scholarly journals Increased Hypermethylation of Glutathione S-Transferase P1, DNA-Binding Protein Inhibitor, Death Associated Protein Kinase and Paired Box Protein-5 Genes in Triple-Negative Breast Cancer Saudi Females

2015 ◽  
Vol 16 (2) ◽  
pp. 541-549 ◽  
Author(s):  
Mohamed M. Hafez ◽  
Othman A. Al-Shabanah ◽  
Salim S. Al-Rejaie ◽  
Naif O. Al-Harbi ◽  
Zeinab K. Hassan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Dna Binding ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Protein Inhibitor ◽  
Glutathione S Transferase ◽  
Death Associated Protein Kinase

scholarly journals The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion

Oncogene ◽  
2021 ◽  
Author(s):  
Qiuping Xu ◽  
Jingwei Zhang ◽  
Brian A. Telfer ◽  
Hao Zhang ◽  
Nisha Ali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Tumor Growth ◽  
Focal Adhesion ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Metastatic Breast ◽  
Adhesion Protein ◽  
Focal Adhesion Protein

AbstractThere is overwhelming clinical evidence that the extracellular-regulated protein kinase 5 (ERK5) is significantly dysregulated in human breast cancer. However, there is no definite understanding of the requirement of ERK5 in tumor growth and metastasis due to very limited characterization of the pathway in disease models. In this study, we report that a high level of ERK5 is a predictive marker of metastatic breast cancer. Mechanistically, our in vitro data revealed that ERK5 was critical for maintaining the invasive capability of triple-negative breast cancer (TNBC) cells through focal adhesion protein kinase (FAK) activation. Specifically, we found that phosphorylation of FAK at Tyr397 was controlled by a kinase-independent function of ERK5. Accordingly, silencing ERK5 in mammary tumor grafts impaired FAK phosphorylation at Tyr397 and suppressed TNBC cell metastasis to the lung without preventing tumor growth. Collectively, these results establish a functional relationship between ERK5 and FAK signaling in promoting malignancy. Thus, targeting the oncogenic ERK5-FAK axis represents a promising therapeutic strategy for breast cancer exhibiting aggressive clinical behavior.

scholarly journals c-erbB-2 promoter-specific DNA-binding protein isolated from human breast cancer tissues displays mitogenic activity.

1994 ◽  
Vol 269 (16) ◽  
pp. 12285-12289
Author(s):  
F.H. Sarkar ◽  
M.R. Smith ◽  
T. Hoover ◽  
G. Princler ◽  
J.D. Crissman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Binding ◽  
Human Breast Cancer ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Mitogenic Activity ◽  
Human Breast ◽  
Cancer Tissues

scholarly journals Damaged DNA Binding Protein 2 Plays a Role in Breast Cancer Cell Growth

PLoS ONE ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. e2002 ◽  
Author(s):  
Zilal Kattan ◽  
Sophie Marchal ◽  
Emilie Brunner ◽  
Carole Ramacci ◽  
Agnès Leroux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Dna Binding ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Damaged Dna

scholarly journals MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis

2014 ◽  
Vol 35 (10) ◽  
pp. 2254-2263 ◽  
Author(s):  
Brock Humphries ◽  
Zhishan Wang ◽  
Aaron L. Oom ◽  
Theresa Fisher ◽  
Dongfeng Tan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Triple Negative Breast Cancer ◽  
Cancer Metastasis ◽  
Triple Negative ◽  
Breast Cancer Metastasis ◽  
Protein Kinase Cα

Abstract 3271: The RNA binding protein HuR controls angiogenesis in triple negative breast cancer

2010 ◽  
Author(s):  
Ulus Atasoy ◽  
Matthew Gubin ◽  
Bob Calaluce ◽  
Wade Davis ◽  
Joseph Magee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

Regulation of meiosis: From DNA binding protein to protein kinase

BioEssays ◽  
1989 ◽  
Vol 11 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Maureen McLeod
Keyword(s):  
Protein Kinase ◽  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein
Sign in / Sign up

Export Citation Format

Share Document