scholarly journals Risk factor comparison in young patients presenting with acute coronary syndrome with atherosclerotic coronary artery disease vs. angiographically normal coronaries

2021 ◽  
Vol 18 (15) ◽  
pp. 3526-3532
Author(s):  
Sarah Jamil ◽  
Gohar Jamil ◽  
Hanaa Mesameh ◽  
Anwer Qureshi ◽  
Juma AlKaabi ◽  
...  
Cor et Vasa ◽  
2017 ◽  
Vol 59 (6) ◽  
pp. e553-e556
Author(s):  
Petra Kupková ◽  
Marcel Heczko ◽  
Vladimír Kaučák ◽  
Radim Kryza

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Giulia De Santis ◽  
Lorenzo Pistelli ◽  
Marco Franzino ◽  
Claudio Nicolo ◽  
Francesca Parisi ◽  
...  

Abstract Aims Distribution of wall motion abnormalities (WMA) in young patients presenting with acute coronary syndrome (ACS) is not well described. Methods and results We included 91 consecutive young patients (≤45 years at presentation) with ACS with obstructive or without obstructive coronary artery disease referred from October 2013 until March 2021 to our clinic. Wall motion abnormalities, wall motion score index (WMSI) and left ventricle ejection fraction (LVEF) were evaluated. A wall motion abnormality in at least one segment was present in 78.7% of patients. Mean LVEF was 50.9 ± 8.8% and mean WMSI was 1.38 ± 0.37%. Akinesia of at least one segment was present in 49.4%, dyskinesia and aneurysm were rare (1.1%, respectively). Ventricular thrombus was observed in 4.7%. Distribution of wall motion abnormalities is presented in Figure A. Most frequently WMA affected the apex and the basal inferior wall. The severity of WMA for each segment is presented in Figure B. The mean highest severity of WMA affected the apex, and the inferior and infero-septal wall. In the subgroup of patients presenting without obstructive coronary artery disease, WMA were less prevalent (37.5%), LVEF was higher (57.1% vs. 50.4% P = 0.032), and WMSI was lower (1.16% vs. 1.40% P = 0.07), but similarly affected with higher frequency the apex area. Conclusions In conclusion, WMA are frequent in young patients presenting with ACS, mostly affecting the apex. More severe abnormalities of wall kinesis affect the apex and the inferior and infero-septal wall.


2017 ◽  
Vol 69 (11) ◽  
pp. 254 ◽  
Author(s):  
Amar N. Patnaik ◽  
Pankajkumar A. Kasar ◽  
Raju V.R.C. Pusapati ◽  
K. Jagadishbabu ◽  
Naveenkrishna Kamana ◽  
...  

2017 ◽  
Vol 24 (01) ◽  
pp. 26-30
Author(s):  
Ahmed Zeeshan ◽  
Zaheer Ahmad ◽  
Ghulam Abbas Tahir ◽  
Yasir Yaqoob

Microalbuminuria is a strong and independent indicator of increased cardiovascularrisk among individuals with and without diabetes and hypertension. The pathophysiologicmechanism underlying the association between albumin excretion and cardiovascular disease(CVD) is that microalbuminuria can be a predictor of CVD risk as it reflects the vascular damagein kidneys. It also shows endothelial damage predicting CV disease risk. Based on this theory,periodic screening for microalbuminuria could allow early identification of vascular diseaseand help stratify overall cardiovascular risk, especially in patients with risk factors such ashypertension or diabetes. Therefore microalbuminuria can be used for stratification of risk forcardiovascular disease. Once microalbuminuria is present, cardiovascular risk factor reductionshould be aggressive. Objectives: The objective of the study was to determine the role ofmicroalbuminuria as an atherosclerotic risk factor and its association with coronary arterydisease. Study Design: Cross-sectional study. Duration of Study: Duration of study was6 months with first patient enrolled on 16-03-2007 and last patient enrolled on 15-09-2007.Setting: Medical Unit-III and CCU Allied Hospital, Faisalabad. Subjects: 300 patients withacute coronary syndrome, admitted in Allied hospital Faisalabad were enrolled. Methods: 300patients diagnosed as having acute coronary syndrome admitted in Allied hospital Faisalabad,were included in the study. Early morning urine as well as 24 hour urine had been collectedin sterilized urine bags and microalbuminuria was tested. Results: In this study 300 patientshaving acute coronary syndrome were enrolled. Microalbuminuria was positive in 66 (22%)patients and 234 (78%) patients had no microalbuminuria. There was significant associationbetween microalbuminuria and atherosclerotic coronary artery disease. Conclusion: It isconcluded that microalbuminuria is an atherosclerotic risk factor and it is strongly associatedwith coronary artery disease.


2013 ◽  
Vol 11 (1) ◽  
pp. 4-8 ◽  
Author(s):  
Ajay Rajbhandari ◽  
Dipendra Raj Pandeya ◽  
Madhur Dev Bhattarai ◽  
Ravi Malla

Introduction: Diabetes Mellitus is a potent risk factor for Coronary Artery Diseases, but Impaired Glucose Tolerance is increasingly known risk factor for Coronary Artery Diseases. The aim of this study was to correlate blood glucose level in the patients with Coronary Artery Diseases with Acute Coronary Syndrome and to determine the relati onship of other risk factors. Methods: This was a cross-secti onal prospecti ve study of consecutive patients admitted in coronary care unit of Bir Hospital and Shaid Gangalal National Heart Center, with diagnosis of Acute Coronary Syndrome. Results: Total 209 patients were enrolled. 90.9% (190) had dyslipidemia, 78.5% were smokers with mean Standard Deviation of duration of smoking were 25.35 years. Abnormal waist to hip ratio in male and female are 56.3% and 76.1% respectively. 14.4 % (30) had Random Blood Glucose > 200mg%, 17.2 % had Impaired Fasting Glucose (110-126 mg% World Health Organizati on); 34.4% had Impaired Fasting Glucose (100-126 mg% American Diabeti c Associati on) 28.2% had Impaired Glucose Tolerance (postprandial blood glucose 140-200mg %).19.1% were old diabetes, 21.3% had recent diabetes mellitus, 52.7% had impaired glycemia.93.1% of total patients had Glucose Intolerance of any form. Conclusions: Almost all patients had diabetic or glucose intolerance of any form prior to coronary artery disease with acute coronary syndrome. This study consisted with Asian criteria of body mass index and Waist circumference for overweight or obesity. Medical Journal of Shree Birendra Hospital; Jan-June 2012/vol.11/Issue1/4-8 DOI: http://dx.doi.org/10.3126/mjsbh.v11i1.7758


2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Marco Franzino ◽  
Lorenzo Pistelli ◽  
Francesca Parisi ◽  
Giulia Azzurra De Santis ◽  
Claudio Nicolò ◽  
...  

Abstract Aims The distribution of coronary lesions in young patients presenting with acute coronary syndrome (ACS) is not known. Methods and results We included 82 consecutive young patients (≤45 years at presentation) with ACS and obstructive coronary artery disease referred from October 2013 until March 2021 to our clinic. Significant coronary lesions (>50%) at each segment during coronary angiography were evaluated. A total of 158 lesions have been evaluated. Multivessel disease was observed in 37% of patients. Lesions at proximal and mid left anterior descending (LAD) coronary artery were the most common observation (Figure A). Roughly one in three lesions affected a proximal coronary segment (i.e. segment 1, 5, 6, or 11), and 45.1% of patients presented at least one lesion in these segments. Within each segment, lesions affected the ostium in 15.8%, proximal third in 26.8%, mid-third in 32.9%, and distal-third in 15.9% of cases. Among those presenting with ST-segment elevated myocardial infarction, culprit lesion distribution is presented in Figure B. Proximal segments were affected in 33.9%, while culprit lesion of the LAD, left circumflex, and right coronary artery was observed in 51.8%, 16.1%, and 32.1% respectively. Conclusions In conclusion, coronary artery disease in patients presenting with ACS occur more often in the LAD and in proximal coronary segments. A significant lesion in a proximal coronary segment affected roughly half of young patients presenting with ACS.


2003 ◽  
Vol 2 (2) ◽  
pp. 39-42
Author(s):  
Man Bahadur KC

Coronary Artery disease is emerging as a growing epidemic in whole of the South Asia region. South Asians are genatically most predisposed people to Coronary Artery disease. In this background of genetic predisposition to Coronary Artery disease and changes in life style, which increases the vulnerability to acquire this disease, many Nepalese people are getting Coronary Artery disease with increasing number every year.


2019 ◽  
Vol 9 (7) ◽  
pp. 741-747 ◽  
Author(s):  
Agnes Wahrenberg ◽  
Patrik KE Magnusson ◽  
Andrea Discacciati ◽  
Lina Ljung ◽  
Tomas Jernberg ◽  
...  

Background: The value of family history of coronary artery disease (CAD) in diagnosing acute coronary syndrome (ACS) in chest pain patients is uncertain, especially in relation to high-sensitivity assays for cardiac troponin T (hs-cTnT), which have improved ACS diagnostics. Our objective was to investigate the association between verified family history of CAD and ACS in chest pain patients, overall and in different strata of initial hs-cTnT. Methods: Data on chest pain patients visiting four emergency departments in Sweden during 2013–2016 were cross-referenced with national registers of kinship, diseases and prescriptions. Family history of early CAD was defined as the occurrence of myocardial infarction or coronary revascularization before the age of 55 years in male and 65 years in female first-degree relatives. The outcome was combined including ACS and cardiovascular death within 30 days of presentation. Results: Of 28,188 patients, 4.7% of patients had ACS. In total, 8.2% and 32.4% had a family history of early and ever-occurring CAD, respectively. Family history of CAD was positively associated with the outcome, independently of age, gender, cardiovascular risk factors and electrocardiogram findings. The strongest association was observed for family history of early CAD (odds ratio 1.62, 95% confidence interval 1.35–1.94). Stronger associations were observed in young patients (e.g. <65 years) and in patients with non-elevated initial hs-cTnT levels ( p-value for interaction = 0.004 and 0.001, respectively). Conclusions: Family history of CAD is associated with ACS in chest pain patients, especially in patients of young age or with non-elevated initial hs-cTnT levels.


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