scholarly journals Development and Characterization of Liposome-Enriched Ketoprofen Liposomal Hydrogels

2019 ◽  
pp. 1-7
Author(s):  
Muhammad Wahab Amjad ◽  
Maria Abdul Ghafoor Raja
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Time Interval ◽  
Topical Drug Delivery ◽  
Sustained Drug Delivery ◽  
Dosing Frequency ◽  
Chloroform Methanol ◽  
Vitro Release

The purpose of this study was to develop liposome-enriched Ketoprofen liposomal hydrogels and carry out in vitro release profile experiment. The aim was to achieve sustained topical drug delivery for extended time interval from liposomal gels. Phosphatidylcholine, Cholesterol and Ketoprofen were dissolved in chloroform/methanol (2:1, v/v) mixture and subsequently transferred to a flask attached to rotavapor. The liposomes were assessed for particle size and percent drug entrapment. F-7 and F-8 batches were found to be optimized batches having optimum sizes, drug entrapment efficiencies and cumulative drug releases. F-8 batch was further evaluated for stability. The results show that the prepared liposomes of Ketoprofen might turn out to be potential candidates for effective and safe sustained drug delivery thereby resulting in the reduction of dosing frequency.

scholarly journals In vitro release of chlorhexidine from UV-cured PEGDA drug delivery scaffolds

2021 ◽  
Vol 7 (2) ◽  
pp. 519-522
Author(s):  
Natalia Rekowska ◽  
Alexander Riess ◽  
Robert Mau ◽  
Thomas Eickner ◽  
Hermann Seitz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Biological Properties ◽  
Promising Candidate ◽  
Glycol Diacrylate ◽  
Pentaerythritol Triacrylate ◽  
Poly Ethylene ◽  
Vitro Release

Abstract Drug delivery systems (DDS) are suitable for controlled local drug release in order to ensure safety and effectiveness of medical treatment. The choice and characterization of biomaterials that can be used as a DDS is a challenging step in the administration of drugs. Novel 3D printing photopolymerization-based techniques create the possibility for designing individual, patient-tailored DDS. Poly(ethylene glycol) diacrylate`s (PEGDA`s) chemical and biological properties make it a suitable photopolymerisable resin for the creation of DDS. This study describes the in vitro release of the antiseptic drug chlorhexidine (CHX) from UV-cured PEGDA and its copolymers (butanediol diacrylate, pentaerythritol triacrylate and pentaerythritol tetraacrylate) samples. A substantial decrease in CHX release with increasing concentration of the copolymers in comparison to pure PEGDA was obtained only for butanediol diacrylate. For pentaerythritol triacrylate and pentaerythritol tetraacrylate only a tendency of decreased CHX release with increasing concentration was detected. Therefore, release profiles of the low molecular drug CHX from PEGDA samples could be modified by the addition of copolymers with a different number of acrylate groups and PEGDA can be considered as a promising candidate for the preparation of novel DDS.

scholarly journals Synthesis and characterization of new macromolecule systems for colon-specific drug delivery

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
M. Galehassadi ◽  
M. Mahkam ◽  
F. Hosseinzadeh
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Network Polymers ◽  
Release Studies ◽  
Silyl Groups ◽  
Silyl Derivatives ◽  
Derivatives Of ◽  
Vitro Release

AbstractNetwork polymers containing silyl groups were synthesized. Silyl derivatives of 2-hydroxyethylmethacrylate (HEMA), and methacrylic acid (MAA) were copolymerized with 1,2-bis(vinylphenyl)ethane (BVPE) and divinylbenzene (DVB) as cross-linking agents by radical polymerization using α,α′-azobis (isobutyronitrile) (AIBN) as initiator to produce network polymers. Then mesalasine (MZ) were loaded to these network polymers, and amount of drug entrapped was determined. In vitro release studies showed that drug delivery property was modified and showed considerable difference in swelling at pH 1 and 7.4. Incorporation of silyl groups in new macromolecule system modified network polymers for drug delivery. Monomers and polymers were characterized by spectroscopic methods.

Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles

2002 ◽  
Vol 234 (1-2) ◽  
pp. 195-203 ◽  
Author(s):  
Hak Soo Choi ◽  
Sun-Ah Seo ◽  
Gilson Khang ◽  
John M. Rhee ◽  
Hai Bang Lee
Keyword(s):  
In Vitro Release ◽  
Plga Microspheres ◽  
Vitro Release ◽  
Release Profiles

Montmorillonite-Alginate Nanocomposites as a Drug Delivery System: Intercalation and In Vitro Release of Vitamin B1 and Vitamin B6

2009 ◽  
Vol 25 (2) ◽  
pp. 161-177 ◽  
Author(s):  
Bhavesh D. Kevadiya ◽  
Ghanshyam V. Joshi ◽  
Hasmukh A. Patel ◽  
Pravin G. Ingole ◽  
Haresh M. Mody ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Vitamin B6 ◽  
In Vitro Release ◽  
Vitamin B1 ◽  
Vitro Release

scholarly journals EFFECT OF NATURAL AND SYNTHETIC POLYMERS ON THE PROPERTIES OF CANDESARTAN CILEXETIL MATRIX TABLET PREPARED BY DRY GRANULATION

2016 ◽  
Vol 9 (9) ◽  
pp. 161
Author(s):  
Omar Saeb Salih ◽  
Roaa Abdalhameed Nief
Keyword(s):  
Drug Delivery ◽  
Candesartan Cilexetil ◽  
Oral Drug Delivery ◽  
In Vitro Release ◽  
Oral Drug ◽  
Matrix Tablet ◽  
Sustained Release Formulation ◽  
Weight Variation ◽  
Vitro Release

ABSTRACTObjective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,32 mg and 48 mg) respectively beside to the combination effect of polymers on the release of the drug from the tablet.Results: In vitro release showed that formula 13 had the faster release (100% after 4 h) which contained acacia (1:1) and the lowest sustain releasewas showed for F7 (73% after 8 h) which contained HPMC K100M (1:1). Formula 1 was an 89 % release after 8 h which contain eudragit RS100; F4was a 100 % release after 5 h which contain Na CMC, F10 was a 100% after 8 h which contain xanthan gum and F16 was a 100 % release after 5 hwhich contain tragacanth polymer. Formula 9 had a lower release than F7 and F8 respectively. Formula 7 can be used for sustain oral drug delivery ofcandesartan cilexetil while Formula 13 can be used in contrary as fast release tablets for faster response.Conclusion: Controlled drug delivery system is promising for less dosing and higher patient compliance.Keywords: Angiotensin II receptor antagonist, Hypertension, Matrix system, Control release.

Synthesis, characterization of dextran hydrogels and their in vitro release of gentamycin sulphate

2015 ◽  
Vol 13 (3) ◽  
pp. 0-0 ◽  
Author(s):  
Rui Guo ◽  
Peizhe Chen ◽  
Yunfei Mo ◽  
Yong Lan ◽  
Wei Xue ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Vitro Release
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