This study aimed to assess the use of pesticides and their impact on the triple-rice crops in Phu Can commune, Tieu Can district, Tra Vinh province by directly interviewed 60 farmers in the study area. The results showed that during cultivation, the farmers used pesticides with a very high dose and spray frequency. The farmers often applied various types of pesticides belonging to toxicity categories II, III, and IV according to the World Health Organization (WHO) classification. The treatments of bottles and packages of the pesticides after use by burying, disposing of in the rice field, selling to the vendors, and burning were improper practices. Consequently, these practices could pollute the environment with pesticides. The findings of the present study revealed that rice farming in the study area potentially poses a high risk to the surrounding environments and human health. Local authorities and environmental managers should pay more attention to solving this problem.