scholarly journals Cancer of unknown primary origin: a case report

2013 ◽  
Vol 7 (1) ◽  
pp. 27-34
Author(s):  
Elisa De Carlo ◽  
Ciro Rossetto ◽  
Gianpiero Fasola
Keyword(s):  
Treatment Approach ◽  
Histopathological Examination ◽  
Imaging Techniques ◽  
Primary Tumour ◽  
Molecular Diagnostic ◽  
Diagnostic Tools ◽  
Unknown Primary ◽  
Apparent Absence ◽  
Primary Origin ◽  
Unknown Primary Origin

Carcinoma of unknown primary origin (CUP) accounts for 2-10% of all malignancies. The apparent absence of the primary tumour, the development of early, uncommon systemic metastases and the resistance to therapy and poor prognosis are hallmarks of this heterogeneous clinical entity and are a challenge for physicians. The diagnostic workup of patients with CUP includes a large amount of histopathological examination, as well as the use of imaging techniques that often fail to identify the primary tumour. Therefore, the optimal workup and treatment for these patients remains to be determined. Molecular diagnostic tools, such as DNA microarray analysis, could help in the search for "lost" CUP origin and guide the further treatment approach. We report the case of a 66-year-old man, with mediastinal lymph nodes metastasis of carcinoma and neurological syndrome with diplopia and balance disorders, in which many exams have been performed without finding the primary tumour.

Current concepts in the diagnosis and management of neuroendocrine neoplasms of unknown primary origin

2020 ◽  
Vol 44 (4) ◽  
Author(s):  
Krystallenia I. Alexandraki ◽  
Marina Tsoli ◽  
Georgios Kyriakopoulos ◽  
Anna Angelousi ◽  
Georgios Nikolopoulos ◽  
...  
Keyword(s):  
Unknown Primary ◽  
Neuroendocrine Neoplasms ◽  
Diagnosis And Management ◽  
Primary Origin ◽  
Unknown Primary Origin

Adenocarcinoma of Unknown Primary Origin

1981 ◽  
Vol 71 (12) ◽  
pp. 1431-1434 ◽  
Author(s):  
S. RAJU INDUPALLI ◽  
AGOP Y. BEDIKIAN ◽  
GERALD P. BODEY
Keyword(s):  
Unknown Primary ◽  
Primary Origin ◽  
Unknown Primary Origin

scholarly journals Cervical Malignant Tumors of Unknown Primary Origin; From View of Roentgen Diagnosis.

1994 ◽  
Vol 87 (10) ◽  
pp. 1419-1426
Author(s):  
Katsuhiko FUKAMOTO ◽  
Masafumi NAKAGAWA ◽  
Naoyuki KONO
Keyword(s):  
Malignant Tumors ◽  
Unknown Primary ◽  
Roentgen Diagnosis ◽  
Primary Origin ◽  
Unknown Primary Origin

scholarly journals Expression of Glycolysis-Related Proteins in Cancer of Unknown Primary Origin

2021 ◽  
Vol 11 ◽  
Author(s):  
Murilo Bonatelli ◽  
Isabella Fernandes Fornari ◽  
Priscila Neves Bernécule ◽  
Lara Esquiapatti Pinheiro ◽  
Ricardo Filipe Alves Costa ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Nodes ◽  
Glucose Transporter ◽  
Metastatic Cancer ◽  
Multivariable Analysis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Origin ◽  
Related Proteins ◽  
Unknown Primary Origin

IntroductionCancer of unknown primary origin (CUP) is defined as metastatic cancer without identification of the primary site. Considering that only 15–20% of patients with CUP show a favorable outcome, identifying biomarkers may help improve the clinical management of patients who do not respond well to conventional therapies. In this context, the study of the metabolic profile of CUP may pave the way to establish new biomarkers and/or therapeutic targets; therefore, this study aimed to characterize the expression of metabolism-related proteins in CUP.Materials and MethodsThe expression of monocarboxylate transporters MCT1, MCT2 and MCT4, their chaperone CD147, the glucose transporter GLUT1 and the pH regulator CAIX was evaluated by immunohistochemistry in a series of 118 CUP patients, and the results were associated with the available clinicopathological information.ResultsThe metabolism-related proteins MCT1, MCT4, CD147, GLUT1 and CAIX were expressed in a critical portion of the CUP (approximately 20 to 70%). MCT1 and CD147 were both more frequently expressed in cases with lymph nodes as metastasis dominant sites (p = 0.001) as well as in samples from lymph nodes (p <0.001 and p = 0.002, respectively), while MCT1 expression was more frequently expressed in squamous cell carcinomas (p = 0.045). A higher overall survival was observed in patients with tumors positive for GLUT1 and CAIX expression (p = 0.011 and p = 0.041, respectively), but none of the proteins was an independent prognostic factor for overall survival in multivariable analysis.ConclusionThe results suggest that a portion of CUPs present a hyperglycolytic phenotype, which is associated with higher overall survival.

A case with widespread cutaneous metastases of unknown primary origin: Grave prognostic finding in cancer

2005 ◽  
Vol 11 (1) ◽  
Author(s):  
Rafet Koca ◽  
Yucel Ustundag ◽  
Eksal Kargi ◽  
Gamze Numanoglu ◽  
H Cevdet Altinyazar
Keyword(s):  
Unknown Primary ◽  
Cutaneous Metastases ◽  
Primary Origin ◽  
Unknown Primary Origin

scholarly journals Metastatic Carcinoma of the Neck of Unknown Primary Origin: Evolution and Efficacy of the Modern Workup

2009 ◽  
Vol 135 (10) ◽  
pp. 1024-1029 ◽  
Author(s):  
J. D. Waltonen ◽  
E. Ozer ◽  
N. C. Hall ◽  
D. E. Schuller ◽  
A. Agrawal
Keyword(s):  
Metastatic Carcinoma ◽  
Unknown Primary ◽  
Primary Origin ◽  
Unknown Primary Origin

Choriogonadotropin-mediated thyrotoxicosis in a man

1991 ◽  
Vol 37 (6) ◽  
pp. 1127-1131 ◽  
Author(s):  
Heather J Cain ◽  
Peter R Pannall ◽  
Dusan Kotasek ◽  
Robert J Norman
Keyword(s):  
Unknown Primary ◽  
Rare Occurrence ◽  
Human Choriogonadotropin ◽  
Primary Origin ◽  
Unknown Primary Origin

Abstract A 38-year-old man with a metastatic gonadotropin-secreting tumor of unknown primary origin presented with both clinical and biochemical findings of hyperthyroidism in association with markedly increased concentrations of human choriogonadotropin (hCG) in plasma. After chemotherapy, the concentrations of both hCG and free thyroxin decreased and the patient became euthyroid. We discuss the rare occurrence of this presumably hCG-driven hyperthyroidism in men and compare it with the relatively more common eumetabolic hyperthyroidism associated with choriocarcinoma in women.

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