scholarly journals Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham Heart Study

2013 ◽  
Vol 74 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Ida K Haugen ◽  
Vasan S Ramachandran ◽  
Devyani Misra ◽  
Tuhina Neogi ◽  
Jingbo Niu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lower Limb ◽  
Framingham Heart Study ◽  
Cardiovascular Events ◽  
Physical Inactivity ◽  
Hand Osteoarthritis ◽  
Coronary Insufficiency ◽  
Heart Study ◽  
Increased Risk

ObjectivesTo study whether hand osteoarthritis (OA) is associated with increased mortality and cardiovascular events in a large community based cohort (Framingham Heart Study) in which OA, mortality and cardiovascular events have been carefully assessed.MethodsWe examined whether symptomatic (≥1 joint(s) with radiographic OA and pain in the same joint) and radiographic hand OA (≥1 joint(s) with radiographic OA without pain) were associated with mortality and incident cardiovascular events (coronary heart disease, congestive heart failure and/or atherothrombotic brain infarction) using Cox proportional hazards models. In the adjusted models, we included possible confounding factors from baseline (eg, metabolic factors, medication use, smoking/alcohol). We also adjusted for the number of painful joints in the lower limb and physical inactivity.ResultsWe evaluated 1348 participants (53.8% women) with mean (SD) age of 62.2 (8.2) years, of whom 540 (40.1%) and 186 (13.8%) had radiographic and symptomatic hand OA, respectively. There was no association between hand OA and mortality. Although there was no significant relation to incident cardiovascular events overall or a relation of radiographic hand OA with events, we found a significant association between symptomatic hand OA and incident coronary heart disease (myocardial infarction/coronary insufficiency syndrome) (HR 2.26, 95% CI 1.22 to 4.18). The association remained after additional adjustment for pain in the lower limb or physical inactivity.ConclusionsSymptomatic hand OA, but not radiographic hand OA, was associated with an increased risk of coronary heart disease events. The results suggest an effect of pain, which may be a possible marker of inflammation.

Abstract 17237: Physical Inactivity, Mortality and Incident Coronary Heart Disease in Blacks: The Jackson Heart Study

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Daisuke Kamimura ◽  
Loretta Cain ◽  
Donald T Clark ◽  
Cameron S Guild ◽  
Paul D Loprinzi ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sex Education ◽  
Physical Inactivity ◽  
Jackson Heart Study ◽  
Incident Coronary Heart Disease ◽  
Heart Study ◽  
Increased Risk ◽  
Significant Difference ◽  
Overall Mortality

Introduction: Despite reductions in overall mortality in recent decades, blacks continue to have higher death rates compared to whites. According to a recent CDC report, blacks were more likely to have a higher prevalence of unhealthy behaviors such as physical inactivity/sedentariness compared to whites. We assessed the associations between physical activity (PA) and incident coronary heart disease (CHD) and overall mortality in blacks in the Jackson Heart Study (JHS). Methods: Among the 5306 participants enrolled in JHS at baseline (2000-2004), we examined overall mortality through 2016, and among 3507 participants without prevalent CHD at baseline, clinically adjudicated incident CHD events (CHD hospitalizations and fatal myocardial infarction). Based on participant responses and the American Heart Association’s Life’s Simple 7 metrics, participants were classified as having poor (0 minutes/week), intermediate (&rt;0 and <75 minutes/week) or ideal (<=150 minutes/week) PA based on number of minutes of moderate of vigorous PA per week. Cox proportional hazard ratios (HR) were used to assess the relationships between PA categories and incident CHD and overall mortality. Results: Through 2016, there were 992 deaths (18.7% mortality rate) with higher rates in men (21.5%) compared with women (17.1%, p<0.0001). After adjustment for age, sex, education, systolic blood pressure, hypertension medications, diabetes, cholesterol, alcohol use and current smoking at baseline, poor PA was associated with increased mortality (HR 1.53, 95% CI 1.18, 1.98) compared to those with ideal PA. However, there was no significant difference in incident CHD events between those with ideal and poor PA (HR 1.05, 95% CI 0.66, 1.67). Compared with ideal PA, there was no significant difference in mortality in those with intermediate PA (HR 1.23, 95% CI 0.93, 1.62). Conclusions: In a large community-based cohort of blacks, lower PA was associated with higher overall mortality but was not associated with increased risk of incident CHD events.

scholarly journals Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190549 ◽  
Author(s):  
Meeshanthini V. Dogan ◽  
Isabella M. Grumbach ◽  
Jacob J. Michaelson ◽  
Robert A. Philibert
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Framingham Heart Study ◽  
Heart Study

scholarly journals The Relationship Between Vegetarian Diet and The Risk of Coronary Heart Disease

2020 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
A. Andrianto ◽  
R. I. Gunadi
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Framingham Heart Study ◽  
Developed Countries ◽  
Vegetarian Diet ◽  
P Value ◽  
Spearman Correlation ◽  
Chd Risk ◽  
Heart Study ◽  
The Relationship

Background. Coronary heart disease (CHD) is a major cause of death in developed countries whereas most cases can be prevented by addressing behavioral risk factors, such as unhealthy diet. Vegetarian dietary patterns reduce CHD risk and mortality by 40%. The Framingham Heart Study on Hard CHD calculates a 10-year risk assessment with six predictors, two of which are lipid profile types. Aims. To discover the relationship between vegetarian diet and the risk of coronary heart disease, we did a cross-sectional analytical observation in North Jakarta using 30 healthy vegetarians and 30 healthy non-vegetarians aged of 20-34 years in 2010. Framingham Heart Study on Hard CHD 10-year risk assessments were done on both groups. Methods. Results were compared and analyzed using Mann-Whitney U and Spearman correlation tests. Results. Mann-Whitney U test showed significant differences on total cholesterol and total FHS risk points (p-value 0.000; pvalue 0.000). Spearman correlation analysis on total risk points confirms a moderate negative degree for vegetarian diet and CHD risk (r = -0.525, p-value 0.000). In conclusion, there is a significant relationship between vegetarian diet and a reduced risk of coronary heart disease in 20-34 years of age.

scholarly journals Levels and Change in Galectin‐3 and Association With Cardiovascular Events: The ARIC Study

2020 ◽  
Vol 9 (13) ◽  
Author(s):  
David Aguilar ◽  
Caroline Sun ◽  
Ron C. Hoogeveen ◽  
Vijay Nambi ◽  
Elizabeth Selvin ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Cardiovascular Events ◽  
Total Mortality ◽  
Cox Proportional Hazards ◽  
Prognostic Information ◽  
Incident Coronary Heart Disease ◽  
Increased Risk ◽  
Galectin 3

Background Circulating galectin‐3 levels provide prognostic information in patients with established heart failure (HF), but the associations between galectin‐3 levels and other incident cardiovascular events in asymptomatic individuals at midlife and when remeasured ≈15 years later are largely uncharacterized. Methods and Results Using multivariable Cox proportional hazards models, we identified associations between plasma galectin‐3 levels (hazard ratio [HR] per 1 SD increase in natural log galectin‐3) and incident coronary heart disease, ischemic stroke, HF hospitalization, and total mortality in ARIC (Atherosclerosis Risk in Communities) participants free of cardiovascular disease at ARIC visit 4 (1996–1998; n=9247) and at ARIC visit 5 (2011–2013; n=4829). Higher galectin‐3 level at visit 4 (median age 62) was independently associated with incident coronary heart disease (adjusted HR, 1.30; 95% CI, 1.06–1.60), ischemic stroke (HR, 1.42; 95% CI, 1.01–2.00), HF (HR, 1.44; 95% CI, 1.17–1.76), and mortality (HR, 1.56; 95% CI, 1.35–1.80). At visit 5 (median age, 74), higher galectin‐3 level was associated with incident HF (HR, 1.93; 95% CI, 1.15–3.24) and total mortality (HR, 1.70; 95% CI, 1.15–2.52), but not coronary heart disease or stoke. Individuals with the greatest increase in galectin‐3 levels from visit 4 to visit 5 were also at increased risk of incident HF and total mortality. Conclusions In a large, biracial community‐based cohort, galectin‐3 measured at midlife and older age was associated with increased risk of cardiovascular events. An increase in galectin‐3 levels over this period was also associated with increased risk.

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