scholarly journals Development of a Lymphoid Variant of Acute Leukemia after Five-fold Treatments of Ovulation Induction

2019 ◽  
pp. 1-6
Author(s):  
L. A. Ivanova ◽  
I. V. Korol ◽  
U. S. Kovalenko ◽  
E. A. Kokova ◽  
A. V. Mezinova ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Bone Marrow ◽  
Acute Respiratory Distress Syndrome ◽  
Acute Leukemia ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Distress Syndrome ◽  
Epigastric Pain ◽  
Ovarian Hyperstimulation ◽  
Stimulation Of

Ovarian hyperstimulation syndrome is a complication of IVF procedure. Describes the case of a 31-year-old patient with body mass index 22 kg/m 2. After 5 IVF procedures with the previous stimulation of ovulation she complaints of weakness, dyspnea, pain in the chest, unproductive cough, epigastric pain, fever, pain in the hip and spine, ascites, hydropericardium, hydrothorax, acute respiratory distress syndrome reveal themselves. "Ovarian hyperstimulation syndrome" was made.  The treatment with glucocorticosteroids improved the condition of the patient. After a bone marrow puncture the diagnosis "lymphoid variant of acute leukemia" was confirmed.

scholarly journals Prevention of Ovarian Hyperstimulation Syndrome: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Vinayak Smith ◽  
Tiki Osianlis ◽  
Beverley Vollenhoven
Keyword(s):  
Gnrh Agonist ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Best Practice ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Ovarian Hyperstimulation ◽  
Management Options ◽  
Broad Perspective ◽  
Single Method

The following review aims to examine the available evidence to guide best practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands, there is no single method to completely prevent OHSS. There seems to be a benefit, however, in categorizing women based on their risk of OHSS and individualizing treatments to curtail their chances of developing the syndrome. At present, both Anti-Müllerian Hormone and the antral follicle count seem to be promising in this regard. Both available and upcoming therapies are also reviewed to give a broad perspective to clinicians with regard to management options. At present, we recommend the use of a “step-up” regimen for ovulation induction, adjunct metformin utilization, utilizing a GnRH agonist as an ovulation trigger, and cabergoline usage. A summary of recommendations is also made available for ease of clinical application. In addition, areas for potential research are also identified where relevant.

scholarly journals A Mutation in the Follicle-Stimulating Hormone Receptor as a Cause of Familial Spontaneous Ovarian Hyperstimulation Syndrome

2004 ◽  
Vol 89 (4) ◽  
pp. 1255-1258 ◽  
Author(s):  
Lucia Montanelli ◽  
Anne Delbaere ◽  
Costantino Di Carlo ◽  
Carmine Nappi ◽  
Guillaume Smits ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Ovarian Hyperstimulation Syndrome ◽  
Follicle Stimulating Hormone ◽  
High Sensitivity ◽  
Ovarian Hyperstimulation ◽  
Satisfactory Explanation ◽  
Vitro Fertilization ◽  
Increased Sensitivity ◽  
Stimulation Of

Abstract Ovarian hyperstimulation syndrome (OHSS) occurs mainly after excessive stimulation of the ovaries by exogenous gonadotropins administrated in the context of in vitro fertilization procedures (iatrogenic OHSS). Recently, spontaneous and recurrent occurrence of the disease (spontaneous OHSS) was shown in two families to be caused by mutations affecting the follitropin receptor (FSHr). The two mutant FSHr (T449I, D567N) harbor aminoacid substitutions in the serpentine portion of the receptor and display abnormally high sensitivity to the pregnancy hormone hCG, thus providing a satisfactory explanation to the phenotype. In addition, mutant D567N showed also increased sensitivity to thyrotopin (TSH) and displayed increase in basal (ligand-independent) activity. In this report, we describe a new familial case of recurrent OHSS. The affected women were heterozygous for a different mutation involving codon 449, where an alanine was substituted for threonine. Similar to D567N, the T449A FSHr mutant shows an increase of its sensitivity to both hCG and TSH, together with an increase in basal activity. Together with the two previous studies, this report shows that inappropriate stimulation of the FSHr by hCG is a cause of spontaneous OHSS.

Ovarian hyperstimulation syndrome

2016 ◽  
Author(s):  
Stergios K. Doumouchtsis ◽  
S. Arulkumaran ◽  
Kamal Ojha
Keyword(s):  
Vascular Permeability ◽  
Peritoneal Cavity ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Ovarian Hyperstimulation

This chapter outlines ovarian hyperstimulation syndrome (OHSS), the most serious complication of ovulation induction. OHSS is characterized by massive cystic enlargement of the ovaries, an increase in vascular permeability, and a shift of fluid to the extravascular compartments (mainly the peritoneal cavity), with the formation of ascites. The management and prevention of OHSS is described in this chapter.

scholarly journals A Early Development of Severe Ovarian Hyperstimulation Syndrome following Ovulation Induction

JMS SKIMS ◽  
2011 ◽  
Vol 14 (1) ◽  
pp. 30-32
Author(s):  
Fayaz A Sofi ◽  
Wasim Ahmed ◽  
Ghulam Nabi Dhobi ◽  
Showkat Ali Mufti ◽  
Rafi Ahmed Jan ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Capillary Permeability ◽  
Ovarian Hyperstimulation ◽  
Fatal Complication ◽  
Vitro Fertilization ◽  
Severe Ovarian Hyperstimulation Syndrome

Ovarian Hyperstimulation is a rare but potentially fatal complication of ovarian stimulation during treatment of infertility. Worldwide the incidence of this syndrome is increasing due to liberal use of invitro fertilization for management of infertility. The syndrome is characterized by cystic ovarian enlargement and abnormal capillary permeability due to secretion of vasogenic substances by ovaries. The syndrome is classified into early and late variants with early variants usually mild to moderate in severity. We present a case of severe ovarian hyperstimulation syndrome (OHSS) developing early in a 25-year female while undergoing In-vitro fertilization (IVF). Six days after ovulation induction, the woman developed ascites, bilateral pleural effusion and acute renal failure with ultrasound abdomen revealing bilateral cystic enlargement of ovaries. JMS 2011;14(1):30-32

scholarly journals OVARIAN HYPERSTIMULATION SYNDROME;

2014 ◽  
Vol 21 (03) ◽  
pp. 580-582
Author(s):  
ASMA Batool ◽  
Saima Perveen ◽  
Mussarat Sultana
Keyword(s):  
Abdominal Pain ◽  
Ovulation Induction ◽  
Ovarian Hyperstimulation Syndrome ◽  
Ovarian Hyperstimulation ◽  
Rare Entity ◽  
Ovulatory Cycle ◽  
Successful Management ◽  
Multiple Gestations ◽  
Prompt Diagnosis ◽  
Ovarian Syndrome

It is known that most cases of Ovarian Hyperstimulation Syndrome (OHSS) areassociated with the therapies for ovulation induction. However, OHSS may rarely be associatedwith a spontaneous ovulatory cycle, usually in the case of multiple gestations, hypothyroidism orpolycystic ovarian syndrome. We report a case of moderate OHSS in spontaneously conceivedtwin pregnancy in a 24 years old woman. The clinical picture showed amenorrhea,nausea,vomiting, abdominal pain and moderate ascites. After examinations, imaging and laboratoryinvestigations, the diagnosis was established. The patient was managed expectantly with nocomplications. Although spontaneous ovarian hyperstimulation is a rare entity, it is important thatthe physician recognizes this condition. Prompt diagnosis and successful management is likelyto avoid serious complications, which may develop rapidly.

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