CORONARY HEART DISEASE: ANGINA PECTORIS, ACUTE CORONARY INSUFFICIENCY AND CORONARY OCCLUSION

1944 ◽  
Vol 20 (4) ◽  
pp. 661 ◽  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Angina Pectoris ◽  
Coronary Occlusion ◽  
Coronary Insufficiency ◽  
Acute Coronary Insufficiency

scholarly journals Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham Heart Study

2013 ◽  
Vol 74 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Ida K Haugen ◽  
Vasan S Ramachandran ◽  
Devyani Misra ◽  
Tuhina Neogi ◽  
Jingbo Niu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lower Limb ◽  
Framingham Heart Study ◽  
Cardiovascular Events ◽  
Physical Inactivity ◽  
Hand Osteoarthritis ◽  
Coronary Insufficiency ◽  
Heart Study ◽  
Increased Risk

ObjectivesTo study whether hand osteoarthritis (OA) is associated with increased mortality and cardiovascular events in a large community based cohort (Framingham Heart Study) in which OA, mortality and cardiovascular events have been carefully assessed.MethodsWe examined whether symptomatic (≥1 joint(s) with radiographic OA and pain in the same joint) and radiographic hand OA (≥1 joint(s) with radiographic OA without pain) were associated with mortality and incident cardiovascular events (coronary heart disease, congestive heart failure and/or atherothrombotic brain infarction) using Cox proportional hazards models. In the adjusted models, we included possible confounding factors from baseline (eg, metabolic factors, medication use, smoking/alcohol). We also adjusted for the number of painful joints in the lower limb and physical inactivity.ResultsWe evaluated 1348 participants (53.8% women) with mean (SD) age of 62.2 (8.2) years, of whom 540 (40.1%) and 186 (13.8%) had radiographic and symptomatic hand OA, respectively. There was no association between hand OA and mortality. Although there was no significant relation to incident cardiovascular events overall or a relation of radiographic hand OA with events, we found a significant association between symptomatic hand OA and incident coronary heart disease (myocardial infarction/coronary insufficiency syndrome) (HR 2.26, 95% CI 1.22 to 4.18). The association remained after additional adjustment for pain in the lower limb or physical inactivity.ConclusionsSymptomatic hand OA, but not radiographic hand OA, was associated with an increased risk of coronary heart disease events. The results suggest an effect of pain, which may be a possible marker of inflammation.

The condition of the production of cytokines, soluble co-stimulatory molecules, intracellular signaling pathways and nitric oxide in patients with coronary heart disease on the background of low-intensity microwave therapy

2016 ◽  
Vol 10 (1) ◽  
pp. 0-0 ◽  
Author(s):  
Аржников ◽  
V. Arzhnikov ◽  
Логаткина ◽  
A. Logatkina ◽  
Бондарь ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Angina Pectoris ◽  
Microwave Radiation ◽  
Interstitial Fluid ◽  
Radiation Frequency ◽  
Coronary Syndrome ◽  
Low Intensity ◽  
Caspase 1

The concentration of cytokines of the family IL-10 (IL-10, IL-22, IL-24), interferon-gamma, soluble forms of co-stimulatory molecules CD28, CD80, CD152, as well as NO was investigated in patients with coronary heart disease in interstitial fluid. In addition, the level of caspase-1, inducible and endothelial forms of NO synthasis (eNOS, iNOS), protein kinase AKT1 and AMPK and the total antioxidant activity from the cell culture supernantat were evaluatedin the agranulocytic patients. In the current study (in vitro) the impact on production of these mediators of low-intensity microwave radiation frequency of 1000 MHz, generated by an apparatus of low-intensity physiotherapy "Aquaton" was evaluated. Material of this study was whole venous blood of patients with angina pectoris and acute coronary syndrome. The analysis of the results revealed a reduced level of NO, IL-24, as well as increased production of IL-10, IL-22 and the concentration of soluble forms of CD28, CD80, CD152 in patients with coronary artery disease in the interstitial fluid in comparison with practically healthy persons. At a single irradiation of cell cultures whole blood by low-intensity microwave radiation frequency of 1000 MHz in patients with angina pectoris and acute coronary syndrome there were an increasing of NO production by 20,6 and 25,5‰, IL-24 by 18,6 and 33,6‰, and a reduction in intracellular caspase-1 by 32,5 and 25,8‰, as well as increasing of the levels of IL-10 by 3,5 and 3,1‰, IL-22 by 28,7 and 26,5‰ and reduction of the levels of CD28 by 3,6 and 3,9‰, CD80 6,8 and 5,7‰, CD152 by 9,4 and 11,3‰, respectively. In addition, in terms of irradiation there is an increase in interstitial fluid levels of antioxidants by 37,1 and 49,2‰.

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