important antioxidant defense system to prevent oxidative damage. One of these defenses are antioxidant enzymes, such as catalase, which is involved in the detoxification of hydrogen peroxide produced under oxidative conditions. Here, we reported the isolation and partial characterization of an Antarctic bacterium belonging to the Serratia genus that was resistant to UV-C radiation and well-adapted to cold temperatures. This microorganism, denominated strain I1P, was efficient at decreasing reactive oxygen species levels produced after UV-C irradiation. Genomic and activity assays suggested that the enzymatic antioxidant defense mechanisms of strain I1P, especially its catalase enzyme, may confer UV resistance. This catalase was active in a wide range of temperatures (20–70 °C), showing optimal activity at 50 °C (at pH 7.0), a remarkable finding considering its psychrotolerant origin. In addition, this enzyme was thermostable, retaining around 60% of its activity after 6 h of incubation at 50 °C. The antioxidant defense systems of strain I1P, including its surprisingly thermoactive and thermostable catalase enzyme, make this microorganism a good source of biocompounds with potential biotechnological applications.

scholarly journals The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species

2020 ◽  
Vol 88 (4) ◽  
Author(s):  
Jiangbei Yuan ◽  
Zihan Zheng ◽  
Liting Wang ◽  
Haiying Ran ◽  
Xiangyu Tang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Listeria Monocytogenes ◽  
Membrane Proteins ◽  
Defense Mechanisms ◽  
Reactive Oxygen ◽  
Cellular Membrane ◽  
Oxygen Species ◽  
Dynein Light Chain ◽  
Mitochondrial Reactive Oxygen Species ◽  
Content Type

ABSTRACT Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry analyses, we depicted the dynamic expression landscape of membrane proteins upon L. monocytogenes infection in dendritic cells. We showed that Dynein light chain 1 (Dynll1) formed a persistent complex with the mitochondrial cytochrome oxidase Cox4i1, which is disturbed by pathogen insult. We discovered that the dissociation of the Dynll1-Cox4i1 complex is required for the release of mitochondrial reactive oxygen species and serves as a regulator of intracellular proliferation of Listeria monocytogenes. Our study shows that Dynll1 is an inhibitor of mitochondrial reactive oxygen species and can serve as a potential molecular drug target for antibacterial treatment.

scholarly journals Exogenous Tebuconazole and Trifloxystrobin Regulates Reactive Oxygen Species Metabolism Toward Mitigating Salt-Induced Damages in Cucumber Seedling

Plants ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 428 ◽  
Author(s):  
Sayed Mohsin ◽  
Mirza Hasanuzzaman ◽  
M. Bhuyan ◽  
Khursheda Parvin ◽  
Masayuki Fujita
Keyword(s):  
Reactive Oxygen Species ◽  
Salt Stress ◽  
Antioxidant Defense ◽  
Ion Homeostasis ◽  
Reactive Oxygen ◽  
Cucumber Plant ◽  
Enzymatic Antioxidants ◽  
Oxygen Species ◽  
Exogenous Application ◽  
Antioxidant Defense Systems

The present study investigated the role of tebuconazole (TEB) and trifloxystrobin (TRI) on cucumber plants (Cucumis sativus L. cv. Tokiwa) under salt stress (60 mM NaCl). The cucumber plants were grown semi-hydroponically in a glasshouse. Plants were exposed to two different doses of fungicides (1.375 µM TEB + 0.5 µM TRI and 2.75 µM TEB + 1.0 µM TRI) solely and in combination with NaCl (60 mM) for six days. The application of salt phenotypically deteriorated the cucumber plant growth that caused yellowing of the whole plant and significantly destructed the contents of chlorophyll and carotenoids. The oxidative damage was created under salinity by increasing the contents of malondialdehyde (MDA), hydrogen peroxide (H2O2), and electrolytic leakage (EL) resulting in the disruption of the antioxidant defense system. Furthermore, in the leaves, stems, and roots of cucumber plants increased Na+ content was observed under salt stress, whereas the K+/Na+ ratio and contents of K+, Ca2+, and Mg2+ decreased. In contrast, the exogenous application of TEB and TRI reduced the contents of MDA, H2O2, and EL by improving the activities of enzymatic and non-enzymatic antioxidants. In addition, ion homeostasis was regulated by reducing Na+ uptake and enhanced K+ accumulation and the K+/Na+ ratio after application of TEB and TRI. Therefore, this study indicates that the exogenous application of TEB and TRI enhanced salt tolerance in cucumber plants by regulating reactive oxygen species production and antioxidant defense systems.

scholarly journals Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Glutathione in Detoxification of Reactive Oxygen Species and Methylglyoxal and in Heavy Metal Chelation

2012 ◽  
Vol 2012 ◽  
pp. 1-37 ◽  
Author(s):  
Mohammad Anwar Hossain ◽  
Pukclai Piyatida ◽  
Jaime A. Teixeira da Silva ◽  
Masayuki Fujita
Keyword(s):  
Reactive Oxygen Species ◽  
Heavy Metal ◽  
Antioxidant Defense ◽  
Plant Cells ◽  
Reactive Oxygen ◽  
Antioxidant Defense System ◽  
Peroxidation Of Lipids ◽  
Oxygen Species ◽  
Defense System ◽  
Glyoxalase System

Heavy metal (HM) toxicity is one of the major abiotic stresses leading to hazardous effects in plants. A common consequence of HM toxicity is the excessive accumulation of reactive oxygen species (ROS) and methylglyoxal (MG), both of which can cause peroxidation of lipids, oxidation of protein, inactivation of enzymes, DNA damage and/or interact with other vital constituents of plant cells. Higher plants have evolved a sophisticated antioxidant defense system and a glyoxalase system to scavenge ROS and MG. In addition, HMs that enter the cell may be sequestered by amino acids, organic acids, glutathione (GSH), or by specific metal-binding ligands. Being a central molecule of both the antioxidant defense system and the glyoxalase system, GSH is involved in both direct and indirect control of ROS and MG and their reaction products in plant cells, thus protecting the plant from HM-induced oxidative damage. Recent plant molecular studies have shown that GSH by itself and its metabolizing enzymes—notably glutathione S-transferase, glutathione peroxidase, dehydroascorbate reductase, glutathione reductase, glyoxalase I and glyoxalase II—act additively and coordinately for efficient protection against ROS- and MG-induced damage in addition to detoxification, complexation, chelation and compartmentation of HMs. The aim of this review is to integrate a recent understanding of physiological and biochemical mechanisms of HM-induced plant stress response and tolerance based on the findings of current plant molecular biology research.

scholarly journals Interaction between Bean and Colletotrichum gloeosporioides: Understanding Through a Biochemical Approach

Plants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 345 ◽  
Author(s):  
Nilanjan Chakraborty ◽  
Kabita Mukherjee ◽  
Anik Sarkar ◽  
Krishnendu Acharya
Keyword(s):  
Reactive Oxygen Species ◽  
Defense Mechanisms ◽  
Colletotrichum Gloeosporioides ◽  
Developmental Stages ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Biochemical Basis ◽  
Pathogen Invasion ◽  
Defense Molecules ◽  
Bean Leaves

In addition to its role in animals, nowadays nitric oxide (NO) is considered as an emerging signaling molecule in plant systems. It is now believed that NO exerts its pivotal role in various plant physiological processes, such as in seed germination, plant developmental stages, and plant defense mechanisms. In this study, we have taken an initiative to show the biochemical basis of defense response activation in bean leaves during the progression of Colletotrichum gloeosporioides (Penz.) Penz. and Sacc. in detached bean leaves. Stages of pathogen penetration and colonization were successfully established in the detached bean leaves. Results showed up-regulation of different defense-related enzymes and other defense molecules, such as phenols, flavonoids, callose, and lignin molecules, along with NO at early stages of pathogen invasion. Although in the later stages of the disease, development of NO and other defense components (excluding lignin) were down-regulated, the production of reactive oxygen species in the form of H2O2 became elevated. Consequently, other stress markers, such as lipid peroxidation, proline content, and chlorophyll content, were changed accordingly. Correlation between the disease index and other defense molecules, along with NO, indicate that production of NO and reactive oxygen species (ROS) might influence the development of anthracnose in common bean.

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