In vitro release of chlorhexidine from UV-cured PEGDA drug delivery scaffolds

Abstract Drug delivery systems (DDS) are suitable for controlled local drug release in order to ensure safety and effectiveness of medical treatment. The choice and characterization of biomaterials that can be used as a DDS is a challenging step in the administration of drugs. Novel 3D printing photopolymerization-based techniques create the possibility for designing individual, patient-tailored DDS. Poly(ethylene glycol) diacrylate`s (PEGDA`s) chemical and biological properties make it a suitable photopolymerisable resin for the creation of DDS. This study describes the in vitro release of the antiseptic drug chlorhexidine (CHX) from UV-cured PEGDA and its copolymers (butanediol diacrylate, pentaerythritol triacrylate and pentaerythritol tetraacrylate) samples. A substantial decrease in CHX release with increasing concentration of the copolymers in comparison to pure PEGDA was obtained only for butanediol diacrylate. For pentaerythritol triacrylate and pentaerythritol tetraacrylate only a tendency of decreased CHX release with increasing concentration was detected. Therefore, release profiles of the low molecular drug CHX from PEGDA samples could be modified by the addition of copolymers with a different number of acrylate groups and PEGDA can be considered as a promising candidate for the preparation of novel DDS.

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Synthesis, characterization of biodegradable dextran–allyl isocyanate–ethylamine/polyethylene glycol–diacrylate hydrogels and their in vitro release of albumin

Carbohydrate Polymers ◽

10.1016/j.carbpol.2006.01.015 ◽

2006 ◽

Vol 65 (3) ◽

pp. 273-287 ◽

Cited By ~ 41

Author(s):

Guoming Sun ◽

Chih-Chang Chu

Keyword(s):

Polyethylene Glycol ◽

In Vitro Release ◽

Polyethylene Glycol Diacrylate ◽

Glycol Diacrylate ◽

Vitro Release

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Combination of injectable ethinyl estradiol and drospirenone drug-delivery systems and characterization of their in vitro release

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2012.08.009 ◽

2012 ◽

Vol 47 (4) ◽

pp. 790-800 ◽

Cited By ~ 4

Author(s):

Stefanie Nippe ◽

Sascha General

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Ethinyl Estradiol ◽

In Vitro Release ◽

Delivery Systems ◽

Vitro Release

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Development and Characterization of Liposome-Enriched Ketoprofen Liposomal Hydrogels

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2019/v27i130159 ◽

2019 ◽

pp. 1-7

Author(s):

Muhammad Wahab Amjad ◽

Maria Abdul Ghafoor Raja

Keyword(s):

Drug Delivery ◽

In Vitro Release ◽

Time Interval ◽

Topical Drug Delivery ◽

Sustained Drug Delivery ◽

Dosing Frequency ◽

Chloroform Methanol ◽

Vitro Release

The purpose of this study was to develop liposome-enriched Ketoprofen liposomal hydrogels and carry out in vitro release profile experiment. The aim was to achieve sustained topical drug delivery for extended time interval from liposomal gels. Phosphatidylcholine, Cholesterol and Ketoprofen were dissolved in chloroform/methanol (2:1, v/v) mixture and subsequently transferred to a flask attached to rotavapor. The liposomes were assessed for particle size and percent drug entrapment. F-7 and F-8 batches were found to be optimized batches having optimum sizes, drug entrapment efficiencies and cumulative drug releases. F-8 batch was further evaluated for stability. The results show that the prepared liposomes of Ketoprofen might turn out to be potential candidates for effective and safe sustained drug delivery thereby resulting in the reduction of dosing frequency.

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Preparation and characterization of nimesulide loaded poly (methyl methacrylate)/poly (ethylene oxide) blend microspheres: In vitro release studies

Asian Journal of Pharmaceutics ◽

10.4103/0973-8398.120086 ◽

2013 ◽

Vol 7 (3) ◽

pp. 118 ◽

Cited By ~ 1

Author(s):

KChowdoji Rao ◽

B Mallikarjuna ◽

CV Prasad ◽

K Sudhakar ◽

KMadhusudana Rao ◽

...

Keyword(s):

Ethylene Oxide ◽

Methyl Methacrylate ◽

In Vitro Release ◽

Poly Methyl Methacrylate ◽

Release Studies ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Vitro Release

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Microfluidic synthesis of dye-loaded polycaprolactone- block -poly(ethylene oxide) nanoparticles: Insights into flow-directed loading and in vitro release for drug delivery

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2016.04.010 ◽

2016 ◽

Vol 475 ◽

pp. 136-148 ◽

Cited By ~ 20

Author(s):

Aman Bains ◽

Jeremy E. Wulff ◽

Matthew G. Moffitt

Keyword(s):

Drug Delivery ◽

Ethylene Oxide ◽

In Vitro Release ◽

Oxide Nanoparticles ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Vitro Release

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Synthesis and characterization of new macromolecule systems for colon-specific drug delivery

e-Polymers ◽

10.1515/epoly.2007.7.1.314 ◽

2007 ◽

Vol 7 (1) ◽

Author(s):

M. Galehassadi ◽

M. Mahkam ◽

F. Hosseinzadeh

Keyword(s):

Drug Delivery ◽

In Vitro Release ◽

Network Polymers ◽

Release Studies ◽

Silyl Groups ◽

Silyl Derivatives ◽

Derivatives Of ◽

Vitro Release

AbstractNetwork polymers containing silyl groups were synthesized. Silyl derivatives of 2-hydroxyethylmethacrylate (HEMA), and methacrylic acid (MAA) were copolymerized with 1,2-bis(vinylphenyl)ethane (BVPE) and divinylbenzene (DVB) as cross-linking agents by radical polymerization using α,α′-azobis (isobutyronitrile) (AIBN) as initiator to produce network polymers. Then mesalasine (MZ) were loaded to these network polymers, and amount of drug entrapped was determined. In vitro release studies showed that drug delivery property was modified and showed considerable difference in swelling at pH 1 and 7.4. Incorporation of silyl groups in new macromolecule system modified network polymers for drug delivery. Monomers and polymers were characterized by spectroscopic methods.

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