Unicentric Castleman Disease With Systemic Symptoms: A Rare Case From Family Practice

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

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A Rare Case of HHV-8 Associated Hemophagocytic Lymphohistiocytosis in a Stable HIV Patient

Case Reports in Infectious Diseases ◽

10.1155/2019/3297463 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3

Author(s):

Nonso Osakwe ◽

Diane Johnson ◽

Natalie Klein ◽

Dalia Abdel Azim

Keyword(s):

Hemophagocytic Lymphohistiocytosis ◽

Rare Case ◽

Viral Infections ◽

Rare Condition ◽

Lymph Node Biopsy ◽

Castleman Disease ◽

Human Herpes Virus 8 ◽

Case Presentation ◽

Multicentric Castleman Disease ◽

History Of

Background. Hemophagocytic lymphohistiocytosis (HLH) is a rare condition associated with viral infections including HIV. Cases have been reported mainly in advanced HIV/AIDS. This is a rare case that reports HLH associated with human herpes virus-8 (HHV-8) associated multicentric Castleman disease in a stable HIV patient. Case Presentation. A 70-year-old Asian male patient with history of stable HIV on medications with CD 4 cell count above 200 presented with cough and fever and was initially treated for pneumonia as an outpatient. Persisting symptoms prompted presentation to the hospital. The patient was found to have anemia which persisted despite repeated transfusion of packed red cells. A bone marrow biopsy to investigate anemia revealed hemophagocytosis. A CT scan revealed multiple enlarged lymph nodes and hepatosplenomegaly. An excisional lymph node biopsy revealed HHV-8 associated multicentric Castleman disease. The patient deteriorated despite initiation of treatment. Conclusion. HLH can occur at any stage of HIV, rapid diagnosis to identify possible underlying reactive infectious etiology and prompt initiation of treatment is crucial to survival.

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Chronic Myelomonocytic Leukemia following Multicentric Castleman Disease

Case Reports in Hematology ◽

10.1155/2018/5895903 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4

Author(s):

Feng Li ◽

Xiaomei Zhang ◽

Yanting Guo ◽

Yuandong Zhu ◽

Yicun Wu ◽

...

Keyword(s):

Lymphoproliferative Disorder ◽

Pluripotent Stem Cell ◽

Underlying Mechanism ◽

Castleman Disease ◽

Chronic Myelomonocytic Leukemia ◽

Cell Precursor ◽

Multicentric Castleman Disease ◽

Night Sweats ◽

Systemic Symptoms ◽

Myelomonocytic Leukemia

Multicentric Castleman disease (MCD) is a rare nonmalignant lymphoproliferative disorder presenting systemic symptoms such as fever, night sweats, fatigue, anemia, effusions, and multifocal lymphadenopathy. The etiology of MCD has not been clarified to date. The coexistence of MCD with chronic myelomonocytic leukemia (CMML) has been rarely reported. Although the pathogenesis remains unclear, this association probably reflects an incidental and fortuitous finding rather than the alteration of a common pluripotent stem cell precursor. Herein, we report on one case of MCD coexisting with CMML and elucidate the underlying mechanism of pathology in some aspects.

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A Rare Case of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) Syndrome with Cholecystitis in a Patient on Levetiracetam

Cureus ◽

10.7759/cureus.4245 ◽

2019 ◽

Author(s):

Tushi Singh ◽

Masooma Niazi ◽

Kishore Karri ◽

Donald Rudikoff ◽

Efrain Gonzalez

Keyword(s):

Drug Reaction ◽

Rare Case ◽

Systemic Symptoms

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A Rare Case of Localized Argyria on the Face

Case Reports in Dermatology ◽

10.1159/000494610 ◽

2019 ◽

Vol 11 (1) ◽

pp. 23-27 ◽

Cited By ~ 2

Author(s):

Verena Isak ◽

Tobias Beerli ◽

Antonio Cozzio ◽

Lukas Flatz

Keyword(s):

Topical Application ◽

Rare Case ◽

Sunlight Exposure ◽

Silver Sulfadiazine ◽

Topical Agent ◽

The Face ◽

Systemic Symptoms ◽

Treatment Of Wounds

Due to its antibacterial actions, silver sulfadiazine is widely used as a topical agent in the treatment of wounds, including burns. Widespread or prolonged topical application of silver sulfadiazine dressings can lead to argyria including systemic symptoms due to the resorption of silver. Here, we report a patient experiencing localized argyria due to sunlight exposure after topical use of silver sulfadiazine cream on his face.

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A Rare Case of Bilateral Orbital Castleman Disease

Orbit ◽

10.3109/01676830.2014.904381 ◽

2014 ◽

Vol 33 (4) ◽

pp. 314-317

Author(s):

Bipasha Mukherjee ◽

Mohammad Shahid Alam ◽

S. Krishnakumar

Keyword(s):

Rare Case ◽

Castleman Disease

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Reactivation of Old Scars in an Elderly Man Revealing Löfgren's Syndrome

Case Reports in Rheumatology ◽

10.1155/2013/736143 ◽

2013 ◽

Vol 2013 ◽

pp. 1-3

Author(s):

Vishnu Vardhan Reddy Munagala ◽

Vaishali Tomar ◽

Amita Aggarwal

Keyword(s):

Rare Case ◽

Erythema Nodosum ◽

Febrile Illness ◽

High Resolution Computed Tomography ◽

Short Course ◽

Oral Steroids ◽

Hilar Adenopathy ◽

Löfgren’S Syndrome ◽

Systemic Symptoms ◽

Noncaseating Granulomas

Here, we report the case of a 55-year-old man with reactivation of old cutaneous scars associated with a febrile illness, episcleritis, polyarthralgias, erythema nodosum and hilar adenopathy. High-resolution computed tomography (HRCT) revealed right paratracheal, bilateral hilar, and subcarinal lymphadenopathy without any nodular densities in both lung fields. A scar biopsy revealed multiple noncaseating granulomas and confirmed the diagnosis of sarcoidosis. A short course of oral steroids led to regression of systemic symptoms, and the scars returned to baseline size. This patient represented a rare case of simultaneous Löfgren’s syndrome and scar sarcoidosis.

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Drug Reaction with Eosinophilia and Systemic Symptoms: DRESS following Initiation of Oxcarbazepine with Elevated Human Herpesvirus-6 Titer

Case Reports in Dermatological Medicine ◽

10.1155/2014/853281 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Seth L. Cornell ◽

Daniel DiBlasi ◽

Navin S. Arora

Keyword(s):

Drug Reaction ◽

Rare Case ◽

Human Herpesvirus ◽

Complete Recovery ◽

Human Herpesvirus 6 ◽

Delayed Onset ◽

Aggressive Management ◽

Herpesvirus 6 ◽

Systemic Symptoms ◽

Severe Cutaneous Reaction

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal severe cutaneous reaction, which has a delayed onset after the initiation of an inciting medication. After recognition and withdrawal of the causative agent, along with aggressive management, a majority of patients will have complete recovery over several months. We present a rare case of DRESS secondary to oxcarbazepine with an elevated human herpesvirus-6 titer.

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A rare case of retroperitoneal castleman disease

Indian Journal of Pathology and Oncology ◽

10.18231/j.ijpo.2019.096 ◽

2019 ◽

Vol 6 (3) ◽

pp. 500-502

Author(s):

Nithin Diwagar ◽

Sri Devi M ◽

Padma Priya ◽

Rashmi R

Keyword(s):

Rare Case ◽

Castleman Disease

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DAPSONE INDUCED DRESS: A CASE REPORT

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i5.17554 ◽

2017 ◽

Vol 10 (5) ◽

pp. 4 ◽

Cited By ~ 2

Author(s):

Balaji Ommurugan ◽

Amita Priya ◽

Manu Matthew George ◽

Meena Kuamri Kamalkishore ◽

Mohan Babu Vittalrao Amberkar

Keyword(s):

Rare Case ◽

Liver Toxicity ◽

Tertiary Care Hospital ◽

Drug Effect ◽

Tertiary Care ◽

Organ Damage ◽

Multiple Organ ◽

Care Hospital ◽

First Line ◽

Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms. is a very dangerous adverse drug effect causing rashes, eosinophilia, and multiple organ damage. Many drugs are implicated in causing DRESS with most common ones being antimicrobials and antiepileptics. Dapsone used in the treatment of Hansen’s disease as a first-line agent is known for causing many side effects ranging from nausea, vomiting, insomnia, anaphylaxis, hypersensitivity reactions, rashes, muscle weakness, abdominal pain, and so on. Hence, we report a rare case of dapsone-induced DRESS in a tertiary care hospital in South India.Keywords: Dapsone, Adverse effect, Liver toxicity, Rashes, Eosinophilia.

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