A Rare Case of Salmonella Typhi Presenting with Tonsillitis

Typhoid fever is an endemic infection in developing countries like India. Oral manifestations of enteric fever and typhoid tonsillitis have rarely been reported in the literature. We report a 20 year old male, showing tonsillitis to be an integral part of clinical presentation of typhoid fever.The patient presented with fever, throat pain and oral ulcers. Blood culture and swab from tonsils showed significant growth of Salmonella typhi.This case report adds light to tonsillitis as a rare clinical manifestation of typhoid fever.

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Culture proven Salmonella typhi co-infection in a child with Dengue fever: a case report

The Journal of Infection in Developing Countries ◽

10.3855/jidc.5230 ◽

2015 ◽

Vol 9 (09) ◽

pp. 1033-1035 ◽

Cited By ~ 1

Author(s):

Rangan Srinivasaraghavan ◽

Parameswaran Narayanan ◽

Thandapani Kanimozhi

Keyword(s):

Risk Factors ◽

Developing Countries ◽

Case Report ◽

Infectious Diseases ◽

Typhoid Fever ◽

Dengue Fever ◽

Salmonella Typhi ◽

Infectious Agents ◽

Dengue Outbreak ◽

Concurrent Infections

Infectious diseases are one of the major causes of morbidity and mortality in developing countries. Sometimes concurrent infections with multiple infectious agents may occur in one patient, which make the diagnosis and management a challenging task. The authors here present a case of co-infection of typhoid fever with dengue fever in a ten-year-old child and discuss the pertinent issues. The authors emphasize that the risk factors predicting the presence of such co-infections, if developed, will be immensely useful in areas where dengue outbreak occurs in the background of high transmission of endemic infections.

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A rare case of septic arthritis of the knee caused by Salmonella typhi with preexisting typhoid fever in a healthy, immunocompetent child – A case report

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2020.12.003 ◽

2021 ◽

Vol 78 ◽

pp. 76-80

Author(s):

Aryadi Kurniawan ◽

Immanuel Panca Sitorus ◽

Tonny Loho ◽

Witantra Dhamar Hutami

Keyword(s):

Case Report ◽

Typhoid Fever ◽

Septic Arthritis ◽

Rare Case ◽

Salmonella Typhi ◽

Immunocompetent Child

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Typhoid fever with multiorgan involvement: pulmonary, hepatic and renal complications with dyselectrolytemia

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20185213 ◽

2018 ◽

Vol 6 (1) ◽

pp. 215

Author(s):

Manish Verma ◽

Jaisingh Jat ◽

Khushboo Agarwal

Keyword(s):

Developing Countries ◽

Renal Failure ◽

Young Child ◽

Typhoid Fever ◽

Rare Case ◽

Enteric Fever ◽

Pulmonary Complication ◽

Young Female ◽

Unique Case ◽

Important Health

Typhoid fever is an important health problem in developing countries like India, especially among young children. It may involve a number of systems and may present with various complications specially if untreated. We report a rare case of typhoid fever with multiple complications in 4 years young female who presented with fever, toxemia, bronchopneumonia, icteric hepatitis and also developed AKI, hyponatremia. Enteric fever with its complications has been reported previously but mostly reported with surgical complications, pulmonary complication, Myocarditis, hepatitis, hepatitis with renal failure etc but this seems to be unique case as presented with multiorgan involvement e.g. bronchopneumonia, icteric hepatitis, AKI and dyselectrolytemia. Previously reported cases were usually adolescents while this case is just 4 years young child. Despite multiple complications, patient responded well to treatment of enteric fever and discharged successfully.

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Study on the efficacy of ceftriaxone versus azithromycin for the treatment of uncomplicated enteric fever among the patients admitted in a tertiary level hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20214883 ◽

2021 ◽

Vol 11 (1) ◽

pp. 1

Author(s):

Sougata Mitra ◽

Masuma Khanam ◽

M. Iqbal Hossain ◽

Rukhsana Quadir

Keyword(s):

Blood Culture ◽

Physical Examination ◽

Typhoid Fever ◽

Clinical Cure ◽

Enteric Fever ◽

Salmonella Typhi ◽

Clearance Time ◽

Medical College ◽

Fever Clearance Time ◽

Culture Positive

Background: Typhoid fever is a severe debilitating and potentially life threating illness. In Bangladesh, typhoid fever is a round the year problem which sometimes take epidemic proportions. The reasons behind such occurrences are unsafe water supply, defective sewage system and unhygienic food handling practice. This study aimed to compare the efficacy of ceftriaxone and azithromycin in the treatment of uncomplicated enteric fever.Methods: An observational study was conducted at the department of pharmacology in Dhaka medical college, Dhaka, Bangladesh. Data were collected from blood culture positive patients for Salmonella typhi and Salmonella paratyphi, who admitted in the Dhaka medical college and hospital, Dhaka during the period of July 2015 to June 2016. Data was collected by using a structured questioner, face to face interview, physical examination and investigation reports. Patients were hospitalized during the entire treatment period and at admission evaluation was made by history and physical examination in a structured format. Subjects ware asked regarding changes in symptoms and possible adverse effects of the study drugs. All patients were asked to return two weeks after completion of treatment for follow up. Blood culture of Salmonella typhi or Salmonella paratyphi were done in all cases. Total 91 patients were culture positive for either S. typhi or S. paratyphi which were finally studied.Results: During the study period out of 91 patients, 51 were receiving ceftriaxone and 40 were receiving azithromycin. Clinical cure was achieved in 46 patients (90%) of ceftriaxone group and in 31 patients (78%) in the azithromycin group. There were no significant differences of clinical cure between both treatment groups (p>0.05). Mean fever clearance time in ceftriaxone group was 3±1.4 days and was 4±1.6 days for azithromycin group. Difference in fever clearance time was statistically significant (p<0.05). No clinical relapses were detected in any study subject. No major side effects of both drugs occurred in any subject.Conclusions: These results indicated that both ceftriaxone and azithromycin were effective against enteric fever caused by sensitive organisms and multi drug resistant S. typhi and S. paratyphi. It is concluded that ceftriaxone is more effective and can be a convenient alternative for the treatment of enteric fever, especially in developing countries like us where medical resources are scarce.

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A rare case of extensively drug-resistant Salmonella typhi meningitis in a 9-year old: a case report

Future Microbiology ◽

10.2217/fmb-2020-0257 ◽

2021 ◽

Vol 16 (13) ◽

pp. 931-933

Author(s):

Hina Bukhari ◽

Seerat F Tu Zahra ◽

Sarmad Zahoor ◽

Muhammad AN Saqib ◽

Muhammad S Afzal

Keyword(s):

Developing Countries ◽

Drug Resistance ◽

Case Report ◽

Rare Case ◽

Salmonella Typhi ◽

Drug Resistant ◽

Routine Testing ◽

High Burden ◽

Extensively Drug Resistant ◽

Culture Sensitivity

Meningitis caused by Salmonella typhi is rare and is generally seen in infants. We report a case of a 9-year-old boy with extensively drug-resistant S. typhi meningitis. The patient was diagnosed using a culture sensitivity test and successfully treated with meropenem. Culture sensitivity may be included in routine testing for the diagnosis of S. typhi especially in developing countries due to high burden of disease and emergence of drug resistance.

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Cephalosporin-resistant typhoid

SAGE Open Medical Case Reports ◽

10.1177/2050313x20917835 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2091783

Author(s):

Noella Maria Delia Pereira ◽

Ira Shah

Keyword(s):

Developing Countries ◽

Cerebrospinal Fluid ◽

Blood Culture ◽

Typhoid Fever ◽

Antimicrobial Stewardship ◽

Salmonella Typhi ◽

Third Generation ◽

Sanitation And Hygiene ◽

Cerebrospinal Fluid Examination ◽

Third Generation Cephalosporins

Typhoid fever is endemic in developing countries like India. An increasing prevalence of resistance to cephalosporins and fluoroquinolones by Salmonella isolates is seen. We present an 8-month-old boy with invasive Salmonella typhi disease. Blood culture showed S. typhi sensitive to ampicillin–sulbactam and cotrimoxazole but resistant to fluoroquinolones and third-generation cephalosporins. Cerebrospinal fluid examination revealed an aseptic meningitic picture. He was treated with intravenous meropenem and azithromycin following which his condition improved. This case highlights the need for improvement in environment sanitation and hygiene combined with early vaccination against typhoid fever and antimicrobial stewardship to help reduce the emerging resistance to cephalosporins and fluoroquinolones.

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Clinical Features and Socio – Demographic Factors Affecting the Prevalence of Enteric Fever: A Prospective Observational Study

Bangladesh Critical Care Journal ◽

10.3329/bccj.v8i2.50025 ◽

2020 ◽

Vol 8 (2) ◽

pp. 86-90

Author(s):

Sadia Saber ◽

Md Tarek Alam ◽

Nazi Yasmin ◽

Mohammad Monwer Hossain ◽

Rafi Faria Alam

Keyword(s):

Abdominal Pain ◽

Seasonal Variation ◽

Blood Culture ◽

Observational Study ◽

Typhoid Fever ◽

Marital Status ◽

Enteric Fever ◽

Salmonella Typhi ◽

Age Group ◽

Socio Demographic Factors

Background: Enteric fever otherwise called Typhoid fever is a systemic disease caused by Salmonella typhi and Salmonella paratyphi, having reservoir in contaminated water and food. It affects considerable number of populations of the world but regions of South Asia are most commonly affected. Aims and Objective: The objective of this study to find the prevalence of Typhoid fever with respect to age, gender, marital status, occupation, seasonal variation, treatment of drinking domestic water source, and clinical features. Methodology: This is a cross- sectional observational study conducted at Bangladesh Medical College Hospital (BMCH), Dhanmondi, Dhaka from January to December 2019. Those presenting both outpatient departments or admitted to the inpatient units with complains of fever and abdominal pain underwent blood culture for the diagnosis of Typhoid fever. Patients with informed consent and positive blood culture report (including both Salmonella typhi and Salmonella paratyphi) were included in the study. Results: Total 1375 tests were performed, out of which 407 came out to be positive blood culture report (including both Salmonella typhi and Salmonella paratyphi). Out of these tests 31.65% were males and 27.35% were females. Highest occurrence of typhoid fever was observed among males of age group 18 – 45 years and least with patients between age group above 75 years. As for the influence of occupation, male civil servants recorded the highest occurrence in the hospitals while artisans recorded the least. The influence of marital status revealed the highest occurrence in the single males with the married females had the least. In relation to months the prevalence was the highest in the month of July - September (11.42%). Water quality, vaccination and season have great impact on the burden of typhoid fever in population. Fever, diarrhea and abdominal pain are the major symptoms associated with typhoid fever. Conclusion: Socio-demographic factors such as age, gender, marital status, and seasonal variation, treatment of drinking water supply, occupation and presenting complaints influenced the distribution pattern of typhoid fever among the population in BMCH, Dhanmondi, Dhaka. Bangladesh Crit Care J September 2020; 8(2): 86-90

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Empyema due to salmonella typhi in a diabetic patient: a rare case report

Indian Journal Of Applied Research ◽

10.15373/2249555x/june2013/136 ◽

2011 ◽

Vol 3 (6) ◽

pp. 405-406

Author(s):

Dr. Nale Swati S Dr. Nale Swati S ◽

◽

Dr.Ghadage Dnyaneshwari P ◽

Bhore Arvind V

Keyword(s):

Case Report ◽

Diabetic Patient ◽

Rare Case ◽

Salmonella Typhi ◽

Rare Case Report

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A Rare Case Report of Dabigatran Induced Oral Ulcers

Current Drug Safety ◽

10.2174/1574886315666200212093453 ◽

2020 ◽

Vol 15 (2) ◽

pp. 160-162

Author(s):

Ajeet Singh ◽

Neel Prabha ◽

Hitesh Yadav

Keyword(s):

Case Report ◽

Rare Case ◽

Warfarin Therapy ◽

Systemic Embolism ◽

Vein Thrombosis ◽

Oral Ulcers ◽

Retrosternal Pain ◽

Novel Oral Anticoagulant ◽

Rare Case Report ◽

Deep Vein

Background: Dabigatran is a novel oral anticoagulant molecule which is a direct thrombin (Factor IIa) inhibitor and is used for prevention of stroke and systemic embolism. It is easy to administer as compared to warfarin therapy as it does not require routine laboratory monitoring and has fewer drug interactions. Objective: To present a rare case of oral ulcers secondary to dabigatran in a patient with deep vein thrombosis. Case report: A 68-year-old female presented with painful oral ulcers, retrosternal pain and difficulty in swallowing. She had been taking capsule Dabigatran for the prevention of systemic embolism for 2 months. She had experienced symptoms of onset taking dabigatran for 7 days. Clinical examination revealed three tender, well-defined, clean looking ulcers of various sizes present over the dorsum of the tongue. Dabigatran was withdrawn and the patient was on oral proton pump inhibitors. Patient showed remarkable improvement in oral ulcers after 2 weeks. Conclusion: Patient education and counseling should be done regarding this side effect of dabigatran and proper intake of this medicine.

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