scholarly journals Amphotericin B Induced Anaphylactic Reaction and Electrolyte Imbalance: A Case Report

2021 ◽  
pp. 735-739
Author(s):  
Sheik Haja Sherief ◽  
Shilpa Johny Chackupurackal ◽  
S. Sengottuvelu ◽  
Mercy Dora ◽  
V. Manivannan ◽  
...  
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Anaphylactic Reaction ◽  
Cardiac Toxicity ◽  
Electrolyte Imbalance ◽  
Allergic Reactions ◽  
Chest Discomfort ◽  
Life Threatening ◽  
Streptomyces Nodosus

Amphotericin B, a polyene antifungal antibiotic derived from a strain of Streptomyces nodosus. It acts by binding to sterols in the cell membrane of susceptible fungi, with a resultant change in the permeability of the membrane. Amphotericin B can cause allergic reactions, electrolyte imbalance and severe side effects, such as chest discomfort accompanied by dyspnea, flushing, agitation, tachypnea, tachycardia, hypoxemia, hypotension, or hypertension, are likely to develop following the injection of Amphotericin B. Anaphylaxis, cardiac toxicity and respiratory failure have also been associated to different formulations of Amphotericin B as life-threatening acute events. This case report is on a 57-year-old male patient who was admitted with a condition of left diabetic foot with non-healing medial supra heel ulcer and fungal infection on the site of wound. The patient was given Amphotericin B in emulsion form due to the high priority of fungal infection and the need for antifungal medicine, which led to anaphylactic reaction and electrolyte imbalance, which were treated immediately and the same preparation was continued with a low infusion rate. When infusion is discontinued, antihistamines can assist to alleviate the symptoms. In this case, it is recommended that the patient's condition and clinical parameters should be closely followed after the medicine has been administered.

scholarly journals Pulmonary Mucormycosis with Diabetes Mellitus: A Case Report

2018 ◽  
Vol 2 (2) ◽  
pp. 33-34
Author(s):  
Shikha Jain ◽  
Bharat Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Immunocompromised Patients ◽  
Pulmonary Mucormycosis ◽  
Life Threatening

Mucormycosis is an uncommon but life threatening fungal infection that generally occurs mostly in immunocompromised patients. Patients do not respond to the antibiotics and so the condition may prove to be fatal if not timely detected. In this report, we summarize a case of pulmonary mucormycosis in a patient with diabetes mellitus who was cured using Amphotericin B.

scholarly journals An Unusual Presentation of Postpartum Spontaneous Coronary Artery Dissection

2019 ◽  
Vol 3 (3) ◽  
pp. 228-232
Author(s):  
Jonathan Alterie ◽  
Francis Villanueva ◽  
Mohamed Arekat ◽  
April Brill
Keyword(s):  
Emergency Department ◽  
Case Report ◽  
Coronary Artery ◽  
Cardiac Biomarkers ◽  
Artery Dissection ◽  
Spontaneous Coronary Artery Dissection ◽  
Chest Discomfort ◽  
Coronary Artery Dissection ◽  
Life Threatening ◽  
Multiparous Female

The postpartum population is one with a unique physiologic profile that predisposes these patients to rare and often life-threatening conditions. Herein, we discuss a case of a 37-year-old, multiparous female who presented to the emergency department with vague chest discomfort 14 days after delivering her sixth child via vaginal delivery. The patient was found to have elevated cardiac biomarkers and was ultimately diagnosed with pregnancy-related spontaneous coronary artery dissection (P-SCAD). This case report discusses the evaluation, pathophysiology, workup, and management of P-SCAD.

scholarly journals Sporobolomyces salmonicolor: A case report of a rare cutaneous fungal infection

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984415
Author(s):  
Rahina Damji ◽  
Atreyi Mukherji ◽  
Farheen Mussani
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Multiple Organ ◽  
Liposomal Amphotericin B ◽  
Cutaneous Eruption ◽  
Organ Systems ◽  
Cutaneous Fungal Infection

We report a case of a 47-year-old male diagnosed with a cutaneous Sporobolomyces salmonicolor infection after suffering with an extensive cutaneous eruption for 4 years. Treatment can be difficult and options include voriconazole and liposomal amphotericin B. This infectious disease is extremely rare and can have extensive impact on multiple organ systems, including the skin.

scholarly journals Efficacy of Liposomal Amphotericin B and Posaconazole in Intratracheal Models of Murine Mucormycosis

2013 ◽  
Vol 57 (7) ◽  
pp. 3340-3347 ◽  
Author(s):  
Guanpingsheng Luo ◽  
Teclegiorgis Gebremariam ◽  
Hongkyu Lee ◽  
Samuel W. French ◽  
Nathan P. Wiederhold ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Intratracheal Instillation ◽  
Cortisone Acetate ◽  
Liposomal Amphotericin B ◽  
Immunocompromised Patients ◽  
Content Type ◽  
Pulmonary Mucormycosis ◽  
Life Threatening

ABSTRACTMucormycosis is a life-threatening fungal infection almost uniformly affecting diabetics in ketoacidosis or other forms of acidosis and/or immunocompromised patients. Inhalation ofMucoralesspores provides the most common natural route of entry into the host. In this study, we developed an intratracheal instillation model of pulmonary mucormycosis that hematogenously disseminates into other organs using diabetic ketoacidotic (DKA) or cyclophosphamide-cortisone acetate-treated mice. Various degrees of lethality were achieved for the DKA or cyclophosphamide-cortisone acetate-treated mice when infected with different clinical isolates ofMucorales. In both DKA and cyclophosphamide-cortisone acetate models, liposomal amphotericin B (LAmB) or posaconazole (POS) treatments were effective in improving survival, reducing lungs and brain fungal burdens, and histologically resolving the infection compared with placebo. These models can be used to study mechanisms of infection, develop immunotherapeutic strategies, and evaluate drug efficacies against life-threateningMucoralesinfections.

scholarly journals COVID-19 Associated Rhino-Orbital Mucormycosis Complicated by Gangrenous and Bone Necrosis—A Case Report from Honduras

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 826
Author(s):  
Elsa Yolanda Palou ◽  
María Auxiliadora Ramos ◽  
Emec Cherenfant ◽  
Adoni Duarte ◽  
Itzel Carolina Fuentes-Barahona ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Early Diagnosis ◽  
Fungal Infection ◽  
Invasive Fungal Infection ◽  
Immunocompromised Patients ◽  
Bone Necrosis ◽  
Inappropriate Use ◽  
Prompt Treatment ◽  
Life Threatening

Background: Mucormycosis is a life-threatening invasive fungal infection most commonly observed in immunocompromised patients. Throughout the COVID-19 pandemic, a growing number of Mucorales associated infections, now termed COVID-19 associated mucormycosis (CAM), have been reported. Despite an increase in fatality reports, no cases of rhino-orbital CAM complicated with gangrenous bone necrosis have been described in the literature to date. Case: A 56-year-old male with a recent COVID-19 diagnosis developed rhino-orbital mucormycosis after 22 days of treatment with dexamethasone. Cultures and histopathological assessment of tissue biopsy confirmed the diagnosis. The patient survived after treatment with amphotericin B. Conclusions: Mucormycosis is an invasive fungal infection affecting mostly immunocompromised patients. Along with the COVID-19 pandemic, the inappropriate use of steroids, in addition to concurrent risk factors, such as diabetes, has led to an increase in the occurrence of these devastating mycoses, leading to the development of severe presentations and complications, as observed in many cases. Early diagnosis and prompt treatment are crucial in order to avoid dissemination and fatal outcomes.

scholarly journals Pulmonary Mucormycosis in Chronic Lymphocytic Leukemia and Neutropenia

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Izza Mir ◽  
Sijan Basnet ◽  
David Ellsworth ◽  
Elan Mohanty
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Thoracoscopic Surgery ◽  
Left Lung ◽  
Lymphocytic Leukemia ◽  
Pulmonary Mucormycosis ◽  
Life Threatening ◽  
History Of ◽  
Video Assisted Thoracoscopic Surgery

Pulmonary mucormycosis is a rare life-threatening fungal infection associated with high mortality. We present the case of a 61-year-old man with history of chronic lymphocytic leukemia who presented with fever and cough, eventually diagnosed with pulmonary mucormycosis after right lung video-assisted thoracoscopic surgery. The patient was successfully treated with amphotericin B and right lung pneumonectomy; however, he later died from left lung pneumonia.

scholarly journals Life-threatening onset of coeliac disease: a case report and literature review

2020 ◽  
Vol 7 (1) ◽  
pp. e000406 ◽  
Author(s):  
Matteo Guarino ◽  
Edoardo Gambuti ◽  
Franco Alfano ◽  
Andrea Strada ◽  
Rachele Ciccocioppo ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Coeliac Disease ◽  
Transglutaminase 2 ◽  
Duodenal Mucosa ◽  
Electrolyte Imbalance ◽  
Clear Correlation ◽  
Histopathological Analysis ◽  
Emergency Setting ◽  
Life Threatening

BackgroundCoeliac disease (CD) results from an immune-mediated reaction to gluten in genetically predisposed individuals. In rare cases CD may occur with acute features deferring the diagnosis and exposing these patients to possible life-threatening complications. Herein we present the case of a young woman with a coeliac crisis, that is, a sudden clinical onset characterised by severe electrolyte imbalance due to an unknown (previously unrecognised) CD.MethodsThis is a case report and literature review revealing that coeliac crisis is under-reported, with a total of 48 adult cases so far published. The diagnosis in our case was established by histopathological analysis of multiple duodenal biopsies. The patient’s serum was tested by enzyme-linked immunoassay to detect antitransglutaminase IgA antibodies.ResultsIn contrast to cases reported in the literature, with male gender predominance and a mean age of 50±17 years, our patient was a young female case of coeliac crisis. However, like in our patient, a higher incidence of coeliac crisis was associated with the human leucocyte antigen (HLA)-DQ2 haplotype, versus HLA-DQ8, and a severe (Marsh-Oberhüber 3c) duodenal mucosa atrophy. Notably, there is no clear correlation between the antitissue transglutaminase 2 IgA antibody titre and coeliac crisis onset/severity, as confirmed by our case report.ConclusionsThe present case highlights that CD may manifest quite abruptly with a severe malabsorption syndrome, that is, electrolyte abnormalities and hypoproteinaemia. Our case should alert physicians, in particular those in the emergency setting, that even a typically chronic disorder, such as CD, may show life-threatening complications requiring urgent management.

scholarly journals Successful Drug Desensitization to Ustekinumab in a Patient with Crohn’s Disease

2021 ◽  
pp. 657-661
Author(s):  
Barrie Cohen ◽  
Gitit Tomer ◽  
Tatyana Gavrilova
Keyword(s):  
Monoclonal Antibody ◽  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Multidisciplinary Approach ◽  
Allergic Reactions ◽  
Treatment Needs ◽  
Inflammatory Conditions ◽  
Life Threatening ◽  
Desensitization Protocol

Ustekinumab is a monoclonal antibody used as treatment for various inflammatory conditions. We present a pediatric patient with Crohn’s disease who did not tolerate infliximab and was then changed to ustekinumab. He developed anaphylaxis to the medication after the second dose. A drug desensitization protocol was created by the allergy team leading to successful administration of both intravenous and then subcutaneous ustekinumab. As monoclonal agents become mainstays of therapy for inflammatory conditions, there are increased reports of allergic reactions. Prior reports and protocols of ustekinumab desensitization have not been reported. This case report highlights successful desensitization to ustekinumab as well as the importance of a multidisciplinary approach to addressing treatment needs of patients who develop life-threatening reactions to such medications.

Rhinocerebral mucormycosis with orbital and intracranial extension: a case report and review of optimum management

2006 ◽  
Vol 121 (2) ◽  
pp. 192-195 ◽  
Author(s):  
N Munir ◽  
N S Jones
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Surgical Debridement ◽  
Liposomal Amphotericin B ◽  
Intracranial Extension ◽  
Rhinocerebral Mucormycosis ◽  
Optimum Management

Rhinocerebral mucormycosis is a devastating, rapidly progressive and often fatal opportunistic fungal infection predominantly affecting individuals with underlying metabolic and/or immunological compromise. Intracranial extension of the disease has invariably been associated with mortality.We present a review of optimum management of rhinocerebral mucormycosis and a case report of sinonasal mucormycosis with intracranial and orbital extension which was treated successfully with a combination of systemic liposomal amphotericin B therapy and wide surgical debridement.

Anaphylactic and Hemorrhagic Shock during Disseminated Abdominal Hydatidosis Surgery: A Case Report

2021 ◽  
Vol 6 (12) ◽  
pp. 895-898
Author(s):  
Yassine Kherchttou ◽  
Aicha Driouich ◽  
Youssef Elouardi ◽  
Mohammed Khallouki
Keyword(s):  
Case Report ◽  
Hemorrhagic Shock ◽  
Effective Treatment ◽  
Anaphylactic Shock ◽  
Allergic Reactions ◽  
Hepatic Surgery ◽  
Hydatid Cysts ◽  
Life Threatening ◽  
Peritoneal Hydatidosis ◽  
Abdominal Hydatidosis

Hydatidosis is a frequent pathology which remains endemic in Morocco. Its preferred location is the liver while the peritoneal location remains rare, even more rarely the pelvic location. The treatment is mainly surgical, but this surgery can be complicated (intraoperatively) by potentially serious accidents, it can be implicated in the occurrence of severe allergic reactions which can be life-threatening, more rarely by hemorrhagic accidents, especially if the cysts keep important and close vascular contact. We report the observation of a case of disseminated peritoneal hydatidosis supra-mesocolic, sub-mesocolic, pelvic and hepatic surgery complicated first by anaphylactic shock and secondarily by hemorrhagic shock. We insist on the need for its rapid recognition in order to quickly institute an adequate and effective treatment. The prevention of this accident is based on surgical precautions to prevent leaks or accidental intraoperative ruptures of hydatid cysts.

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