Gut Microbiota Profile - Autism Spectrum Disorder Relationship: Relative Lower Microbiota Diversity and Imbalance in Probiotics

2021 ◽  
pp. 99-105
Author(s):  
Holy Rabetafika ◽  
Hary Razafindralambo
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Microbiota Diversity

scholarly journals Gene variations in autism spectrum disorder are associated with alteration of gut microbiota, metabolites and cytokines

Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1-16
Author(s):  
Zhi Liu ◽  
Xuhua Mao ◽  
Zhou Dan ◽  
Yang Pei ◽  
Rui Xu ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Gut Bacteria Shared by Children and Their Mothers Associate with Developmental Level and Social Deficits in Autism Spectrum Disorder

mSphere ◽  
2020 ◽  
Vol 5 (6) ◽  
Author(s):  
Yu Chen ◽  
Hui Fang ◽  
Chunyan Li ◽  
Guojun Wu ◽  
Ting Xu ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Gut Bacteria ◽  
Spectrum Disorder ◽  
Developmental Level ◽  
Social Deficits ◽  
Microbial Structure

Gut microbiota may contribute to the pathogenesis and development of autism spectrum disorder. The maternal gut microbiota influences offspring gut microbial structure and composition.

Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder

Gut ◽  
2021 ◽  
pp. gutjnl-2020-324015
Author(s):  
Yating Wan ◽  
Tao Zuo ◽  
Zhilu Xu ◽  
Fen Zhang ◽  
Hui Zhan ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Chinese Children ◽  
Chronological Age ◽  
Microbiome Composition ◽  
Children With Asd ◽  
Faecal Microbiome

ObjectiveThe gut microbiota has been suggested to play a role in autism spectrum disorder (ASD). We postulate that children with ASD harbour an altered developmental profile of the gut microbiota distinct from that of typically developing (TD) children. Here, we aimed to characterise compositional and functional alterations in gut microbiome in association with age in children with ASD and to identify novel faecal bacterial markers for predicting ASD.DesignWe performed deep metagenomic sequencing in faecal samples of 146 Chinese children (72 ASD and 74 TD children). We compared gut microbial composition and functions between children with ASD and TD children. Candidate bacteria markers were identified and validated by metagenomic analysis. Gut microbiota development in relation to chronological age was assessed using random forest model.ResultsASD and chronological age had the most significant and largest impacts on children’s faecal microbiome while diet showed no correlation. Children with ASD had significant alterations in faecal microbiome composition compared with TD children characterised by increased bacterial richness (p=0.021) and altered microbiome composition (p<0.05). Five bacterial species were identified to distinguish gut microbes in ASD and TD children, with areas under the receiver operating curve (AUC) of 82.6% and 76.2% in the discovery cohort and validation cohort, respectively. Multiple neurotransmitter biosynthesis related pathways in the gut microbiome were depleted in children with ASD compared with TD children (p<0.05). Developing dynamics of growth-associated gut bacteria (age-discriminatory species) seen in TD children were lost in children with ASD across the early-life age spectrum.ConclusionsGut microbiome in Chinese children with ASD was altered in composition, ecological network and functionality compared with TD children. We identified novel bacterial markers for prediction of ASD and demonstrated persistent underdevelopment of the gut microbiota in children with ASD which lagged behind their respective age-matched peers.

scholarly journals Sa1925 – Alteration in Gut Microbiota is Associated with Dysregulation of Metabolism of Autism Spectrum Disorder in China

2019 ◽  
Vol 156 (6) ◽  
pp. S-455-S-456
Author(s):  
Zhou Dan ◽  
Xuhua Mao ◽  
Qisha Liu ◽  
Xingyin Liu
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder

The link between autism spectrum disorder and gut microbiota: A scoping review

Autism ◽  
2020 ◽  
Vol 24 (6) ◽  
pp. 1328-1344 ◽  
Author(s):  
Amanda Nitschke ◽  
Raywat Deonandan ◽  
Anne TM Konkle
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Scoping Review ◽  
Bacterial Species ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Exclusion Criteria ◽  
The Past ◽  
Gastrointestinal Distress ◽  
Special Diets

Gut dysfunction and microbial dysbiosis comorbidities are of particular interest in recent autism research, as gastrointestinal distress is present in up to 90% of autism spectrum disorder cases and therefore may play a key role in the pathogenesis of this disorder. This scoping review aims to integrate the results of studies conducted in the past 6 years examining the association between gut microbiota and autism spectrum disorder, specifically with regard to the characterization of autism spectrum disorder microbiota and potential therapeutic interventions. Studies related to the gastrointestinal microbiome of subjects with autism spectrum disorder were identified through PubMed, SCOPUS, PsycInfo, and Google Scholar databases. Studies were screened and selected based on defined inclusion and exclusion criteria; 19 studies were included. Research continues to report differences between microbiota of individuals with autism spectrum disorder and controls; however, the types and abundances of bacteria present remain inconsistent. Promising treatment interventions for autism spectrum disorder, including special diets, dietary supplementation, and of particular interest, microbiota transfer therapy, are also being explored. Research regarding the link between gut microbiota and autism spectrum disorder renders exciting results; however, it is still in its infancy of investigation. Rigorous methodologies are required to support and strengthen the reliability of existing results, and to further our understanding of the pathogenesis of autism spectrum disorder. Lay abstract Gastrointestinal distress and gut microbial imbalances are commonly found in children with autism spectrum disorder, and therefore may play a key role in the development of the disorder. This scoping review aimed to examine the extent, range and nature of research conducted in the past 6 years that focused on furthering our understanding of autism spectrum disorder and its association with gut microbiota. A literature review was performed with predetermined key words. Studies were screened and selected based on defined inclusion and exclusion criteria. A total of 19 studies were included for final analysis. While there are continuous reports of differences in gut microbiota between autism spectrum disorder and neurotypical individuals, knowledge about the consistency in the presence and abundance of bacterial species, as well as metabolites, remains deficient. Treatments such as special diets, vitamin, prebiotic, probiotic, and microbiota transfer therapy show promising therapeutic potential, yet are in their infancy of investigation. Overall, further research with rigorous methodologies is required to support and strengthen the reliability of existing findings. Future research should aim to increase sample sizes, eliminate biases, and subgroup autism spectrum disorder groups to help accommodate for inter-individual variation. As increasing evidence of a unique autism spectrum disorder microbiome and metabolome is acquired, autism spectrum disorder-specific biomarkers can be identified. These biomarkers have great implications in terms of elucidating the molecular mechanisms of autism spectrum disorder, preventing the onset of autism spectrum disorder, and improving treatments for individuals with autism spectrum disorder.

scholarly journals Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lorena Coretti ◽  
Claudia Cristiano ◽  
Ermanno Florio ◽  
Giovanni Scala ◽  
Adriano Lama ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Microbiota Composition ◽  
Btbr Mouse ◽  
Gut Microbiota Composition

Disturbance of trace element and gut microbiota profiles as indicators of autism spectrum disorder: A pilot study of Chinese children

2019 ◽  
Vol 171 ◽  
pp. 501-509 ◽  
Author(s):  
Qixiao Zhai ◽  
Shi Cen ◽  
Jinchi Jiang ◽  
Jianxin Zhao ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Pilot Study ◽  
Gut Microbiota ◽  
Trace Element ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Chinese Children
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