scholarly journals Giant Mixed Vesical Calculus in a Patient in North Central, Nigeria: A Case Report

2021 ◽  
pp. 96-99
Author(s):  
Saleh A. Longwap ◽  
Ahmed M. Rabiu ◽  
Cecilia N. Edeh ◽  
Daniel O. Aina ◽  
Ayuba Affi ◽  
...  
Keyword(s):  
Lower Abdominal Pain ◽  
Thyroid Function Test ◽  
Liver Function Tests ◽  
Focal Neurological Deficit ◽  
Sodium Potassium ◽  
Vesical Calculus ◽  
North Central ◽  
Accident And Emergency ◽  
Function Test ◽  
History Of

A 30-year old male Business man presented at the accident and emergency unit of Abnira Medical Centre in Jos city on account of inability to pass urine for over fifteen hours. There was concomitant excruciating lower abdominal pain and swelling that is tender to touch. A positive history of generalized weakness, fatigue, nausea, heamaturia was given. However, no fever, vomiting, headache nor history of fainting attacks. On examination, he was afebrile, acyanosed with associated tachycardia (pulse rate 121bpm) and tachypnea (respiratory rate of 27c/min).He was oriented in place, person and time with no focal neurological deficit. There were no cardiac and other respiratory signs picked on examination. His abdomen was soft and non-tender, with normal bowel sounds. However, there was renal angle tenderness. Biochemical investigations done on presentation showed normal sodium, potassium, chlorite, and bicarbonate. He has some evidence of dehydration and pre-renal azotemia (increased creatinine, urea and uric acid).His liver function tests, lipase, thyroid function test, phosphate, magnesium and albumin-corrected calcium were all normal.

scholarly journals SKLEROSIS SISTEMIK (SKLERODERMA) TERBATAS PADA SEORANG ANAK LAKI-LAKI

2018 ◽  
Vol 13 (1) ◽  
pp. 31
Author(s):  
M. Tobing ◽  
S. Darmad ◽  
Yuliasih .
Keyword(s):  
Thyroid Function Test ◽  
Liver Function Tests ◽  
Diffuse Fibrosis ◽  
Folic Acid Deficiency ◽  
Schirmer Test ◽  
Internal Organs ◽  
Chronic Disorder ◽  
Acid Deficiency ◽  
Function Test ◽  
History Of

Systemic Sclerosis is a chronic disorder characterized by diffuse fibrosis of the skin and internal organs. The cause of systemicsclerosis is unknown, but immune responses against unknown antigens have been implicated. Symptoms usually appear in the thirdto fifth decades, and women are affected three times more frequent than men. A 13 year old boy presented with hardening of left legskin since 1 year before admittance. He was unable to both hands. The laboratory results showed slighty decreased hemoglobin, normalleucocytes and platelets, increased ESR, normal kidney and liver function tests, positive ANA test (weak), negative ENA and anti Scl-70.Other examination results showed normal X-Ray, Esophagogram, Schirmer test. Thyroid function test showed an euthyroid state. SystemicSclerosis is established based on history of illness, physical examination and laboratory tests. ESR and CRP are increased in systemicsclerosis. Anemia in scleroderma can be due to various causes such as chronic disease, iron deficiency by gastrointestinal bleeding, B12deficiency and folic acid deficiency. ANA test (IIF Hep-2) is positive in 60 –90%. Specific autoantibodies are Scl-70 and anticentromer.The anti Scl-70 can be used for prognosis.

scholarly journals MULTIGRAVIDA WITH UNCONTROLLED HYPERTHYROID AND BILATERAL PLEURAL EFFUSION

2020 ◽  
Vol 4 (2) ◽  
pp. 198-203
Author(s):  
Muhammad Al Farisi Sutrisno ◽  
Herlambang Herlambang ◽  
Firmansyah Firmansyah
Keyword(s):  
Pleural Effusion ◽  
Fetal Heart ◽  
Gestational Hypertension ◽  
Thyroid Function Test ◽  
Bilateral Pleural Effusion ◽  
Thyroid Gland Function ◽  
Drug Of Choice ◽  
Function Test ◽  
History Of ◽  
Gland Function

BACKGROUND: Hyperthyroid is a hypermetabolic condition caused by abnormal thyroid gland function resulting in overproduction and overexpression of thyroid hormone. The prevalence of hyperthyroid during pregnancy is 0.1-0.4%, where 85% of case are presented as grave’s disease. OBJECTIVE: To report the treatment of uncontrolled hyperthyroid during pregnancy.METHOD: Case Report CASE:  Ms. S, Female, 33 years old, presenting with brethlessness since 5 days before admission. Breathlessness persist and aggravated by lying down position. The patient has history of hyperthyroid since 1 years before admission. The blood pressure was 120/80 mmHg, respiration rate 28 times/min, and body temperature 36,7oC. Uterus fundal height 26 cm, cephalic presentation, fetal heart rate 130 times/min, single fetus intrauterine and alive. Laboratoric test for leukocyte: 21,300/ul, T4 level 22.8 mg/dl dan T3 level 2.9 mg/dl. The patient diagnosed with G3P2A0 31-week gestational age single alive fetus intrauterine with uncontrolled hyperthyroid and bilateral pleural effusion. Treatment consist of propylthiouracil as the drug of choice for anti-thyroidal drug, nifedipine for gestational hypertension and furosemide to treat the pleural effusion.  CONCLUSION: History taking, physical examination, thyroid function test, and maintaining euthyroidism during pregnancy is a key to reduce the risk of maternal and fetal complication.KEYWORDS : hyperthyroid, pregnancy, IUGR

scholarly journals Oral antifungal: the safety and efficacy of oral itraconazole in dermatophytosis

2019 ◽  
Vol 8 (11) ◽  
pp. 2470
Author(s):  
Vaishali Thakare ◽  
Nandita K. Patel ◽  
Sharmila Patil ◽  
Navin Modi
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Tertiary Care ◽  
Liver Function Tests ◽  
Hepatic Function ◽  
Care Hospital ◽  
Hepatic Transaminases ◽  
Function Test ◽  
History Of ◽  
Oral Itraconazole

Background: The systemic antifungals like Griseofulvin, Itraconazole, Terbinafine, Ketoconazole and Fluconazole are widely used for superficial fungal infection. Hepatotoxicity with oral antifungals is well established fact. The rate of transient asymptomatic changes in liver function tests accounts for about 0.5 - 10% of all patients treated with systemic antifungals. Clinical hepatic toxicity is seen less frequently. The aim of this study is to evaluate the effect of oral Itraconazole on hepatic function and it’s efficacy in patients with extensive dermatophytosis.Methods: The total of 524 patients with extensive dermatophytosis were included in our study which was conducted in a tertiary care hospital in Navi Mumbai.Results: Itraconazole, a systemic antifungal agent is efficiently used in treatment of superficial and deep mycoses. It inhibits fungal cytochrome P450 dependent enzyme and thus impaires conversion of lanosterol to ergosterol. Adverse reactions to itraconazole includes drug reactions, gastrointestinal upset, headache, dizziness, thrombocytopenia, gynecomastia, reversible edema of extremities and metabolic side effects like hypokalemia, and hypertriglyceridemia. The level of hepatic transaminases increases in about 1%-5% of patients who have received continuous therapy with systemic itraconazole. Clinical hepatitis rarely occurs in patients and, recovery generally ensues with the cessation of medication.Conclusions: The baseline and post treatment liver function test is important to monitor if patient is on higher dose and longer duration of itraconazole therapy. The screening for high risk patients like poor liver function test, history of alcoholism, history of liver disease should be taken before stating the therapy.

scholarly journals Prevalence of Thyroid Dysfunction in Community of Duwakot, Bhaktapur

2017 ◽  
Vol 7 (2) ◽  
pp. 1184-1187
Author(s):  
Binita Pradhan ◽  
Sailesh Bahadur Pradhan
Keyword(s):  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Endocrine Disorders ◽  
Free Triiodothyronine ◽  
Function Test ◽  
History Of ◽  
The Common ◽  
Primary Hyperthyroidism

Background: Thyroid dysfunction is one of the major public health problems in the Nepalese community and of the common endocrine disorders diagnosed in community primary health care centres.  The aim of this study is to analyze the prevalence of Thyroid dysfunction in Duwakot, NepalMaterials and Methods:  All the patients from Duwakot community who presented with the history of weight gain with tiredness and weight loss with palpitation were subjected to thyroid function test free triiodothyronine, free thyroxine and thyroid stimulating hormone. Results: Thyroid dysfunction was  found in 26% with M:F ratio of 1:5.  Subclinical hypothyroidism 62 (11.44%) was the most prevalent one followed by Primary hypothyroidism  48 (8.85%), primary hyperthyroidism 16 (2.95%) and subclinical hyperthyroidism 15 (2.76%).Conclusion: Thyroid dysfuntion has been observed despite of nationwide program regarding supplementation of micronutrient iodised salt.  Key words: Euthyroid, Hyperthroidism, Hypothyroidism, Iodine, Prevalence, Thyroid dysfunction

scholarly journals Pomalidomide-induced hypothyroidism

2017 ◽  
Vol 2017 ◽  
Author(s):  
Sulaiman Haji Ali ◽  
K Aljenaee ◽  
W A Wan Mahmood ◽  
M Hatunic
Keyword(s):  
Multiple Myeloma ◽  
Thyroid Function ◽  
Side Effect ◽  
Reference Range ◽  
Past History ◽  
Thyroid Function Test ◽  
Overt Hypothyroidism ◽  
List Type ◽  
Function Test ◽  
History Of

Summary Hypothyroidism is a recognized side effect of thalidomide drugs. We herein report a case of 83-year-old Irish female with a diagnosis of multiple myeloma and a background history of type 2 diabetes mellitus and hypertension. Our patient received pomalidomide and multiple courses of chemotherapy and achieved very good initial response for her multiple myeloma but subsequently she relapsed. She did not have any past history of thyroid disease or family history of thyroid disorders. Prior to treatment with pomalidomide, her thyroid function test was completely normal. She was commenced on pomalidomide in February 2017. Four weeks post treatment, she presented with worsening fatigue, and as a part of her workup, a thyroid function test was performed. Her free T4 was low at 7.2 pmol/L (reference range: 9.0–20.0) while her TSH was elevated at 44.7 mIU/L (reference range: 0.35–4.94). Pomalidomide treatment was terminated, and she was commenced on thyroid hormonal therapy replacement therapy with thyroxine with good clinical and biochemical response. Practitioners prescribing pomalidomide should be aware of this potential complication and patients who are receiving immunomodulatory drugs like pomalidomide should undergo regular thyroid hormone levels screen. Learning points: Overt hypothyroidism is a side effect of pomalidomide. Thyroid function test should be included as a screening test with regular review in patients receiving pomalidomide. Unexplained worsening fatigue in patients receiving pomalidomide should raise the possibility of overt hypothyroidism.

scholarly journals MULTIGRAVIDA WITH UNCONTROLLED HYPERTHYROID AND BILATERAL PLEURAL EFFUSION

2020 ◽  
Vol 4 (2) ◽  
pp. 167-172
Author(s):  
Muhammad Al Farisi Sutrisno ◽  
Herlambang Herlambang ◽  
Firmansyah Firmansyah
Keyword(s):  
Pleural Effusion ◽  
Fetal Heart ◽  
Gestational Hypertension ◽  
Thyroid Function Test ◽  
Bilateral Pleural Effusion ◽  
Thyroid Gland Function ◽  
Drug Of Choice ◽  
Function Test ◽  
History Of ◽  
Gland Function

Background: Hyperthyroid is a hypermetabolic condition caused by abnormal thyroid gland function resulting in overproduction and overexpression of thyroid hormone. The prevalence of hyperthyroid during pregnancy is 0.1-0.4%, where 85% of case are presented as grave’s disease. Objective: To report the treatment of uncontrolled hyperthyroid during pregnancy.Method: Case Report Case:  Ms. S, Female, 33 years old, presenting with brethlessness since 5 days before admission. Breathlessness persist and aggravated by lying down position. The patient has history of hyperthyroid since 1 years before admission. The blood pressure was 120/80 mmHg, respiration rate 28 times/min, and body temperature 36,7oC. Uterus fundal height 26 cm, cephalic presentation, fetal heart rate 130 times/min, single fetus intrauterine and alive. Laboratoric test for leukocyte: 21,300/ul, T4 level 22.8 mg/dl dan T3 level 2.9 mg/dl. The patient diagnosed with G3P2A0 31-week gestational age single alive fetus intrauterine with uncontrolled hyperthyroid and bilateral pleural effusion. Treatment consist of propylthiouracil as the drug of choice for anti-thyroidal drug, nifedipine for gestational hypertension and furosemide to treat the pleural effusion.  Conclusion: History taking, physical examination, thyroid function test, and maintaining euthyroidism during pregnancy is a key to reduce the risk of maternal and fetal complication.Keywords: hyperthyroid, pregnancy , IUGR

DETERMINATION OF BLOOD CORTICOIDS USING THE IN VITRO RESIN UPTAKE OF 3H-PREDNISOLONE

1968 ◽  
Vol 57 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Hironori Nakajima ◽  
Mitsunori Murala ◽  
Masumitsu Nakata ◽  
Takeshi Naruse ◽  
Seiji Kubo
Keyword(s):  
Thyroid Function Test ◽  
Normal Subjects ◽  
Adrenal Function ◽  
Function Test ◽  
Before And After ◽  
Adrenal Response ◽  
Suppression Test

ABSTRACT The in vitro resin uptake of 3H-prednisolone was used for the determination of blood cortisol after addition of radioactive prednisolone followed by Amberlite CG 400 Type 1 to the test serum, and incubation of the mixture. The radioactivity of the supernatant was compared before and after the addition of the resin. The principle of this method is similar to that of the 131I-triiodothyronine resin uptake for the thyroid function test. The tests for the specificity, reproducibility and sensitivity gave satisfactory results. The mean basal value ± SD of the 3H-prednisolone resin uptake was 35.3 ± 9.2% in normal subjects, and 27.1 ± 4.8% in pregnant women. This method was valid in various adrenal function tests, i. e. the adrenal circadian rhythm, corticotrophin (ACTH) test, dexamethasone suppression test and the adrenal response to lysine-8-vasopressin. It proved to be a sensitive indicator of the adrenal function. These results suggest that this method should be useful for a routine adrenal function test.

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