scholarly journals Rhein induces liver cancer cells apoptosis via activating ROS-dependent JNK/Jun/caspase-3 signaling pathway

2020 ◽  
Vol 11 (2) ◽  
pp. 500-507 ◽  
Author(s):  
Aili Wang ◽  
Huihong Jiang ◽  
Yuanyuan Liu ◽  
Jing Chen ◽  
Xue Zhou ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Caspase 3 ◽  
Liver Cancer Cells

scholarly journals Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway

2021 ◽  
Vol 9 (4) ◽  
pp. 1833-1841
Author(s):  
Lian‐Hui Wei ◽  
Yan Dong ◽  
Yu‐Feng Sun ◽  
Xue‐Song Mei ◽  
Xue‐Song Ma ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Bioactive Peptides ◽  
Liver Cancer Cells

scholarly journals miR-125a inhibits the migration and invasion of liver cancer cells via suppression of the PI3K/AKT/mTOR signaling pathway

2015 ◽  
Vol 10 (2) ◽  
pp. 681-686 ◽  
Author(s):  
HAO TANG ◽  
RONG-PING LI ◽  
PING LIANG ◽  
YA-LONG ZHOU ◽  
GUANG-WEI WANG
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Migration And Invasion ◽  
Mtor Signaling Pathway ◽  
Liver Cancer Cells

scholarly journals Sorafenib kills liver cancer cells by disrupting SCD1‐mediated synthesis of monounsaturated fatty acidsviathe ATP‐AMPK‐mTOR‐SREBP1 signaling pathway

2019 ◽  
Vol 33 (9) ◽  
pp. 10089-10103 ◽  
Author(s):  
Ge Liu ◽  
Shan Kuang ◽  
Ruobing Cao ◽  
Ju Wang ◽  
Quancai Peng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Liver Cancer Cells

Effect of Bmi-1-mediated NF-κB signaling pathway on the stem-like properties of CD133+ human liver cancer cells

2018 ◽  
Vol 22 (3) ◽  
pp. 575-585 ◽  
Author(s):  
De-Qiang Ma ◽  
Yin-Hua Zhang ◽  
De-Ping Ding ◽  
Juan Li ◽  
Lin-Li Chen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Liver ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

scholarly journals Dichloroacetate enhances the antitumor effect of pirarubicin via regulating the ROS-JNK signaling pathway in liver cancer cells

2020 ◽  
Author(s):  
Xiao-Jing Yan ◽  
Peng Xie ◽  
Xu-Fang Dai ◽  
Ling-Xi Chen ◽  
Liang-Bo Sun ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Antitumor Effect ◽  
Jnk Signaling ◽  
Liver Cancer Cells ◽  
Jnk Signaling Pathway

scholarly journals Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells byPI3K/Akt signaling pathway

2018 ◽  
Vol 14 (7) ◽  
pp. 1124 ◽  
Author(s):  
Jijin Yang ◽  
Yibin Hou ◽  
Ge Sun ◽  
Xu Jiang ◽  
Zhongsheng Zhu
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Liver Cancer Cells ◽  
Forkhead Box ◽  
Forkhead Box O3a

scholarly journals Cu(II) Coordination Polymer Inhibits Liver Cancer Development via Targeting BCL-2 Protein and Activating Apoptotic Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jing Zhou ◽  
Xiaowen Peng ◽  
Xuejiao Li ◽  
Xiaoyu Kong
Keyword(s):  
Liver Cancer ◽  
Coordination Polymer ◽  
Cancer Cells ◽  
Cell Apoptosis ◽  
Caspase 3 ◽  
Human Cancer ◽  
Solvothermal Reaction ◽  
Ros Generation ◽  
Caspase 9 ◽  
Liver Cancer Cells

In the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO3)2·3H2O in the existence of 1,3-H2bdc, the second assistant ligand (in which 1,3-H2bdc is benzene-1,3-dicarboxylic acid and HL is 1-(4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole), and the chemical composition of this compound is [Cu2(L)2(1,3-bdc)(H2O)2]n (1). In the biological aspect, we screened the antiproliferation activity of the Cu(II) coordination polymer on five kinds of human cancer cell lines. IC50 and MTT assay results indicated that complex 1 had a spectral antiproliferative activity against liver cancer cells, peculiarly on human HepG2 liver cancer cells. From the data of Annexin V-FITC/PI assay and ROS detection, we can find that complex 1 exerts an antitumor effect by inducing ROS generation and cell apoptosis. Caspase-3 and caspase-9 activity detection revealed that activation of caspase-3 and caspase-9 plays vital roles in HepG2 cell apoptosis. These outcomes indicate that 1 is an excellent compound in treating cancer.

scholarly journals Influence of miR‑101 on proliferation of liver cancer cells through the MAPK/ERK signaling pathway

2019 ◽  
Author(s):  
Xuan Meng ◽  
Yong Shi ◽  
Xin Xiang ◽  
Chonghui Li ◽  
Xinlan Ge ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Erk Signaling ◽  
Liver Cancer Cells

scholarly journals Sonic Hedgehog signaling pathway in primary liver cancer cells

2014 ◽  
Vol 7 (9) ◽  
pp. 735-738 ◽  
Author(s):  
Lian-Yi Guo ◽  
Pei Liu ◽  
Ying Wen ◽  
Wei Cui ◽  
Ying Zhou
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Primary Liver Cancer ◽  
Hedgehog Signaling Pathway ◽  
Sonic Hedgehog Signaling ◽  
Liver Cancer Cells ◽  
Sonic Hedgehog Signaling Pathway

scholarly journals Activated δ-opioid receptors inhibit hydrogen peroxide-induced apoptosis in liver cancer cells through the PKC/ERK signaling pathway

2014 ◽  
Vol 10 (2) ◽  
pp. 839-847 ◽  
Author(s):  
KAIQI JIA ◽  
DEGUANG SUN ◽  
SUNBIN LING ◽  
YU TIAN ◽  
XUEJUN YANG ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Opioid Receptors ◽  
Erk Signaling ◽  
Liver Cancer Cells ◽  
Induced Apoptosis
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