scholarly journals An 18-hole round of golf acutely elevates serum interleukin-6 and brain-derived neurotrophic factor concentration - a pilot study

2022 ◽  
Vol 11 (1) ◽  
pp. 1-7
Author(s):  
Yoshinori Yasuoka ◽  
Takeshi Nakamura ◽  
Yasunori Umemoto ◽  
Tokio Kinoshita ◽  
Sven P. Hoekstra ◽  
...  
Keyword(s):  
Pilot Study ◽  
Interleukin 6 ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Concentration

Relationships between serum brain-derived neurotrophic factor concentration and parameters for health scores in community-dwelling older adults

2017 ◽  
Vol 18 (3) ◽  
pp. 456-461 ◽  
Author(s):  
Mitsugu Hachisu ◽  
Masahiro Hashizume ◽  
Hisashi Kawai ◽  
Hirohiko Hirano ◽  
Motonaga Kojima ◽  
...  
Keyword(s):  
Older Adults ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Community Dwelling ◽  
Community Dwelling Older Adults ◽  
Factor Concentration

Decreased serum brain-derived neurotrophic factor concentration in young nonobese subjects with low insulin sensitivity

2011 ◽  
Vol 44 (10-11) ◽  
pp. 817-820 ◽  
Author(s):  
Monika Karczewska-Kupczewska ◽  
Marek Strączkowski ◽  
Agnieszka Adamska ◽  
Agnieszka Nikołajuk ◽  
Elżbieta Otziomek ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Concentration

scholarly journals Systemic brain derived neurotrophic factor but not intestinal barrier integrity is associated with cognitive decline and incident Alzheimer’s disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0240342
Author(s):  
Robin M. Voigt ◽  
Shohreh Raeisi ◽  
Jingyun Yang ◽  
Sue Leurgans ◽  
Christopher B. Forsyth ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Pilot Study ◽  
Neurotrophic Factor ◽  
Intestinal Barrier ◽  
Brain Derived Neurotrophic Factor ◽  
Barrier Dysfunction ◽  
Barrier Integrity ◽  
Risk Of Death ◽  
Intestinal Barrier Integrity ◽  
Global Cognition

The inflammatory hypothesis posits that sustained neuroinflammation is sufficient to induce neurodegeneration and the development of Alzheimer’s disease (AD) and Alzheimer’s dementia. One potential source of inflammation is the intestine which harbors pro-inflammatory microorganisms capable of promoting neuroinflammation. Systemic inflammation is robustly associated with neuroinflammation as well as low levels of brain derived neurotrophic factor (BDNF) in the systemic circulation and brain. Thus, in this pilot study, we tested the hypothesis that intestinal barrier dysfunction precedes risk of death, incident AD dementia and MCI, cognitive impairment and neuropathology. Serum BDNF was associated with changes in global cognition, working memory, and perceptual speed but not risk of death, incident AD dementia, incident MCI, or neuropathology. Neither of the markers of intestinal barrier integrity examined, including lipopolysaccharide binding protein (LBP) nor intestinal fatty acid binding protein (IFABP), were associated with risk of death, incident AD dementia, incident mild cognitive impairment (MCI), change in cognition (global or domains), or neuropathology. Taken together, the data in this pilot study suggest that intestinal barrier dysfunction does not precede diagnosis of AD or MCI, changes in cognition, or brain pathology. However, since MCI and AD are related to global cognition, the findings with BDNF and the contiguous cognitive measures suggest low power with the trichotomous cognitive status measures. Future studies with larger sample sizes are necessary to further investigate the results from this pilot study.

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