scholarly journals Treatment Disparities Faced by Undocumented Workers From Low- and Middle-Income Countries in the United States With Hematologic Malignancies

2016 ◽  
Vol 14 (4) ◽  
pp. 483-486 ◽  
Author(s):  
Sara E. Nunnery ◽  
Andrew E. Fintel ◽  
W. Clay Jackson ◽  
Jason C. Chandler ◽  
Michael O. Ugwueke ◽  
...  
Keyword(s):  
United States ◽  
Hematologic Malignancies ◽  
The United States ◽  
Undocumented Workers ◽  
Middle Income ◽  
Middle Income Countries ◽  
Treatment Disparities ◽  
Low And Middle Income

scholarly journals COVID-19 Therapeutics for Low- and Middle-Income Countries: A Review of Candidate Agents with Potential for Near-Term Use and Impact

2021 ◽  
Author(s):  
Daniel Maxwell ◽  
Kelly C. Sanders ◽  
Oliver Sabot ◽  
Ahmad Hachem ◽  
Alejandro Llanos-Cuentas ◽  
...  
Keyword(s):  
United States ◽  
European Union ◽  
The United States ◽  
Middle Income ◽  
Middle Income Countries ◽  
Negative Results ◽  
Clinical Trial Registries ◽  
Oral Agents ◽  
Near Term ◽  
Low And Middle Income

Low- and middle-income countries (LMICs) face significant challenges in the control of COVID-19, given limited resources, especially for inpatient care. In a parallel effort to that for vaccines, the identification of therapeutics that have near-term potential to be available and easily administered is critical. Using the United States, European Union, and WHO clinical trial registries, we reviewed COVID-19 therapeutic agents currently under investigation. The search was limited to oral or potentially oral agents, with at least a putative anti-SARS-CoV-2 virus mechanism and with at least five registered trials. The search yielded 1,001, 203, and 1,128 trials, in the United States, European Union, and WHO trial registers, respectively. These trials covered 13 oral or potentially oral repurposed agents that are currently used as antimicrobials and immunomodulatory therapeutics with established safety profiles. The available evidence regarding proposed mechanism of actions, potential limitations, and trial status is summarized. The results of the search demonstrate few published studies of high quality, a low proportion of trials completed, and the vast majority with negative results. These findings reflect limited investment in COVID-19 therapeutics development compared with vaccines. We also identified the need for better coordination of trials of accessible agents and their combinations in LMICs. To prevent COVID-19 from becoming a neglected tropical disease, there is critical need for rapid and coordinated effort in the evaluation and deployment of those agents found to be efficacious.

scholarly journals COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries

2021 ◽  
Author(s):  
Julio S. Solís Arce ◽  
Shana S. Warren ◽  
Niccolò F. Meriggi ◽  
Alexandra Scacco ◽  
Nina McMurry ◽  
...  
Keyword(s):  
United States ◽  
Large Scale ◽  
Health Workers ◽  
Immunization Coverage ◽  
The United States ◽  
Vaccine Acceptance ◽  
Middle Income ◽  
Middle Income Countries ◽  
Global Pandemic ◽  
Low And Middle Income

AbstractWidespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs.

scholarly journals Estimating the impact of donor programs on child mortality in low- and middle-income countries: a synthetic control analysis of child health programs funded by the United States Agency for International Development

2020 ◽  
Author(s):  
William M. Weiss ◽  
Piya Bhumika ◽  
Althea Andrus ◽  
Robert Cohen
Keyword(s):  
United States ◽  
International Development ◽  
The United States ◽  
Health Programs ◽  
Control Analysis ◽  
Synthetic Control ◽  
Middle Income ◽  
Middle Income Countries ◽  
The Impact ◽  
Low And Middle Income

Abstract Background Significant levels of funding have been provided to low- and middle-income countries for development assistance for health, with most funds coming through direct bilateral investment led by the United States and the United Kingdom. Direct attribution of impact to large scale programs funded by donors remains elusive due the difficulty of knowing what would have happened without those programs, and the lack of detailed contextual information to support causal interpretation of changes. Methods This study uses the synthetic control analysis method to estimate the impact of one donor’s funding (United States Agency for International Development, USAID) on under-five mortality across several low- and middle-income countries that received above average levels of USAID funding for maternal and child health programs between 2000 and 2016. Results In the study period (2000-16), countries with above average USAID funding had an under-fiver mortality rate lower than the synthetic control by an average of 29 deaths per 1,000 live births (year to year range of 2 – 38). This finding was stable across several sensitivity analyses. Conclusions The synthetic control method is a valuable addition to the range of approaches for quantifying the impact of large-scale health programs in low- and middle-income countries. The findings suggest that adequately funded donor programs (in this case USAID) help countries to reduce child mortality to significantly lower rates than would have occurred without those investments.

scholarly journals Estimating the Impact of Donor Programs on Child Mortality in Low- and Middle-income Countries: A Synthetic Control Analysis of Child Health Programs Funded by the United States Agency for International Development

2020 ◽  
Author(s):  
William Weiss ◽  
Bhumika Piya ◽  
Andrus Althea ◽  
Robert Cohen
Keyword(s):  
United States ◽  
International Development ◽  
The United States ◽  
Health Programs ◽  
Control Analysis ◽  
Synthetic Control ◽  
Middle Income ◽  
Middle Income Countries ◽  
The Impact ◽  
Low And Middle Income

Abstract BackgroundSignificant levels of funding have been provided to low- and middle-income countries for development assistance for health, with most funds coming through direct bilateral investment led by the United States and the United Kingdom. Direct attribution of impact to large scale programs funded by donors remains elusive due the difficulty of knowing what would have happened without those programs, and the lack of detailed contextual information to support causal interpretation of changes. MethodsThis study uses the synthetic control analysis method to estimate the impact of one donor’s funding (United States Agency for International Development, USAID) on under-five mortality across several low- and middle-income countries that received above average levels of USAID funding for maternal and child health programs between 2000 and 2016. ResultsIn the study period (2000-16), countries with above average USAID funding had an under-fiver mortality rate lower than the synthetic control by an average of 29 deaths per 1,000 live births (year to year range of 2 – 38). This finding was stable across several sensitivity analyses. ConclusionsThe synthetic control method is a valuable addition to the range of approaches for quantifying the impact of large-scale health programs in low- and middle-income countries. The findings suggest that adequately funded donor programs (in this case USAID) help countries to reduce child mortality to significantly lower rates than would have occurred without those investments.

scholarly journals The Tobacco Epidemic in Youth and Adolescents in the United States

2021 ◽  
Author(s):  
Rohit Saralaya ◽  
Keyword(s):  
United States ◽  
Tobacco Use ◽  
Smokeless Tobacco ◽  
The United States ◽  
Middle Income ◽  
Middle Income Countries ◽  
The World ◽  
Tobacco Epidemic ◽  
Low And Middle Income

There are 1.1 billion smokers in the world. An estimated 37 million tobacco users are youth aged 13-15 years, of which 13 million use smokeless tobacco. Tobacco use in youth is hence labeled as a “pediatric epidemic”. 90% of smokers start smoking and get addicted before the age of 25. Tobacco kills more than 8 million people globally each year, which accounts for 1 in 10 deaths worldwide. By 2030, 80% of these deaths will be in low and middle income countries (WHO Report on the Global Tobacco Epidemic, 2011).

scholarly journals COVID-19 Vaccine Acceptance and Hesitancy in Low and Middle Income Countries, and Implications for Messaging

2021 ◽  
Author(s):  
Julio S. Solís Arce ◽  
Shana S. Warren ◽  
Niccoló F. Meriggi ◽  
Alexandra Scacco ◽  
Nina McMurry ◽  
...  
Keyword(s):  
United States ◽  
Social Science ◽  
Health Workers ◽  
The United States ◽  
Science Center ◽  
Vaccine Acceptance ◽  
Middle Income ◽  
Middle Income Countries ◽  
Trinity College Dublin ◽  
Low And Middle Income

SummaryBackgroundAs vaccination campaigns are deployed worldwide, addressing vaccine hesitancy is of critical importance to ensure sufficient immunization coverage. We analyzed COVID-19 vaccine acceptance across 15 samples covering ten low- and middle-income countries (LMICs) in Asia, Africa, and South America, and two higher income countries (Russia and the United States).MethodsStandardized survey responses were collected from ‘45,928 individuals between June 2020 and January 2021. We estimate vaccine acceptance with robust standard errors clustered at the study level. We analyze stated reasons for vaccine acceptance and hesitancy, and the most trusted sources for advice on vaccination, and we disaggregate acceptance rates by gender, age, and education level.FindingsWe document willingness to take a COVID-19 vaccine across LMIC samples, ranging from 67% (Burkina Faso) to 97% (Nepal). Willingness was considerably higher in LMICs (80%) than in the United States (65%) and Russia (30%). Vaccine acceptance was primarily explained by an interest in personal protection against the disease (91%). Concern about side effects (40%) was the most common reason for reluctance. Health workers were considered the most trusted sources of information about COVID-19 vaccines.InterpretationGiven high levels of stated willingness to accept a COVID-19 vaccine across LMIC samples, our study suggests that prioritizing efficient and equitable vaccine distribution to LMICs will yield high returns in promoting immunization on a global scale. Messaging and other community-level interventions in these contexts should be designed to help translate intentions into uptake, and emphasize safety and efficacy. Trusted health workers are ideally positioned to deliver these messages.FundingBeyond Conflict, Bill and Melinda Gates Foundation, Columbia University, Givewell.org, Ghent University, HSE University Basic Research Program, International Growth Centre, Jameel Poverty Action Lab Crime and Violence Initiative, London School of Economics and Political Science, Mulago Foundation, NOVAFRICA at the Nova School of Business and Economics, NYU Abu Dhabi, Oxford Policy Management, Social Science Research Council, Trinity College Dublin COVID19Response Funding, UK Aid, UKRI GCRF/Newton Fund, United Nations Office for Project Services, Weiss Family Fund, WZB Berlin Social Science Center, Yale Institute for Global Health, Yale Macmillan Center, and anonymous donors to IPA and Y-RISE

Trump's Declaration of the Global Gag Rule

2021 ◽  
pp. 277-294
Author(s):  
Sudeep Uprety ◽  
Obindra B. Chand
Keyword(s):  
United States ◽  
Health Research ◽  
The United States ◽  
Middle Income ◽  
Government Organization ◽  
Middle Income Countries ◽  
Us Government ◽  
Securitization Theory ◽  
The Media ◽  
The Impact

The current expanded policy on the Global Gag Rule by the United States (US) government and President Donald Trump has led to wider debate and discussions among the non-government organization (NGO) sector, especially in low and middle income countries (LMICs) such as Nepal that are heavily reliant on US funding for health research and intervention projects. Debates and discussions are also shaped by how the media shapes the narrative. Using the securitization theory, this chapter attempts to unfold the trend and the nature of stories reported in Nepali media on the Global Gag Rule declaration, meticulously unfolding the impact it has had in Nepal.

scholarly journals Implementation of Multicolor Melt Curve Analysis for High-Risk Human Papilloma Virus Detection in Low- and Middle-Income Countries: A Pilot Study for Expanded Cervical Cancer Screening in Honduras

2018 ◽  
pp. 1-8 ◽  
Author(s):  
Scott A. Turner ◽  
Sophie J. Deharvengt ◽  
Kathleen Doyle Lyons ◽  
Jorge Arturo Plata Espinal ◽  
Ethan P.M. LaRochelle ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Medical Center ◽  
Virus Detection ◽  
The United States ◽  
Middle Income ◽  
Rural Village ◽  
Middle Income Countries ◽  
Dartmouth Hitchcock Medical ◽  
Low And Middle Income

Purpose Cervical cancer is a leading cause of cancer-related mortality in low- and middle-income countries (LMICs) and screening in LMICs is extremely limited. We aimed to implement on-site high-risk human papillomavirus (hrHPV) DNA testing in cohorts of women from an urban factory and from a rural village. Methods A total of 802 women were recruited for this study in partnership with La Liga Contra el Cancer through the establishment of women’s health resource fairs at two locations in Honduras: a textile factory (n = 401) in the city of San Pedro Sula and the rural village of El Rosario (n = 401) in Yoro. Participants received a routine cervical examination during which three sterile cytobrushes were used to collect cervical samples for testing. hrHPV genotyping was performed using a hrHPV genotyping assay and a real-time polymerase chain reaction instrument. Results hrHPV status across all participants at both sites was 13% hrHPV positive and 67% hrHPV negative. When hrHPV status was compared across all three testing sites, hrHPV-positive rates were approximately equal among the factory (13%), village (12%), and confirmatory testing at Dartmouth-Hitchcock Medical Center (Lebanon, NH; 14%). hrHPV genotype was compared across sites, with HPV16 showing the highest infection rate (15%), followed by HPV59 (12%), and HPV68 (11%). There was a low prevalence of HPV18 observed in both populations compared with the hrHPV-positive population in the United States. Conclusion In collaboration with oncologists and pathologists from La Liga Contra el Cancer, we were able to provide a continuum of care once health-fair testing was performed. We established a method and implementation plan for hrHPV testing that is sustainable in LMICs.

scholarly journals The Intellectual Property Chapter of the Trans-Pacific Partnership Agreement and Investment in Developing Nations

2017 ◽  
Author(s):  
Krista L. Cox
Keyword(s):  
United States ◽  
Developing Countries ◽  
Intellectual Property ◽  
The United States ◽  
Intellectual Property Protection ◽  
Middle Income ◽  
Middle Income Countries ◽  
Property System ◽  
Negative Impacts ◽  
Partnership Agreement

The United States has some of the highest standards of intellectual property protection in the world, though many copyright and patent laws in the United States are limited through balancing provisions that provide exceptions to the exclusive rights conferred by the intellectual property system. The United States has engaged in efforts to raise intellectual property standards worldwide through creation of new global norms, such as through negotiations of free trade agreements like the currently negotiated Trans-Pacific Partnership Agreement. Higher levels of intellectual property protection may be unnecessary to attract investment in developing countries. In fact, increasing intellectual property standards may actually result in negative impacts on development for low- and middle-income countries. This paper examines the role of intellectual property rules in attracting investment for developing countries. It uses the proposals for the TPP's intellectual property chapter as an example on how higher levels of intellectual property enforcement may harm rather than promote investment.

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