scholarly journals A clinical study on linear dermatoses at a teriary care teaching hospital in Davangere

2021 ◽  
Vol 7 (2) ◽  
pp. 201
Author(s):  
Sowmya Manangi ◽  
Anirudh M. ◽  
Aishwarya Sivuni ◽  
Hosalli Smrutha ◽  
Suga Reddy
Keyword(s):  
Lichen Planus ◽  
Skin Lesions ◽  
Epidermal Nevus ◽  
Linear Lesions ◽  
Cosmetic Reason ◽  
Histopathological Correlation ◽  
Lichen Striatus ◽  
History Of Disease ◽  
History Of ◽  
Blaschko’S Lines

<p class="abstract"><strong>Background:</strong> Skin lesions present with innumerable patterns like discoid, petaloid, arcuate, annular, polycyclic, livedo, reticulate, target, stellate, digitate, linear, serpiginous and whorled. Most of the linear lesions follow the Blaschko’s lines. Aim was to study the incidence of linear dermatoses, the age and sex incidence, various types of clinical presentation, various sites of distribution and their clinical correlation.  </p><p class="abstract"><strong>Methods:</strong> Detailed history including family history, History of disease documented with clinical examination. After counselling and after recording their consent for the test, skin biopsy along with routine investigations was done wherever needed and the results were evaluated. <strong></strong></p><p class="abstract"><strong>Results:</strong> Lichen striatus was seen in 29.91% followed by linear herpes zoster in 24.7%, linear lichen planus in 18.22%, linear verrucous epidermal nevus in 14.01%, segmental vitiligo in 3.73%, nevus depigmentation in 2.33% and others. Maximal cases were asymptomatic and reported for cosmetic reason. Intense itching was the main reason to bring the lichen planus patients and few cases of the lichen striatus patients for treatment.  </p><p class="abstract"><strong>Conclusions:</strong> Lichen striatus was found to be more common, female preponderance. Majority of patients showed unilateral distribution more on the extremities. Histopathological correlation shows the importance of histopathology which ultimately changes the management in any given condition.</p><p> </p>

scholarly journals Study on linear dermatoses

2018 ◽  
Vol 4 (2) ◽  
pp. 190 ◽  
Author(s):  
Saraswathy P. ◽  
Nithya Gayathri Devi D. ◽  
Sivaranjani J.
Keyword(s):  
Tertiary Care ◽  
Outpatient Department ◽  
Incontinentia Pigmenti ◽  
Care Hospital ◽  
Epidermal Nevus ◽  
Koebner Phenomenon ◽  
Linear Lesions ◽  
Histopathological Correlation ◽  
Lichen Striatus ◽  
Linear Psoriasis

<p class="abstract"><strong>Background:</strong> The objective of the study was to study the incidence, age and sex distribution, association, distribution, clinical presentation, histopathological correlation of linear dermatoses at the skin Outpatient Department.</p><p class="abstract"><strong>Methods:</strong> A prospective study was conducted over a period of 1 year in 90 patients, attending the Department of Dermatology, at a tertiary care hospital, Chennai. Data collection, clinical examination and skin biopsy were recorded and analyzed statistically. Inclusion criteria were all patient with linear dermatoses. Exclusion criteria were Koebner phenomenon.<strong></strong></p><p class="abstract"><strong>Results:</strong> The incidence of linear dermatoses in our outpatient department- 0.2% per year. Among the linear dermatoses, lichen striatus was found to be the most common. The other dermatoses following Blaschko’s lines, in the descending order of frequency seen in this study were linear epidermal nevus, linear lichen planus, linear morphoea, inflammatory linear verrucous epidermal nevus, segmental vitiligo, hypomelanosis of ito, linear lichenoid dermatitis, linear psoriasis, segmental neurofibromatosis, linear whorled nevoid hypermelanosis, incontinentia pigmenti, nevus depigmentosus, linear porokeratosis. Female preponderance was noted. Majority of patients showed unilateral distribution mostly on the extremities.</p><p class="abstract"><strong>Conclusions:</strong> Most of the linear lesions are arranged along Blaschko’s line. The importance of histopathological correlation is obvious. Cases which were clinically diagnosed as lichen striatus, showed histopathological features of psoriasis and linear epidermal verrucous nevus. One case diagnosed clinically as epidermal nevus was found to be super imposed by psoriasis histologically. Another case clinically diagnosed as linear psoriasis clinically, was found to be linear porokeratosis on histopathology. Very few associations were noted.</p>

scholarly journals Clinico-pathological correlation of linear dermatoses along the lines of Blaschko: An observational study

2021 ◽  
Vol 7 (4) ◽  
pp. 288-295
Author(s):  
Gajanan A Pise ◽  
Shilpa V Dastikop ◽  
Manjunath S ◽  
Naveen Manohar ◽  
Malteshgauda N Patil
Keyword(s):  
Histopathological Examination ◽  
Epidemiological Studies ◽  
Epidermal Nevus ◽  
Hypomelanosis Of Ito ◽  
Histopathological Features ◽  
Linear Lesions ◽  
Lichen Striatus ◽  
Pathological Correlation ◽  
Lines Of Blaschko ◽  
Blaschko’S Lines

Several epidemiological studies have described linear dermatoses; however, only few studies have correlated linear dermatoses along Blaschko’s lines with the histopathological findings. The aims of this study were to investigate the clinical patterns of various linear dermatological lesions along Blaschko’s lines and investigate the correlations between these dermatological lesions and their histopathological features. Patients who attended our dermatology out-patient department with linear dermatoses along the Blaschko’s lines were included in the study. Detailed history was obtained, clinical examination was performed, and a final provisional clinical diagnosis was noted. Subsequently, biopsy of the lesions was performed for histopathological examination. Of 62 patients who presented with linear lesions along the Blaschko’s lines, 45 patients underwent biopsy and histopathological examination. Of 45 patients who underwent biopsy, clinico-pathological correlation was observed in 100% of those diagnosed with lichen striatus and linear morphea, 89% of those diagnosed with hypomelanosis of Ito, 80% of those diagnosed with linear epidermal nevus, 75% of those diagnosed with lichen planus, and 67% of those diagnosed with nevus depigmentosus. The importance of correlation of linear lesions with their histopathological features in dermatology cannot be over emphasized. However, 100% correlation may be wishful thinking, and a correlation can help choose the appropriate line of management. Our results highlight this discrepancy and add to the knowledge on linear dermatosis.

scholarly journals Porokeratotic Eccrine Ostial and Dermal Duct Nevus

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Mona Masoumeh Naraghi ◽  
Azita Nikoo ◽  
Azadeh Goodarzi
Keyword(s):  
Granular Layer ◽  
Clinical Presentation ◽  
Late Onset ◽  
Skin Lesions ◽  
Pathologic Examination ◽  
Lateral Ankle ◽  
History Of ◽  
Characteristic Features ◽  
Blaschko’S Lines ◽  
Pruritic Skin

PEODDN is a rare benign cutaneous disorder that clinically resembles comedo nevus but favors the palms and soles, where pilosebaceous follicles are absent. Widespread involvement along Blaschko’s lines can also occur. It is a disorder of keratinization involving the intraepidermal eccrine duct (acrosyringium) and is characterized by eccrine hamartoma and cornoid lamellation in pathology. The patient is a 29-year-old man with an 8-year history of pruritic skin lesions on his right lateral ankle. In the pathologic examination, multiple small epidermal invagination with overlying parakeratotic cornoid lamellation, loss of granular layer, and few dyskeratotic cells at the base of epidermal invagination are revealed. After clinic-pathologic correlation, the diagnosis of porokeratotic eccrine ostial and dermal duct nevus (PEODDN) was made. Late-onset and rare clinical presentation as pruritic lesion are the characteristic features that make this patient an extraordinary presentation of PEODDN.

The Burden of Psoriasis in Canada: Insights from the pSoriasis Knowledge IN Canada (SKIN) Survey

2009 ◽  
Vol 13 (5) ◽  
pp. 235-252 ◽  
Author(s):  
Charles W. Lynde ◽  
Yves Poulin ◽  
Lyn Guenther ◽  
Christine Jackson
Keyword(s):  
Telephone Survey ◽  
Burden Of Illness ◽  
Skin Lesions ◽  
Severe Psoriasis ◽  
Similar Data ◽  
Daily Lives ◽  
Substantial Problem ◽  
History Of Disease ◽  
History Of ◽  
The Mean

Background: Although some data addressing the burden of illness associated with psoriasis and psoriatic arthritis (PsA) have been reported for American and European patient populations, similar data have been lacking for Canadians with these diseases. Objective: We sought to characterize the natural history of disease in a sample of Canadians with a history of moderate to severe psoriasis, with or without diagnosed PsA or other recognized comorbid conditions, and to identify factors that influenced their perception of psoriasis as a problem in their daily lives. Methods: A nationwide telephone survey, pSoriasis Knowledge IN Canada (SKIN), was conducted between April 30 and June 2, 2007, on 500 people who indicated that they had been diagnosed with psoriasis and that their skin lesions had at some time affected an area at least as large as three palms of their hand (3% of body surface area [BSA]). Results: The mean age at diagnosis for psoriasis among SKIN survey respondents was 28 years, with 31% (155 of 500) indicating that they developed the disease prior to age 18 years. At the time of the survey, 54% (269 of 500) of respondents were experiencing lesions affecting a BSA equivalent to at least three palms (3%). In response to questions on the burden of illness, 35% (176 of 500) of respondents indicated that they considered psoriasis to be a substantial problem in their daily life. Both affected BSA at the time of the survey and self-reported extent of skin involvement at the height of the condition (BSAmax) correlated with the perception of psoriasis as a substantial problem. Other subpopulations in which psoriasis was commonly identified as a substantial problem included women and individuals with diagnosed PsA. Whereas 18% (88 of 500) of respondents were diagnosed with PsA, the number who reported joint pain or stiffness was substantially higher (51%; 256 of 500), suggesting that some respondents may have had incipient or undiagnosed PsA. Conclusions: This survey reveals that psoriasis, PsA, and their associated comorbidities impose a severe burden on the daily lives of Canadians with a history of moderate to severe psoriasis.

scholarly journals Vulvar and Perianal Condyloma Superimposed Inflammatory Linear Verrucous Epidermal Nevus: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Sümeyra Nergız Avcioğlu ◽  
Sündüz Özlem Altinkaya ◽  
Mert Küçük ◽  
Hasan Yüksel ◽  
Selda Demircan-Sezer ◽  
...  
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Review Of The Literature ◽  
Epidermal Nevus ◽  
Lichen Striatus ◽  
Genetic Mosaicism ◽  
Lines Of Blaschko ◽  
Linear Psoriasis

Inflammatory linear verrucous epidermal nevus (ILVEN) is a benign cutaneous hamartoma characterized by intensely erythematous, pruritic, and inflammatory papules that occur as linear bands along the lines of Blaschko. There is a considerable clinical and histological resemblance between ILVEN and linear psoriasis, lichen striatus, linear lichen planus, and invasion of epidermal nevus by psoriasis. The pathogenesis of ILVEN is unknown. It is regarded as a genetic dyskeratotic disease reflecting genetic mosaicism. Here, a case of vulvar and perianal condyloma superimposed ILVEN is presented.

scholarly journals Treatment of Verrucous Epidermal Nevus by Radiofrequency Ablation: a Case Report

2015 ◽  
Vol 7 (1) ◽  
pp. 15-22
Author(s):  
Dragana Ljubisavljević ◽  
Zorana Zlatanović ◽  
Radmila Milenković ◽  
Danijela Popović ◽  
Mirjana Paravina
Keyword(s):  
First Trimester ◽  
Skin Lesions ◽  
Molecular Techniques ◽  
Epidermal Nevus ◽  
Genetic Mosaicism ◽  
Functional Problem ◽  
Lines Of Blaschko ◽  
The Face ◽  
History Of ◽  
The Right

Abstract Verrucous epidermal nevi are noninflammatory, congenital, cutaneous hamartomas composed of keratinocytes, abnormal clone(s) of cells that reflect genetic mosaicism arising from different somatic mutations. Some of these mutations are well recognized, but some are still unidentified. Molecular techniques are used for identification and classification of molecular causes of certain epidermal nevi, whereas all verrucous epidermal nevi are divided into epidermolytic and non-epidermolytic types. They are typically present at birth, but may appear during childhood, even later. Their prevalence in adults ranges from 0.1 to 0.5%, equally affecting both sexes, and about 1 in 1000 newborns. Warty, brown papules without inflammation distinguish verrucous nevi from other epidermal nevi, while presence at birth and persistance distinguish verrucous epidermal nevi from linear viral warts. Epidermolytic and non-epidermolytic verrucous epidermal nevi are almost always hard to distinguish, except by histology. As a rule, verrucous epidermal nevi are asymptomatic, they have a benign course, except occasionally, and therapy is mostly used for cosmetic reasons. Simple excision is usually the treatment of choice. Topical agents are rarely curative, as well as surgery which is associated with relapses, unless both epidermis and the underlying dermis are removed or destroyed at the same time. We present a case of an otherwise healthy 21-year-old female patient, who presented with a solitary congenital verrucous cauliflower-like lesion in the right zygomatic region of the face. The lesion was present from birth. Due to its gradual growth during years, the lesion became a great esthetic and functional problem for this young patient. There was no family history of similar or any other tumorous skin lesions in the family. On examination, the patient had a solitar unilateral, well defined yellowish cauliflower-like verrucous lesion confined to the right malar side of the face. The lesion was distributed along the lines of Blaschko extending horizontally, from its wider 1.5 cm cauliflower-like part on the right zygomatic region, towards its tail-like 0.5 cm thick end on the preauricular region, in approximately 3 cm long tail-like manner without crossing the midline. Since the patient refused biopsy, no exact differentiation between epidermolytic and non-epidermolytic nevi was possible. The diagnosis of verrucous epidermal nevus was based on history and clinical presentation, as a diagnosis of exclusion. Due to the fact that patients with epidermolytic verrucous epidermal nevi are at risk of parenting a child with bullous ichthyosiform erythroderma, the patient was counseled on this risk, and on the possibility of first-trimester antenatal diagnosis. The lesion was successfully treated by radio-wave surgery.

scholarly journals Zosteriform lichen planus as a manifestation of Wolf’s isotopic response

2021 ◽  
Vol 5 (5) ◽  
pp. 549-553
Author(s):  
George Glinos ◽  
Madeline Hooper ◽  
G. Eli Morey ◽  
Lucai Seminario-Vidal
Keyword(s):  
Herpes Zoster ◽  
Literature Review ◽  
Lichen Planus ◽  
Topical Therapy ◽  
Skin Lesions ◽  
Case Description ◽  
Inflammatory Dermatosis ◽  
Histopathological Evaluation ◽  
History Of ◽  
Tissue Reactions

Background Wolf’s isotopic response has been described in association with malignancy, infections, and inflammatory disorders. Lichenoid tissue reactions are a rare but recognized example of this phenomenon; only 41 cases of zosteriform lichen planus exist in publication. This case adds to the minimal literature describing lichenoid inflammatory dermatosis compatible with Wolf’s isotopic response.   Methods Literature review and case description.   Results A man in his 30s with a history of herpes zoster presented with a pruritic rash on his left arm. Clinical and histopathological evaluation were consistent with lichen planus in the distribution of a healed herpes zoster rash. The skin lesions improved after six weeks of treatment with clobetasol 0.05% ointment twice daily.   Conclusions The presentation of lichen planus as Wolf’s isotopic response is uncommon, but responsive to standard topical therapy.

scholarly journals Linear lichen planus associated with primary aldosteronism

2021 ◽  
Vol 12 (4) ◽  
pp. 468-469
Author(s):  
Natsuko Matsumura ◽  
Toshiyuki Yamamoto
Keyword(s):  
T Lymphocytes ◽  
Lichen Planus ◽  
Primary Aldosteronism ◽  
Histopathological Examination ◽  
Metastatic Cancer ◽  
Lymphocytic Infiltration ◽  
Skin Lesions ◽  
Unknown Etiology ◽  
Cd8 T Lymphocytes ◽  
History Of

Sir, Lichen planus (LP) is categorized as a chronic inflammatory skin disease of unknown etiology that involves immune reactions. It is characterized by flat-topped, polygonal, violaceous papules and plaques. It has various clinical presentations, such as classical LP, hypertrophic LP, LP pigmentosus, and linear LP (LLP). Primary aldosteronism (PA) is known to pose a higher risk of causing multiple autoimmune diseases [1]. Herein, we report a case with LLP and PA present at the same time. A 72-year-old Japanese female presented herself to our hospital with a three-month history of slightly itchy skin lesions on the lower right leg. A physical examination revealed flat-topped plaques on the lower right limb extending from the middle of the leg to the dorsum of the foot (Fig. 1a). There was no oral or nail involvement. The patient had a history of hypertension from the age of 62 years and was diagnosed with PA afterward. The patient had been treated with an antihypertensive drug since then without change in internal medication. The patient had no history of a preceding trauma, dental metal fillings, hepatitis, metastatic cancer, or any other infections. A histopathological examination of a skin biopsy from a lesion on the right leg revealed hyperkeratosis, a saw-tooth appearance of the epidermis, and severe liquefaction degeneration. A band-like lymphocytic infiltration was present in the upper dermis (Figs. 2a and 2b), as well as lichenoid infiltration into the dermis composed of CD4+ and CD8+ T lymphocytes. Predominantly, CD8+ T lymphocytes infiltrated into the epidermis (Figs. 2c and 2d). Clinical and histological findings confirmed the diagnosis of LPP.

Isolated Plexiform Neurofibroma of the Nasal Tip - A Rare Case Report

2021 ◽  
Vol 8 (33) ◽  
pp. 3169-3171
Author(s):  
Subhadeep Chowdhury ◽  
Tithi Debnath
Keyword(s):  
Plexiform Neurofibroma ◽  
Skin Lesions ◽  
The Body ◽  
Neurogenic Tumour ◽  
Nasal Tip ◽  
Cosmetic Reason ◽  
Café Au Lait Spots ◽  
Rare Case Report ◽  
History Of ◽  
Similar Kind

A 28-year-old female patient presented at ENT OPD with complaints of a slowly growing mass over nasal tip since last 5 years. There were no complaints of pain, nasal obstruction, or epistaxis. There were no skin changes or ulceration over the swelling and sensation was preserved. There was no history of similar kind of swelling in other parts of the body. History of trauma or any form of surgical intervention were excluded. Family history was insignificant. The swelling did not respond to any medications. The patient attended for cosmetic reason solely. Clinical examination showed a soft non-tender 4 cm by 4 cm mass over nasal tip and supratip area. Mobility of the mass was restricted and fixed to the alar cartilages. There was no evidence of café au lait spots or any other skin lesions. Anterior rhinoscopy was unremarkable. Diagnostic nasal endoscopy was also performed but no abnormality was detected. CT scan showed non-specific infiltrative subcutaneous lesions. T1W MRI showed an ill-defined hypodense mass over the nasal tip which was abutting the alar cartilages which showed mild enhancement with contrast (figure 1). T2W MRI showed hyperintense and or hypodense central focus (target sign). FNAC was done and report was suggestive of neurogenic tumour, most probably neurofibroma.

Voices and Visions: Mind, Body and Affect in Medieval Writing

2018 ◽  
Author(s):  
Corinne Saunders
Keyword(s):  
Medical Humanities ◽  
Family Care ◽  
Literary Texts ◽  
Cultural Perspective ◽  
Historical Sources ◽  
Disease Treatment ◽  
History Of Disease ◽  
Health And Illness ◽  
History Of ◽  
Cultural Texts

A properly critical medical humanities is also a historically grounded medical humanities. Such historical grounding requires taking a long cultural perspective, going beyond traditional medical history – typically the history of disease, treatment and practice – to trace the origins and development of the ideas that underpin medicine in its broadest sense – ideas concerning the most fundamental aspects of human existence: health and illness, body and mind, gender and family, care and community. Historical sources can only go so far in illuminating such topics; we must also look to other cultural texts, and in particular literary texts, which, through their imaginative worlds, provide crucial insights into cultural and intellectual attitudes, experience and creativity. Reading from a critical medical humanities perspective requires not only cultural archaeology across a range of discourses, but also putting past and present into conversation, to discover continuities and contrasts with later perspectives. Medical humanities research is illuminated by cultural and literary studies, and also brings to them new ways of seeing; the relation is dynamic. This chapter explores the ways mind, body and affect are constructed and intersect in medieval thought and literature, with a particular focus on how voice-hearing and visionary experience are portrayed and understood.

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