scholarly journals The link between gender and post-extraction complications of teeth

2020 ◽  
Vol 16 (12) ◽  
pp. 1128-1133
Author(s):  
Madhuluxmi Madhuluxmi ◽  
Keyword(s):  
Wound Healing ◽  
Surgical Procedures ◽  
Surgical Complications ◽  
Null Hypothesis ◽  
Patient Records ◽  
Common Procedure ◽  
Age And Gender ◽  
Patient Reports ◽  
And Gender

Extraction of teeth is a common procedure in dentistry. Recalling patients for monitoring wound healing is a concern in surgical procedures. It allows foreseeing signs or/and symptoms possibly related to surgical complications. Therefore, it is of interest to document the link between gender and complications in post extraction. The null hypothesis was age and gender had no impact on post dental extraction. We used patient records at Saveetha Dental College, India for this study. The overall follow-up rate post-extraction is less compared to known literature. Data shows that males outnumbered the females and those “above 40 years” than “below 40 years” in follow-up. Thus, we report that factors such as gender, age and the presence of a post-operative complication play a key role in determining whether a patient reports back for follow-up after routine extractions.

scholarly journals LV-GLS is a predictor of all-cause death and cardiovascular MACE events in patients with neuro-immunological disorders

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Khanna ◽  
I Wen ◽  
A Gupta ◽  
A Thakur ◽  
A Bhat ◽  
...  
Keyword(s):  
Systolic Function ◽  
Global Longitudinal Strain ◽  
Autoimmune Encephalitis ◽  
Left Ventricular ◽  
Major Adverse Cardiovascular Events ◽  
Age And Gender ◽  
Immunological Disorders ◽  
Significant Difference ◽  
And Gender

Abstract Background Neuro-immunological disorders encompass several disease states, including multiple sclerosis (MS), autoimmune encephalitis (AE) and myasthenia gravis (MG). These autoimmune conditions are mediated via pro-inflammatory cytokines, and there is growing evidence to suggest cardiovascular involvement within these inflammatory states. Left ventricular global longitudinal strain (LV-GLS) is proposed to be a more sensitive measure of LV systolic function when compared to standard two-dimensional measures such as LV ejection fraction (LVEF). Purpose The purpose of this study was to assess for subclinical cardiac dysfunction in a cohort of patients with neuro-immunological disorders and correlate this with the development of outcomes on follow-up. Methods Consecutive patients with MS, AE and MG admitted to our institution during 2013–2020 were assessed (n=102). Patients without pre-existing cardiovascular disease, LVEF <50% or lack of comprehensive transthoracic echocardiography during their index admission were included (n=55). This group was compared to age- and gender-matched controls (n=55) LV-GLS was measured offline using vendor-independent software (TomTec Arena, Germany v4.6) by two cardiologists blinded to the patient group or outcomes. These patients were followed for up for the composite outcome of all-cause death and major adverse cardiovascular events (MACE). Results A total of 55 patients (31 MS, 14 AE and 10 MG) were age- and gender- matched to 55 controls. There was no significant difference in baseline demographic characteristics or cardiovascular risk factors between groups. Patients with neuro-immunological disorders demonstrated impaired LV-GLS (−17.6±3.5 vs −20.8±1.9; p<0.01) when compared to healthy controls, despite an LVEF within the normal range (60.9±7.7 vs 64.1±5.7; p=0.02) in both groups. There were a total of 9 (16.4%) outcomes during a mean follow-up of 41.0±33.0 months. LV-GLS was the only significant echocardiographic predictor of all-cause death and MACE events (p=0.013) on multi-variate analysis. Conclusions Our results suggest that patients with neuro-immunological disorders have subclinical LV dysfunction as assessed by LV-GLS which has prognostic capacity in this population. Further larger studies are required to further characterize this phenomenon. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Age- and gender-related differences in the evolution of psychological and cognitive status after the lockdown for the COVID-19 outbreak: a follow-up study

2021 ◽  
Author(s):  
Gianpaolo Maggi ◽  
Ivana Baldassarre ◽  
Andrea Barbaro ◽  
Nicola Davide Cavallo ◽  
Maria Cropano ◽  
...  
Keyword(s):  
Cognitive Status ◽  
Age And Gender ◽  
Follow Up Study ◽  
And Gender

scholarly journals The association of tissue doppler E/e' ratio with poor survival is modified by gender and is attenuated with advanced age

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
Y Wasserstrum ◽  
R Gilead ◽  
R Kuperstein ◽  
S Ben-Zekry ◽  
O Vatury ◽  
...  
Keyword(s):  
Cox Regression ◽  
Mitral Annulus ◽  
Tissue Doppler ◽  
Outcome Data ◽  
Poor Survival ◽  
Age And Gender ◽  
Risk Of Death ◽  
Increased Risk ◽  
And Gender

Abstract Introduction Contemporary guidelines recommend a universal cutoff of 14 for the ratio between early mitral flow wave and early diastolic mitral annulus velocity measured by tissue doppler (E/e' ratio). While age-dependent normal E/e' values have been suggested, outcome data is lacking. Purpose We sought to evaluate the modification effect of age and gender on the prognostic value of the E/e' ratio. Methods Consecutive patients who underwent echocardiographic evaluation between 2009 and 2021 (N=104,315) in a single tertiary cardiovascular center. Patients with left or right ventricular dysfunction, any significant valvular disease, structural heart disease or evidence of pulmonary hypertension were excluded. Cancer and mortality data were available for all subjects from national registries. Patients with a metastatic malignancy at baseline or during follow up were excluded. Cox regression models were applied. Results Overall, 44,541 patients were included in the final analysis. Mean age was 55±17, 59% were male and 63% of the exams were performed in an outpatient setting. An elevated E/e' ratio above 14 was documented in 2,598 (7%) patients. During a median follow-up of 5.7 (IQR 2.8–9.1) years, 5,015 (11.3%) patients died. Kaplan Meier survival analysis demonstrated that the cumulative probability of death at 6 years was 23.4% (21.6–25.3) among patients with elevated E/e' ratio compared with 9.7% (9.3–10.0) among patients with E/e'<14 (p Log rank <0.001). This difference was less significant as age progressed (figure 1). Multivariate cox-regression model yielded consistent results such that an elevated E/e' ratio was associated with 2.66-fold increased risk of death during follow up (95% CI 2.44–2.89, p<0.001), and there was a decline in the increased risk and significant as age advanced in both genders (figure 2). Interaction analysis was significant for both gender and age such the association of elevated E/e' ratio with poor survival was more significant among men compared with women and among young vs. older subjects. Among women, elevated E/e' was associated with 2.4-fold increased risk of death versus 2.7-fold increased risk among men. Similarly, the hazard ratio for death associated with elevated E/e' was 2.29 (95% CI 1.74–3.02), 1.8 (95% CI 1.5–2.1), 1.13 (95% CI 0.97–1.31) and 1.07 (95% CI 0.92–1.25) for the age groups of <60, 60–70, 70–80 and >80, respectively. In a sensitivity analysis, similar findings were seen in when excluding patients with mild hypertrophy (maximal wall thickness >12mm) and without any mitral annulus calcification. Conclusion In apparently normal hearts, an elevated E/e' ratio is independently associated with increased mortality. This association is more pronounced among men and is attenuated with increased age. This study supports the need for gender-specific and age-specified outcome data with respect to measures of diastolic dysfunction. FUNDunding Acknowledgement Type of funding sources: None. Survival by age and gender groups E/e' >14 and mortality by age and gender

Risk of stroke in patients with Chagas cardiomyopathy is associated with depressed LV function but not with LV myocardial fibrosis or apical aneurysm: a study using cardiovascular magnetic resonance

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Schmidt ◽  
H Turin Moreira ◽  
G.J Volpe ◽  
M.F Braggion Santos ◽  
J.A Marin Neto
Keyword(s):  
Atrial Fibrillation ◽  
Magnetic Resonance ◽  
Myocardial Fibrosis ◽  
Age And Gender ◽  
Chagas Cardiomyopathy ◽  
History Of ◽  
And Gender ◽  
Apical Aneurysm ◽  
Normal Lvef

Abstract Background Chronic Chagas cardiomyopathy (CCC) is classically related to higher occurrence of thromboembolic events, especially stroke, particularly in patients with atrial fibrillation (AF). However, risk factors for stroke in patients with CCC but no atrial fibrillation have not been well established. Purpose We aimed to assess the relationship between left ventricular (LV) structure and function, as evaluated with cardiac magnetic resonance (CMR), with stroke in individuals with CCC. Methods We prospectively collected data from 141 patients with CCC who underwent CMR from October 2009 to December 2013 and who were thereafter followed for a median period of 6.8 years. The outcome was the occurrence of stroke during the follow-up period. The only exclusion criteria were history of previous stroke, AF or use of oral anticoagulant (OAC) at the time of CMR. CMR-derived LV parameters were: LV ejection fraction (LVEF), extension of LV myocardial fibrosis, assessed by late gadolinium enhancement, and presence of LV apical aneurysm. LVEF was classified as follows: (I) normal ≥55%; (II) mid-range <55% and ≥40%; and (III) reduced <40%. Age and gender were covariates in the adjusted Cox proportional hazard model. Results Of the initial 141 CCC participants, 25 subjects were excluded due to previous stroke (n=2), history of AF (n=11), or use of OAC (n=12). The remaining 116 individuals had a mean age of 56±14 years, 51% women. Normal, mid-range and reduced LVEF were found in 48 (41%), 43 (37%), and 25 (22%) patients, respectively. Myocardial fibrosis was detected in 79 of 111 (71%) subjects in whom the detection method was feasible. The extension of LV fibrosis was evaluated as a median of 4.6% [interquartile range: 0–10]. LV apical aneurysm was identified in 36 (31%) patients. During the follow-up (median 6.8 years), stroke was reported in 9 participants. In the univariate analysis, reduced LVEF was significantly associated with higher risk of stroke compared to normal LVEF (HR: 9.2, 95% CI: 1.8–48.4), while there was no significant difference between mid-range and normal LVEF (HR: 1.2, 95% CI: 0.2–8.2). The association of reduced LVEF and stroke remained significant in the multivariable model, adjusted for age and gender (HR: 12.6, 95% CI: 1.9–83.2). Kaplan-Meier curves are presented in figure 1 (logrank p-value <0.001). Neither the extension of LV myocardial fibrosis (HR: 1.0, 95% CI: 0.9–1.1) nor the presence of LV apical aneurysm (HR: 1.9, 95% CI: 0.5–7.2) was related to higher risk of stroke. Conclusion In patients with CCC, reduced LVEF assessed by CMR, but not LV fibrosis or presence of apical aneurysm, was a significant predictor of stroke. Funding Acknowledgement Type of funding source: None

scholarly journals Metachronous neoplasms in patients with laterally spreading tumours during surveillance

2020 ◽  
pp. 205064062096531
Author(s):  
Roel MM Bogie ◽  
Bjorn Winkens ◽  
Sean JJ Retra ◽  
Chantal MC le Clercq ◽  
Mariëlle W Bouwens ◽  
...  
Keyword(s):  
Colorectal Neoplasms ◽  
Colorectal Neoplasm ◽  
Submucosal Invasion ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Age And Gender ◽  
Metachronous Neoplasms ◽  
Metachronous Colorectal Cancer ◽  
And Gender

Background Laterally spreading tumours represent a major challenge for endoscopic detection and resection. Objective To examine synchronous and metachronous neoplasms in patients with laterally spreading tumours. Methods We prospectively collected colonoscopy and histopathology data from patients who underwent colonoscopy in our centre at up to 6 years’ follow-up. Post-resection surveillance outcomes between laterally spreading tumours, flat colorectal neoplasms 10 mm or greater, and large polypoid colorectal neoplasms, polypoid colorectal neoplasms 10 mm or greater, were compared. Results Between 2008 and 2012, 8120 patients underwent colonoscopy for symptoms (84.6%), screening (6.7%) or surveillance (8.7%). At baseline, 151 patients had adenomatous laterally spreading tumours and 566 patients had adenomatous large polypoid colorectal neoplasms. Laterally spreading tumour patients had more synchronous colorectal neoplasms than large polypoid colorectal neoplasm patients (mean 3.34 vs. 2.34, P < 0.001). Laterally spreading tumour patients significantly more often developed metachronous colorectal neoplasms (71.6% vs. 54.2%, P = 0.0498) and colorectal neoplasms with high grade dysplasia/submucosal invasion than large polypoid colorectal neoplasm patients (36.4% vs. 15.8%, P < 0.001). After correction for age and gender, laterally spreading tumour patients were more likely than large polypoid colorectal neoplasm patients to develop a colorectal neoplasm with high grade dysplasia or submucosal invasion (hazard ratio 2.9, 95% confidence interval 1.8–4.6). The risk of metachronous colorectal cancer was not significantly different in laterally spreading tumours compared to large polypoid colorectal neoplasm patients. Conclusion Patients with laterally spreading tumours developed more metachronous colorectal neoplasms with high grade dysplasia/submucosal invasion than large polypoid colorectal neoplasm patients. Based on these findings endoscopic treatment and surveillance recommendations for patients with laterally spreading tumours should be optimised.

Age and gender differences in incidence and case fatality trends for myocardial infarction: a 30-year follow-up. The Tromsø Study

2011 ◽  
Vol 19 (5) ◽  
pp. 927-934 ◽  
Author(s):  
Jan Mannsverk ◽  
Tom Wilsgaard ◽  
Inger Njølstad ◽  
Laila Arnesdatter Hopstock ◽  
Maja-Lisa Løchen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Gender Differences ◽  
Case Fatality ◽  
Age And Gender ◽  
Age And Gender Differences ◽  
And Gender

Harm Avoidance as an Endophenotype of Schizophrenia: Comparative Study of First-degree Relatives, Schizophrenia Probands, and Healthy Controls

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Sim ◽  
J.H. Kim ◽  
S.J. Yim ◽  
O.H. Kwon ◽  
S.J. Cho ◽  
...  
Keyword(s):  
List Type ◽  
Healthy Controls ◽  
Personality Profile ◽  
Significant Group ◽  
Age And Gender ◽  
First Degree Relatives ◽  
Character Inventory ◽  
And Gender ◽  
Genetic Loading

Objective:Schizophrenia is highly familial neuropsychiatric disorder with heritability estimated at 60-90%. Even unaffected first-degree relatives of schizophrenia manifested some neuropsychological abnormalities as well as neurologic soft sign and morphologic anomalies. the aim of this study was to evaluate personality profile in first-degree relatives of schizophrenia compared to their schizophrenia probands and healthy controls and whether personality profile might be endophenotype of schizophrenia.Methods:The subjects were 97 first-degree relatives of schizophrenia, 48 their schizophrenia probands, and 106 healthy controls, who completed Temperament and Character Inventory (TCI) scale. Relatives were further divided into presumed carriers and pesumed non-carriers by schizophrenia genetic loading. Group difference in TCI scores were compared by general linear model using age and gender as covariates.Results:1.There were significant group differences in HA scores between healthy controls, relatives, and probands after controlling age and gender, in that HA scores were increased by healthy controls, relatives, and probands in order.2.Presumed carriers have higher HA scores than presumed non-carriers and healthy controls.3.Proband group showed significantly lower RD and lower P in temperament dimension and lower SD, lower C, and higher ST in character dimension compared to other groups.Conclusion:We found that HA scores of first-degree relatives of schizophrenia is intermediate level between schizophrenia probands and healthy controls. Considering increase of HA with schizophrenia genetic loading, HA may be potential endophenotype of schizophrenia. Further research with longitudinal follow up is needed to elucidate the clinical implication of high HA observed in schizophrenia family.

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