scholarly journals Linear lichen planus associated with primary aldosteronism

2021 ◽  
Vol 12 (4) ◽  
pp. 468-469
Author(s):  
Natsuko Matsumura ◽  
Toshiyuki Yamamoto
Keyword(s):  
T Lymphocytes ◽  
Lichen Planus ◽  
Primary Aldosteronism ◽  
Histopathological Examination ◽  
Metastatic Cancer ◽  
Lymphocytic Infiltration ◽  
Skin Lesions ◽  
Unknown Etiology ◽  
Cd8 T Lymphocytes ◽  
History Of

Sir, Lichen planus (LP) is categorized as a chronic inflammatory skin disease of unknown etiology that involves immune reactions. It is characterized by flat-topped, polygonal, violaceous papules and plaques. It has various clinical presentations, such as classical LP, hypertrophic LP, LP pigmentosus, and linear LP (LLP). Primary aldosteronism (PA) is known to pose a higher risk of causing multiple autoimmune diseases [1]. Herein, we report a case with LLP and PA present at the same time. A 72-year-old Japanese female presented herself to our hospital with a three-month history of slightly itchy skin lesions on the lower right leg. A physical examination revealed flat-topped plaques on the lower right limb extending from the middle of the leg to the dorsum of the foot (Fig. 1a). There was no oral or nail involvement. The patient had a history of hypertension from the age of 62 years and was diagnosed with PA afterward. The patient had been treated with an antihypertensive drug since then without change in internal medication. The patient had no history of a preceding trauma, dental metal fillings, hepatitis, metastatic cancer, or any other infections. A histopathological examination of a skin biopsy from a lesion on the right leg revealed hyperkeratosis, a saw-tooth appearance of the epidermis, and severe liquefaction degeneration. A band-like lymphocytic infiltration was present in the upper dermis (Figs. 2a and 2b), as well as lichenoid infiltration into the dermis composed of CD4+ and CD8+ T lymphocytes. Predominantly, CD8+ T lymphocytes infiltrated into the epidermis (Figs. 2c and 2d). Clinical and histological findings confirmed the diagnosis of LPP.

A Rare Case of Spinal Leprosy Mimicking Spinal Tuberculosis

2019 ◽  
pp. 33
Author(s):  
K Thuraikumar ◽  
V Naveen ◽  
Mustaqim A ◽  
Arieff AA ◽  
K Shri ◽  
...  
Keyword(s):  
Back Pain ◽  
Soft Tissue ◽  
Histopathological Examination ◽  
Posterior Instrumentation ◽  
Spinal Tuberculosis ◽  
Previous History ◽  
Skin Lesions ◽  
Titanium Implants ◽  
Paravertebral Abscess ◽  
History Of

Introduction: Spinal tuberculosis is the most common manifestation of extrapulmonar y tuberculosis. A combination of leprosy and tuberculosis is a rare entity.Case report: A 44-year-old male patient working as a laborer presented to our hospital with complaints of severe back pain and swelling over the back, difficulty in walking, associated with constitutional symptoms. On admission, he was febrile and had leukocytosis. Initial spine X-ray showed end plate destruction and increase in soft tissue shadow at the level of T8-T9. CT spine revealed thoracic paravertebral collection extending from T7 to T9 levels, suggest ive of tuberculous spondylitis with cold abscess. Patient refused a transpedicular biopsy and was started on anti-tubercular therapy. Two weeks after commencement of treatment, he developed worsening back pain and weakness of the lower extremities. MRI spine showed a paravertebral abscess and posterior soft tissue edema involving level of T7 to T11. Patient underwent a posterior decompression, debridement and posterior instrumentation. He was discharged well, there was improvement of his lower limb power. Upon clinic review, he complained of multiple hyperpigmented, painless, nonpruritic skin lesions over the trunk and back. No previous history of eczema, psoriasis and Tinea corporis. Given the history of allergy, initial impression was hypersensitivity reaction towards the titanium implants, and he was started on anti-histamines. However, there was no improvements seen. Histopathological examination of skin lesions revealed presence of granuloma within the dermis layer, composed of epitheloid, histiocytes, lymphocytes and plasma cells. Wade-Fite stain for Mycobacterium leprae is positive. Slit skin smear shows multibacillary leprosy. Patient was started on multidrug therapy (rifampicin, clofazimine and dapsone) for 1 year. He has recovered well.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 33

scholarly journals A clinical study on linear dermatoses at a teriary care teaching hospital in Davangere

2021 ◽  
Vol 7 (2) ◽  
pp. 201
Author(s):  
Sowmya Manangi ◽  
Anirudh M. ◽  
Aishwarya Sivuni ◽  
Hosalli Smrutha ◽  
Suga Reddy
Keyword(s):  
Lichen Planus ◽  
Skin Lesions ◽  
Epidermal Nevus ◽  
Linear Lesions ◽  
Cosmetic Reason ◽  
Histopathological Correlation ◽  
Lichen Striatus ◽  
History Of Disease ◽  
History Of ◽  
Blaschko’S Lines

<p class="abstract"><strong>Background:</strong> Skin lesions present with innumerable patterns like discoid, petaloid, arcuate, annular, polycyclic, livedo, reticulate, target, stellate, digitate, linear, serpiginous and whorled. Most of the linear lesions follow the Blaschko’s lines. Aim was to study the incidence of linear dermatoses, the age and sex incidence, various types of clinical presentation, various sites of distribution and their clinical correlation.  </p><p class="abstract"><strong>Methods:</strong> Detailed history including family history, History of disease documented with clinical examination. After counselling and after recording their consent for the test, skin biopsy along with routine investigations was done wherever needed and the results were evaluated. <strong></strong></p><p class="abstract"><strong>Results:</strong> Lichen striatus was seen in 29.91% followed by linear herpes zoster in 24.7%, linear lichen planus in 18.22%, linear verrucous epidermal nevus in 14.01%, segmental vitiligo in 3.73%, nevus depigmentation in 2.33% and others. Maximal cases were asymptomatic and reported for cosmetic reason. Intense itching was the main reason to bring the lichen planus patients and few cases of the lichen striatus patients for treatment.  </p><p class="abstract"><strong>Conclusions:</strong> Lichen striatus was found to be more common, female preponderance. Majority of patients showed unilateral distribution more on the extremities. Histopathological correlation shows the importance of histopathology which ultimately changes the management in any given condition.</p><p> </p>

scholarly journals Wells’ Syndrome Successfully Treated with Colchicine

2017 ◽  
Vol 9 (2) ◽  
pp. 65-69 ◽  
Author(s):  
Álvaro Iglesias Puzas ◽  
Laura Mesa Álvarez ◽  
Ángeles Flórez Menéndez ◽  
Susana Romero Yuste ◽  
Olga Prieto Gómez
Keyword(s):  
Skin Lesions ◽  
Unknown Etiology ◽  
First Line ◽  
Steroid Resistant ◽  
Chronic Disorder ◽  
Eosinophilic Cellulitis ◽  
History Of ◽  
Excellent Safety Profile ◽  
Wells Syndrome

Eosinophilic cellulitis is an uncommon, inflammatory and chronic disorder of unknown etiology. Corticosteroids are currently considered as the first-line treatment but they are not without significant disadvantages such as contraindications in steroid-resistant cases and patients with frequent recurrences. We report a patient suffering from Wells’ syndrome with a 24-year history of symptomatic and generalized skin lesions. After consultation in our department, treatment with colchicine 1 mg/day was prescribed resulting in large clinical improvement. No side effects have been recorded. To our knowledge, this is an original disease approach. Although small, our clinical experience supports the inclusion of colchicine in the drug armamentarium when treating patients suffering from Wells’ syndrome. Indeed, its excellent safety profile makes it very attractive for patients with frequent recurrent episodes who need secure options for the medium- and long-term disease control.

scholarly journals Grinspan’s Syndrome: A Rare Case with Malignant Transformation

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Numan Kökten ◽  
Lokman Uzun ◽  
Ayşe Serap Karadağ ◽  
Tülay Zenginkinet ◽  
M. Tayyar Kalcıoğlu
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Buccal Mucosa ◽  
Histopathological Examination ◽  
Split Thickness Skin Graft ◽  
Thickness Skin ◽  
Exophytic Tumor ◽  
History Of ◽  
Stratified Squamous Epithelium

Aim. Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan’s syndrome in 1966. We aim to present a case of Grinspan’s syndrome with malignant transformation. Case Presentation. A 60-year-old man who presented with a ten-year history of OLP diagnosed clinically and histologically was referred to our otolaryngology department with a painless swallowing in the left buccal mucosa for 3 months. Clinical examination revealed several plaques, striated white lesions in the buccal mucosa bilaterally, and an exophytic tumor in the left buccal mucosa. Histopathological examination showed lichen planus bilaterally and oral squamous cell carcinoma in the left buccal mucosa. The tumor had been developed on the preexisting areas of lichen planus which had been histologically proven before. The tumor was removed completely, and the tissue defect on the buccal mucosa was repaired with a split-thickness skin graft. Conclusion. Patients with OLP should be followed up periodically in a long term at close intervals for early diagnosis of malignant transformation.

CD8+ T lymphocytes reactive against Epstein-Barr virus antigens in skin lesions of a patient with Sézary syndrome

2005 ◽  
Vol 53 (5) ◽  
pp. 897-900 ◽  
Author(s):  
Anne-Chantal Knol ◽  
Yannick Guilloux ◽  
Gaëlle Quéreux ◽  
Sonia Marques-Briand ◽  
Marie-Christine Pandolfino ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Epstein Barr Virus ◽  
Skin Lesions ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Barr Virus ◽  
Cd8 T Lymphocytes ◽  
Virus Antigens ◽  
Epstein Barr

scholarly journals Oral Mucous Membrane Pemphigoid with Contact Dermatitis - A Rare Clinical Entity.

2018 ◽  
Vol 08 (03) ◽  
pp. 041-044
Author(s):  
Santhosh Shenoy ◽  
Madhurya N Kedlaya ◽  
Sajna H R. ◽  
Amitha Ramesh
Keyword(s):  
Case Report ◽  
Contact Dermatitis ◽  
Mucous Membrane ◽  
Histopathological Examination ◽  
Spontaneous Remission ◽  
Corticosteroid Treatment ◽  
Skin Lesions ◽  
Mucous Membrane Pemphigoid ◽  
History Of ◽  
Periodontal Maintenance

AbstractMucous membrane pemphigoid (MMP) is a rare inflammatory, autoimmune, subepithelial vesiculobullous lesion. Oral mucosa is affected in almost 90% of cases. Its development is chronic with a possible involvement of ocular, laryngeal and genital mucosa. Spontaneous remission is rare. Currently, improving oral hygiene, topical corticosteroid treatment is used to control the oral lesions of MMP. In the present case report, a 53 year old female patient with a known history of hypothyroidism reported to the department of Periodontology with a complaint of burning sensation and tenderness in the gums on intake of spicy food for the past one week .The patient had also noticed the formation of blisters on the gums which would break off on their own. Hence provisional diagnosis of MMP was considered based on the clinical and histopathological examination which was later confirmed with immunofluorescent interpretations. The treatment objective is to suppress extensive blister formation, to promote healing, and to prevent scarring. The above objectives were met in our case by thorough periodontal maintenance and steroid therapy. She also presented with skin lesions due to contact dermatitis caused by occupational exposure to tobacco which makes this case report unique.

Syphilis gastritis: a case report

2017 ◽  
Vol 29 (7) ◽  
pp. 723-725
Author(s):  
Kuan Lai ◽  
Nicolas Pinto-Sander ◽  
Daniel Richardson ◽  
Shanshan Wei ◽  
Kang Zeng
Keyword(s):  
Gastric Mucosa ◽  
Histopathological Examination ◽  
Epigastric Pain ◽  
Treponema Pallidum ◽  
Clinical Manifestations ◽  
Maculopapular Rash ◽  
Skin Lesions ◽  
Lymphoplasmacytic Infiltrate ◽  
Assay Result ◽  
History Of

Awareness of the spectrum of clinical manifestations of syphilis, especially uncommon changes, is essential for diagnosis and effective management of patients. A 48-year-old Han businessman presented to the ear, nose and throat surgeons with an eight-week history of epigastric pain, a four-week history of a widespread non-itchy rash including the scrotal skin and a one-week history of tinnitus and dizziness. On examination, he was afebrile with widespread lymphadenopathy and a maculopapular rash affecting his trunk and scrotum. His abdomen was soft but tender in the epigastrium. The Treponema pallidum particle agglutination assay result was positive, and the rapid plasma reagin was 1:2. Gastroscopy showed ulcers in the gastric antrum and pylorus. Histopathological examination of gastric mucosa lesions showed a large amount of lymphoplasmacytic infiltrate detected in the lamina propria of the gastric mucosa. The T. pallidum Liferiver real time polymerase chain reaction kit assay performed on specimens from skin lesions and gastric mucosal tissue were positive. The patient was treated with intravenous sodium penicillin followed by intramuscular benzathine penicillin. On the fourth day of the treatment, the rash, epigastric pain and lymphadenopathy subsided. Two weeks after treatment, the tinnitus alleviated and vertigo disappeared.

scholarly journals Zosteriform lichen planus as a manifestation of Wolf’s isotopic response

2021 ◽  
Vol 5 (5) ◽  
pp. 549-553
Author(s):  
George Glinos ◽  
Madeline Hooper ◽  
G. Eli Morey ◽  
Lucai Seminario-Vidal
Keyword(s):  
Herpes Zoster ◽  
Literature Review ◽  
Lichen Planus ◽  
Topical Therapy ◽  
Skin Lesions ◽  
Case Description ◽  
Inflammatory Dermatosis ◽  
Histopathological Evaluation ◽  
History Of ◽  
Tissue Reactions

Background Wolf’s isotopic response has been described in association with malignancy, infections, and inflammatory disorders. Lichenoid tissue reactions are a rare but recognized example of this phenomenon; only 41 cases of zosteriform lichen planus exist in publication. This case adds to the minimal literature describing lichenoid inflammatory dermatosis compatible with Wolf’s isotopic response.   Methods Literature review and case description.   Results A man in his 30s with a history of herpes zoster presented with a pruritic rash on his left arm. Clinical and histopathological evaluation were consistent with lichen planus in the distribution of a healed herpes zoster rash. The skin lesions improved after six weeks of treatment with clobetasol 0.05% ointment twice daily.   Conclusions The presentation of lichen planus as Wolf’s isotopic response is uncommon, but responsive to standard topical therapy.

scholarly journals Cutaneous Plasmacytosis with Perineural Involvement

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Elizabeth A. Brezinski ◽  
Maxwell A. Fung ◽  
Nasim Fazel
Keyword(s):  
Plasma Cell ◽  
Plasma Cells ◽  
Skin Lesions ◽  
Unknown Etiology ◽  
Cell Infiltrate ◽  
Lambda Light Chain ◽  
Chemotherapeutic Regimen ◽  
History Of ◽  
Systemic Symptoms

Importance. Cutaneous and systemic plasmacytosis are rare conditions of unknown etiology with characteristic red-brown skin lesions and a mature polyclonal plasma cell infiltrate within the dermis. Perineural plasma cell infiltrates may be a histologic clue to the diagnosis of cutaneous plasmacytosis.Observations. Our patient had a five-year history of persistent reddish-brown plaques on the neck and trunk without systemic symptoms. Histologic examination showed dermal perivascular and perineural plasma cells with excess lambda light chain expression. Due to decreased quality of life caused by his skin lesions, he was placed on a chemotherapeutic regimen with bortezomib.Conclusions and Relevance. The patient was diagnosed with cutaneous plasmacytosis based on classic histopathology results with a recently characterized pattern of perineural involvement. Bortezomib therapy was initiated to manage his skin eruption, which has not been previously described as a treatment for this chronic condition.

scholarly journals Multicentric Reticulohistiocytosis Presenting with Papulonodular Skin Lesions and Arthritis Mutilans

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Raya Saba ◽  
Shawn G. Kwatra ◽  
Bishwas Upadhyay ◽  
Aibek E. Mirrakhimov ◽  
Farah N. Khan
Keyword(s):  
Histopathological Examination ◽  
Giant Cells ◽  
Skin Lesions ◽  
Left Knee ◽  
Unknown Etiology ◽  
Multisystem Disorder ◽  
Internal Organs ◽  
Multicentric Reticulohistiocytosis ◽  
Eosinophilic Cytoplasm ◽  
Mucous Membranes

Multicentric reticulohistiocytosis is a rare multisystem disorder of unknown etiology that is characterized by erosive polyarthritis and papulonodular lesions on the skin, mucous membranes, and internal organs. We report the case of a 54-year-old female who was misdiagnosed as having rheumatoid arthritis and underwent numerous joint replacement surgeries for progressively destructive arthritis in her hands, shoulders, hips, and knees. The patient finally received a diagnosis of multicentric reticulohistiocytosis after histopathological examination of the patient’s left knee arthroplasty which revealed a diffuse histiocytic infiltrate, multinucleated giant cells, and finely granulated eosinophilic cytoplasm with a ground-glass appearance.

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