scholarly journals Correlation between Peripheral Blood Eosinophilia and the Histopathological Changes in Nasal Mucosal in Chronic Rhinosinusitis

2021 ◽  
pp. 440-448
Author(s):  
Jahnavi Narayanan ◽  
K. Nithin Diwagar ◽  
Ganthimathy Sekhar
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyp ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
P Value ◽  
Blood Eosinophilia ◽  
Tissue Eosinophilia ◽  
Group 2 ◽  
Peripheral Blood Eosinophilia ◽  
Group 1

Background: Chronic rhinosinusitis(CRS) has emerged as one of the major causes of significant morbidity in otorhinolaryngology, as it is often noted to be refractory to medical management and has a tendency to recur post-surgery. Limited research has shown that peripheral eosinophilia is related to the presence of nasal polyps, the extent of the mucosal disease, the severity of tissue eosinophilia, and the risk of recurrence. Aim: This study aimed to establish the significance of peripheral blood eosinophilia, both differential (EC) and absolute eosinophil counts (AEC) - in adult CRS, to correlate the tissue eosinophilia and peripheral blood eosinophilia, and compare the observations in the two types of CRS with nasal polyp and without nasal polyp. Material and Methods: A total of 50 adult patients with CRS who underwent FESS were included in the study and were divided based on the presence (Group 1) or absence (Group 2) of peripheral blood eosinophilia. Results: There were equal number of cases of chronic rhinosinusitis with nasal polyp (CRSwNP) and without polyp (CRSsNP); 25 each.  With regard to clinical features, Group 1 had a higher number of cases with nasal obstruction (p-value = 0.023), post-nasal drip (p-value = 0.035), and hyposmia (p-value = 0.021) when compared to Group 2. On histopathology, Group 1 had more areas of edema (p-value = 0.027), and mucous gland hyperplasia (p-value = 0.013) while Group 2 had prominent lymphoplasmacytic infiltrates (p-value = 0.035), neutrophilia (p-value = 0.047), and tissue infiltration of macrophages (p-value = 0.027).  Tissue eosinophilia was present in 32 out of the total cases; 20 (71.43%) in Group 1 and 12 (53.33%) in Group 2. The group with tissue eosinophilia had significantly higher eosinophil count (9.24 ± 4.26% vs 5.32 ± 2.9%; p-value < 0.01) as well as AEC (823.335 ± 434.357/µl vs 485.128 ± 285/µl. 907; p-value < 0.01). Conclusion: The study demonstrated that CRS cases with tissue eosinophilia exhibit an elevated peripheral eosinophil count when compared to non-eosinophilic CRS.

scholarly journals Clinicopathological Correlation between Peripheral Blood Eosinophilia and Inferior Turbinate Tissue Eosinophils

2014 ◽  
Vol 6 (2) ◽  
pp. 58-60
Author(s):  
UP Santosh ◽  
Aniketh Shyamsunder Pandurangi
Keyword(s):  
Allergic Rhinitis ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Case Series ◽  
Inferior Turbinate ◽  
Outpatient Department ◽  
Clinicopathological Correlation ◽  
Blood Eosinophilia ◽  
Tissue Eosinophilia ◽  
Peripheral Blood Eosinophilia

ABSTRACT Background and objectives Allergic rhinitis affects up to 20% of the general population and is one of the most common reasons for presentations to the outpatient department. We hereby present a case series which attempts to have a correlation between tissue eosinophilia (inferior turbinate) and increased eosinophil count in blood (> 440 cells/mm3). Materials and methods Thirty-six patients presented to the Outpatient Department of Bapuji Hospital and Chigateri General Hospital (Teaching Hospitals attached to JJM Medical College), Davangere, with nasal obstruction and symptoms suggestive of allergic rhinitis with turbinate hypertrophy who were posted for elective bilateral partial inferior turbinectomy with/without submucous resection/septoplasty. These patients had increased absolute eosinophil count in blood. Formalin fixed inferior turbinectomy specimens were routinely processed for histopathology. Eosinophils in the mucosa and submucosal region were counted by method of Shioda and Mishima. Results Ten patients out of 36 showing increased eosinophil count in blood show ‘significant eosinophilia’ in turbinates (27.7%). Conclusion Peripheral eosinophilia does not always correlate with tissue eosinophilia which opens up a possibility of using nasal mucosa biopsy for confirmation of presence of eosinophils. Further studies are needed to explore the demonstration of ‘activated’ tissue eosinophils in the diagnosis of allergic rhinitis. How to cite this article Santosh UP, Sunil KB, Pandurangi AS. Clinicopathological Correlation between Peripheral Blood Eosinophilia and Inferior Turbinate Tissue Eosinophils. Int J Otorhinolaryngol Clin 2014;6(2):58-60.

Microfilaria: not always associated with eosinophilia

2019 ◽  
Vol 49 (3) ◽  
pp. 210-212
Author(s):  
Neha Garg ◽  
Shilpi More ◽  
Monika Sharma ◽  
Mrinalini Kotru
Keyword(s):  
Low Power ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Blood Smear ◽  
Parasitic Infection ◽  
Peripheral Blood Smear ◽  
Buffy Coat ◽  
Blood Eosinophilia ◽  
Wet Mount ◽  
Peripheral Blood Eosinophilia

Filariasis is a parasitic infection seen predominantly in tropical and subtropical countries including India. In clinically suspected cases, examining a thick wet mount smear or a buffy coat film is most informative. In unsuspected cases, however, eosinophilia in a peripheral blood smear (PBS) may be the sole indicator of parasitaemia. A few cases of tissue microfilaria with the absence of peripheral blood eosinophilia (PBE) have been reported. Here, we report two cases of microfilaria in PBS in the absence of PBE. A routine screening of the tail end of all PBS at low power magnification is also advised as it may facilitate the detection of asymptomatic cases when there is a normal eosinophil count.

scholarly journals Acute Cerebral Phaeohyphomycosis due to Wangiella dermatitidis Accompanied by Cerebrospinal Fluid Eosinophilia

2000 ◽  
Vol 38 (5) ◽  
pp. 1965-1966 ◽  
Author(s):  
Chulhun Ludgerus Chang ◽  
Dae-Seong Kim ◽  
Dong June Park ◽  
Hak Jin Kim ◽  
Chang Hun Lee ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Black Yeast ◽  
Wangiella Dermatitidis ◽  
Immunocompetent Adult ◽  
Blood Eosinophilia ◽  
Peripheral Blood Eosinophilia

We report a case of cerebral phaeohyphomycosis due toWangiella dermaitidis in an immunocompetent adult man. His cerebrospinal fluid (CSF) showed pleocytosis with a high eosinophil count but without peripheral blood eosinophilia. The present case suggested that this black yeast-like fungus should be included when the causes of CSF eosinophilia are considered, even though it is an extremely rare pathogen.

scholarly journals Hypereosinophilia and hepatitis C

2015 ◽  
Vol 5 (2S) ◽  
pp. 41-45
Author(s):  
Carlo Bussolino ◽  
Valter Saracco
Keyword(s):  
Heart Failure ◽  
Hepatitis C ◽  
Hospital Stay ◽  
Peripheral Blood ◽  
Eosinophil Count ◽  
Liver Enzymes ◽  
Hcv Rna ◽  
Blood Eosinophilia ◽  
History Of ◽  
Peripheral Blood Eosinophilia

We report a case of a 59-year-old Italian man with a history of alcoholic abuse and sustained peripheral blood eosinophilia since 2 years. He arrived at our hospital with progressive oedema, palpitations, dyspnea by heart failure. During hospital stay a diagnosis of CEL-NOS, heart failure and hepatitis C was made. Due to the severe hepatopathy and the mild HCV genotype, along with the therapeutic effect of interferon in chronic myeloid disorders, the patient was treated with PEG-interferon alpha-2a 180 μg weekly and ribavirin 1,000 mg daily. At the end of the treatment the patient showed an important decrease of eosinophil count, normalisation of liver enzymes and the absence of circulating HCV-RNA.

A Case of Allergic Granulomatous Angiitis with Peripheral Blood Eosinophilia Revealing Resistance to Systemic Steroid

2006 ◽  
Vol 68 (1) ◽  
pp. 19-23
Author(s):  
Yuki SUZUKI ◽  
Hideaki WATANABE ◽  
Amane KITAMI ◽  
Hirohiko SUEKI ◽  
Masafumi IIJIMA ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Systemic Steroid ◽  
Granulomatous Angiitis ◽  
Blood Eosinophilia ◽  
Allergic Granulomatous Angiitis ◽  
Peripheral Blood Eosinophilia

scholarly journals P318 Left atrial dysfunction assessed by echocardiography in relation to left atrial fibrosis in patients undergoing ablation for atrial fibrillation

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
E Pilichowska ◽  
J Baran ◽  
P Kulakowski ◽  
B Zaborska
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Systolic Function ◽  
Electrophysiological Study ◽  
Stiffness Index ◽  
P Value ◽  
Group 2 ◽  
Left Atrial Dysfunction ◽  
Left Atrial Fibrosis ◽  
Group 1

Abstract PURPOSE Left atrial (LA) fibrosis is the hallmark of LA remodeling in atrial fibrillation (AF), alters LA function and may predict poor catheter ablation (CA) outcome. LA fibrosis may be assessed invasively using electroanatomical mapping (EAM) during electrophysiological study. The aim was to assess LA function parameters in relation to degree of LA fibrosis derived from EAM in patients with AF. METHODS Patients (pts) n = 39 (79% males, mean age 56+/-10) with non-valvular AF were studied with TTE and TEE before first CA during sinus rhythm. LA strain (LAS) and strain rate (LASR) were analyzed in reservoir (r), conduit (cd) and contractile (ct) phases. The velocities of mitral A, E" and A" were measured with Doppler. E/E" and LA stiffness index - the ratio of E/E" to LASr were assessed. LA appendage flow velocity (LAAv) was measured in TEE. LA volume using biplane area-length method was calculated. The EAM of LA was build using Carto System before CA. Low amplitude potentials area (LAPA) was quantitatively analyzed and expressed as a percentage of LA surface using the cut-off &lt;0.5 mV to detect sites of fibrosis. LA parameters were compared between mild (LAPA &lt;10%) moderate (LAPA 10-40%) and extensive degree of LA fibrosis (LAPA &gt;40%) (table). RESULTS The mean LA volume was 35 ± 11 mL/m². The LAPA ranged from 2 to 78 % of LA surface. Reduced LA function was observed in the LAPA &gt;40% group. Extensive LAPA altered mainly LA compliance parameters. Traditional LA systolic function parameters did not differ in relation to degree of LAPA. CONCLUSION LA compliance is mostly affected by LA fibrosis, thus LA diastolic parameters may be useful in the noninvasive assessment of LA fibrosis. Whether these parameters should be a part of the proper selection of candidates for CA requires further studies. LA function parameters LA parameters Group 1 LAPA &lt;10% n = 13 Group 2 LAPA &gt;10% &lt;40% n = 13 Group 3 LAPA &gt;40% n = 13 P-value Group 1 + 2 vs 3 Mitral A 0.55 ± 0.10 0.55 ± 0.24 0.73 ± 0.32 0.077 A" 9.19 ± 1.74 7.85 ± 1.43 7.92 ± 2.40 0.376 LASr 31.48 ± 4.52 26.48 ± 8.79 19.63 ± 6.76 &lt;0.001 LAScd 17.30 ± 3.05 15.44 ± 6.93 10.91 ± 4.04 0.003 LASct 14.18 ± 5.36 11.05 ± 3.67 8.72 ± 4.78 0.024 LASRr 1.22 ± 0.19 1.24 ± 0.21 0.92 ± 0.20 &lt;0.001 LASRct -1.71 ± 0.46 -1.37 ± 0.34 -1.04 ± 0.33 &lt;0.001 LA stiffness 0.20 ± 0.07 0.34 ± 0.17 0.63 ± 0.29 &lt;0.001 LAAv 0.83 ± 0.18 0.55 ± 0.17 0.60 ± 0.16 0.178

Does Presurgical Nasoalveolar Molding Have a Long-Term Effect on Nasal and Upper Airway Dimensions?

2020 ◽  
pp. 105566562098023
Author(s):  
Ashwina S. Banari ◽  
Sanjeev Datana ◽  
Shiv Shankar Agarwal ◽  
Sujit Kumar Bhandari
Keyword(s):  
Upper Airway ◽  
P Value ◽  
Airway Patency ◽  
The Mean ◽  
Group 2 ◽  
Acoustic Pharyngometry ◽  
Nasoalveolar Molding ◽  
Area And Volume ◽  
Group 1

Objectives: To compare nasal and upper airway dimensions in patients with cleft lip and palate (CLP) who underwent nasoalveolar molding (NAM) with those without NAM during infancy using acoustic pharyngometry and rhinometry. Materials and Methods: Eccovision acoustic pharyngometry and rhinometry (Sleep Group Solutions) was used for assessment of mean area and volume of nasal and upper airway in patients with complete unilateral CLP (age range 16-21 years) treated with NAM (group 1, n = 19) versus without NAM (group 2, n = 22). Results: The mean nasal cross-sectional areas and volume were higher in group 1 compared to group 2 on both cleft ( P value <.001) and noncleft side ( P value >.05). The mean area and volume of upper airway were also significantly higher in group 1 compared to group 2 ( P value <.05). Conclusions: Nasoalveolar molding being one of the first interventions in chronology of treatment of patients with CLP, its long-term outcome on nasal and upper airway patency needs to be ascertained. The results of the present study show that the patients with CLP who have undergone NAM during infancy have better improvement in nasal and upper airway patency compared with those who had not undergone NAM procedure. The basic advantages of being noninvasive, nonionizing and providing dynamic assessment of nasal and upper airway patency make acoustic pharyngometry and rhinometry a diagnostic tool of choice to be used in patients with CLP.

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