scholarly journals Anti-inflammatory and Antioxidant Potential of Hyaluronic Acid Mediated Zinc Nanoparticles

2020 ◽  
pp. 33-37
Author(s):  
N. Akash ◽  
Lakshminarayanan Arivarasu ◽  
S. Rajeshkumar
Keyword(s):  
Antioxidant Activity ◽  
Zinc Oxide ◽  
Hyaluronic Acid ◽  
Antioxidant Potential ◽  
Inflammatory Activity ◽  
Therapeutic Drug ◽  
Zinc Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Anti Inflammatory

Aim: The aim of the study is to interpret the hyaluronic acid mediated with zinc oxide nanoparticle and its anti-inflammatory and antioxidant activity. Introduction: Hyaluronic acid has a role as ‘physiological selector’ for spermatozoa prior to intracy to plasmic sperm injection (icsi). They are mostly seen in the synovial joints and act as a shock absorber. The objective of this study is to analyse the results achievable by the introduction of a routine HA. Hyaluronic acid is an immune neutral polysaccharide that is ubiquitous in the human body, and it is crucial for many cellular and tissue functions. Nanoparticles are the compounds which respond to the applied magnetic fields, magnetic separation labelled cells, therapeutic drug, gene and radionuclide delivery and other biological entities. Materials and Methods: Hyaluronic acid mediated with zno nanoparticles were evaluated for its anti inflammatory activity and antioxidant potential using photometry analysis. Results and Discussion: Zinc nanoparticles shows a higher efficiency of antibacterial activity, but sublethal concentration causes adverse effects and results in increased biofilm formation of V. cholerae Hyaluronic acid mediated zinc oxide nanoparticle show good result in anti inflammatory activity as well as in antioxidant activity. The biosynthesis of the nanoparticle was done by addition of hyaluronic acid with zinc nanoparticles in a scarese amount. This was kept in the orbital shaker, hence they take a long time for the synthesis. The colour change was observed, hence the synthesized nanoparticles proceeded with the anti-inflammatory and antioxidant tests.

scholarly journals Antioxidant and Anti-Inflammatory Potential of Chromium Picolinate Mediated Zinc Oxide Nanoparticle

2020 ◽  
pp. 118-121
Author(s):  
C. M. Aathira ◽  
Lakshminarayanan Arivarasu ◽  
S. Rajeshkumar
Keyword(s):  
Antioxidant Activity ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Protein Denaturation ◽  
The Body ◽  
Chromium Picolinate ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Anti Inflammatory

Aim: To study the anti-inflammatory and antioxidant activity of chromium Picolinate mediated Zinc oxide nanoparticles. Introduction: Chromium is required by the body in a noticeable amount, even though it’s mechanism and required dietary allowance is not known clearly. It is found in supplements. It is expected to enhance insulin production and weight loss. Zinc oxide also has its own beneficial role in various biomedical applications. In the present study the antioxidant and anti-inflammatory potential of the chromium picolinate mediated Zinc oxide nanoparticle is evaluated. Nanoparticles are of great interest nowadays in research and study. The outcomes of using metal nanoparticles were fascinating as color pigments in luster and glass technology. Materials and Methods: DPPH assay for antioxidant activity and Protein denaturation assay was performed for anti-inflammatory activity. Results and Discussion: Chromium Picolinate mediated Zinc oxide nanoparticles showed good anti-inflammatory and antioxidant activity at higher concentration against standard.

Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

2020 ◽  
Vol 16 ◽  
Author(s):  
Bhim Bahadur Chaudhari ◽  
Alka Bali ◽  
Ajitesh Balaini
Keyword(s):  
Antioxidant Activity ◽  
Oral Absorption ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Antioxidant Potential ◽  
Inflammatory Activity ◽  
In Vivo Models ◽  
Standard Drug ◽  
Hybrid Molecules ◽  
Anti Inflammatory

Background: NSAIDs are the most widely prescribed medications worldwide for their anti-inflammatory, antipyretic, and analgesic effects However, their chronic use can lead to several adverse drug events including GI toxicity. The selective COX-2 inhibitors developed as gastro-sparing NSAIDs also suffer from serious adverse effects which limit their efficacy. Objective: Local generation of reactive oxygen species is implicated in NSAID-mediated gastric ulceration and their combination with H2 antagonists like famotidine reduces the risk of ulcers. The objective of this work was to design and synthesize novel methanesulphonamido isoxazole derivatives by hybridizing the structural features of NSAIDs with those of antiulcer drugs (ranitidine, famotidine, etc.) to utilize a dual combination of anti-inflammatory activity and reducing (antioxidant) potential. Method: The designing process utilized three dimensional similarity studies and utilized an isoxazole core having a potential for anti-inflammatory as well as radical scavenging antioxidant activity. The compounds were assayed for their antiinflammatory activity in established in vivo models. The in vitro antioxidant activity was assessed in potassium ferricyanide reducing power (PFRAP) assay employing ascorbic acid as the standard drug. Results: Compounds (5, 6, 9 and 10) showed anti-inflammatory activity comparable to the standard drugs and were also found to be non-ulcerogenic at the test doses. Compounds 6-10 exhibited good antioxidant effect in the concentration range of 1.0-50.0 µmol/ml. The test compounds were also found to comply with the Lipinski rule suggesting good oral absorption. Conclusion: A new series of isoxazole based compounds is being reported with good anti-inflammatory activity coupled with antioxidant potential as gastro-sparing anti-inflammatory agents.

Molecular mechanisms underlying zinc oxide nanoparticle induced insulin resistance in mice

2019 ◽  
Vol 14 (1) ◽  
pp. 59-76
Author(s):  
Hailong Hu ◽  
Qian Guo ◽  
Xingpei Fan ◽  
Xiangjuan Wei ◽  
Daqian Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Zinc Oxide ◽  
Molecular Mechanisms ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals A critical review of synthesis parameters affecting the properties of zinc oxide nanoparticle and its application in wastewater treatment

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
E. Y. Shaba ◽  
J. O. Jacob ◽  
J. O. Tijani ◽  
M. A. T. Suleiman
Keyword(s):  
Zinc Oxide ◽  
Metal Oxides ◽  
Zinc Oxide Nanoparticles ◽  
Textural Properties ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Synthesis Parameters ◽  
Metal Precursors ◽  
Removal Of Heavy Metals ◽  
Oxide Nanoparticle

AbstractIn this era, nanotechnology is gaining enormous popularity due to its ability to reduce metals, metalloids and metal oxides into their nanosize, which essentially alter their physical, chemical, and optical properties. Zinc oxide nanoparticle is one of the most important semiconductor metal oxides with diverse applications in the field of material science. However, several factors, such as pH of the reaction mixture, calcination temperature, reaction time, stirring speed, nature of capping agents, and concentration of metal precursors, greatly affect the properties of the zinc oxide nanoparticles and their applications. This review focuses on the influence of the synthesis parameters on the morphology, mineralogical phase, textural properties, microstructures, and size of the zinc oxide nanoparticles. In addition, the review also examined the application of zinc oxides as nanoadsorbent for the removal of heavy metals from wastewater.

scholarly journals Mechanisms and effects of zinc oxide nanoparticle transformations on toxicity to zebrafish embryos

2021 ◽  
Author(s):  
Gyudong Lee ◽  
Byongcheun Lee ◽  
Ki-Tae Kim
Keyword(s):  
Zinc Oxide ◽  
Physicochemical Properties ◽  
Zebrafish Embryos ◽  
Zinc Ions ◽  
Zno Nps ◽  
Zinc Oxide Nanoparticle ◽  
Toxicity Reduction ◽  
Oxide Nanoparticle

Environmental transformations modify the physicochemical properties of ZnO NPs, modulate their ability to reduce zinc ions, and determine the degree of toxicity reduction in zebrafish embryos.

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