scholarly journals A Case of Mixed Adenoneuroendocrine Carcinoma of the Stomach With Focal Intestinal Metaplasia and Hypergastrinemia

2015 ◽  
Vol 100 (3) ◽  
pp. 562-567 ◽  
Author(s):  
Hayato Yamauchi ◽  
Shinji Sakurai ◽  
Nobuhiro Nakazawa ◽  
Tomonori Yoshida ◽  
Yuichi Tabe ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
World Health ◽  
Neuroendocrine Neoplasms ◽  
World Health Organization Classification ◽  
Mixed Adenoneuroendocrine Carcinoma ◽  
Japanese Male ◽  
Old Japanese ◽  
History Of ◽  
Health Organization

Among neuroendocrine neoplasms, mixed exocrine and endocrine characteristics with at least 30% of each component are classified into mixed adenoneuroendocrine carcinoma (MANEC), according to the 2010 World Health Organization classification. We experienced a rare case of MANEC of the stomach with focal intestinal metaplasia and hypergastrinemia. A 76-year-old Japanese male was diagnosed as having gastric adenocarcinoma and underwent total gastrectomy. The pathologic diagnosis was MANEC of the stomach accompanied by unusual mucosal atrophy without Helicobacter pylori infection, the characteristics of which were different from both type A and type B atrophic gastritis. The patient has a history of long-term use of a proton pump inhibitor. Additional serum chemistry examination using preoperatively obtained plasma from the patient revealed hypergastrinemia. The mechanism of gastric MANEC carcinogenesis is still unclear, but that might be correlated with unusual intestinal metaplasia and hypergastrinemia in this case.

scholarly journals Lipomatous meningioma: A rare subtype of benign metaplastic meningiomas

2017 ◽  
Vol 08 (01) ◽  
pp. 140-142 ◽  
Author(s):  
Mehmet Onur Yüksel ◽  
Mehmet Sabri Gürbüz ◽  
Osman Tanrıverdi ◽  
Sevilay Akalp Özmen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
World Health ◽  
Histopathological Diagnosis ◽  
Resonance Imaging ◽  
Cranial Magnetic Resonance Imaging ◽  
World Health Organization Classification ◽  
The World ◽  
History Of ◽  
Health Organization

ABSTRACTLipomatous meningiomas are extremely rare subtypes of benign meningiomas and are classified as metaplastic meningioma in the World Health Organization classification. We present a 77-year-old man presented with the history of a gradually intensifying headache for the last 3 months. A right frontoparietal mass was detected on his cranial magnetic resonance imaging. The patient was operated on via a right frontoparietal craniotomy, and histopathological diagnosis was lipomatous meningioma. Distinctive characteristics of lipomatous meningiomas were discussed with special emphasis to importance of immunohistochemical examinations, particularly for its differentiation from the tumors showing similar histology though having more aggressive character.

scholarly journals Co-existence of gastric adenocarcinoma and neuroendocrine carcinoma: a rare entity

2017 ◽  
Vol 7 (2) ◽  
pp. 1221-1223 ◽  
Author(s):  
Nirajan Mainali ◽  
Niraj Nepal ◽  
Prabesh Kumar Choudhary ◽  
Amrita Sinha ◽  
Saroj Rajbanshi ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Partial Gastrectomy ◽  
Endoscopic Biopsy ◽  
World Health ◽  
Neuroendocrine Neoplasms ◽  
World Health Organization Classification ◽  
Well Differentiated ◽  
Health Organization ◽  
Histopathology Examination

A mixed adenoneuroendocrine carcinoma is a tumor composed of both adenocarcinoma and neuroendocrine carcinoma components, with each comprising  at least one-third of the lesion, as defined by the World Health Organization classification of neuroendocrine neoplasms in 2010.. A 67-years-old male was admitted to the hospital with symptoms suggesting gastric cancer. Histopathology examination from endoscopic biopsy revealed adenocarcinoma. Later partial gastrectomy specimen examination the lesion show presence of well differentiated adenocarcinoma along with neuro endocrine carcinoma.

scholarly journals Long-Term GeneXpert Positivity after Treatment for Pulmonary Tuberculosis

2020 ◽  
Author(s):  
Luisa Costantini ◽  
Marco Marando ◽  
Pietro Gianella
Keyword(s):  
Nucleic Acid Amplification Test ◽  
Nucleic Acid Amplification ◽  
World Health ◽  
Diagnostic Process ◽  
The Us ◽  
History Of ◽  
Health Organization ◽  
Positive Results ◽  
Culture Negative

Tuberculosis (TB) is a cause of ill health and death worldwide. Since 2010, the diagnostic process has strongly relied on GeneXpert assays on biological specimens. Xpert MTB/RIF is an automated nucleic acid amplification test (NAAT) for Mycobacterium tuberculosis and rifampicin resistance, endorsed by the World Health Organization and the US Food and Drug Administration. Xpert is used in many countries as the initial diagnostic test for tuberculosis. Nevertheless, the reliability of GeneXpert positive tests in patients with a history of TB is largely unknown, due to possible false-positive results (i.e., GeneXpert-positive but culture-negative patients). We present a case report of a patient with a history of pulmonary TB, who was GeneXpert positive but culture negative on bronchoalveolar lavage 22 months after completion of appropriate antitubercular therapy.

scholarly journals A Clinicopathologic and Molecular Update of Pancreatic Neuroendocrine Neoplasms With a Focus on the New World Health Organization Classification

2019 ◽  
Vol 143 (11) ◽  
pp. 1317-1326 ◽  
Author(s):  
Jiayun M. Fang ◽  
Jiaqi Shi
Keyword(s):  
World Health Organization ◽  
Pancreatic Neuroendocrine Tumor ◽  
Tumor Grade ◽  
Differential Diagnoses ◽  
World Health ◽  
Molecular Characteristics ◽  
Neuroendocrine Neoplasms ◽  
World Health Organization Classification ◽  
Pancreatic Neuroendocrine Carcinoma ◽  
Health Organization

Context.— According to the 2017 World Health Organization classification, pancreatic neuroendocrine neoplasms (PanNENs) include a new category of pancreatic neuroendocrine tumor, grade 3, which is often difficult to differentiate from pancreatic neuroendocrine carcinoma. However, pancreatic neuroendocrine tumor grade 3 and pancreatic neuroendocrine carcinoma are distinct entities with very different clinical presentation, prognosis, and therapeutic strategies. Recent discoveries on the molecular characteristics of pancreatic neuroendocrine tumors also play an essential role in the pathologic differential diagnosis of PanNENs. In addition, the histopathologic varieties of PanNENs bring in many differential diagnoses with other pancreatic neoplasms, especially acinar cell carcinoma, solid pseudopapillary neoplasm, and ductal adenocarcinoma. Objective.— To provide a brief update of the World Health Organization classification; the clinical, histopathologic, immunohistochemical, and molecular characteristics; and the differential diagnoses and biological behavior of PanNENs. Data Sources.— Analysis of the pertinent literature (PubMed) and authors' clinical practice experience based on institutional and consultation materials. Conclusions.— The evolving clinical, histopathologic, immunohistochemical, and molecular features of PanNENs are reviewed. Important differential diagnoses with other neoplasms of the pancreas are discussed.

A Study of Aetiological Factors at Critical Periods of Development in Autistic Children

1973 ◽  
Vol 7 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Sara Williams ◽  
Juliet Harper
Keyword(s):  
Sensory Deprivation ◽  
Working Party ◽  
Infantile Autism ◽  
World Health ◽  
Critical Periods ◽  
Educational Placement ◽  
World Health Organization Classification ◽  
History Of ◽  
Health Organization

Ninety-seven children were diagnosed as suffering from infantile autism according to the nine points of the British Working Party and the World Health Organization classification of Mental Disorders in Childhood. Data on these cases were analyzed in terms of aetiology as known, social class of parents, year of onset, its relationship to the presence of an organic cerebral defect, and outcome in terms of the present educational placement of the child. Findings suggested that infantile autism was a disorder with a multiple aetiology and the causes, both organic and environmental, were interrelated. It was postulated that the most consistent effect present in the early backgrounds of these children was a history of sensory deprivation at a critical period of development.

Mixed Intraepithelial Neoplasia—Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination

2021 ◽  
pp. 106689692098698
Author(s):  
Bence Kővári ◽  
Sándor Turkevi-Nagy ◽  
Gregory Y. Lauwers ◽  
Kun Jiang
Keyword(s):  
Intraepithelial Neoplasia ◽  
World Health ◽  
Neuroendocrine Neoplasms ◽  
Invasive Adenocarcinoma ◽  
World Health Organization Classification ◽  
First Case ◽  
Intraepithelial Neoplasms ◽  
Well Differentiated ◽  
Health Organization ◽  
Neuroendocrine Carcinomas

Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this location. Occasionally, NEN may present as a part of a mixed neoplasm, with a coexisting non-neuroendocrine component. The latest World Health Organization classification denotes these lesions as mixed neuroendocrine–non-NENs (MiNENs). A novel type of MiNEN, the mixed adenoma well-differentiated NET (MANET), has been increasingly recognized and reported. In such lesions, a dysplastic noninvasive neoplasm and a NET represent the exocrine and endocrine component, respectively. MANETs have mostly been identified in the colon, small intestines, and stomach. In this article, we report, we believe, the first case of mixed gallbladder neoplasm with both biliary intraepithelial neoplasia (BilIN) and NET components, which may be regarded as a variant of MANET. Given the expectably favorable prognoses of MANETs, it is imperative not to misdiagnose the infiltrative yet indolent neuroendocrine component as an invasive adenocarcinoma or a NEC.

scholarly journals Increased neutrophil–lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takayuki Miura ◽  
Hideo Ohtsuka ◽  
Takeshi Aoki ◽  
Shuichi Aoki ◽  
Tatsuo Hata ◽  
...  
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Neuroendocrine Neoplasm ◽  
Neuroendocrine Neoplasms ◽  
World Health Organization Classification ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Pancreatic Neuroendocrine Neoplasm ◽  
Well Differentiated ◽  
Health Organization

Abstract Background The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed the ability to predict the recurrence of such markers after curative resection in patients with these neoplasms. Methods Circulating/systemic neutrophil–lymphocyte, monocyte–lymphocyte, platelet–lymphocyte, and platelet–white cell ratios were evaluated in 120 patients who underwent curative resection for well-differentiated pancreatic neuroendocrine neoplasms without synchronous distant metastasis between 2001 and 2018. Recurrence-free-survival and overall survival were compared using Kaplan–Meier analysis and log-rank tests. Univariate or multivariate analyses, using a Cox proportional hazards model, were used to calculate hazard ratios with 95% confidence intervals. Results Univariate analysis demonstrated that preoperative neutrophil–lymphocyte ratio, tumor size, European Neuroendocrine Tumor Society TMN classification, 2017 World Health Organization classification, and venous invasion were associated with recurrence. The optimal preoperative neutrophil–lymphocyte ratio cut-off value was 2.62, based on receiver operating characteristic curve analysis. In multivariate analysis, a higher preoperative neutrophil–lymphocyte ratio (HR = 3.49 95% CI 1.05–11.7; P = 0.042) and 2017 World Health Organization classification (HR = 8.81, 95% CI 1.46–168.2; P = 0.015) were independent recurrence predictors. Conclusions The circulating/systemic neutrophil–lymphocyte ratio is a useful and convenient preoperative prognostic marker of recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification.

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