Control of Dissolution Rate of Sodium-Alginate/Polyacrylamide Hydrogel for Selectively Dissolvable Water-Blocking Device

Polymer Korea ◽  
2021 ◽  
Vol 45 (6) ◽  
pp. 841-848
Author(s):  
Gwang-Mook Choi ◽  
Jin-Ju Choi ◽  
Woo-Cheol Kim ◽  
Hwanmin Hwang ◽  
Myungwoong Kim ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Sodium Alginate ◽  
Polyacrylamide Hydrogel ◽  
Water Blocking ◽  
Blocking Device

Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs

2016 ◽  
Vol 137 ◽  
pp. 350-359 ◽  
Author(s):  
Paola Aline Amarante Borba ◽  
Marihá Pinotti ◽  
Carlos Eduardo Maduro de Campos ◽  
Bianca Ramos Pezzini ◽  
Hellen Karine Stulzer
Keyword(s):  
Dissolution Rate ◽  
Sodium Alginate ◽  
Solid Dispersion ◽  
Water Solubility

scholarly journals Control of Drug Dissolution Rate from Film Dosage Forms Containing Valsartan

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Yoshifumi Murata ◽  
Kyoko Kofuji ◽  
Chieko Maida
Keyword(s):  
Dissolution Rate ◽  
Sodium Alginate ◽  
Antihypertensive Drug ◽  
Alginic Acid ◽  
Dosage Forms ◽  
The Other ◽  
Drug Dissolution ◽  
Dissolution Medium ◽  
Casting Method ◽  
Initial Dissolution Rate

Film dosage forms (FDs) containing valsartan (VST), a popular antihypertensive drug, were prepared using a casting method with sodium alginate and other polysaccharides as the film base. Drug dissolution profiles of the FDs were investigated in limited medium. The FDs were 170–200 μm thick and were easy to handle. All FDs immediately swelled and disintegrated in the medium. About 23% of the VST incorporated into the FD prepared with 1.5% sodium alginate dissolved at 5 min. The initial dissolution rate of VST increased upon the addition of chitosan to the film base; this effect was not observed in the case of chitin. On the other hand, the rate apparently decreased upon modification with alginic acid. In addition, the solubility of VST in the dissolution medium was changed by the addition of chitosan or alginic acid. FDs prepared with polysaccharides are useful for simplifying the administration of drugs to patients, and the drug dissolution rate from FDs can be controlled by modification.

Facile synthesis of self-healing and layered sodium alginate/polyacrylamide hydrogel promoted by dynamic hydrogen bond

2021 ◽  
Vol 256 ◽  
pp. 117580
Author(s):  
Dingwei Zhao ◽  
Mi Feng ◽  
Ling Zhang ◽  
Bin He ◽  
Xinyan Chen ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Sodium Alginate ◽  
Self Healing ◽  
Polyacrylamide Hydrogel ◽  
Facile Synthesis

Effects of nanocellulose on sodium alginate/polyacrylamide hydrogel: Mechanical properties and adsorption-desorption capacities

2019 ◽  
Vol 206 ◽  
pp. 289-301 ◽  
Author(s):  
Yiying Yue ◽  
Xianhui Wang ◽  
Jingquan Han ◽  
Lei Yu ◽  
Jianqiang Chen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Sodium Alginate ◽  
Polyacrylamide Hydrogel ◽  
Adsorption Desorption

Sodium alginate assisted construction of ZnSnO 3 microspheres enhanced HCHO sensing performance under UV illumination at room temperature

2019 ◽  
Vol 14 (14) ◽  
pp. 1381-1384
Author(s):  
Jie Chen ◽  
Zhihua Ying ◽  
Peng Zheng ◽  
Rongfa Gao ◽  
Jinbang Mei
Keyword(s):  
Sodium Alginate ◽  
Room Temperature ◽  
Uv Illumination ◽  
Sensing Performance

Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique

2016 ◽  
Vol 2 (2) ◽  
pp. 91-95
Author(s):  
Neelima Rani T ◽  
Pavani A ◽  
Sobhita Rani P ◽  
Srilakshmi N
Keyword(s):  
Dissolution Rate ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Onset Of Action ◽  
Kneading Method ◽  
Wetting Property ◽  
Poorly Soluble ◽  
Dispersion Technique ◽  
Low Solubility

This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

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