scholarly journals Author response: Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

2018 ◽  
Author(s):  
Chang-Hui Tsao ◽  
Chien-Chun Chen ◽  
Chen-Han Lin ◽  
Hao-Yu Yang ◽  
Suewei Lin
Keyword(s):  
Author Response ◽  
Mushroom Bodies ◽  
Seeking Behavior ◽  
Food Seeking

scholarly journals Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Chang-Hui Tsao ◽  
Chien-Chun Chen ◽  
Chen-Han Lin ◽  
Hao-Yu Yang ◽  
Suewei Lin
Keyword(s):  
Dopaminergic Neurons ◽  
Mushroom Body ◽  
Energy State ◽  
Fruit Fly ◽  
Mushroom Bodies ◽  
Kenyon Cells ◽  
Control Food ◽  
Seeking Behavior ◽  
Output Neurons ◽  
Food Seeking

The fruit fly can evaluate its energy state and decide whether to pursue food-related cues. Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to control food-seeking behavior. We have discovered five pathways in the MB essential for hungry flies to locate and approach food. Blocking the MB-intrinsic Kenyon cells (KCs) and the MB output neurons (MBONs) in these pathways impairs food-seeking behavior. Starvation bi-directionally modulates MBON responses to a food odor, suggesting that hunger and satiety controls occur at the KC-to-MBON synapses. These controls are mediated by six types of dopaminergic neurons (DANs). By manipulating these DANs, we could inhibit food-seeking behavior in hungry flies or promote food seeking in fed flies. Finally, we show that the DANs potentially receive multiple inputs of hunger and satiety signals. This work demonstrates an information-rich central circuit in the fly brain that controls hunger-driven food-seeking behavior.

scholarly journals The sigma-1 receptor as key common factor in cocaine and food-seeking behaviors

2019 ◽  
Vol 63 (4) ◽  
pp. R81-R92 ◽  
Author(s):  
David Aguinaga ◽  
Mireia Casanovas ◽  
Rafael Rivas-Santisteban ◽  
Irene Reyes-Resina ◽  
Gemma Navarro ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Drugs Of Abuse ◽  
Common Factor ◽  
G Protein Coupled Receptors ◽  
Sigma 1 Receptor ◽  
New Findings ◽  
Sigma 1 ◽  
Seeking Behavior ◽  
Food Seeking ◽  
G Protein Coupled

Addiction and eating disorders involve brain reward circuits. Binge eating predisposes to addictive behavior, while the cessation of exposure to drugs of abuse leads to reward activities, including intake of tasty foods. Cocaine use is associated with a decrease in food intake, with reversal after drug use is discontinued. Exciting new findings show that receptors for the ‘hunger’ hormone, ghrelin, directly interact with the sigma-1 receptor (σ1R), which is a target of cocaine. σ1Rs are key players in regulating dopaminergic neurotransmission and ghrelin-mediated actions. This review focuses on the σ1 receptor as a general neuroendocrine regulator by directly interacting with neuronal G-protein-coupled receptors. This review also covers the early mechanisms by which cocaine binding to σ1 blocks the food-seeking behavior triggered by ghrelin. Those findings appear as fundamental to understand common mechanisms in drug addiction and eating disorders.

Cannabinoid Cb1 Receptor Antagonists/Inverse Agonists and Food-Seeking Behavior

2011 ◽  
pp. 441-456
Author(s):  
John D. Salamone ◽  
Kelly Sink ◽  
Kristen N. Segovia ◽  
Patrick A. Randall ◽  
Peter J. McLaughlin ◽  
...  
Keyword(s):  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Receptor Antagonists ◽  
Inverse Agonists ◽  
Seeking Behavior ◽  
Food Seeking ◽  
Cb1 Receptor Antagonists

Changes in activity rates in the cherry shrimp Neocaridina davidi Bouvier, 1904 (Decapoda: Caridea: Atyidae) in response to concentrations of neuropeptides and glucose

2019 ◽  
Vol 39 (6) ◽  
pp. 689-694
Author(s):  
Joseph S Stout ◽  
Carla L Granda ◽  
Molly L Mancuso
Keyword(s):  
Food Pellet ◽  
Inhibitory Effect ◽  
Dopaminergic Drugs ◽  
Behavioral Studies ◽  
Seeking Behavior ◽  
Food Seeking ◽  
And Behavior ◽  
Rats And Mice ◽  
Reduced Activity ◽  
Over Time

Abstract Although behavioral studies of whole animals are usually undertaken on rats and mice, studies in crustaceans offer an alternative group that provides new evolutionary insights into the relationship between physiology and behavior. In the cherry shrimp Neocaridina davidi (Bouvier, 1904), food-seeking movement increases in response to glutamate (MSG), decreases when exposed to dopamine, and increases when exposed to glucose. Activity of shrimp individuals was observed in 4l tanks over twenty minutes after individuals were exposed to treatments applied directly into the water. Glutamate-stimulated seeking behavior was statistically similar to seeking behavior after exposure to food pellet filtrate. Glucose also stimulated seeking behavior, but with a reduction over time, whereas MSG-stimulated seeking behavior increased over time. Insulin reduced activity but showed no effect when paired with glucose, whereas dopamine increased activity when paired with glucose. This was contrary to the reduced activity observed when dopamine was paired with MSG. The decrease in activity after exposure to dopamine also contrasts with vertebrate (rat) models where dopaminergic drugs such as caffeine and cocaine are stimulants. The stimulatory effect of dopamine paired with glucose was unexpected given its inhibitory effect on its own or when paired with MSG. This crustacean-based model aims to give new insights regarding the role of inhibitory and stimulatory neurotransmitters on the behavior of whole crustacean individuals. These mechanisms show different results than predicted by vertebrate models, implying either differences in underlying physiology, problems with the vertebrate models, or both.

Cocaine-but not food-seeking behavior is reinstated by stress after extinction

1997 ◽  
Vol 132 (3) ◽  
pp. 289-295 ◽  
Author(s):  
S. H. Ahmed ◽  
George F. Koob
Keyword(s):  
Seeking Behavior ◽  
Food Seeking

scholarly journals Effect of intrahippocampal administration of anti-melanin-concentrating hormone on spatial food-seeking behavior in rats

Peptides ◽  
2016 ◽  
Vol 76 ◽  
pp. 130-138 ◽  
Author(s):  
Luciane Valéria Sita ◽  
Giovanne Baroni Diniz ◽  
Newton Sabino Canteras ◽  
Gilberto Fernando Xavier ◽  
Jackson Cioni Bittencourt
Keyword(s):  
Seeking Behavior ◽  
Melanin Concentrating Hormone ◽  
Food Seeking
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