Assessment of risk of depression and diabetes among overweight and obese subjects with unsuccessful efforts to reduce body weight: Observation from clinical trial participants of weight loss intervention

Background. In clinical practice, there is the diffuse conviction that obese subjects with metabolic syndrome may be more difficult to treat. Objectives and Methods. The aim of the present study was that to investigate the effectiveness of a 3-week in-hospital body weight reduction program (BWRP) in a large population of obese subjects with and without metabolic syndrome (n = 1922; 222 men and 1700 women, age range 18–83 yr). Outcomes such as body mass index (BMI), total (TOT) and HDL cholesterol, systolic and diastolic blood pressures (SBP and DBP, respectively), coronary heart disease (CHD) score, fatigue severity score (FSS), and stair climbing test (SCT) time were evaluated before and after the intervention (Δ). A sex-, BMI-, and age-related stratification of the obese population with or without metabolic syndrome was applied. Results. When compared to obese subjects without metabolic syndrome, at the basal conditions, obese subjects had a poorer cardiometabolic profile, as demonstrated by higher triglycerides, TOT-cholesterol, DBP, SBP, and CHD score, and a more compromised muscle performance (evaluated by SCT), associated with more perception of fatigue (measured by FSS). Nevertheless, obese subjects with metabolic syndrome obtained more benefits from BWRP than those without metabolic syndrome for some outcomes (i.e., ΔTOT-cholesterol, ΔSBP, and ΔCHD score). Despite these differences, the BWRP-induced weight loss was similar between the two groups (i.e., ΔBMI) as well as the gain of muscle performance (i.e., ΔSCT) and the reduction of fatigue (i.e., ΔFSS). Interestingly, the potentially deleterious fall in HDL-cholesterol levels after BWRP was less evident in obese subjects with metabolic syndrome than those without metabolic syndrome. When pooling all data, the ΔCHD score was associated with age, sex, and metabolic syndrome. The remaining outcomes, such as ΔBMI, ΔFSS, and ΔSCT time, were associated with sex and age but not with metabolic syndrome. Finally, ΔBMI was positively correlated with ΔCHD score, ΔFSS, and ΔSCT time in both obese subjects without metabolic syndrome and obese subjects with metabolic syndrome. Conclusions. When comparing obese subjects undergoing a BWRP, metabolic syndrome is not a negative predictive factor affecting the effectiveness of this intervention in terms of weight loss, muscle performance, and psychological well-being.

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An open study of the effectiveness of a multi-component weight-loss intervention for adults with intellectual disabilities and obesity

British Journal Of Nutrition ◽

10.1017/s0007114510005362 ◽

2011 ◽

Vol 105 (10) ◽

pp. 1553-1562 ◽

Cited By ~ 50

Author(s):

Craig A. Melville ◽

Susan Boyle ◽

Susan Miller ◽

Susan Macmillan ◽

Victoria Penpraze ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Waist Circumference ◽

Intellectual Disabilities ◽

Sedentary Behaviour ◽

Energy Deficit ◽

Controlled Study ◽

Weight Loss Intervention ◽

Before And After ◽

Adults With Intellectual Disabilities

Adults with intellectual disabilities experience high rates of obesity. Despite this higher risk, there is little evidence on the effectiveness of weight-loss interventions for adults with intellectual disabilities and obesity. The present study examined the effectiveness of the TAKE 5 multi-component weight-loss intervention. Adults with obesity were invited using specialist intellectual disability services to participate in the study. Obesity was defined as a BMI of 30 kg/m2 or greater. TAKE 5 included a daily energy-deficit diet of 2510 kJ (600 kcal), achieved via a personalised dietary prescription. Participants' body weight, BMI, waist circumference and levels of physical activity and sedentary behaviour were measured before and after the intervention. A total of fifty-four individuals consented to participate, of which forty-seven (87 %) completed the intervention in the study period. There was a significant decrease in body weight (mean difference − 4·47 (95 % CI − 5·91, − 3·03) kg; P < 0·0001), BMI ( − 1·82 (95 % CI − 2·36, − 1·29) kg/m2; P < 0·0001), waist circumference ( − 6·29 (95 % CI − 7·85, − 4·73) cm; P < 0·0001) and daily sedentary behaviour of participants ( − 41·40 (95 % CI − 62·45, − 20·35) min; P = 0·00 034). Of the participants who completed the intervention, seventeen (36·2 %) lost 5 % or more of their initial body weight. Findings from the study suggest that TAKE 5 is an effective weight-loss intervention for adults with intellectual disabilities and obesity. The effectiveness of TAKE 5 should be examined further in a controlled study.

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Effects of green tea on weight maintenance after body-weight loss

British Journal Of Nutrition ◽

10.1079/bjn20041061 ◽

2004 ◽

Vol 91 (3) ◽

pp. 431-437 ◽

Cited By ~ 144

Author(s):

Eva M. R. Kovacs ◽

Manuela P. G. M. Lejeune ◽

Ilse Nijs ◽

Margriet S. Westerterp-Plantenga

Keyword(s):

Weight Loss ◽

Body Weight ◽

Green Tea ◽

Weight Regain ◽

Weight Maintenance ◽

Epigallocatechin Gallate ◽

Body Weight Loss ◽

Caffeine Consumption ◽

Very Low Energy Diet ◽

Obese Subjects

The present study was conducted to investigate whether green tea may improve weight maintenance by preventing or limiting weight regain after weight loss of 5 to 10% in overweight and moderately obese subjects. The study had a randomised, parallel, placebo-controlled design. A total of 104 overweight and moderately obese male and female subjects (age 18–60 years; BMI 25–35kg/m2) participated. The study consisted of a very-low-energy diet intervention (VLED; 2·1MJ/d) of 4 weeks followed by a weight-maintenance period of 13 weeks in which the subjects received green tea or placebo. The green tea contained caffeine (104mg/d) and catechins (573mg/d, of which 323mg was epigallocatechin gallate). Subjects lost 6·4 (sd 1·9) kg or 7·5 (sd 2·2) % of their original body weight during the VLED (P<0·001). Body-weight regain was not significantly different between the green tea and the placebo group (30·5 (sd 61·8) % and 19·7 (sd 56·9)%, respectively). In the green tea treatment, habitual high caffeine consumption was associated with a higher weight regain compared with habitual low caffeine consumption (39 (sd 17) and 16 (sd 11)%, respectively; P<0·05). We conclude that weight maintenance after 7·5% body-weight loss was not affected by green tea treatment and that habitual caffeine consumption affected weight maintenance in the green tea treatment.

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Does a single dose of a homoeopathic ultramolecular dilution of Thyroidinum 30CH affect the decrease of body weight of fasting patients after stagnation of weight loss? A randomised placebo-controlled double-blind GCP-conforming clinical trial

Focus on Alternative and Complementary Therapies ◽

10.1111/j.2042-7166.2001.tb02834.x ◽

2010 ◽

Vol 6 (1) ◽

pp. 91-91 ◽

Cited By ~ 1

Author(s):

J M Schmidt ◽

B Ostermayr

Keyword(s):

Clinical Trial ◽

Weight Loss ◽

Body Weight ◽

Single Dose ◽

Double Blind

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Relationship between sympathetic reactivity and body weight loss in morbidly obese subjects

International Journal of Obesity ◽

10.1038/sj.ijo.0802620 ◽

2004 ◽

Vol 28 (7) ◽

pp. 906-911 ◽

Cited By ~ 14

Author(s):

E Bobbioni-Harsch ◽

O Bongard ◽

F Habicht ◽

D Weimer ◽

H Bounameaux ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Body Weight Loss ◽

Morbidly Obese ◽

Obese Subjects

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Weight Loss Prior to Pregnancy and Early Gestational Glycemia: Prepare, a Randomized Clinical Trial

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab547 ◽

2021 ◽

Author(s):

Erin S Leblanc ◽

Ning X Smith ◽

Kimberly K Vesco ◽

Teresa A Hillier ◽

Victor J Stevens

Keyword(s):

Clinical Trial ◽

Weight Loss ◽

Gestational Diabetes ◽

Usual Care ◽

Randomized Clinical Trial ◽

Early Pregnancy ◽

Diabetes Diagnosis ◽

Weight Loss Intervention ◽

Positive Effects ◽

Pregnancy Weight

Abstract Purpose To determine whether pre-pregnancy weight loss improved the early metabolic environment as measured by early gestational diabetes diagnosis. Methods This was a secondary analysis of a pragmatic randomized clinical trial conducted between May 2015 and October 2019 in an integrated health system that encouraged first trimester gestational diabetes screening for high-risk women, including those with obesity. Women aged 18-40 years with BMI ≥27 kg/m 2 who were planning pregnancy were randomized to a behavioral weight loss intervention or usual care. Clinical care decisions and data collection were blind to condition assignment. We compared rates of diagnosis with gestational diabetes in early pregnancy between the groups using logistic regression. Results Of 326 participants, 168 (89 in the intervention and 79 in usual care) had singleton pregnancies during the study period. At baseline, mean age was 31.3±3.5 years and BMI was 34.8±5.8kg/m 2. Fifty-nine (66%) intervention participants and 57 (72%) usual care participants underwent early screening. Among those, intervention participants were 73% less likely to be diagnosed with gestational diabetes than usual care participants (aOR 0.27 [95%; 0.09, 0.80]). There was no difference in diagnosis of gestational diabetes in later pregnancy (aOR 1.08 [0.41, 2.81]). Main Conclusions Participation in a pre-pregnancy weight loss intervention led to lower rates of gestational diabetes diagnosis in early pregnancy. This suggests positive effects of pre-pregnancy weight loss on the early metabolic environment, a critical factor in offspring metabolic risk.

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Hypocaloric diet with lower meal frequency did not affect weight loss, body composition and insulin responsiveness, but improved lipid profile: a randomized clinical trial

Food & Function ◽

10.1039/d1fo00484k ◽

2021 ◽

Author(s):

Érika Duarte Grangeiro ◽

Mariana Silva Trigueiro ◽

Leysimar de Oliveira Siais ◽

Hilana Moreira Paiva ◽

Mauro Sola-Penna ◽

...

Keyword(s):

Clinical Trial ◽

Weight Loss ◽

Body Composition ◽

Body Weight ◽

Lipid Profile ◽

Randomized Clinical Trial ◽

Body Weight Loss ◽

Hypocaloric Diet ◽

Meal Frequency ◽

Insulin Responsiveness

Dietary approaches are essential to control obesity, but the effectiveness of changes in meal frequency (MF) as a strategy for body weight loss or maintenance remain unclear.

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