scholarly journals Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Theranostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1845-1863
Author(s):  
Meng Zhao ◽  
Yizhuo Wang ◽  
Ling Li ◽  
Shuyun Liu ◽  
Chengshi Wang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Mitochondrial Dysfunction ◽  
Kidney Injury ◽  
Mitochondrial Ros ◽  
Ischemic Acute Kidney Injury

Polydatin Inhibits Mitochondrial Dysfunction in the Renal Tubular Epithelial Cells of a Rat Model of Sepsis-Induced Acute Kidney Injury

2015 ◽  
Vol 121 (5) ◽  
pp. 1251-1260 ◽  
Author(s):  
Youguang Gao ◽  
Zhenhua Zeng ◽  
Tao Li ◽  
Siqi Xu ◽  
Xingmin Wang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Epithelial Cells ◽  
Mitochondrial Dysfunction ◽  
Rat Model ◽  
Kidney Injury ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular

scholarly journals N-acetyl-cysteine increases cellular dysfunction in progressive chronic kidney damage after acute kidney injury by dampening endogenous antioxidant responses

2018 ◽  
Vol 314 (5) ◽  
pp. F956-F968 ◽  
Author(s):  
David M. Small ◽  
Washington Y. Sanchez ◽  
Sandrine F. Roy ◽  
Christudas Morais ◽  
Heddwen L. Brooks ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Mitochondrial Dysfunction ◽  
Transforming Growth Factor ◽  
Multiphoton Microscopy ◽  
Kidney Injury ◽  
Peroxisome Proliferator ◽  
Fluorescence Lifetime Imaging ◽  
Antioxidant Responses ◽  
Acetyl Cysteine

Oxidative stress and mitochondrial dysfunction exacerbate acute kidney injury (AKI), but their role in any associated progress to chronic kidney disease (CKD) remains unclear. Antioxidant therapies often benefit AKI, but their benefits in CKD are controversial since clinical and preclinical investigations often conflict. Here we examined the influence of the antioxidant N-acetyl-cysteine (NAC) on oxidative stress and mitochondrial function during AKI (20-min bilateral renal ischemia plus reperfusion/IR) and progression to chronic kidney pathologies in mice. NAC (5% in diet) was given to mice 7 days prior and up to 21 days post-IR (21d-IR). NAC treatment resulted in the following: prevented proximal tubular epithelial cell apoptosis at early IR (40-min postischemia), yet enhanced interstitial cell proliferation at 21d-IR; increased transforming growth factor-β1 expression independent of IR time; and significantly dampened nuclear factor-like 2-initiated cytoprotective signaling at early IR. In the long term, NAC enhanced cellular metabolic impairment demonstrated by increased peroxisome proliferator activator-γ serine-112 phosphorylation at 21d-IR. Intravital multiphoton microscopy revealed increased endogenous fluorescence of nicotinamide adenine dinucleotide (NADH) in cortical tubular epithelial cells during ischemia, and at 21d-IR that was not attenuated with NAC. Fluorescence lifetime imaging microscopy demonstrated persistent metabolic impairment by increased free/bound NADH in the cortex at 21d-IR that was enhanced by NAC. Increased mitochondrial dysfunction in remnant tubular cells was demonstrated at 21d-IR by tetramethylrhodamine methyl ester fluorimetry. In summary, NAC enhanced progression to CKD following AKI not only by dampening endogenous cellular antioxidant responses at time of injury but also by enhancing persistent kidney mitochondrial and metabolic dysfunction.

scholarly journals Negative Regulation of TGFβ Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129561 ◽  
Author(s):  
Troy D. Camarata ◽  
Grant C. Weaver ◽  
Alexandr Vasilyev ◽  
M. Amin Arnaout
Keyword(s):  
Acute Kidney Injury ◽  
Stem Cell ◽  
Kidney Injury ◽  
Negative Regulation ◽  
Tgfβ Signaling ◽  
Cell Antigen ◽  
Ischemic Acute Kidney Injury

Ischemic acute kidney injury and klotho in renal transplantation

2018 ◽  
Vol 55 ◽  
pp. 3-8 ◽  
Author(s):  
Fatemeh Panah ◽  
Amir Ghorbanihaghjo ◽  
Hassan Argani ◽  
Maryam Asadi Zarmehri ◽  
Saeed Nazari Soltan Ahmad
Keyword(s):  
Acute Kidney Injury ◽  
Renal Transplantation ◽  
Kidney Injury ◽  
Ischemic Acute Kidney Injury

Trehalose attenuates mitochondrial dysfunction in cisplatin‐induced acute kidney injury by activating autophagy

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Lingling Zhu ◽  
Yujia Yuan ◽  
Hongxia Li ◽  
Younan Chen ◽  
Yanrong Lu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Mitochondrial Dysfunction ◽  
Kidney Injury

Low-energy extracorporeal shock wave ameliorates ischemic acute kidney injury in rats

2019 ◽  
Vol 23 (5) ◽  
pp. 597-605 ◽  
Author(s):  
Mai Yoshida ◽  
Takashi Nakamichi ◽  
Takefumi Mori ◽  
Kenta Ito ◽  
Hiroaki Shimokawa ◽  
...  
Keyword(s):  
Shock Wave ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Low Energy ◽  
Extracorporeal Shock Wave ◽  
Ischemic Acute Kidney Injury
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