scholarly journals Coleoptera genome and transcriptome sequences reveal numerous differences in neuropeptide signaling between species

2019 ◽  
Author(s):  
Jan A Veenstra
Keyword(s):  
Sequence Data ◽  
The Other ◽  
Beetle Species ◽  
Genome Sequences ◽  
Original Sequence ◽  
Insect Order ◽  
Neuropeptide Receptors ◽  
Transcriptome Sequences ◽  
Insect Neuropeptides ◽  
The One

Background. Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results suggest significant neuropeptide variation between different orders, but much less is known of neuropeptidome variability within an insect order. I therefore compared the neuropeptidomes of a number of Coleoptera. Methodology. Publicly available genome sequences, transcriptomes and the original sequence data in the form of short sequence read archives (SRAs) were analyzed for the presence or absence of genes coding neuropeptides as well as some neuropeptide receptors in seventeen beetle species. Results. Significant differences exist between the Coleoptera analyzed here, while many neuropeptides that were previously characterized from Tribolium castaneum appear very similar in all species, some are not and others are lacking in one or more species. On the other hand, leucokinin, which was presumed to be universally absent from Coleoptera, is still present in non-Polyphaga beetles. Conclusion. The variability in neuropeptidome composition between insect species from from the same insect order may be as large as the one that exists between species from different orders.

scholarly journals Coleoptera genome and transcriptome sequences reveal numerous differences in neuropeptide signaling between species

2019 ◽  
Author(s):  
Jan A Veenstra
Keyword(s):  
Sequence Data ◽  
The Other ◽  
Beetle Species ◽  
Genome Sequences ◽  
Original Sequence ◽  
Insect Order ◽  
Neuropeptide Receptors ◽  
Transcriptome Sequences ◽  
Insect Neuropeptides ◽  
The One

Background. Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results suggest significant neuropeptide variation between different orders, but much less is known of neuropeptidome variability within an insect order. I therefore compared the neuropeptidomes of a number of Coleoptera. Methodology. Publicly available genome sequences, transcriptomes and the original sequence data in the form of short sequence read archives (SRAs) were analyzed for the presence or absence of genes coding neuropeptides as well as some neuropeptide receptors in seventeen beetle species. Results. Significant differences exist between the Coleoptera analyzed here, while many neuropeptides that were previously characterized from Tribolium castaneum appear very similar in all species, some are not and others are lacking in one or more species. On the other hand, leucokinin, which was presumed to be universally absent from Coleoptera, is still present in non-Polyphaga beetles. Conclusion. The variability in neuropeptidome composition between insect species from from the same insect order may be as large as the one that exists between species from different orders.

scholarly journals Coleoptera genome and transcriptome sequences reveal numerous differences in neuropeptide signaling between species

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7144 ◽  
Author(s):  
Jan A. Veenstra
Keyword(s):  
Sequence Data ◽  
The Other ◽  
Beetle Species ◽  
Genome Sequences ◽  
Original Sequence ◽  
Insect Order ◽  
Neuropeptide Receptors ◽  
Transcriptome Sequences ◽  
Insect Neuropeptides ◽  
The One

Background Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results suggest significant neuropeptide variation between different orders, but much less is known of neuropeptidome variability within an insect order. I therefore compared the neuropeptidomes of a number of Coleoptera. Methodology Publicly available genome sequences, transcriptomes and the original sequence data in the form of short sequence read archives were analyzed for the presence or absence of genes coding neuropeptides as well as some neuropeptide receptors in seventeen beetle species. Results Significant differences exist between the Coleoptera analyzed here, while many neuropeptides that were previously characterized from Tribolium castaneum appear very similar in all species, some are not and others are lacking in one or more species. On the other hand, leucokinin, which was presumed to be universally absent from Coleoptera, is still present in non-Polyphaga beetles. Conclusion The variability in neuropeptidome composition between species from the same insect order may be as large as the one that exists between species from different orders.

Ein Beitrag zur Erfassung und Kenntnis der Kurzflügelkäfer (Coleoptera, Staphylinidae) in den Naturparks von Mecklenburg-Vorpommern

2019 ◽  
Vol 56 ◽  
pp. 61-73
Author(s):  
Andreas Kleeberg
Keyword(s):  
Human Impact ◽  
The Other ◽  
Federal State ◽  
Sampling Effort ◽  
Pitfall Traps ◽  
Beetle Species ◽  
Rove Beetles ◽  
Sampling Locations ◽  
Nature Parks ◽  
The One

In sieben Naturparks sowie drei Naturschutzgebieten in Mecklenburg-Vorpommern wurden in einer, auf Spinnen ausgerichteten saisonalen Aufnahme mit Bodenfallen mit gebietsweise unterschiedlichem Fangaufwand (April bis Oktober 2017 und April bis September 2018) insgesamt 377 Kurzflügelkäfer in 83 Arten nachgewiesen. An den feuchten und trockenen Fallenstandorten wurden hauptsächlich laufaktive, größere Arten (Staphylininae: Staphylinina) nachgewiesen. Die kleinen und artenreichen Aleocharinae waren im Vergleich dazu deutlich unterrepräsentiert. Faunistisch bemerkenswert für das Bundesland und seine Naturparks sind die Nachweise folgender 12 Arten: Zyras collaris (Paykull, 1800), Astenus immaculatus Stephens, 1833, Rugilus angustatus (Geoffroy, 1785), Quedius nigriceps Kraatz, 1857, Q. suturalis Kiesenwetter, 1845, Ocypus aeneocephalus (DeGeer, 1774), O. fuscatus (Gravenhorst, 1802), Platydracus fulvipes (Scopoli, 1763), P. latebricola (Gravenhorst, 1806), Staphylinus dimidiaticornis Gemminger, 1851, Tasgius globulifer (Geoffroy, 1785) und T. winkleri (Bernhauer, 1906). Einerseits belegt das Vorkommen von überregional seltenen Käferarten die besondere Bedeutung der naturräumlichen Ausstattung der Naturparks. Andererseits besteht damit eine wesentliche Verantwortung, die ausgewiesenen Gebiete möglichst naturnah zu belassen und den Einfluss des Menschen einzuschränken. In seven nature parks and three nature reserves in Mecklenburg-West Pomerania, rove beetles were captured with pitfall traps originally designed for assessing spiders during several seasons (April to October 2017 and April to September 2018). With sampling effort varying among locations, 377 rove beetles out of 83 species were recorded. At the wet and dry sampling locations, larger species (Staphylininae: Staphylinina) were recorded that are mainly running-active runners. In comparison, the small and speciose Aleocharinae were clearly underrepresented. Records of the following 12 species are faunistically remarkable for the federal state and its nature parks: Zyras collaris (Paykull, 1800), Astenus immaculatus Stephens, 1833, Rugilus angustatus (Geoffroy, 1785), Quedius nigriceps Kraatz, 1857, Q. suturalis Kiesenwetter, 1845, Ocypus aeneocephalus (DeGeer, 1774), O. fuscatus (Gravenhorst, 1802), Platydracus fulvipes (Scopoli, 1763), P. latebricola (Gravenhorst, 1806), Staphylinus dimidiaticornis Gemminger, 1851, Tasgius globulifer (Geoffroy, 1785) und T. winkleri (Bernhauer, 1906). On the one hand, the presence of widely rare beetle species attests the high value of the nature-specific endowment of the nature parks. On the other hand, following from this it is a strong obligation to leave the focal areas as naturally intact as possible, and to restrict human impact.

Note on Selection of Coordinate Systems for Geodynamics

1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen
Keyword(s):  
Sea Level ◽  
The Other ◽  
Coordinate Systems ◽  
Mean Sea Level ◽  
The Earth ◽  
The One ◽  
Static Systems ◽  
Selection Of

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.

Stories and the Self

2020 ◽  
Vol 32 (2) ◽  
pp. 47-58 ◽  
Author(s):  
Stefan Krause ◽  
Markus Appel
Keyword(s):  
Meta Analysis ◽  
The Self ◽  
The Other ◽  
Lower Degree ◽  
Contrast Effects ◽  
Self Perception ◽  
Self Perceptions ◽  
Other Hand ◽  
The One ◽  
Implicit And Explicit

Abstract. Two experiments examined the influence of stories on recipients’ self-perceptions. Extending prior theory and research, our focus was on assimilation effects (i.e., changes in self-perception in line with a protagonist’s traits) as well as on contrast effects (i.e., changes in self-perception in contrast to a protagonist’s traits). In Experiment 1 ( N = 113), implicit and explicit conscientiousness were assessed after participants read a story about either a diligent or a negligent student. Moderation analyses showed that highly transported participants and participants with lower counterarguing scores assimilate the depicted traits of a story protagonist, as indicated by explicit, self-reported conscientiousness ratings. Participants, who were more critical toward a story (i.e., higher counterarguing) and with a lower degree of transportation, showed contrast effects. In Experiment 2 ( N = 103), we manipulated transportation and counterarguing, but we could not identify an effect on participants’ self-ascribed level of conscientiousness. A mini meta-analysis across both experiments revealed significant positive overall associations between transportation and counterarguing on the one hand and story-consistent self-reported conscientiousness on the other hand.

Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome

2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Primary Tumour ◽  
The Other ◽  
Haematopoietic Stem Cell ◽  
Other Hand ◽  
Primary Reduction ◽  
The One ◽  
Acute Myeloid

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

Das Ende der Postdemokratie, den Pessimismus überwinden.

2017 ◽  
Vol 47 (188) ◽  
pp. 487-494
Author(s):  
Daniel Mullis
Keyword(s):  
Political Thought ◽  
Social Dynamics ◽  
Social Conditions ◽  
The Other ◽  
Economic Decline ◽  
Far Right ◽  
Windows Of Opportunity ◽  
Political Events ◽  
Political Struggles ◽  
The One

In recent years, political and social conditions have changed dramatically. Many analyses help to capture these dynamics. However, they produce political pessimism: on the one hand there is the image of regression and on the other, a direct link is made between socio-economic decline and the rise of the far-right. To counter these aspects, this article argues that current political events are to be understood less as ‘regression’ but rather as a moment of movement and the return of deep political struggles. Referring to Jacques Ranciere’s political thought, the current conditions can be captured as the ‘end of post-democracy’. This approach changes the perspective on current social dynamics in a productive way. It allows for an emphasis on movement and the recognition of the windows of opportunity for emancipatory struggles.

Tolerance is theoretical and practical principles

1996 ◽  
pp. 13-23
Author(s):  
Mykhailo Babiy
Keyword(s):  
Religious Diversity ◽  
The Other ◽  
Nodal Points ◽  
Characteristic Features ◽  
The One ◽  
Ukrainian Society

Political ideological pluralism, religious diversity are characteristic features of modern Ukrainian society. On the one hand, multiculturalism, socio-political, religious differentiation of the latter appear as important characteristics of its democracy, as a practical expression of freedom, on the other - as a factor that led to the deconsocialization of society, gave rise to "nodal points" of tension, confrontational processes, in particular, in political and religious spheres.

The Salvage of Ideas: Schumpeter and the Core Problems Still Confronting Economics

2003 ◽  
pp. 15-26
Author(s):  
P. Wynarczyk
Keyword(s):  
The Other ◽  
The Core ◽  
Other Hand ◽  
The One

Two aspects of Schumpeter' legacy are analyzed in the article. On the one hand, he can be viewed as the custodian of the neoclassical harvest supplementing to its stock of inherited knowledge. On the other hand, the innovative character of his works is emphasized that allows to consider him a proponent of hetherodoxy. It is stressed that Schumpeter's revolutionary challenge can lead to radical changes in modern economics.

Hidden “holes” in the capital of banks and the supply of credit to the real sector of economy

2018 ◽  
pp. 49-68 ◽  
Author(s):  
M. E. Mamonov
Keyword(s):  
Credit Risk ◽  
The Other ◽  
Real Sector ◽  
Capital Management ◽  
Loan Loss ◽  
Short Term ◽  
The Real ◽  
Ex Post ◽  
The One

Our analysis documents that the existence of hidden “holes” in the capital of not yet failed banks - while creating intertemporal pressure on the actual level of capital - leads to changing of maturity of loans supplied rather than to contracting of their volume. Long-term loans decrease, whereas short-term loans rise - and, what is most remarkably, by approximately the same amounts. Standardly, the higher the maturity of loans the higher the credit risk and, thus, the more loan loss reserves (LLP) banks are forced to create, increasing the pressure on capital. Banks that already hide “holes” in the capital, but have not yet faced with license withdrawal, must possess strong incentives to shorten the maturity of supplied loans. On the one hand, it raises the turnovers of LLP and facilitates the flexibility of capital management; on the other hand, it allows increasing the speed of shifting of attracted deposits to loans to related parties in domestic or foreign jurisdictions. This enlarges the potential size of ex post revealed “hole” in the capital and, therefore, allows us to assume that not every loan might be viewed as a good for the economy: excessive short-term and insufficient long-term loans can produce the source for future losses.

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