6 THE EVOLUTIONARY ROLE OF TERROIR

2021 ◽  
pp. 69-79
Keyword(s):  
Evolutionary Role

Evolutionary role of the community pharmacist A review

2017 ◽  
Vol 4 (4) ◽  
pp. 136-139
Author(s):  
Firdous Fatima ◽  
◽  
Bushra Ali Sherazi
Keyword(s):  
Community Pharmacist ◽  
Evolutionary Role

What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells

Physiology ◽  
2021 ◽  
Vol 36 (5) ◽  
pp. 292-306
Author(s):  
Heather A. Drummond
Keyword(s):  
Transient Receptor Potential ◽  
Molecular Model ◽  
Receptor Potential ◽  
Transient Receptor Potential Channels ◽  
Potential Channels ◽  
Transient Receptor ◽  
Paradigm Shifting ◽  
G Protein Coupled ◽  
Evolutionary Role

Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled receptors or integrins as transducers. Degenerin channels may also mediate the response. This review addresses the 1) evolutionary role of these molecules in mechanosensing, 2) limitations to identifying mechanosensitive molecules, and 3) paradigm shifting molecular model for a VSMC mechanosensor.

scholarly journals Evolution of molecular determinants for SUMO-activating enzyme subcellular localization in plants

2020 ◽  
Author(s):  
Abraham Más ◽  
Laura Castaño-Miquel ◽  
Lorenzo Carretero-Paulet ◽  
Núria Colomé ◽  
Francesc Canals ◽  
...  
Keyword(s):  
Nuclear Localization ◽  
Regulatory Mechanism ◽  
Large Subunit ◽  
Post Translational Modification ◽  
Nuclear Localization Signals ◽  
Sumo Conjugation ◽  
Phylogenetic Studies ◽  
Molecular Determinants ◽  
Evolutionary Role

AbstractPost-translational modification by Small Ubiquitin-related Modifier (SUMO) is an essential regulatory mechanism in eukaryotes. In the cell, SUMO conjugates are highly enriched in the nucleus and, consistently, SUMOylation machinery components are mainly nuclear. Nonetheless, cytosolic SUMO targets also exist and the mechanisms that facilitate SUMO conjugation in the cytosol are unknown. Here, we show that the nuclear localization of the Arabidopsis SUMO activating enzyme large subunit SAE2 is dependent on two nuclear localization signals, the canonical NLS1 and the non-canonical NLS2 identified and validated here. NLS2 is proteolytic processed from SAE2 during seed development, facilitating SAE2 enrichment in the cytosol. Results obtained using transgenic plants expressing different SAE2 proteoforms suggest that SAE2 cytosolic enrichment could constitute a rapid signal for growth arrest. Phylogenetic studies indicated that the Arabidopsis NLS1-NLS2 structural organization is conserved only in seed plants, providing a potential evolutionary role of cytosolic SUMOylation in seed appearance.

The Evolutionary Role of Higher Education in Sustainable Development: Pandemic 2020–2021

2021 ◽  
Vol 2 (60) ◽  
Author(s):  
Gulbakhyt Dinzhanova ◽  
Massimo Bianchi
Keyword(s):  
Higher Education ◽  
Sustainable Development ◽  
Human Capital ◽  
Economic Development ◽  
Human Capital Development ◽  
Current State ◽  
Relational Mechanism ◽  
Capital Development ◽  
Evolutionary Role

This article investigates the role of higher education in the economic development of the country. The research aims to investigate the theoretical and methodological basis of the role of higher education and human capital in economic growth, evaluate the current state of higher education within pandemic COVID-19, and develop scientifically and applied recommendations to strengthen capacity and improve the competitiveness of human capital in the developing countries. An analysis of the existing researches and debates is made. We defined the state of higher education in Kazakhstan and considered the changes in education within the context of COVID-19. We made multiple correlations and regression analysis based on the education coverage index and GDP(mln KZT), where defined the moderate correlation between two variables. Statistical data is studied in a period from 2000 to 2019. This paper contributes to the literature by fulfilling a theory of human capital development in the knowledge economy, revealing the relational mechanism between higher education, sustainable development, and the economic boundary of this relationship. It also contributes to the further understanding of the role of higher education in economic development. This study result implies to strengthen capacity and improve the competitiveness of human capital, draft human capital development policy. Keywords: SDG; COVID-19, human capital, higher education

The value of philosophical analysis of history for ecological education

2021 ◽  
pp. 37-41
Author(s):  
N.V. Popkova ◽  
Keyword(s):  
Historical Analysis ◽  
Ecological Crisis ◽  
Negative Consequences ◽  
New Concepts ◽  
Historical Processes ◽  
Man And Nature ◽  
The Relationship ◽  
Evolutionary Role ◽  
Comprehensive Study

Discussed is the need for a historical analysis of the relationship between man and nature for the formation of the theoretical basis of environmental education is considered. It is shown that a holistic picture of the historical interaction between mankind and the Earth’s biosphere is necessary for understanding modern global processes: the disclosure of the causes of the ecological crisis will help to create programs for the greening of human activity. Traditional historical approaches developed by the philosophy of history are not suitable for solving this problem, since they do not take into account the natural limitations of technological progress and the evolutionary role of humanity in the biosphere. The article discusses new concepts proposed for a comprehensive study of historical processes and the biosphere transformations caused by them. It is concluded that the level of their development does not yet allow using them for educational purposes. Nevertheless, the analysis of the consequences of technical development made with their help in the context of historical reality makes it possible to reflect the trend of technologization of man and nature. The main regularities of the relationship between mankind and the biosphere can be distinguished on the basis of the ratio of biological and technological factors, on which the life of people depended in different eras. Understanding the nature of the modern ecological crisis is necessary for the development of scientifically grounded programs to neutralize the negative consequences of the formation and expansion of technical reality.

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