Determining the Anti-Inflammatory and Anti-Microbial Activity of Chalcone from Dalbergia sissoo Roxb. Leaves

2021 ◽  
pp. 147-154
Author(s):  
Padma C. Behera ◽  
S. M. Verma ◽  
Posa Mahesh Kumar ◽  
Nalin B. Das ◽  
Pravat M. Mishra ◽  
...  
2017 ◽  
Vol 176 (6) ◽  
pp. 32-37
Author(s):  
B. S. Sukovatykh ◽  
V. A. Zhukovskiy ◽  
Yu. Yu. Blinkov ◽  
A. I. Itinson ◽  
E. A. Elenskaya ◽  
...  

OBJECTIVE. The study substantiated the possibility of application of sodium hypochlorite for treatment of infected pancreatonecrosis. MATERIAL AND METHODS. The experimental study was conducted on 288 rats. Clinical research was carried out on 94 patients who were divided into two statistically homogenous groups. «Levomecol» ointment was used in the first group for sanation of omental bursae (lesser sac). The immobilized form of sodium hypochlorite was applied for the second group. RESULTS. Anti-inflammatory activity of immobilized form of sodium hypochlorite exceeded this activity in case of «Levomecol» application in 1,2-1,4 times. Anti-microbial activity was higher in 1,6-1,8 times at different terms of treatment of experimental animals. The proposed method of treatment of infected pancreatonecrosis allowed doctors to decrease the number of postoperative complications in patients on 11,2 % and lethality - on 9,2 %. CONCLUSIONS. It was stated that the application of immobilized forms of sodium hypochlorite for sanation of the omental bursae was pathogenically justified and efficient.


2012 ◽  
Vol 22 (3) ◽  
pp. 1450-1455 ◽  
Author(s):  
Rajesh H. Tale ◽  
Atish H. Rodge ◽  
Girish D. Hatnapure ◽  
Ashish P. Keche ◽  
Kalpana M. Patil ◽  
...  

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
S Seifert ◽  
B Kopeinig ◽  
R Bauer ◽  
A Pahl ◽  
J Haunschild

Fitoterapia ◽  
2001 ◽  
Vol 72 (2) ◽  
pp. 131-139 ◽  
Author(s):  
S.W Hajare ◽  
S Chandra ◽  
J Sharma ◽  
S.K Tandan ◽  
J Lal ◽  
...  

2021 ◽  
Vol 19 (4) ◽  
pp. 533-542
Author(s):  
Yeon-Je Cho ◽  
Yun-Hee Choi ◽  
Byung-Loc Kim ◽  
Min-Hee Han ◽  
Hak-Sung Lee ◽  
...  

Purpose: This study was conducted to select the optimal mixing ratio (OMR) of extracts including Dendropanax, sea salt, and others from Jeollanam-do and to develop functional cosmetics that can help alleviate hair loss symptoms.Methods: Our research team determined the OMR through cytotoxicity and cell proliferation tests, and confirmed the anti-inflammatory and anti-microbial effects of the final selected OMR.Results: The cytotoxicity was low when the OMR was 0.1:1:5:1, but cell proliferation was high, and anti-inflammatory activity effectively inhibited the expression of IL–6 and iNOS. The anti-microbial activity also had an effect on Pseudomonas aeruginosa and Staphylococcus aureus.Conclusion: This study selected OMR (1:0.1:5:1) to develop functional cosmetics that can help alleviate hair loss symptoms. The final selection of OMR confirmed low cytotoxicity, high cell proliferation, inhibition of expression of IL–6 and iNOS, and anti-microbial activity. Therefore, it is expected to serve as a functional cosmetic that can help alleviate hair loss symptoms in the future.


Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1945
Author(s):  
Magdalena Paczkowska-Walendowska ◽  
Anna Gościniak ◽  
Daria Szymanowska ◽  
Dominik Szwajgier ◽  
Ewa Baranowska-Wójcik ◽  
...  

Blackberry fruits are recognized as functional foods while blackberry leaves are outside this classification and they also contain active compounds with health-promoting potential. Therefore, the aim of this study was the phytochemical analysis of blackberry leaves of varieties (Chester, Loch Ness, Loch Tay and Ruczaj) and screening of their biological activity (antioxidant potential, possibility of inhibition of enzymes, anti-inflammatory and microbial activity). The following compounds from selected groups: phenolic acids (caffeic acid, ellagic acid, gallic acid, syringic acid), flavonols (quercetin, kaempferol) and their glycosides (rutin, isoquercetin, hyperoside) and flavon-3-ols (catechin, epicatechin) were chromatographically determined in the aqueous and hydroalcoholic leaves extracts. All tested blackberry leaves extracts showed antioxidant effects, but the highest compounds content (TPC = 101.31 mg GAE/g) and antioxidant activity (e.g., DPPH IC50 = 57.37 μg/mL; ABTS IC50 = 24.83 μg/mL; CUPRAC IC50 = 62.73 μg/mL; FRAP IC50 = 39.99 μg/mL for hydroalcoholic extracts) was indicated for the Loch Tay variety. Blackberry leaf extracts’ anti-inflammatory effect was also exceptionally high for the Loch Tay variety (IC50 = 129.30 μg/mL), while leaves extracts of the Loch Ness variety showed a significant potential for microbial activity against Lactobacillus spp. and Candida spp. Summarizing, the best multidirectional pro-health effect was noted for leaves extracts of Loch Tay variety.


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